--- Log opened Fri Feb 15 00:00:01 2013 00:14 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 00:17 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has quit [Ping timeout: 256 seconds] 00:19 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 244 seconds] 00:48 -!- sivoais [~zaki@unaffiliated/sivoais] has quit [Ping timeout: 245 seconds] 00:51 -!- sivoais [~zaki@unaffiliated/sivoais] has joined ##hplusroadmap 01:21 < eleitl> springerkink, huh 01:21 <@kanzure> hahah 01:21 <@kanzure> yes :) 01:21 < eleitl> Is that a real project? 01:21 < eleitl> It better ber. 01:21 < eleitl> That would be indeed glorious to behold. 01:21 <@kanzure> it's in the early idea phase 01:21 <@kanzure> i'm open to suggestions 01:27 < eleitl> I'm swamped. But Rule 34 sounds like a good start. 01:27 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has joined ##hplusroadmap 01:31 < eleitl> Bolide rain over Ural. 50 people hurt. 01:32 < eleitl> The pressure wave broke many windows. 01:33 < eleitl> http://de.rian.ru/society/20130215/265530539.html 01:33 < eleitl> see amateur video there 01:43 <@kanzure> crater: http://www.youtube.com/watch?v=XDYdh7V0vyU 01:46 < eleitl> That's burning coal. 01:47 < eleitl> Sorry, gas. Darvaz: http://www.hoax-slayer.com/door-to-hell.shtml 01:47 < eleitl> Thought I remembered it. 01:52 <@kanzure> darn. 01:53 < eleitl> Real impact craters are different. 01:55 < eleitl> Here's a big local one: http://passc.net/EarthImpactDatabase/ries.html 01:56 < eleitl> 24 km diameter, 14.3-14.5 MYrs 01:56 < eleitl> crater rim still very visible: http://en.wikipedia.org/wiki/File:Ries_Crater_Rim.jpg 02:02 <@kanzure> http://www.youtube.com/watch?v=NuKtVGdPESM http://youtube.com/watch?v=-OAcrmjmHp4 02:02 <@kanzure> living in the future is pretty neat 02:05 <@kanzure> ""We can only register stones coming from the direction of the night sky," Malkov explained." .. seems like a rather critical flaw. 02:08 <@kanzure> eleitl: http://bettercryonics.com/BetterCryonics 02:13 < eleitl> Luke Parrish's work 02:14 < eleitl> News from Parallella: http://www.parallella.org/ 02:15 < eleitl> Zynq-7020 onboard, with 48 FPGA pins, with 8 GByte/s throughput 02:15 < jrayhawk> pretty 02:15 < eleitl> this is begging to implement a custom MPI interface 02:16 < eleitl> with 6 links you'll get 8 pins/link 02:16 < eleitl> maybe even space for a primitive Bresenham router 02:33 < eleitl> Roman will be publishing a guide explaining how to replace the bit stream of the default Parallella Ubuntu 12.04 SD image distribution with a custom bit stream. It is quite straightforward.(as long as the content of the FPGA bitstream is valid..) 02:34 < eleitl> how far can an FPGA pin drive a signal directly? 02:34 < eleitl> 10 cm? 02:35 < archels> It depends on what it is that it's driving. 02:35 < archels> Otherwise, just stick a cheap off-the-shelf buffer on there. 02:35 < eleitl> just FPGA to FPGA, with shorterst distance and smallest cable geometry 02:36 < archels> At a GHz or so, 10 cm should be no trouble at all. 02:36 < eleitl> can you get 1 GByte/s with 8 pins? 02:36 < archels> With the right FPGA, sure. 02:36 < eleitl> Zynq-7020 02:38 < eleitl> http://www.youtube.com/watch?v=RH1DpTOuheI 02:38 -!- cryptic [~cryptic@pool-71-125-31-38.nycmny.fios.verizon.net] has quit [Ping timeout: 255 seconds] 02:39 < archels> eleitl: its DDR3 interface is only 800 Mb/s 02:39 < eleitl> if it's a switch it needs to be able to cut-through 02:39 < eleitl> so it wouldn't need RAM 02:40 -!- Urchin[Emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 248 seconds] 02:41 -!- cryptic [~cryptic@pool-71-125-31-38.nycmny.fios.verizon.net] has joined ##hplusroadmap 02:42 < archels> its internal logic tops out at 1412 MHz for the highest speed grade 02:42 < archels> but achieving 1 GB/s relies on more things than just raw speed 02:42 < eleitl> what does that mean in practical terms? Less than 1 GByte/s througput through each 8 pins? 02:43 < eleitl> 800 MByte/s would be quite ok for MPI 02:43 < eleitl> it's latency that counts 02:43 < eleitl> that way you could keep GBit Ethernet NIC for admin stuff 02:43 < archels> if it's a burst transfer and not sustained, you can probably do it 02:43 < eleitl> thanks, archels 02:44 < archels> sure 02:44 < eleitl> really looking forward to take my board for the spin 02:44 < eleitl> if it's good I'm going to order 8 02:44 < archels> cool, any specific application plans for it or just playing around? 02:45 < eleitl> MD and neural stuff 02:45 < eleitl> I want to see what you can do with 32 kBytes/DSP core 02:45 < eleitl> I think one can do plenty 02:46 < archels> What type of neurons though? 02:46 < eleitl> As biologically realistic as possible. I'll start small, and see how far I can get. 02:46 < eleitl> Something like Openworm would be great. 02:48 < archels> What can the FPGA offer you at this point that a general-purpose processor cannot? 02:48 < eleitl> the FPGA is just for the MPI interface 02:48 < eleitl> the 16-64 DSP cores are for heavy lifting 02:48 < archels> I don't think we're at a point yet where speed is the bottleneck for neural simulations 02:48 < archels> we just don't know what we're doing, mostly :) 02:49 < eleitl> I'm going to start with the smallest numerics footprint I can, and work myself upwards 02:49 < archels> sure, but why on the FPGA board and not on your desktop in NEURON or Moose or so? 02:50 < eleitl> not on the FPGA board 02:50 < eleitl> the FPGA is part of the Epiphany board, so it's free 02:50 < eleitl> the idea is to extend the on-die fabric by MPI in FPGA, for a 3d torus 02:51 < eleitl> the board is credit-card sized, and air-coolable, so you could build a nice cubic latice numerics box 02:51 < archels> that does sound nice, but on the other hand it's going to take a lot of time to implement this, whereas you can have NEURON up and running in about 5 minutes 02:51 < archels> I'm probably being dense, but I don't see the added value if the purpose is neuronal simulation 02:52 < archels> if the purpose is exploring hardware/firmware options for neuronal simulation, then I do see the point 02:53 < eleitl> I need a cheap numerics box that is scalable. 99 USD/board is cheap. 02:53 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 02:54 < eleitl> I want something that can do realtime neurons 02:54 < eleitl> i.e. kHz scale events in realtime on that iron 02:54 < eleitl> something that can scale O(1) by throwing hardware at it 02:55 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 248 seconds] 02:55 < eleitl> 3d lattice with local communication only 02:57 < eleitl> the 16 or 64 DSP cores with embedded memory are effectively local 02:57 < eleitl> the idea is to scale this across a 3d lattice 02:57 < eleitl> it's basically a SHARC cluster on a die 02:58 < eleitl> I very much doubt Neuron would scale across that, especially as O(1) 02:59 < eleitl> O(1) meaning here that your runtime stays constant with problem size if you match that with hardware 03:02 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has quit [Quit: Nettalk6 - www.ntalk.de] 03:04 < archels> ah, realtime emulation--having a scaleable solution for that would be nice. 03:04 < eleitl> yep 03:05 < archels> I'm sure you could still accomplish that on a desktop for the C. elegans brain, but not for brains much larger than that 03:07 < eleitl> I would like 20 kNeurons 03:10 -!- sylph_mako [~mako@103-9-42-11.flip.co.nz] has quit [Ping timeout: 240 seconds] 03:17 < archels> Hmm, how many neurons are there again in an average cortical column? 03:17 < archels> About that order of magnitude? 03:18 < eleitl> maybe 03:18 < eleitl> I'm looking at L. stagnalis 03:18 < archels> oh yes, I recall 03:18 < eleitl> Epiphany is almost an order of magnitude more energy-efficient than Blue Gene/Q 03:19 < eleitl> and a lot cheaper, especially if you can buy them in installments 03:20 < archels> Here, we report the number and distribution of NeuN-positive neurons within the C2, D2, and D3 TC projection columns in P27 rat somatosensory barrel cortex based on an exhaustive identification of 89 834 somata in a 1.15 mm3 volume of cortex. A single column contained 19 109 ± 444 neurons (17 560 ± 399 when normalized to a standard-size projection column). 03:22 < archels> then of course we can debate about the functional role of glia... 03:24 < eleitl> the glia don't seem to require a lot of crunch 03:24 < eleitl> so cortical column, just 20 kNeurons? 03:24 < eleitl> that's quite small 03:25 < eleitl> so ~1 mm^3, 20 kNeurons? 03:36 < archels> it's probably an underestimation, as they only looked at NeuN positive cells. 03:37 < eleitl> still, as an order of magnitude estimate it's a good thing to know 03:40 < eleitl> DARPA and UPMC collaboration -- Direct control of prosthetic arm by tetraplegic individual. Electrodes wired into cortex. Watch out for tactile 03:40 < eleitl> +feedback and wireless interface coming soon. 03:41 < eleitl> http://www.yousendit.com/download/UW16YUlqMGNKV1A0WjlVag 03:51 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:53 -!- wizrobe [~aserid@c-76-23-254-105.hsd1.ct.comcast.net] has quit [Ping timeout: 248 seconds] 03:56 -!- eudoxia [~eudoxia@r186-53-134-93.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 04:21 < archels> "We are all interested in the future, for that's where we'll be spending the rest of our lives" --Free The Robots 04:27 -!- Mariu [Jimmy98@89.41.57.33] has joined ##hplusroadmap 04:30 * eleitl has no future 04:30 < eudoxia> it's ok eleitl, if any of the cryo orgs go bankrupt we'll go in and steal your head 04:31 < eleitl> it's probably going to be my own cryo org :/ 04:31 < eleitl> speaking of which, I probably have vitrified some VM-1 yesterday. I haven't had time to look yet. 04:32 < Mariu> :p 04:32 < Mariu> nice one, eudoxia 04:32 < eleitl> first dewar fill blew through some 95 l 04:33 < eleitl> I'm still not convinced the vacuum is very good. but, it will do for time being. 05:16 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 276 seconds] 05:16 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 05:24 < strangewarp> Waking up to meteor videos is pretty weird 05:24 < Mariu> oh 05:40 -!- augur [~augur@208.58.5.87] has quit [Remote host closed the connection] 05:53 <@kanzure> http://aws.amazon.com/redshift/ seems to offer 16 TB storage for $1000/TB-year if you pay $24k up front 05:59 <@kanzure> it's crazy how little space we have available 06:01 <@kanzure> mega.co.nz offers 4 TB for $25/mo 06:02 -!- ManaLord [~manalord@c-4b90e455.37-0081-74657210.cust.bredbandsbolaget.se] has joined ##hplusroadmap 06:05 <@kanzure> heh they are asking for 20 TB minimum per hosting offer https://mega.co.nz/#hosting 06:12 <@kanzure> opera owns the admarvel ad network? 06:22 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has joined ##hplusroadmap 06:47 -!- wizrobe [~aserid@c-76-23-254-105.hsd1.ct.comcast.net] has joined ##hplusroadmap 07:14 -!- eudoxia [~eudoxia@r186-53-134-93.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving] 07:42 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap 08:23 -!- wizrobe [~aserid@c-76-23-254-105.hsd1.ct.comcast.net] has left ##hplusroadmap [] 08:35 -!- eleitl [~root@beryllium.ativel.com] has quit [Quit: Lost terminal] 08:40 -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 08:41 -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 08:43 -!- wizrobe [~userdi@c-76-23-254-105.hsd1.ct.comcast.net] has joined ##hplusroadmap 08:44 -!- yashgaroth [~ffffff@cpe-66-27-118-94.san.res.rr.com] has joined ##hplusroadmap 08:54 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 08:57 -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 256 seconds] 09:00 -!- u-metacognition [~metacogni@99-7-58-96.lightspeed.davlca.sbcglobal.net] has quit [] 09:06 <@kanzure> hosted phantomjs scraping http://tubes.io/ 09:07 -!- nully [elisa@funkykitty.net] has quit [Read error: Operation timed out] 09:07 -!- nully [elisa@funkykitty.net] has joined ##hplusroadmap 09:17 -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 10:55 -!- delinquentme [~asdfasdf@c-69-181-214-53.hsd1.ca.comcast.net] has joined ##hplusroadmap 10:56 -!- BioGuy [~BioGuy@184-76-124-69.war.clearwire-wmx.net] has joined ##hplusroadmap 10:57 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has quit [Read error: Connection reset by peer] 10:57 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has joined ##hplusroadmap 11:08 < archels> Betteridge's law of headlines is an adage that states, "Any headline which ends in a question mark can be answered by the word no." 11:09 <@kanzure> there's a law of laws that says that invariably someone will bring that up in response to a headline like that 11:09 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has quit [Read error: Connection reset by peer] 11:09 -!- augur_ [~augur@129-2-129-35.wireless.umd.edu] has joined ##hplusroadmap 11:09 <@kanzure> delinquentme: have you met SphericalMouse at biocurious yet? 11:10 < delinquentme> nah havn't b een down there yet 11:10 < delinquentme> just attempted to join the langton labs group 11:10 < delinquentme> kanzure, also does anyone in SF that you know need a roomie? 11:11 <@kanzure> langton labs is chronically overbooked 11:11 <@kanzure> klafka might want a roommate. josh gourneau asks often too, i think. 11:12 < klafka> i'm full up atm 11:12 < nmz787> delinquentme: how's SF so far? 11:13 < delinquentme> nmz787, wild 11:13 < delinquentme> i need to do moar 11:13 < nmz787> so there's a kid in the science class I'm teaching who has diabetes... should I mention genetic engineering to him? 11:13 < nmz787> delinquentme: i found SF was too expensive for me to get out much 11:14 < Mariu> delinquentme: what does SF stand for ? 11:14 < nmz787> whether it was taking the train, or paying for parking... 11:14 < delinquentme> *shrug* 11:14 <@kanzure> Mariu: san francisco 11:14 < Mariu> thanks, kanzure 11:14 <@kanzure> nmz787: which diabetes? 11:14 <@kanzure> actual diabetes or the other one? 11:14 < nmz787> i think type 1 11:15 < nmz787> cause he can't eat the snacks the other kids get 11:15 < nmz787> i dunno if it's connected at all, but his dad is blind too 11:15 < nmz787> he sits outside the classroom, I think to give him meds before or afterwards 11:15 < nmz787> i think 11:16 < nmz787> he could just be paranoid after all that shooting crap 11:16 < nmz787> hah, on that topic... the school nor volunteer agency ever asked for any paperwork or IDs 11:16 < nmz787> they know my email address and name from that 11:18 < klafka> i've never been asked for anything either for any job 11:18 < klafka> my work now apparently thought i had a phd for a month after i joined 11:18 < klafka> even though i explicitly told several people i never finished it 11:18 < nmz787> lol 11:18 < nmz787> do u? 11:18 < klafka> i didn't finish it 11:19 < klafka> it's listed on my resume but it's like 2 years 11:19 < nmz787> ur extra smrt, finish phd in 2 years 11:19 < klafka> unless i'm stephen wolfram 11:25 -!- sylph_mako [~mako@103-9-42-11.flip.co.nz] has joined ##hplusroadmap 11:53 -!- docl [~docl@unaffiliated/docl] has joined ##hplusroadmap 11:59 < chris_99> with companies that hold plasmids, do they use PCR to replicate the DNA? 12:03 <@kanzure> there's a popular yeast method of copying plasmids 12:03 < chris_99> ooh interesting 12:09 < chris_99> is there a way to know what DNA will actually function in different cells, for instance with http://2007.igem.org/Edinburgh/Yoghurt/Design#Lemon_Flavour_Production how do they know it'll function in lactobacillus and ecoli, do they actually have to test it, or is there a clever way to know 12:11 -!- BioGuy [~BioGuy@184-76-124-69.war.clearwire-wmx.net] has quit [Ping timeout: 260 seconds] 12:12 < yashgaroth> who uses yeast for amplifying plasmid? 12:13 <@kanzure> maybe i am misremembering 12:13 <@kanzure> chris_99: the answer to your question is yes ;) 12:13 < yashgaroth> "Unfortunately all three of the genes responsible for lemon flavour synthesis have three or more forbidden restriction sites, making their isolation and insertion into biobricks impossible within a short period of time" pffft haha 12:13 <@kanzure> yes they have to test it 12:13 < chris_99> oh 12:13 < chris_99> darn 12:13 < chris_99> that's a bit of a pain surely 12:14 <@kanzure> and yes there is a "clever way to know".. this looks like only one or two enzymes they need to insert. 12:14 < yashgaroth> you can make an educated guess, there are maps of what precursors a species will have, so you gotta make sure those are present 12:14 <@kanzure> chris_99: this is less painful than the majority of other things in biology 12:14 <@kanzure> yep.. but then you also run the risk of things not folding because ph or something 12:14 -!- augur_ [~augur@129-2-129-35.wireless.umd.edu] has quit [Remote host closed the connection] 12:14 <@kanzure> or maybe it doesn't get expressed because you forgot to do codon optimization 12:14 < yashgaroth> true, but you can factor those in 12:15 < yashgaroth> mostly this stuff is metabolic engineering; even if it works and expresses, you're probably only gonna get femtograms of product 12:15 < yashgaroth> so you're tweaking a hundred other genes to generate more substrate, which each require tweaking of their upstream genes, etc 12:16 < chris_99> gotcha 12:17 < yashgaroth> e.g. they eventually got yeast to make arteminisinininin but their final expression was a million-fold higher than when they just shoved the genes in 12:17 < yashgaroth> sorry, artemisinin, that word gives me a stroke 12:17 < chris_99> had to google, that, anti-malaria drug right 12:17 <@kanzure> burnhousesdownisin 12:19 < yashgaroth> chris_99 yep it was previously only made by some shitty plant in small quantities 12:19 < chris_99> heh 12:28 < chris_99> "We analyzed this first beer for limonene content via headspace (SPME needle) GC-MS. Unfortunately we could not yet proof a significant difference between the beer containing limonene and the negative control beer." pity 12:34 -!- archbox_ [~archie@unaffiliated/archbox] has quit [Quit: bye] 12:37 < nmz787> chris_99: generally the first educated guess is to try promoters from other gram-similar species 12:38 < nmz787> a lot of these bugs have small plasmids naturally, so you can often isolate them, then try shoving them in some similar (or not so similar) species to see if it works 12:38 < nmz787> then lots of tweaking and shit like yashgaroth said 12:40 < chris_99> what's gram-similar mean? 12:44 < nmz787> well like you have gram-negative 12:44 < nmz787> and gram-positive 12:45 < nmz787> so a plasmid from a gram-negative will sometimes work in other gran-negatives, just like that 12:45 < nmz787> i mean, unmodified 12:45 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has joined ##hplusroadmap 12:46 < nmz787> so you could theorhetically just be grabbing plasmids from moldy crap in your fridge :P 12:46 < nmz787> rotten but not moldy stuff would work too 12:46 < nmz787> since mold refers to eukaryotes 12:48 < yashgaroth> going to LA, bbl 12:48 -!- yashgaroth [~ffffff@cpe-66-27-118-94.san.res.rr.com] has quit [Quit: Leaving] 12:49 -!- delinquentme [~asdfasdf@c-69-181-214-53.hsd1.ca.comcast.net] has quit [Ping timeout: 252 seconds] 12:49 < chris_99> gotcha, that's interesting 13:40 -!- ManaLord [~manalord@c-4b90e455.37-0081-74657210.cust.bredbandsbolaget.se] has quit [Quit: Leaving] 14:01 -!- augur [~augur@129-2-129-35.wireless.umd.edu] has quit [Remote host closed the connection] 14:01 < nmz787> what's the belgian biohack space? 14:44 -!- delinquentme [~asdfasdf@c-50-131-222-207.hsd1.ca.comcast.net] has joined ##hplusroadmap 14:57 -!- delinquentme [~asdfasdf@c-50-131-222-207.hsd1.ca.comcast.net] has quit [Ping timeout: 255 seconds] 14:58 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] 15:12 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:20 < streety> has anyone pulled datasets from https://www.ncbi.nlm.nih.gov/geo/ and repeated the analyses presented in the papers the dataset was taken from? 15:42 <@kanzure> paperbot: http://genomebiology.com/2013/14/1/104 15:42 < paperbot> no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/f8014bac78038f967709f7cc939d0bd8.txt 15:42 <@kanzure> paperbot: http://genomebiology.com/content/pdf/gb-2013-14-1-104.pdf 15:42 < paperbot> no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/9290087e7f8e79bbfc211b17b085bf8a.txt 15:46 < juri_> ugh. my reading list could kill a small child. 15:47 -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 15:50 -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 248 seconds] 16:12 < abetusk> Did you guys see this: http://www.kickstarter.com/projects/254134422/finding-genes-to-create-perennial-crops 16:14 < ParahSailin> hes not gonna do anything useful with that experiment 16:18 < abetusk> ah, no? 16:18 -!- delinquentme [~asdfasdf@199.241.200.238] has joined ##hplusroadmap 16:20 < abetusk> why not? 16:23 < abetusk> ParahSailin 16:35 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 16:36 <@kanzure> "The market is relatively small compared to smart phones for example but is a huge market ( about 40 BB for life science tools and probably 200BB for diagnostics)" 16:40 -!- delinquentme [~asdfasdf@199.241.200.238] has quit [Ping timeout: 252 seconds] 16:46 <@kanzure> $40B sounds pretty huge to me. 17:02 < ParahSail1n> abetusk, wetlab intuition 17:03 < ParahSail1n> or maybe that disillusionment is just the reason i didnt make it through grad school 17:03 <@kanzure> win 81 17:03 <@kanzure> ack. 17:22 -!- SphericalMouse [62cfd610@gateway/web/freenode/ip.98.207.214.16] has joined ##hplusroadmap 17:24 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has joined ##hplusroadmap 17:37 <@kanzure> SphericalMouse: welcome back 17:37 <@kanzure> Juul: sup 17:37 < Juul> kanzure, learning about oxy-acetylene cutting. Do you have expertise in that area? 17:38 < illusive> get a decent mask 17:39 < illusive> goggles wont keep your beard from catching fire 17:39 <@kanzure> i screwed up a part once, but that's the only time i used an oxy-acetylene torch. 17:39 -!- soylentbomb [~k@d149-67-118-140.col.wideopenwest.com] has joined ##hplusroadmap 17:39 -!- soylentbomb [~k@d149-67-118-140.col.wideopenwest.com] has quit [Changing host] 17:39 -!- soylentbomb [~k@unaffiliated/soylentbomb] has joined ##hplusroadmap 17:39 < Juul> hehe yeah 17:40 < Juul> i'm trying to figure out if the connections are standardized 17:40 < illusive> well if you have to diy 17:40 < illusive> at least youll know whats best to use 17:42 < Juul> mmm 17:42 < Juul> i'm a total noob at this. i didn't even know there was a specific cutting attachment 17:44 < SphericalMouse> yoyo 18:01 <@kanzure> hah i didn't know this part, 18:01 <@kanzure> "This power was used to raise money for the Crown, and was widely abused, as the Crown granted patents in respect of all sorts of common goods (salt, for example). Consequently, the Court began to limit the circumstances in which they could be granted." 18:01 <@kanzure> "After public outcry, James I of England was forced to revoke all existing monopolies and declare that they were only to be used for "projects of new invention". This was incorporated into the Statute of Monopolies in which Parliament restricted the Crown's power explicitly so that the King could only issue letters patent to the inventors or introducers of original inventions for a fixed number of years." 18:08 <@kanzure> weird "England issued its first patents under Elizabeth I and established a patent system in the Statute of Monopolies of 1624, the country's first antitrust law as well as its first patent law (barring all monopolies except over disclosed inventions)." 18:23 -!- illusive is now known as mutagen 18:46 -!- SphericalMouse [62cfd610@gateway/web/freenode/ip.98.207.214.16] has quit [Ping timeout: 245 seconds] 19:05 -!- qu-bit_ [~shroedngr@gateway/tor-sasl/barriers] has joined ##hplusroadmap 19:06 <@kanzure> it's too bad that pastebins fail for data with weird character encodings 19:07 -!- qu-bit [~shroedngr@gateway/tor-sasl/barriers] has quit [Ping timeout: 276 seconds] 19:08 -!- delinquentme [~asdfasdf@c-69-181-214-53.hsd1.ca.comcast.net] has joined ##hplusroadmap 19:08 < delinquentme> yeeeeee 19:08 < delinquentme> soo I'm now a resident 19:08 < delinquentme> fenn, you wan get beer?? 19:09 < delinquentme> ParahSail1n, you around? 19:09 <@kanzure> neither of those two people live in SF 19:09 < delinquentme> O_o;; really? 19:12 < Juul> delinquentme, where'd you end up living? 19:15 < delinquentme> Juul, I'm in the mission atm! 19:15 < delinquentme> for the next 2 months 19:15 < delinquentme> so I'm gonna see how that works out ... and I"ll check to see whats going on with some of the other areas 19:15 < delinquentme> which is kind of what the issue is ... 19:16 < delinquentme> I need to see more of oakland before I move there ... like find out where the hangout spots are 19:17 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has quit [Ping timeout: 276 seconds] 19:21 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has joined ##hplusroadmap 19:22 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has quit [Client Quit] 19:22 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has joined ##hplusroadmap 19:23 < delinquentme> Juul, are there any late night coffee shops? 19:23 < delinquentme> Farleys was decent 19:23 < Juul> delinquentme, where? 19:23 < delinquentme> oakland 19:24 < Juul> sudo room 19:24 < delinquentme> haha this is true 19:25 < Juul> there are a couple of places that advertise 24/7 but the signs are so old that i wouldn't trust them 19:26 < Juul> like the "24/7" burger joint outside sudo room that closes whenever they feel like 19:26 < delinquentme> hahah 19:26 < delinquentme> not bad! 19:29 -!- u-metacognition [~metacogni@99-7-58-96.lightspeed.davlca.sbcglobal.net] has joined ##hplusroadmap 19:30 < delinquentme> Juul, can sudo room get mail? 19:31 < Juul> delinquentme, hm, I don't know. why? 19:31 < delinquentme> For ordering parts 19:31 < delinquentme> shakers , laser cut stuff 19:32 < Juul> nah, there's no-one to receive it 19:32 < delinquentme> and what about cutting utensils ? Is there anything that could chop masonite? 19:32 < Juul> biocurious has a package reception service 19:33 < ParahSail1n> delinquentme, im around 19:33 < Juul> delinquentme, chop it? there are power saws 19:34 < delinquentme> awesome. 19:34 < delinquentme> ParahSail1n, I thought you were in SF 19:34 < delinquentme> but it turns out im wrong haha 19:34 < ParahSail1n> nope 19:41 -!- BioGuy [~BioGuy@c-24-21-161-30.hsd1.or.comcast.net] has joined ##hplusroadmap 19:42 < delinquentme> SO I'm trying to think of some of the kids who I should be bumping shoulders with 19:44 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 19:51 < delinquentme> Juul, do you guys usually hang there through the weekends? 19:51 < Juul> delinquentme, there are generally always people there in the afternoons and evenings yeah. 19:51 < Juul> + sunday evening is cleanup 19:52 < delinquentme> ok wicked 19:55 < ParahSail1n> lol http://www.iamdann.com/2013/02/15/magnet-implants-can-actually-be-pretty-annoying 20:19 <@kanzure> jrayhawk: which versions of linux does CVE-2013-0871 effect? it doesn't seem obvious to me. 20:20 < docl> grr, I can't find anything on perfusing a chicken eye. 20:20 -!- docl [~docl@unaffiliated/docl] has quit [Quit: leaving] 20:33 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Remote host closed the connection] 20:34 -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has quit [Ping timeout: 276 seconds] 20:36 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 20:36 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 20:38 -!- BioGuy [~BioGuy@c-24-21-161-30.hsd1.or.comcast.net] has quit [Ping timeout: 255 seconds] 20:42 -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap 20:46 < nmz787> paperbot: http://pubs.acs.org/doi/abs/10.1021/j100114a038 20:46 < paperbot> error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Analysis%20of%20resolution%20in%20DNA%20sequencing%20by%20capillary%20gel%20electrophoresis.pdf 20:47 < delinquentme> SO 20:47 < delinquentme> so called "biologics" 20:47 < delinquentme> are simply more complex than the normal pharma we're used to 20:48 < delinquentme> IE an organism vrs a chemical 20:49 < nmz787> you gotta think about post-translational modification and shit 20:49 < nmz787> or maybe one company uses a slightly different gene sequence 20:49 < nmz787> mostly the same protein, but how similar does it need to be? 20:50 < nmz787> that's the grey area of biologics 20:50 < nmz787> paperbot: http://pubs.acs.org/doi/abs/10.1021/bi00688a010 20:50 < paperbot> error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Chain%20length%20determination%20of%20small%20double-%20and%20single-stranded%20DNA%20molecules%20by%20polyacrylamide%20gel%20electrophoresis.pdf 21:00 < jrayhawk> haha "cobol on cogs" 21:04 < ParahSail1n> lol 21:22 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Quit: the neuronal action potential is an electrical manipulation of reversible abrupt phase changes in the lipid bilayer] 21:24 < JayDugger> Good evening, everyone. 21:25 < ParahSail1n> hi 21:28 < delinquentme> nmz787, a biologic is more than just a sequence though right? 21:28 < delinquentme> its an actual running organism 21:47 -!- mutagen [~safitan@75-105-12-23.cust.wildblue.net] has quit [Read error: Connection reset by peer] 21:48 -!- mutagen [~safitan@75-105-12-23.cust.wildblue.net] has joined ##hplusroadmap 21:57 -!- soylentbomb [~k@unaffiliated/soylentbomb] has quit [Quit: Leaving] 22:00 -!- lupfantomo [~lupfantom@24-159-24-229.dhcp.jcsn.tn.charter.com] has joined ##hplusroadmap 22:24 -!- Juul [~Juul@50-0-83-116.dsl.static.sonic.net] has quit [Quit: Leaving] 22:25 -!- delinquentme [~asdfasdf@c-69-181-214-53.hsd1.ca.comcast.net] has quit [Ping timeout: 255 seconds] 22:46 -!- qu-bit_ [~shroedngr@gateway/tor-sasl/barriers] has quit [Remote host closed the connection] 22:53 -!- qu-bit [~shroedngr@gateway/tor-sasl/barriers] has joined ##hplusroadmap 22:54 -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 22:58 -!- mutagen is now known as sardonic 23:19 -!- ManaLord [~manalord@c-9ebae455.37-0081-74657210.cust.bredbandsbolaget.se] has joined ##hplusroadmap 23:24 <@kanzure> why is this private https://groups.google.com/group/biocurious-printer-hacking --- Log closed Sat Feb 16 00:00:02 2013