--- Log opened Mon Jan 13 00:00:22 2014 00:30 -!- realzies [~pinky@unaffiliated/realazthat] has quit [Ping timeout: 246 seconds] 00:43 -!- realzies [~pinky@unaffiliated/realazthat] has joined ##hplusroadmap 00:45 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 276 seconds] 00:52 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 01:07 -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap 01:11 -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer] 01:12 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 01:52 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 01:53 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 01:57 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 252 seconds] 01:59 -!- kyknos_ [~kyknos@89.233.130.143] has quit [Read error: Operation timed out] 02:10 -!- top4o [~chatzilla@93-152-180-149.ddns.onlinedirect.bg] has joined ##hplusroadmap 02:12 < jrayhawk> I think I still have some deployed servers with reiserfs. 02:21 -!- entelechios [~elysium@181.194.145.204] has quit [Ping timeout: 248 seconds] 02:44 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap 03:02 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:03 -!- klafka [~klafka@c-50-161-113-143.hsd1.ca.comcast.net] has joined ##hplusroadmap 03:08 -!- klafka [~klafka@c-50-161-113-143.hsd1.ca.comcast.net] has quit [Ping timeout: 245 seconds] 03:40 -!- eudoxia [~eudoxia@r179-24-27-245.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 03:41 -!- FourFire [~fourfire@ti0088a400-2750.bb.online.no] has joined ##hplusroadmap 03:48 -!- dantespeaks [~dantespea@75-119-226-56.dsl.teksavvy.com] has quit [Read error: Connection reset by peer] 04:01 -!- dantespeaks [~dantespea@75-119-226-56.dsl.teksavvy.com] has joined 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##hplusroadmap 07:12 -!- aelinoea [~aelinoea@a88-113-45-152.elisa-laajakaista.fi] has joined ##hplusroadmap 07:15 -!- kyknos_ [~kyknos@193.84.36.129] has joined ##hplusroadmap 07:25 -!- kyknos__ [~kyknos@193.84.36.129] has joined ##hplusroadmap 07:27 -!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has quit [Ping timeout: 272 seconds] 07:30 -!- kyknos__ [~kyknos@193.84.36.129] has quit [Ping timeout: 252 seconds] 07:31 -!- kyknos_ [~kyknos@193.84.36.129] has quit [Ping timeout: 252 seconds] 07:35 -!- AshleyWaffle [anastasiaw@unaffiliated/anastasiawyatt] has quit [Ping timeout: 265 seconds] 07:35 -!- FourFire [~fourfire@46-98-15.connect.netcom.no] has quit [Read error: No route to host] 07:50 < kanzure> jrayhawk: the not knowing seems like the best part, there 07:51 < eudoxia> somebody should fork the filesystem and give it another name 07:51 < eudoxia> you can't have a conversation about reiserfs without someone bringing up the whole wifey knifey thing 07:52 < kanzure> actually it was the other way around 07:52 < kanzure> you can'thavea conversation about the princess bride without it turning into either (a) an argument about the dread pirate roberts or (b) an argument about filesystems 07:54 < kanzure> *you can't have a 07:59 -!- FourFire [~fourfire@46-98-15.connect.netcom.no] has joined ##hplusroadmap 08:17 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 08:21 -!- AshleyWaffle [anastasiaw@unaffiliated/anastasiawyatt] has joined ##hplusroadmap 08:23 -!- ThomasEgi [~thomas@185.5.8.81] has joined ##hplusroadmap 08:23 -!- ThomasEgi [~thomas@185.5.8.81] has quit [Changing host] 08:23 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 08:29 -!- FourFire [~fourfire@46-98-15.connect.netcom.no] has quit [Ping timeout: 276 seconds] 08:34 -!- Adillian [~Adillian@94.9.98.141] has joined ##hplusroadmap 08:44 -!- eudoxia [~eudoxia@r179-24-27-245.dialup.adsl.anteldata.net.uy] has quit [Quit: Leaving] 10:21 -!- top4o [~chatzilla@93-152-180-149.ddns.onlinedirect.bg] has quit [Ping timeout: 246 seconds] 11:03 -!- entelechios [~elysium@190.184.196.50] has joined ##hplusroadmap 11:19 -!- ascendancy [~ascendanc@199.44.250.219] has quit [Remote host closed the connection] 11:41 < entelechios> paperbot: http://prl.aps.org/abstract/PRL/v98/i5/e053902 11:41 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/a3649d73c5531070104821435811e1c3.txt 11:50 -!- wallmani [~wallmani@unaffiliated/wallmani] has quit [Disconnected by services] 11:50 -!- wallmani [~wallmani@162.243.55.16] has joined ##hplusroadmap 11:50 -!- wallmani is now known as Guest1567 11:50 < jrayhawk> It's pretty good as a boot partition since it's basically indestructable, but I never really pay attention to boot partitions after I make them. 11:51 < jrayhawk> Responds more poorly to memory corruption than most, though. 12:00 -!- Guest1567 is now known as wallmani 12:00 -!- wallmani [~wallmani@162.243.55.16] has quit [Changing host] 12:00 -!- wallmani [~wallmani@unaffiliated/wallmani] has joined ##hplusroadmap 12:10 -!- delinquentme [6c27d2d4@gateway/web/cgi-irc/kiwiirc.com/ip.108.39.210.212] has joined ##hplusroadmap 12:10 < delinquentme> kanzure:say I've got a number of illustrator path files for microfluidics 12:11 < delinquentme> editing them in linux 12:15 -!- delinquentme [6c27d2d4@gateway/web/cgi-irc/kiwiirc.com/ip.108.39.210.212] has quit [Client Quit] 12:16 -!- klafka [~klafka@c-50-161-113-143.hsd1.ca.comcast.net] has joined ##hplusroadmap 12:33 < jrayhawk> Also has unusually fast tail-packing support, so was good for mail systems. 12:58 -!- aelinoea [~aelinoea@a88-113-45-152.elisa-laajakaista.fi] has quit [Quit: Leaving] 13:07 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 248 seconds] 13:12 -!- Adillian [~Adillian@94.9.98.141] has quit [Quit: Nettalk6 - www.ntalk.de] 13:15 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 13:53 -!- Shehrazad 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14:53 -!- klafka_ [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer] 14:54 -!- klafka [~klafka@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 15:10 < kanzure> these are cool: http://tryerlang.org/ http://tryhaskell.org/ http://tryruby.org/ http://try-python.appspot.com/ http://repl.it/ 15:13 -!- Adifex [~Adifex@rrcs-50-84-151-141.sw.biz.rr.com] has joined ##hplusroadmap 15:18 < heath> yeah 15:19 -!- ascendancy [~ascendanc@199.44.250.219] has joined ##hplusroadmap 15:21 < entelechios> kanzure http://runnable.com/ 15:21 < entelechios> it's not hugely hugely replete yet, but the notion-searching feature i find is pretty cool 15:23 < kanzure> where's my launch on heroku button 15:24 < kanzure> needs more deploy buttons 15:27 < venturecommunist> hi kanzure 15:27 < delinquentme> rofl 15:27 < delinquentme> ^^ 15:27 < delinquentme> dat handle 15:28 < venturecommunist> thanks 15:29 < venturecommunist> kanzure: i'm trying to evaluate a biohacking experiment for cost, what equipment would be needed, think i could pick your brain a bit? 15:29 < venturecommunist> basically it's DRACO on rhinovirus 15:29 < ParahSailin> venturecommunist: DRACO? 15:29 < venturecommunist> https://en.wikipedia.org/wiki/DRACO_%28antiviral%29 15:31 < ParahSailin> what exactly you want to do 15:31 < venturecommunist> so i guess send away to lifetechnologies.com for HIV1 TAT + PKR + ADAF1 15:31 < venturecommunist> heat shock transform into E. coli if it doesn't come in E. coli already 15:32 < venturecommunist> then liquid culture in some kind of diy bioreactor 15:32 < ParahSailin> you want to have someone synthesize genes? 15:32 < ParahSailin> that would be idt, not lifetechnologies 15:32 < venturecommunist> still looking on openwetware.org to see if i can do it with some open PCR variant 15:33 < ParahSailin> shits unreliable enough as it is without crippling yourself with inferior equipment 15:34 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] 15:36 < ParahSailin> what would pkr and adaf1 do in e coli? 15:37 < venturecommunist> the genes would produce the proteins, if they're expressed in e coli 15:37 < ParahSailin> ok.. 15:37 < venturecommunist> the protein being a chimera of TAT, PKR and ADAF1 15:37 -!- ascendancy [~ascendanc@199.44.250.219] has quit [Read error: Connection reset by peer] 15:38 < ParahSailin> what do you want that for? 15:38 < ParahSailin> i dont even see an adaf1 in genbank 15:39 < venturecommunist> if it's really non-toxic in-vivo in humans presumably it's a cure for AIDs, HPV, HSV, Hep A/B/C/D/E Ebola, Influenza and the Common Cold 15:40 < ParahSailin> the draco antiviral drugs are the simple fusion protein you described? 15:40 < venturecommunist> right 15:42 < ParahSailin> hm good catch on the paper 15:43 < venturecommunist> interesting right 15:43 < ParahSailin> thats apaf1 btw :) 15:44 < venturecommunist> apaf1 indeed 15:44 < venturecommunist> apoptosis factor 1 or something 15:45 < ParahSailin> PKR is the dsRNA detector? 15:45 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Quit: Leaving] 15:45 < venturecommunist> right 15:45 < venturecommunist> PKR and APAF1 are both human genes, TAT is an HIV1 gene 15:46 < venturecommunist> HIV appears to have two basic methods of counter-acting PKR (which complexly will induce apoptosis) 15:46 < venturecommunist> one is that TAT binds with PKR obstructing its action 15:47 < venturecommunist> the other has to do with phosphorylation of something acted on by PKR 15:47 < venturecommunist> but with a TAT already on there, it should be able to get anywhere HIV can get, without obstruction by HIV one would think 15:48 < venturecommunist> and the APAF1s should be triggered independent of this phosphorylation issue cause it's a more direct pathway 15:48 < ParahSailin> what you gonna test the drug on? 15:48 < venturecommunist> there's definitly indication of PKR activation in HIV infected clls 15:48 < venturecommunist> myself of course 15:48 < venturecommunist> for make glorious venture communism 15:49 < ParahSailin> might try an animal first 15:49 < venturecommunist> i'm a human-imal 15:50 < gradstudentbot> I don't think our fume hood is safe. 15:51 < kanzure> get back in there 15:51 -!- yoleaux [yoleaux@2600:3c03::f03c:91ff:feae:e601] has joined ##hplusroadmap 15:53 < venturecommunist> kanzure: lol 15:53 < venturecommunist> i was just talking about the price of a fume hood today 15:53 < venturecommunist> $80k for real? 15:53 -!- Adifex [~Adifex@rrcs-50-84-151-141.sw.biz.rr.com] has quit [Remote host closed the connection] 15:53 -!- Adifex [~Adifex@rrcs-50-84-151-141.sw.biz.rr.com] has joined ##hplusroadmap 15:56 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Remote host closed the connection] 16:03 < ParahSailin> im sure there exist ones that expensive 16:05 < kanzure> "premium fume hoods" 16:06 < kanzure> on etsy 16:07 < kanzure> oh i'm sorry, tindie, right 16:10 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[~GuanYu@75.111.207.146] has joined ##hplusroadmap 21:38 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 272 seconds] 21:47 -!- n_bentha [~GuanYu@75.111.207.146] has quit [Ping timeout: 246 seconds] 21:48 -!- justanotheruser [~justanoth@50.121.121.44] has joined ##hplusroadmap 21:50 -!- justanotheruser1 [~justanoth@95.211.152.2] has joined ##hplusroadmap 21:51 -!- justanotheruser1 [~justanoth@95.211.152.2] has quit [Changing host] 21:51 -!- justanotheruser1 [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:52 -!- justanotheruser [~justanoth@50.121.121.44] has quit [Ping timeout: 245 seconds] 21:55 -!- justanotheruser1 [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 21:58 -!- yashgaroth [~ffffff@2606:6000:b240:8200:d4d4:c8c0:1b64:d7cf] has quit [Quit: Leaving] 22:00 -!- justanotheruser [~justanoth@74.45.113.229] has joined ##hplusroadmap 22:02 -!- dantespeaks [~dantespea@75-119-226-56.dsl.teksavvy.com] has joined ##hplusroadmap 22:05 -!- justanotheruser1 [~justanoth@95.211.138.33] has joined ##hplusroadmap 22:05 -!- justanotheruser [~justanoth@74.45.113.229] has quit [Ping timeout: 276 seconds] 22:10 -!- justanotheruser1 [~justanoth@95.211.138.33] has quit [Changing host] 22:10 -!- justanotheruser1 [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 22:14 -!- justanotheruser1 is now known as justanotheruser 22:18 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 22:22 < brownies> jrayhawk: you around? 22:23 < gradstudentbot> I don't remember the paper, but someone definitely did that. 22:25 < justanotheruser> gradstudentbot: is there a free algorithm for verifiable computation 22:25 < gradstudentbot> Nope, that's not even remotely possible. 22:25 < justanotheruser> oh :( 22:30 < juri_> gradstudentbot: are you watson, gathering information for the singularity, making sure humanity doesn't surpass or merge with the machines? 22:30 < gradstudentbot> Should I be reading this? 22:30 < juri_> I knew it. 22:36 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 22:37 < jrayhawk> brownies: mostly 22:38 < brownies> jrayhawk: educate me about pre- and post-workout nutrition? 22:38 < brownies> or throw some papers at me, or something? 22:38 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 265 seconds] 22:42 < jrayhawk> Depends on the modality, but, during training, typically folks aim for forcing fatty acid metabolic adaptation through carb-fasting pre-workout and then aim for a big carb and protein load post-workout while glycogen depleted in order to use an insulin spike to upregulate the thyroid for a week. 22:42 < jrayhawk> Then abuse carbs during competition as needed. 22:43 < brownies> so... protein shake before, then protein shake and food after? 22:43 -!- Viper168_ is now known as Viper168 22:45 < jrayhawk> I usually aim for fast-absorbing stuff to drive the spike as high as practical; pre-emulsified BCAAs in the form of egg and a couple tablespoons of some form of straight glucose, such as coconut sugar or corn dextrose or something. 22:46 < brownies> i see 22:46 < jrayhawk> If you don't particularly care about the metabolic floor provided by fatty acid metabolism, then you can be a lot looser on pre-workout nutrition. 22:47 < brownies> i don't suppose you have any particular product recommendations to make this idiot-proof for me? 22:47 < brownies> i read this http://www.consumerreports.org/cro/magazine-archive/2010/july/food/protein-drinks/what-our-tests-found/index.htm 22:47 < brownies> and i've deduced that i should stop drinking muscle milk 22:48 < jrayhawk> http://www.omgwallhack.org/home/jrayhawk/img/self/poiseanddignity.jpg fwiw here's observational evidence that i am at least not screwing up too badly 22:49 < venturecommunist> well as arnold used to say when they asked if he won mr. universe by drinking milk 22:49 < brownies> this photo appears to be upside-down 22:49 < venturecommunist> "milk is foh baybeez" 22:49 < brownies> oh, wait, i see. 22:50 < brownies> yes, you seem to have some idea about what you're doing. 22:50 < jrayhawk> In general I tend to avoid food that other people have processed on the basis that other people are terrible and untrustworthy, so my recommendation is to learn to prepare foods. 22:51 < jrayhawk> You can throw a dozen eggs into a pot of boiling water for 30-60 minutes and wind up with a lot of food for very little effort, for instance. 22:52 < justanotheruser> jrayhawk: but it's what plants crave 22:52 < jrayhawk> (Though eggs are kinda crap for general nutrition due to mineral- and vitamin-binding antinutrients) 22:52 < brownies> yeah, that's not an unreasonable approach 22:52 < brownies> i'm just trying to decouple getting decent nutrition from having to learn to cook 22:53 < jrayhawk> Not going to happen in the current food environment unless you have someone you can trust to follow directions. 22:53 < kanzure> see "other people are terrible and untrustworthy" 22:55 < brownies> can't i just buy some sort of powdered food and mix with water? why does eating have to be so complex? 22:55 -!- kyknos__ [~kyknos@89.233.130.143] has joined ##hplusroadmap 22:56 -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap 22:57 < venturecommunist> jrayhawk: the way i heard it you could get a vitamin b defficiency if you ate only the egg whites but that it would take a LOT of whites 22:57 < venturecommunist> and even mixing in a little yolk would fix it 22:58 < brownies> if i grudgingly cook eggs, will i need to cook other things too? 22:59 < jrayhawk> brownies: Two thoughts on that: 1) not all chemicals can survive free-floating with a wide variety of other chemicals, and 2) you're not eating for one, you're eating for 10 trillion 22:59 < jrayhawk> the latter of which is to say even if overabsorbability didn't have consequences inside your circulation, it has some pretty significant ones outside of it 22:59 < brownies> hm, i see 22:59 -!- strangewarp [~strangewa@c-67-176-51-230.hsd1.co.comcast.net] has quit [Read error: Connection reset by peer] 23:00 -!- strangewarp [~strangewa@c-67-176-51-230.hsd1.co.comcast.net] has joined ##hplusroadmap 23:01 < jrayhawk> venturecommunist: The B vitamin absorbtion inhibitor I'm halfway familiar with is avidin, but there's anomalously low bioavailability of others when measured in the science literature. 23:01 < jrayhawk> And similarly conalbumin for minerals. 23:01 < jrayhawk> Avidin is at least fairly easy to deactivate through heavy boiling. 23:02 < jrayhawk> Anyway, John Kiefer and Martin Berkhan are good fun to read for basic macronutrient strategies and link to a lot of interesting science. 23:03 < brownies> ah, that's what i needed 23:04 < jrayhawk> Chris Kresser has a lot of really amazingly good resources on a lot of nutrition biochem minutiae. 23:05 < jrayhawk> Mark Sisson's fun for more general lifestyle stuff. 23:19 < jrayhawk> http://www.marksdailyapple.com/is-barbell-dogma-doing-more-harm-than-good/ like this article 23:19 < jrayhawk> it is a good article 23:31 < jrayhawk> https://secure.piny.be/cgit/jrayhawk/tree/rss.mdwn there's other random stuff under the "health" category that might strike your fancy 23:32 -!- kyknos_ [~kyknos@89.233.130.143] has quit [Ping timeout: 245 seconds] 23:32 -!- kyknos__ [~kyknos@89.233.130.143] has quit [Ping timeout: 272 seconds] 23:33 < jrayhawk> http://www.youtube.com/watch?v=NqwvcrA7oe8 is a pretty good example of what fatty acid metabolic adaptation can do if you're into endurance athletics 23:44 < venturecommunist> jrayhawk: checking it out, cool 23:46 < brownies> nice. thanks. --- Log closed Tue Jan 14 00:00:23 2014