--- Log opened Fri Mar 01 00:00:14 2013
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02:35 <@kanzure> "Though not sure why go the X-Y rectangular axis system at all, and why inkjet technology is needed as the liquid dispenser (which brings with it significant challenges, i.e. clogging, pore size, etc).  You had the working compact disc drive mechanisms with their working polar-axis control system (linear actuator for 'r', drive spindle for theta; perhaps replace the spindle motor with stepper for easy positioning without requiring an encoder ...
02:35 <@kanzure> ... wheel).  Petri dishes are already circular so would integrate well directly with the existing polar (i.e. rotational) disc drive mechanism, i.e. spin the dish and address points in the dish via sector (angle) and track (radius).  The liquid dispensing could be done by very small diameter tubing run through a peristaltic pump from a large well/beaker source which dispenses drops as needed from above, positioned via the linear actuator -- ...
02:35 <@kanzure> ... such pumps are very accurate, to uL's or nL's.  Add multiple lines from multiple pumps for dispensing multiple reagents, arrange these in a row on the radial axis."
02:35 <@kanzure> "X-Y axis as seen in typical lab robotics is needed to mimic the positioning of humans with minds trained for cartesian addresses and grasping by the shape of human hands which have thumbs.  Motors on robots do not have good thumbs, they have spinning shafts and work better with polar axis.  Which is why hard drives, compact discs, floppies, are all circular, rather than square.  When designing new machines and automating protocols, fit the ...
02:35 <@kanzure> ... protocol/equip to the new machine not based on human limitations for best results, rather than build a machine which for traditional/limiting human-style equipment. If there are points to the contrary I'd love to hear them."
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04:35 < streety> paperbot: http://ajrccm.atsjournals.org/content/185/7/744.long
04:35 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/596d7dbd5f7503984c699e48b69ce92c.txt
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04:55 < archels> http://www.frontiersin.org/news/Nature_Publishing_Group_and_Frontiers_form_alliance_to_further_open_science/266
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06:38 < eudoxia> so we hooked up two mice brains and AlonzoTG isn't here talking about how they stole his idea?
06:38 < eudoxia> (i haven't yet read the paper please don't kill me)
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07:07 <@kanzure> "It sees itself as something of an Amazon.com for genomic sequencing. It does not own the content, but through the ecosystem it is setting up, it is facilitating the interaction between physicians, researchers and the interpreters of that data. The company is making it easier to order, store and interpret genome sequence data for physicians.
07:07 <@kanzure> Read more: http://medcitynews.com/2013/02/cloud-based-genomic-sequencing-exchange-could-make-personalized-medicine-easier-for-physicians/#ixzz2MIiHSKrT"
07:07 <@kanzure> oh fuck that site
07:27 <@kanzure> http://www.nature.com/news/neuroscience-as-the-worm-turns-1.12461
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09:42 <@kanzure> heh transcriptic is only three people.
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10:31 < klafka> http://arstechnica.com/tech-policy/2013/03/download-this-gun-3d-printed-semi-automatic-fires-over-600-rounds/
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10:49 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a650c87b Bryan Bishop: another biocurious article
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17:44 <@kanzure> "For those in emerging markets, the problem is compounded. Thai biotech organisations currently pay Malaysian foundries 60 cents/base pair for oligonucleotides (>1 week delivery) and pay 3x what we do for PCR reagent kits and enzymes (also taking several weeks). Gene synthesis costs more than a dollar/base pair and the costs and timeframes for sequencing are similarly unacceptable. It seems the dominance of gene foundry models in the West ...
17:44 <@kanzure> ... cannot easily be translated onto the rest of the world. In emerging markets, it is thus much harder to make DNA a commodity in the same way that it is becoming one in our own."
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19:05 <@kanzure> "I recently came across a company (haven't used them yet) that has developed an NGS service marketplace, basically trying to find and sell "excess capacity": http://www.blueseq.com/ "
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21:55 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e09ea6ee Bryan Bishop: biocurious bioprinter news articles
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