--- Log opened Wed May 22 00:00:34 2013 00:02 < kanzure> ugh http://bamh1.com/2013/05/22/the-renaissance-of-citizen-science-and-the-emergence-diy-bio-start-ups/ 00:03 < kanzure> how is it diy if you are venture backed, ryan. 00:12 < nmz787> paperbot: http://pubs.acs.org/doi/pdf/10.1021/ed074p1055 00:12 < paperbot> error: HTTP 200 http://diyhpl.us/~bryan/papers2/paperbot/Vanillin%3A%20Synthetic%20Flavoring%20from%20Spent%20Sulfite%20Liquor.txt 00:13 < nmz787> sci-hub didn't like that link either 00:16 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 00:26 < kanzure> "Fpv-Uho (fpv-uho.bet) – This offers proxy access through ~20 different university libraries. It worked well on a few papers that I wasn't able to access otherwise. This should be especially useful if you don't normally have VPN access to a library. (If the current proxy doesn't have access to your paper, just click the refresh icon on the right to switch to another proxy.) Again, looks like you'll need a non-US IP." 00:26 < kanzure> so sci-hub is just using 20 schools. 00:26 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 00:27 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ed22907e Bryan Bishop: diybio in pittsburgh 00:27 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cd4fd2c3 Bryan Bishop: where to find pdfs 00:49 < nmz787> where could i find someone to take two images and photoshop them into an svg? 00:49 < nmz787> like for pay 00:49 < nmz787> i think $10 would be good 00:51 < kanzure> fiverr? 00:52 < DonnchaC> Is that site online? fpv-uho? 00:53 < kanzure> DonnchaC: that's rot13 of sci-hub.org 00:53 < kanzure> http://diyhpl.us/wiki/articles 00:57 < DonnchaC> ah right ;) 01:40 -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap 01:48 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 02:28 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has quit [Ping timeout: 248 seconds] 02:36 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap 02:51 < nmz787> paperbot: Jonsson 02:51 < nmz787> paperbot: http://www.sciencedirect.com/science/article/pii/S0960852411008844?np=y 02:52 < paperbot> no translator available, raw dump: http://diyhpl.us/~bryan/papers2/paperbot/Enhanced%20resistance%20of%20.pdf 02:52 < nmz787> paperbot: http://link.springer.com/article/10.1007/s002530051233 02:52 < paperbot> error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Detoxification%20of%20wood%20hydrolysates%20with%20laccase%20and%20peroxidase%20from%20the%20white-rot%20fungus%20Trametes%20versicolor.pdf 03:13 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:23 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has joined ##hplusroadmap 04:05 -!- makoLime [~mako@103-9-42-128.flip.co.nz] has quit [Ping timeout: 246 seconds] 04:14 -!- Burninate [~Burn@pool-108-18-159-219.washdc.fios.verizon.net] has quit [Ping timeout: 248 seconds] 04:19 < Kliment> How does paperbot work? 04:23 -!- OldCoder_ [~OldCoder_@adsl-64-169-36-85.dsl.snfc21.pacbell.net] has joined ##hplusroadmap 04:32 -!- kajetan [122@unaffiliated/kmo] has quit [Quit: Leaving] 04:32 -!- kmo [122@d30-138.icpnet.pl] has joined ##hplusroadmap 04:32 -!- kmo [122@d30-138.icpnet.pl] has quit [Changing host] 04:32 -!- kmo [122@unaffiliated/kmo] has joined ##hplusroadmap 04:33 -!- kmo is now known as kajetan 04:43 -!- OldCoder_ [~OldCoder_@adsl-64-169-36-85.dsl.snfc21.pacbell.net] has quit [Remote host closed the connection] 04:50 -!- OldCoder_ [~OldCoder_@adsl-64-169-36-85.dsl.snfc21.pacbell.net] has joined ##hplusroadmap 05:11 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 256 seconds] 05:26 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 05:29 -!- helleshin [~talinck@69-61-156-24.ubr1.dyn.lebanon-oh.fuse.net] has quit [Ping timeout: 256 seconds] 05:46 -!- ThomasEgi [~thomas@185.5.8.81] has joined ##hplusroadmap 05:46 -!- ThomasEgi [~thomas@185.5.8.81] has quit [Changing host] 05:46 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 06:16 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 06:19 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 264 seconds] 06:30 -!- ryankarason is now known as rk[fishing] 07:20 -!- kanzure [~kanzure@131.252.130.248] has quit [Ping timeout: 264 seconds] 07:20 -!- kanzure [~kanzure@131.252.130.248] has joined ##hplusroadmap 07:39 -!- helleshin [~talinck@69-61-156-24.ubr1.dyn.lebanon-oh.fuse.net] has joined ##hplusroadmap 07:45 -!- kajetan [122@unaffiliated/kmo] has quit [Quit: Leaving] 07:54 -!- underscor [~quassel@192.210.211.75] has quit [Ping timeout: 256 seconds] 08:45 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap 08:59 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 09:01 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 09:02 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 09:11 -!- kmo [~kmo@apn-37-247-248-49.dynamic.lte.plus.pl] has joined ##hplusroadmap 09:11 -!- kmo [~kmo@apn-37-247-248-49.dynamic.lte.plus.pl] has quit [Changing host] 09:11 -!- kmo [~kmo@unaffiliated/kmo] has joined ##hplusroadmap 09:33 < kanzure> Kliment: https://github.com/kanzure/paperbot 09:33 < yoleaux> 09:55Z kanzure: likely you've seen it already, but: https://github.com/ricardobeat/filr 09:34 < kanzure> how kind of him (too bad he's slow) 10:12 -!- klafka [~klafka@204-16-157-18-static.ipnetworksinc.net] has joined ##hplusroadmap 11:00 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has quit [Ping timeout: 276 seconds] 11:00 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has joined ##hplusroadmap 11:33 -!- makoLime [~mako@103-9-42-128.flip.co.nz] has joined ##hplusroadmap 12:38 -!- DonnchaC_ [~donncha@tor.totalimpact.ie] has joined ##hplusroadmap 12:38 -!- zubaz_ [~hexane@24.229.127.72] has joined ##hplusroadmap 12:42 -!- Netsplit *.net <-> *.split quits: zubaz, DonnchaC, abumirqaan 12:42 -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap 13:25 -!- ianmathwiz7 [~chatzilla@68-115-57-210.static.eucl.wi.charter.com] has joined ##hplusroadmap 13:30 < brownies> "In Canada 80% of postdocs earn $38,600 or less per year before tax—the average salary of a construction worker." 13:30 < brownies> how glamorous! 13:42 < kanzure> just think of all that awesome cheap science talent 13:42 < kanzure> i should hire a postdoc just to sit around thinking up death rays or something. 13:42 -!- esclepius [~userdi@c-76-23-254-105.hsd1.ct.comcast.net] has left ##hplusroadmap [] 13:52 -!- makoLime [~mako@103-9-42-128.flip.co.nz] has quit [Ping timeout: 256 seconds] 14:19 -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 260 seconds] 14:44 -!- FooQuuxm1n [~test@c-68-58-79-145.hsd1.il.comcast.net] has joined ##hplusroadmap 14:48 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has quit [Ping timeout: 256 seconds] 14:50 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 14:53 -!- abumirqaan [uid2969@gateway/web/irccloud.com/x-slehvbpfmflkrolv] has joined ##hplusroadmap 15:03 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Read error: Connection reset by peer] 15:13 -!- zdap [~not@69.158.79.13] has quit [Read error: Connection reset by peer] 15:13 < kanzure> "The problem with a modern web browser project is it's expensive to operate. All the ones I know of have extensive regression test suites, both correctness and performance, that get run from continuous integration systems in multiple configurations and on multiple platforms. That's not to mention the continuous fuzz testing farms looking for security bugs. I'm most familiar with the Firefox case: according to ... 15:13 < kanzure> ... https://etherpad.mozilla.org/InfraLoadIdeas a full correctness test run across all platforms is about 120 hours of machine time. Adding performance tests raises that to 177 hours. Combined with the pace of development, that means a build+test farm of 3000+ machines (according to http://oduinn.com/blog/2013/03/27/at-mozilla-releaseengineering-release-automation-continuous-integration/ ) and infrastructure load is still a problem. So any ... 15:13 < kanzure> ... serious project picking up Chromium development would need financial resources to at the very least maintain basic test infrastructure." 15:13 < kanzure> https://news.ycombinator.com/item?id=5743024 15:14 -!- zdap [~not@69.158.79.13] has joined ##hplusroadmap 15:16 -!- FooQuuxm1n is now known as FooQuuxman 15:44 -!- eudoxia [~eudoxia@r190-135-26-96.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 15:56 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Remote host closed the connection] 16:10 -!- eudoxia [~eudoxia@r190-135-26-96.dialup.adsl.anteldata.net.uy] has quit [Ping timeout: 245 seconds] 16:15 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 16:19 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 16:38 -!- underscor [~quassel@192.210.211.75] has joined ##hplusroadmap 16:38 -!- underscor is now known as Guest40600 16:57 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 17:03 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 256 seconds] 17:10 -!- FooQuuxm1n [~test@c-98-215-254-55.hsd1.il.comcast.net] has joined ##hplusroadmap 17:11 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 17:12 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 248 seconds] 17:14 -!- FooQuuxman [~test@c-68-58-79-145.hsd1.il.comcast.net] has quit [Ping timeout: 256 seconds] 17:16 -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has joined ##hplusroadmap 17:23 -!- Guest40600 [~quassel@192.210.211.75] has quit [Ping timeout: 256 seconds] 17:27 -!- FooQuuxm1n is now known as FooQuuxman 17:27 -!- Juul [~Juul@static.3.202.4.46.clients.your-server.de] has quit [Ping timeout: 248 seconds] 17:30 -!- undersco2 [~quassel@192.210.211.75] has joined ##hplusroadmap 17:38 -!- xablor [~chris@74.83.3.21] has joined ##hplusroadmap 17:40 < xablor> Hey all. 17:40 < xablor> 'bout how many lurkers do we have here? 17:41 * FooQuuxman lurks 17:42 < kanzure> xablor: hello 17:42 < xablor> Heya. 17:43 < xablor> Got linked to diyhpl.us on Hacker News, figured I'd drop in. 17:44 < kanzure> that was probably my fault 17:44 < kanzure> i regret everything 17:44 -!- Juul [~Juul@50.140.246.63] has joined ##hplusroadmap 17:44 < xablor> Username matches, anyway? 17:45 < xablor> But yeah, found that the stated ethos matched a lot of what I've been sorta stumbling into, so wth. 17:46 < kanzure> well, see the /topic and such 17:50 < xablor> Yeah, fair enough. Seems to be a fairly healthy group, at least. 17:51 < xablor> Hm. Group? Movement? Temporary loose alignment of likeminded folk? 17:51 < kanzure> uh, irc channel 17:55 -!- rk[fishing] is now known as ryankarason 18:09 < fenn> definitely a cult 18:10 < kanzure> worst cult ever 18:10 < xablor> "Happy occupant of a DHS watchlist"? 18:10 < kanzure> you'd think so, but actually the FBI denies having records on me. 18:10 -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] 18:10 < kanzure> i haven't checked with DHS. 18:11 < xablor> Huh. 18:11 < bkero> kanzure: did you FOIA yourself? 18:11 < xablor> ...are they actually legally bound to tell the truth, there? I am ign'ant of such things. 18:12 < kanzure> bkero: i sent in a FOIA request yes 18:12 < kanzure> xablor: there are some legal obligations, yes. there are some loopholes but they are fairly obscure. 18:12 < xablor> Ah, okay. Thanks. 18:12 < kanzure> like, they don't have a lot of incentive to loophole me on that one. 18:13 < xablor> *nod* 18:13 < xablor> Were there sufficient cause it could be done, but no visible reason to in this case. 18:13 < kanzure> what? 18:13 < kanzure> oh, ok sure. 18:15 < kanzure> this was their response: http://diyhpl.us/~bryan/irc/fbi/foipa/response.html 18:15 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 248 seconds] 18:20 -!- Juul [~Juul@50.140.246.63] has quit [Ping timeout: 264 seconds] 18:20 < xablor> Huh. Interesting of itself. 18:25 -!- Gue______ [~textual@host-2-99-151-83.as13285.net] has joined ##hplusroadmap 18:32 -!- Juul [~Juul@208.87.217.74] has joined ##hplusroadmap 18:35 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 18:39 < kanzure> wow when did virustotal become a subsidiary of google? https://www.virustotal.com/en/about/ 18:46 -!- _Sol_ [~Sol@c-174-57-58-11.hsd1.pa.comcast.net] has joined ##hplusroadmap 18:46 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 256 seconds] 18:48 -!- yashgaroth [~ffffff@cpe-66-27-118-94.san.res.rr.com] has joined ##hplusroadmap 18:49 < xablor> Last Sept, apparently? 18:51 -!- Gue______ [~textual@host-2-99-151-83.as13285.net] has quit [Quit: Computer has gone to sleep.] 18:51 -!- OldCoder_ [~OldCoder_@adsl-64-169-36-85.dsl.snfc21.pacbell.net] has quit [Quit: Leaving] 18:57 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 276 seconds] 19:01 < heath> if dna origami isn't worth the time, then what (outside of some javascript soon)? 19:04 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has quit [Ping timeout: 260 seconds] 19:04 < kanzure> heath: well i would start here http://diyhpl.us/wiki/declaration 19:05 -!- klafka [~klafka@204-16-157-18-static.ipnetworksinc.net] has quit [Remote host closed the connection] 19:06 < heath> "molecular nanotechnology" 19:06 < heath> http://diyhpl.us/~bryan/papers2/nanotech/ 19:07 < kanzure> heath: https://github.com/kanzure/nanoengineer could use some attention 19:07 < heath> you're running into similar problems there as you you do in dna origami, no? 19:07 < kanzure> the problems are related to ancient poorly written software 19:07 < heath> re:molnano 19:07 < kanzure> and no unit tests 19:07 < heath> that's what dna origami is, molnano 19:08 < kanzure> if you say so 19:09 < fenn> wait, who said DNA origami isn't worth the time? 19:09 * heath rereads from last night 19:10 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap 19:10 < fenn> oh. i was talking about transcriptional networks, which is more like playing games with packet storms between routers on a subnet 19:11 < heath> oh, kanzure just seemed to hint he didn't care for winfree 19:11 < heath> and fenn stated 19:11 < heath> [23:53:50] i dont like the whole transcriptional logic idea though, it's trying to draw an analogy where there really isnt one 19:12 < heath> and for some reason i had it in my head there was a log from years ago where you guys were discussing this and cast it in a bad light due to how large a single strand had to be to make anything useful, but that might be my imagination 19:13 < fenn> actually most dna origami is made of short strands these days 19:13 < kanzure> fenn wasn't talking about origami. 19:14 < fenn> oh, right. so, i was talking about the address length required to reliably target a specific promoter (i think) 19:15 < fenn> maybe it was a scheme for using pcr primer tricks to do dna synthesis 19:16 < heath> https://www.youtube.com/watch?v=T7A35Je5Y3U 19:16 < heath> the latest video from rothemund, i think 19:16 < kanzure> .title 19:16 < yoleaux> Recent Advances in the Use of DNA as a Building Material - YouTube 19:16 < heath> it's the same ol' stuf up until around the 20min mark 19:16 < kanzure> the stuff about transcription networks is not very related to the "building objects with dna fragments". 19:17 < heath> ~25 19:17 < kanzure> you can link to different timestamps with #t=whatever 19:17 < kanzure> https://www.youtube.com/watch?v=T7A35Je5Y3U#t=25m 19:18 < heath> http://yanlab.asu.edu/Research.html 19:18 < heath> .t 19:18 < yoleaux> Thu, 23 May 2013 02:18:29 UTC 19:18 < heath> poop 19:19 < heath> http://yanlab.asu.edu/Publication.html is the better link 19:19 -!- Juul [~Juul@208.87.217.74] has quit [Ping timeout: 256 seconds] 19:19 < heath> yoleaux: fetch all the titles of papers linked to, do it. 19:19 < fenn> yay i love dead tree bibliographies 19:20 < fenn> someone remind me why this is still considered acceptable 19:21 < fenn> isnt there a wikipedia bot that automatically links references like this to their DOI? 19:21 < fenn> http://en.wikipedia.org/wiki/User:DOI_bot/Sandbox 19:24 -!- xablor is now known as xablor[away] 19:25 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 19:25 < heath> .paper "Complex Archimedean Tiling Self-Assembled from DNA Nanostructures" 19:26 < heath> .fetch it! 19:26 < heath> paperbot: http://pubs.acs.org/doi/abs/10.1021/ja4035957 19:26 < paperbot> error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Complex%20Archimedean%20Tiling%20Self-Assembled%20from%20DNA%20Nanostructures.txt 19:26 < fenn> that would be pretty cool eh 19:27 * heath likes to think paperbot is jamming away to https://www.youtube.com/watch?v=JIOE_pSTEH4&list=FL_E3LyNEq65lOQPDe0sSJlw and ignoring my requests 19:29 < fenn> i wonder why it failed. anyway, http://fennetic.net/irc/complex_archimedean_tiling_self-assembled_from_DNA_nanostructures.pdf 19:30 < kanzure> how did you have access? 19:31 < fenn> gnusha 19:32 < kanzure> it would be great if some of you could fix paperbot bugs once in a while. 19:32 < kanzure> or throw out my code 19:35 -!- Juul [~Juul@c-67-170-193-114.hsd1.ca.comcast.net] has joined ##hplusroadmap 19:36 < heath> fenn: thanks 19:36 < fenn> that disneyland video is pretty cool 19:37 < fenn> i want a nuclear tunnel borer :( 19:38 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has joined ##hplusroadmap 19:38 < fenn> what most people don't understand is that EPCOT was for real, and disneyland just sorta took over after walt died 19:40 < kanzure> so apparently this is how i met lion kimbro originally: 19:40 < kanzure> http://web.archive.org/web/20020607133707/http://2dnow.zenzer.net/memberlist.php 19:40 < kanzure> i always thought i met him somewhere else.. my first recorded interaction is 2008-04-17 19:41 < kanzure> i remember emailing him because of his journals or notebooks 19:41 < kanzure> but not about meeting him in 2002. 19:44 < heath> http://research4.dfci.harvard.edu/shih/SHIH_LAB/Publications.html :: more dead links 19:45 < kanzure> oh and lion seems to work for pokemon these days 19:45 < kanzure> fascinating. 19:45 < fenn> i was just about to ask 19:46 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Quit: the neuronal action potential is an electrical manipulation of reversible abrupt phase changes in the lipid bilayer] 19:47 < fenn> "how to make a complete map of every thought you think" error meta meta stack overloaded 19:49 < heath> .paper http://pubs.acs.org/doi/abs/10.1021/ja310454k 19:49 < heath> .paper http://pubs.rsc.org/en/Content/ArticleLanding/2013/BM/c2bm00154c 19:49 < heath> .paper http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/C3CC38804B 19:50 < heath> paperbot: http://pubs.acs.org/doi/abs/10.1021/ja310454k 19:50 < paperbot> error: HTTP 500 http://diyhpl.us/~bryan/papers2/paperbot/Direct%20and%20Real-Time%20Observation%20of%20Rotary%20Movement%20of%20a%20DNA%20Nanomechanical%20Device.txt 19:53 < kanzure> heath: https://github.com/kanzure/paperbot 19:54 < fenn> hmm. "Example project: neural network computation with DNA" 19:55 < heath> http://onlinelibrary.wiley.com/doi/10.1002/smll.201101212/full 19:55 < heath> .title 19:55 < yoleaux> Surface-Driven DNA Assembly of Binary Cubic 3D Nanocrystal Superlattices - Noh - 2011 - Small - Wiley Online Library 19:56 < heath> http://pubs.rsc.org/en/content/articlelanding/2011/cp/c0cp02815k 19:56 < heath> .title 19:56 < yoleaux> DNA mediated assembly of single walled carbon nanotubes: role of DNA linkers and annealing - Physical Chemistry Chemical Physics (RSC Publishing) 19:57 < heath> http://dna.caltech.edu/Papers/stacking-bonds2011.pdf 19:57 < heath> .title 19:57 < yoleaux> heath: Sorry, that doesn't appear to be an HTML page. 19:57 < heath> " Programmable Molecular Recognition based on the Geometry of DNA nanostructures" 19:57 < kanzure> heath: you can use .title with the url on the same line, like ".title http://awfulurl.com/" 19:58 < heath> non dead-tree links: http://dna.caltech.edu/DNAresearch_publications.html 20:00 < heath> Theory of Algorithmic Self-Assembly: http://dna.caltech.edu/Papers/algorithmic_tiles2012doty.pdf and http://vimeo.com/54214122 20:01 < fenn> it's nice to have at least an abstract in your list of published works 20:01 < kanzure> .title http://vimeo.com/54214122 20:01 < yoleaux> Theory of Algorithmic Self-Assembly on Vimeo 20:01 < kanzure> oh look heath was kind enough to specify it 20:05 < fenn> it would be great if all science papers came with explanatory videos like this 20:05 < kanzure> you want *video*? 20:07 < fenn> given a choice, i'd rather have the text format, but sometimes video is easier to understand 20:07 < heath> will someone eventually pay me to work on this and not patent every bit of the work? 20:07 < kanzure> to work on what? 20:08 < heath> building stuff with dna 20:08 < heath> fenn, launch a startup, i'll intern until i'm useful 20:08 < fenn> um. it's a little premature 20:08 < kanzure> that's not how you make money 20:08 < kanzure> you say: "i want to be paid x" then people pay you "x" 20:09 < kanzure> if you say "i'll intern until" then you will not be paid, or if you are paid, it will be insulting. 20:09 < kanzure> or illegal 20:09 < fenn> you could go work in winfree's lab 20:09 < kanzure> why are you suddenly interested in dna origami projects? 20:10 < heath> dunno, it's one of the two things i've been consuming a lot 20:11 < heath> the other thing is market making bots 20:12 < kanzure> if you are looking for some small project ideas to make a few bucks, i have a large ~/lists/startup-ideas file 20:12 < heath> .link 20:12 < fenn> market making bots? 20:12 < heath> .link startup-ideas 20:12 < heath> for bitcoin 20:13 < kanzure> yesterday i added two entries. first is a textbook lookahead site to see if a new edition of your textbook is coming out before class starts (so that you can buy the textbook ahead of time if there's no new edition; otherwise, prices will spike). 20:13 < heath> haven't launched a one 20:13 < fenn> i regret to inform you that ".link startup-ideas" doesn't actually paste a link in here 20:13 < heath> fenn: yeah, i'm aware, i just figured bryan would suddenly link though 20:13 < kanzure> second idea was a personal analytics site for tracking down stalkers. you can use lots of different tracking methods to identify who your stalker is. you could even give the stalker a fake android app that reports their gps location to you so that you can be notified when they are physically near you and maybe you are in danger. 20:14 < kanzure> bitcoin ideas.. uh.. uh.. black market for organs and mad science. 20:14 < kanzure> including antibodies. 20:17 < fenn> when you said "analytics site for stalkers" i immediately thought that it was for use by stalkers to determine who/where their victim is 20:17 < kanzure> nope, other way around 20:17 < kanzure> whostalksthestalkers.com 20:17 < fenn> but wouldnt it work equally well either way? 20:18 < kanzure> no, because as a stalker you can't coerce your victim to click your link 20:18 < fenn> that's a totally ungrounded statement, and it's false :P 20:18 < kanzure> you can do phishing i guess 20:18 < kanzure> anyway, stalkers are already quite capable of doing that 20:19 < kanzure> there is no product marketed to people who are actively trying to identify who their creep is 20:19 < kanzure> or who is the person following them around the internet making death threats 20:21 < yashgaroth> there's a girl from diybio san diego who has some stalker trying to contact people from the group and claiming to be her 20:21 < kanzure> is it rachel? 20:21 < kanzure> oh wait, no. ok good. let's never speak that name again. 20:21 < yashgaroth> yeah no 20:22 < kanzure> anyway, yeah, if that's a real stalker, the goal would be to use this tool to help fix those situations. 20:22 < kanzure> the idea would be to figure out as much information as possible, then maybe take that to the police or make recommendations about how to block that person for good. 20:23 < yashgaroth> I figured if the stalker is contacting people, that they could reply with a link that IDs the stalker's IP address or something 20:23 < yashgaroth> like 'hey here's a personal photo etc check it out' and then bam 20:26 < kanzure> yes 20:26 < kanzure> there are other things you can do as well 20:26 < kanzure> for instance, you can look at the headers of the emails that were sent to you 20:26 -!- Juul [~Juul@c-67-170-193-114.hsd1.ca.comcast.net] has quit [Ping timeout: 256 seconds] 20:26 < kanzure> this could provide additional information like what mail servers the creep is using 20:26 < kanzure> or possibly which mail client 20:27 < yashgaroth> I'm guessing they just use some random gmail account, but I have few details from her 20:27 < kanzure> there are two critical problems with this idea as a business 20:27 < kanzure> first, you would be putting yourself in physical danger because stalkers will fucking hate you 20:27 < kanzure> second, it might be a little unethical to charge for this sort of protection/identification service 20:28 < kanzure> "oh sorry about your stalker but since you're poor i can't do fuck all about it" 20:28 < fenn> re first, they're already in danger if they're being stalked (assuming the stalker was a violent person in the first place) 20:28 < kanzure> no, i mean the person running the site. 20:29 < fenn> and second, that applies to any other business 20:29 < kanzure> fair point 20:30 < fenn> well, you'll just have to play pen test games to see if you can figure out who owns the company 20:30 < fenn> mumble mumble corporate veil 20:30 < kanzure> best way would be to make it bitcoin only and just make it a highly anonymized service 20:31 < kanzure> but then you would be cutting off a lot of people that need the service because they don't understand bitcoin, even if you use coinbase or w/e the easiest thing is of the day. 20:31 < fenn> nah anybody with enough savvy to use bitcoin already knows how to reverse-stalk 20:31 < kanzure> no 20:31 < kanzure> coinbase makes it really dead simple to pay in bitcoins on sites 20:31 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 20:32 < kanzure> there are many sites integrating bitcoin these days not because they want to appease the technical hordes of nerds but because there's legitimately easy flows to sign people up through bitcoin (although it's not as seamless as "type in your credit card number".. there's like 2 or 3 more clicks). 20:32 -!- FooQuuxman [~test@c-98-215-254-55.hsd1.il.comcast.net] has quit [Ping timeout: 256 seconds] 20:34 < heath> whotalkstostalkers.com 20:35 < heath> maybe you should purchase that one? :) 20:36 < kanzure> anyway, that was just because you asked 20:36 < kanzure> i don't think i am strongly motivated to work on either one 20:37 < heath> i want an idea around dna computing 20:37 < kanzure> plus the stalker thing has only like 20M potential users/year, and maybe only 50% of those are going to be cyberstalking victims, and then if you get 1% of that market it's just pretty small, etc. 20:37 < kanzure> why do you want dna computing? 20:37 < heath> the guys who did the glowing tree for kickstarter are actually a startup 20:38 < kanzure> they are actually liars and i hate them 20:38 < fenn> oh, they're actually a startup! woohoooooooooooooo 20:38 < kanzure> omri is the owner of "genome compiler" except it's not a real compiler >:( 20:38 < kanzure> and there's nothing "open" about his project, although everyone keeps calling it "open". 20:38 -!- Juul [~Juul@c-67-170-193-114.hsd1.ca.comcast.net] has joined ##hplusroadmap 20:39 < kanzure> Juul: sup with the naming? 20:39 < heath> nanomedicine, re: why 20:40 < fenn> please elaborate 20:40 < heath> a:"why do you like the color red?" b: "it makes me happy" a: "please elaborate" 20:40 < heath> i'm not sure where this is going :) 20:41 < heath> clearly it's not my specialty 20:41 < fenn> how does dna origami or dna computing contribute to nanomedicine, in your opinion 20:41 < fenn> (whatever nanomedicine is) 20:42 < fenn> the current state of dna computing is calculating the square root of 15 20:42 < kanzure> heath: i suggest picking startup ideas based on traction or market numbers 20:42 < heath> sure 20:42 < kanzure> heath: go read about lean startups or something 20:43 < heath> nanomedicine => drug delivery, but also i think of it as interfacing with the brain somehow 20:43 < heath> my reasons will never get any less vague 20:43 < heath> today 20:45 < heath> re: how does it contribute to nanomeds... a very long time from now, we build stuff using these ideas 20:45 < heath> we build larger things which could be used for drug delivery? i dunno 20:45 < kanzure> this is not a very good startup. 20:46 < kanzure> did you read the startup science transcripts? 20:46 < heath> that's why i offered to be an intern :) 20:46 < kanzure> http://diyhpl.us/wiki/transcripts/startup-science-2012/ 20:46 < kanzure> an intern at a startup that you create? 20:46 < heath> hah 20:47 < heath> i haven't read the transcripts, might be something worth looking at though 20:49 < heath> fenn: you making me elaborate makes me feel bad about myself :) 20:51 < fenn> it isn't going to get easier than explaining to your friends in a low pressure setting 20:52 < fenn> i have lots of ideas about dna origami, just wondering what yours were 20:54 < heath> you have been thinking on these ideas a lot longer, it's why i was asking earlier "if not dna origami, then what", because i thought you guys had discovered a better way forward 20:55 < heath> i guess we can get some immediate results with synthetic biology even though the yields are low, there aren't debuggers, etc. 20:56 < heath> from what i can tell, we get higher yields of the desired produce at the genetic level than the cellular level 20:56 < fenn> higher yields of what? 20:57 < kanzure> better way forward for what? 20:57 < yashgaroth> immediate results in what? 20:57 < fenn> i assumed he meant toward something resembling drexlerian molecular nanotechnology 20:59 < heath> and if we can pursue this field using techniques borrowed from computer programming, it seems mores tractable 20:59 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 256 seconds] 21:01 < kanzure> i think you are more likely to make immediate impact on nanoengineer in clean up duty 21:02 < kanzure> https://github.com/kanzure/nanoengineer 21:02 < fenn> i tried to do that with conventional engineering where we can see and interact with the machinery 21:02 < heath> so scratch [22:56:13] from what i can tell, we get higher yields of the desired produce at the genetic level than the cellular level 21:03 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 21:03 < heath> i just heard a guy talk about insertion yields in synthetic biology being low and for some reason that translated to "dna based computing has higher yields of THINGS!" :p 21:03 < heath> re: a better way forward, transhumanism, i mean, this is what we're here for right? 21:04 < fenn> one thing i've learned is that transhumanism never means the same thing to different people 21:05 < kanzure> insertion yields in synthetic biology is about dna synthesis and genomic uptake and colony selection, not about dna computing. 21:05 < fenn> i guess a dna computer would yield answers? 21:08 < fenn> shorter/simpler computations would yield more answers because there would be more processors or more cycles per processor, so the algorithm completes N times more in the alloted reaction time 21:09 < fenn> guh english is starting to fail me 21:09 < fenn> on PCs we typically don't compute the answer more than once 21:09 < kanzure> i think dna synthesis is a better place to work at for the moment if you are interested in making gains related to dna origami or whatever 21:16 < fenn> "Maybe one day I will improve this. But that day is not today. Today is 21:16 < fenn> a day for spitting text out. With God's mercy, I will learn how to 21:16 < fenn> finish big projects. I pray for that ability frequently." 21:17 < heath> i like to think that we can build all sorts of proteins using dnacomp (because i'm tired of typing) which we could assemble into larger structures somehow in some far future 21:19 < fenn> we can already build proteins with dna.. the trick is making sure it folds the way you want 21:19 < heath> https://www.youtube.com/watch?feature=player_detailpage&v=2nqHOnVTxJE#t=2259s 21:19 < heath> who is this guy? 21:19 * heath wonders if he gave a talk prior/after to hers 21:19 < kanzure> 2259 seconds? is that right? 21:20 < heath> yep 21:21 < fenn> sounds russian? 21:22 < heath> not the girl 21:24 < heath> oh, yeah, he has some accent as well 21:24 < heath> where's phreedom when you need him 21:24 < kanzure> i scared him away 21:25 < kanzure> he believed that i sucked at anonymity (and he was right) 21:35 < heath> http://vimeo.com/46304267 : Sight, a short film 21:51 < ParahSail1n> dude asking for electropherogram for illumina reads... 21:52 < ParahSail1n> cmon get with the program, i know you're a wetlabber but what we do over here is not black magic 22:00 -!- Juul [~Juul@c-67-170-193-114.hsd1.ca.comcast.net] has quit [Ping timeout: 264 seconds] 22:01 < heath> electropherogram: " plot of results from an analysis done by electrophoresis automatic sequencing"...google search for `illumina` yields "Illumina | sequencing and array-based solutions for genetic research" 22:01 < heath> seems reasonable? 22:03 < heath> ParahSail1n^ why is it unreasonable to think could get an electropherogram? 22:09 < heath> not trying to knock what you are saying, this is a legitimately ignorant question on my part :) 22:10 < yashgaroth> ok fine, electropherograms refer only to traditional chain-termination sequencing, whereas with illumina and others' high-throughput sequencing you only get the sequence and a quality score for each base 22:12 -!- Juul [~Juul@c-67-170-193-114.hsd1.ca.comcast.net] has joined ##hplusroadmap 22:27 < heath> thanks yashgaroth 22:27 -!- ianmathwiz7 [~chatzilla@68-115-57-210.static.eucl.wi.charter.com] has quit [Ping timeout: 252 seconds] 22:29 < ParahSail1n> yes 22:29 < heath> http://cadnano.org/ is what winfree's lab uses 22:29 < heath> https://github.com/sdouglas/cadnano2 22:30 < heath> mostly written in python too \o/ 22:32 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap 22:37 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 252 seconds] 22:41 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has joined ##hplusroadmap 23:01 < heath> neat: https://www.transcriptic.com/ 23:01 < heath> "Transcriptic is the simplest and lowest cost way to order custom plasmids. Send us source material to start from or synthesize it for only 34 ¢ / bp, all from one workflow. Starting at $275." 23:02 < heath> mentioned in http://diyhpl.us/wiki/transcripts/startup-science-2012/ 23:10 * heath didn't realize that nanoengineer, too, is mostly python 23:19 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has joined ##hplusroadmap 23:21 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has quit [Client Quit] 23:23 -!- makoLime [~mako@wireless-nat-7.auckland.ac.nz] has quit [Ping timeout: 264 seconds] 23:30 < kanzure> heath: before cadnano they were using nanoengineer. that's why some of rothemund's work is in nanoengineer. 23:30 < kanzure> heath: they stopped using nanoengineer when nanorex died. 23:41 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap --- Log closed Thu May 23 00:00:35 2013