--- Log opened Thu Apr 17 00:00:42 2014
00:12 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-vzymqaxypixbsjkk] has quit [Quit: Connection closed for inactivity]
00:17 -!- brownies [~brownies@unaffiliated/brownies] has quit [Ping timeout: 240 seconds]
00:18 -!- brownies [~brownies@184.106.201.58] has joined ##hplusroadmap
00:18 -!- brownies [~brownies@184.106.201.58] has quit [Changing host]
00:18 -!- brownies [~brownies@unaffiliated/brownies] has joined ##hplusroadmap
00:27 -!- audy [~audy@unaffiliated/audy] has quit [Ping timeout: 255 seconds]
00:33 -!- audy [~audy@heyaudy.com] has joined ##hplusroadmap
01:56 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has quit [Remote host closed the connection]
01:57 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has joined ##hplusroadmap
02:06 -!- Adifex is now known as Adifex|zzz
02:20 -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap
02:26 -!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has joined ##hplusroadmap
02:54 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
02:57 -!- entelechios [~elysium@181.194.129.122] has joined ##hplusroadmap
03:13 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap
03:31 -!- kyknos_ [~kyknos@89.233.130.143] has quit [Ping timeout: 250 seconds]
03:55 -!- entelechios [~elysium@181.194.129.122] has quit [Ping timeout: 265 seconds]
04:12 -!- FourFire [~fourfire@191-219-15.connect.netcom.no] has joined ##hplusroadmap
04:28 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-fwavcxnebqqamgca] has joined ##hplusroadmap
04:28 -!- q2p9e4u7t [1000@117.220.70.46] has joined ##hplusroadmap
04:30 -!- q2p9e4u7t [1000@117.220.70.46] has left ##hplusroadmap []
04:53 -!- Allah [~tpi@c-107-4-148-59.hsd1.va.comcast.net] has joined ##hplusroadmap
05:04 -!- kardan [~kardan@199.254.238.144] has quit [Ping timeout: 250 seconds]
05:06 -!- kardan [~kardan@199.254.238.214] has joined ##hplusroadmap
05:52 -!- ThomasEgi [~thomas@185.5.8.81] has joined ##hplusroadmap
05:52 -!- ThomasEgi [~thomas@185.5.8.81] has quit [Changing host]
05:52 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap
05:57 -!- mosasaur [~mosasaur@178.227.144.43] has joined ##hplusroadmap
06:01 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap
06:08 -!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
06:18 -!- kardan [~kardan@199.254.238.214] has quit [Read error: Connection reset by peer]
06:19 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 240 seconds]
06:38 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
06:43 -!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has quit [Ping timeout: 265 seconds]
06:50 -!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap
07:28 -!- nsh [~nsh@host86-158-32-224.range86-158.btcentralplus.com] has joined ##hplusroadmap
07:33 -!- audy [~audy@heyaudy.com] has quit [Changing host]
07:33 -!- audy [~audy@unaffiliated/audy] has joined ##hplusroadmap
07:42 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-fwavcxnebqqamgca] has quit [Quit: Connection closed for inactivity]
07:45 -!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has joined ##hplusroadmap
08:24 < ParahSailin> kanzure: scroll up in strace
08:27 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
08:52 -!- nsh [~nsh@host86-158-32-224.range86-158.btcentralplus.com] has quit [Changing host]
08:52 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap
08:53 -!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]
08:55 <@kanzure> oh duh
08:59 -!- nmz787_i [~nmccorkx@192.55.54.40] has joined ##hplusroadmap
09:05 -!- audy is now known as audy-laboratory
09:13 <@kanzure> these sound like really boring papers: http://peerproduction.net/issues/issue-4-value-and-currency/peer-reviewed-articles/
09:14 <@kanzure> also these: http://peerproduction.net/issues/issue-2/ (except maybe denisa's, but meh)
09:15 -!- fireprfHydra [~fireprfHy@pool-173-70-216-225.nwrknj.fios.verizon.net] has joined ##hplusroadmap
09:21 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
09:24 < nmz787_i> so far the "microfluidics fabrication services" i've contacted have been unhelpful... :/
09:24 <@kanzure> hmm https://github.com/weidai11/extropians/pull/1
09:25 <@kanzure> nmz787_i: go on
09:25 < ParahSailin> is anyone having weird kernel stuff going on on their servers?
09:26 <@kanzure> i haven't noticed anything broken
09:27 < ParahSailin> besides the epoll thing magically appearing since applying heartbleed patches
09:28 <@kanzure> unfortunately i last tried it a month ago, and i might have upgraded stuff prior to heartbleed
09:32 -!- mosasaur [~mosasaur@178.227.144.43] has quit [Quit: Leaving.]
09:46 < nsh> epoll thing magically appearing?
09:46 <@kanzure> http://www.zerohedge.com/news/2014-04-16/ex-chairman-insolvent-uk-bank-busted-possession-cocaine-ketamine-and-crystal-meth
09:47 <@kanzure> nsh: yes see https://github.com/gulpjs/gulp/issues/167#issuecomment-40677759
09:47 < nsh> ty
09:49 < nmz787_i> well basically it seems either A) I don't appear professional enough to these companies because I'm emailing from a gmail address
09:49 < nmz787_i> or B) there isn't enough demand for these things to make them as cheap as stanford was offering (stanford no longer has a foundry for outsiders)
09:49 <@kanzure> would you like to email from blackhatbio.com? maybe that would help
09:50 < nmz787_i> or C) I need to email more companies
09:50 <@kanzure> what were the prices they were quoting?
09:50 < nmz787_i> one company was ridiculous, quoting like $7k for a one-off and they didn't have valve experience, and maybe didn't even do assembly
09:51 < nmz787_i> this company in Connecticut seems like they've got all the experience, can do PDMS, glass, silicon (which they can add electrodes to), do assembly, can send out for optical coating
09:51 < ParahSailin> no, thats about right on the cost
09:51 < nmz787_i> but their responses have been short and unhelpful
09:51 < nmz787_i> ParahSailin: stanford was $450 for a multilayer device
09:51 <@kanzure> that was for a multilayer w/o valves i think
09:52 < nmz787_i> no i don't think they cared
09:52 < nmz787_i> since a valve is just two channels crossing over one another, with a curved profile for one and a square profile for the other
09:52 -!- fireprfHydra [~fireprfHy@pool-173-70-216-225.nwrknj.fios.verizon.net] has quit [Ping timeout: 258 seconds]
09:52 <@kanzure> http://web.archive.org/web/20110222234927/http://www.stanford.edu/group/foundry/
09:52 < ParahSailin> you dont really want pdms unless your use case is disposable
09:52 < nmz787_i> yep
09:53 < nmz787_i> i do0
09:53 < nmz787_i> don't want contam
09:53 < nmz787_i> carryover, etc
09:53 <@kanzure> only push up/push down valves
09:53 < nmz787_i> guess I just need to email more companies... but at $7k I could get tons of shit FIBbed locally
09:54 < ParahSailin> ok why are we still talking about fib
09:54 < nmz787_i> because you don't understand me
09:54 < nmz787_i> :P
09:54 < nmz787_i> because its nano/micro CNC
09:54 < chris_99> they use FIB for microfluidicy stuff?
09:54 < ParahSailin> raster is really slow, and you pay by the hour
09:55 < ParahSailin> chris_99: no, nobody actually does
09:55 -!- audy-laboratory is now known as audy
09:55 < nmz787_i> yep, its not that slow tho
09:55 < nmz787_i> microns per second
09:56 < nmz787_i> chris_99: one local company was interested in my project specifically so they could gain experience in that field, since they primarily do system design (of FIBs)
09:57 < chris_99> cool, which project is this, was it some kind of DNA synthesizer?
09:57 < nmz787_i> yes
09:57 < nmz787_i> i ordered a new harddrive the other night so i could try a bunch of CAD programs (i've had no free space for months)
09:58 < chris_99> they've gone pretty reasonable again, a 4TB is pretty decently priced i found
09:58 < nmz787_i> heh, well this is for my laptop, which can only accept 2.5" x 7mm high
09:58 < chris_99> ah heh
09:58 < nmz787_i> i got a 1TB though for not too terrible a price
09:58 < chris_99> so if they're gonna use FIB what material are you using
09:58 < nmz787_i> glass or silicon
09:59 < nmz787_i> can use that for making PDMS casts, but also for the electrode side of things
09:59 <@kanzure> ParahSailin: it's funny how he ignores your microfluidics experience
09:59 < nmz787_i> at least those guys were helpful when i spoke with them :/
09:59 < nmz787_i> i never knew ParahSailin had any microfluidics experience
09:59 < ParahSailin> who knows, maybe they actually have FIBs that can etch 100 micron wide channels, 20-100 um deep in seconds
10:00 < nmz787_i> all he's ever said was 'them dudes don't use fib'
10:00 < ParahSailin> been a while since i was in that game
10:00 <@kanzure> nah, he's said other things
10:00 <@kanzure> in the past
10:01 < nmz787_i> yes, they do, i've sent the etch rate link before, here it is again http://www.oregon-physics.com/lab_services/fib_micromachining_milling.html
10:02 < nmz787_i> as beam spot size increases, so does mill rate
10:02 < nmz787_i> s/etch/mill/
10:03 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
10:04 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 240 seconds]
10:07 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
10:09 -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 252 seconds]
10:09 <@kanzure> "historical video" https://www.youtube.com/user/britishpathe
10:11 <@kanzure> oh their claim seems to be wrong. they claimed 85,000 video uploads but i only see <200.
10:12 <@kanzure> aha http://www.britishpathe.com/search/recordcategories/Science++Technology/start/1890/end/1920
10:14 <@kanzure> those are much less interesting than i figured
10:14 <@kanzure> see, if i was alive in the 1890s and in charge of collecting videos, i would try to find much more diverse things that are in danger of disappearing, rather than mundane crap
10:15 <@kanzure> i'm not sure i understand this design http://proofmathisbeautiful.tumblr.com/post/82039490406/zerostatereflex-water-experiment-no-33
10:15 <@kanzure> oh they are holes at different locations on each disc
10:15 <@kanzure> disk
10:17 < ParahSailin> those etch rates are still terrible compared to wet or dry etch
10:17 < nmz787_i> seem fine though for rapid prototyping
10:19 < ParahSailin> how do you get to that
10:19 < nmz787_i> it certainly wouldn't cost $7k for one-off
10:25 < ParahSailin> you know what's awesome for rapid prototyping? inkjet printer on transparency + photoresist patterning and wet etch
10:26 < ParahSailin> you even dont need to pay for a couple machine days at $200/hr
10:26 < nmz787_i> I really don't care how it gets done, I just want an easy to deal with contractor
10:28 <@kanzure> ParahSailin: how many prototypes did you have to churn through?
10:28 < ParahSailin> lots
10:29 <@kanzure> how many components, valves, gates, whatever on chip?
10:29 < ParahSailin> heh even without any moving parts
10:29 < ParahSailin> im not sure theres any way to do moving parts without having something to foul
10:30 < ParahSailin> so if you want moving parts, its going to be a disposable
10:31 -!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 240 seconds]
10:33 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap
10:34 < ParahSailin> its actually kinda hard to get a circular reservoir to flush, because of the laminar flow thing
10:34 < ParahSailin> thats what typically takes a lot of prototypes
10:38 < chris_99> what kind of moving parts would you want out of interest on such a thing?
10:38 < nmz787_i> valvels
10:38 < nmz787_i> valves
10:39 < nmz787_i> brb
10:41 < ParahSailin> for serious low cost dna synthesis http://www.mycroarray.com/index.html 20k x 100nt / $1500
10:42 < nmz787_i> but those don't really have very good quality control
10:43 < nmz787_i> which for semi-directed evolution would be fine
10:43 < ParahSailin> yeah error rate is high, you need special shit for ligation
10:43 < ParahSailin> but thats what you want to go with for the raw synthesis part
10:44 < nmz787_i> I want to obliterate transfer steps... text file in, transformed bug culture out
10:44 < nmz787_i> basically its just coupling synthesis with purification and electroporation
10:44 < nmz787_i> :P
10:44 < nmz787_i> *basically*
10:45 < nmz787_i> that price point isn't too bad for today tho
10:45 < ParahSailin> bridge amplification & sequencing + ligation
10:45 < nmz787_i> you could do that, or just size-select and protect already-synthesized from active/destabilizing chemistry
10:46 -!- nmz787_i [~nmccorkx@192.55.54.40] has quit [Remote host closed the connection]
10:47 -!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
10:50 < eudoxia> http://198.170.115.106/reports/CI93.html this was a cool read from a few years back
10:50 < eudoxia> that's allegedly the IP of CI, i don't really care
10:53 <@kanzure> "(he had been taking about 150 pills per day, many of which were Life Extension Foundation products). The sudden loss of supplements was undoubtedly a shock to his system."
10:54 -!- nmz787_i [~nmccorkx@192.55.55.37] has joined ##hplusroadmap
11:01 -!- uberj [~uber@192.241.197.120] has left ##hplusroadmap ["WeeChat 0.4.3"]
11:06 <@kanzure> ioctl(6, FIOCLEX)                       = -1 EBADF (Bad file descriptor)
11:06 <@kanzure> ParahSailin: it's waiting on a bad fd?
11:07 < ParahSailin> thats weird
11:07 < ParahSailin> do you see an epoll_open anywhere returning 6?
11:08 <@kanzure> epoll_ctl(6, EPOLL_CTL_ADD, 7, {EPOLLIN, {u32=7, u64=7}}) = 0
11:09 <@kanzure> no epoll_open anywhere but probably wrong name
11:10 < ParahSailin> epoll_create
11:11 <@kanzure> only one: epoll_create1(O_CLOEXEC)                = 6
11:11 < ParahSailin> ok thats right
11:11 < ParahSailin> so somewhere between that and the ioctl 6 its gone?
11:12 < ParahSailin> is there a close(6 somewhere?
11:12 <@kanzure> 4532 lines
11:12 <@kanzure> there's only: ioctl(6, FIOCLEX); epoll_ctl(6, EPOLL_CTL_ADD, 7, {EPOLLIN, {u32=7, u64=7}}) = 0; epoll_ctl(6, EPOLL_CTL_ADD, 9, {EPOLLIN, {u32=9, u64=9}}) = 0; epoll_wait(6, {{EPOLLIN, {u32=9, u64=9}}}, 1024, 4294967295) = 1; epoll_wait(6,  <unfinished ...>;
11:13 <@kanzure> epoll_create1 is 10-15 lines after ioctl(6, ..)
11:13 < ParahSailin> oh
11:14 < ParahSailin> so its waiting on fds 7 and 9
11:14 <@kanzure> ioctl(7, FIOCLEX)                       = -1 EBADF (Bad file descriptor)
11:14 <@kanzure> same with 9
11:14 <@kanzure> except 9 also has: read(9, "\1\0\0\0\0\0\0\0", 1024)
11:15 <@kanzure> which is near the end next to the broken epoll_wait
11:15 <@kanzure> fd 7r is pipe and fd 9u is anon_inode (same as 6u)
11:16 < ParahSailin> what opens 9
11:17 <@kanzure> no lines end with "= 9"
11:17 <@kanzure> i don't see anything that opens it
11:18 < ParahSailin> you wanna pastebin the whole strace?
11:19 <@kanzure> http://diyhpl.us/~bryan/irc/node-strace.txt
11:20 <@kanzure> can file descriptors be shared between processes?
11:23 < ParahSailin> eventfd2(0, O_NONBLOCK|O_CLOEXEC)       = 9
11:23 < ParahSailin> yeah they can
11:24 <@kanzure> how did i miss that line?
11:25 <@kanzure> oh i was using \W9\W
11:25 -!- cpopell`gaming is now known as cpopell
11:26 < ParahSailin> well typically people dont use sendmsg and recvmsg to send file descriptors through domain sockets
11:27 < ParahSailin> but if theres a fork() anywhere you can bet that file descriptors are acessible to another process
11:28 < dingo> :D
11:30 < eudoxia> that sweet feel when a python script gets killed by the OOM killer
11:31 <@kanzure> hrm so now i have to figure out what's causing that to get called
11:41 < ParahSailin> ah right, clone()
11:41 < ParahSailin> so maybe you need the strace -f or -p whatever it is that makes it follow the whole process group
11:42 <@kanzure> http://diyhpl.us/~bryan/irc/node-strace2.txt
11:44 <@kanzure> 4520 seems to be the hanging pid
11:45 <@kanzure> oh that's the parent
11:45 < ParahSailin> yeah thats teh dad
11:46 < ParahSailin> what exactly are the child procs
11:46 < ParahSailin> just how node does multiprocessing?
11:47 <@kanzure> libuv stuff
11:48 < ParahSailin> when the parent process is left hanging, have the children all died?
11:48 < ParahSailin> yeah i guess so, they get detached
11:48 < ParahSailin> so the children die, and nobody is left to write to the eventfd
11:48 -!- Auctus [~Auctus@unaffiliated/auctus] has joined ##hplusroadmap
11:50 -!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has quit [Ping timeout: 252 seconds]
11:51 -!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has joined ##hplusroadmap
11:53 -!- Auctus [~Auctus@unaffiliated/auctus] has quit [Ping timeout: 250 seconds]
11:57 -!- eudoxia [~eudoxia@r179-25-190-85.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]
12:01 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
12:12 -!- heath [quassel@unaffiliated/ybit] has quit [Ping timeout: 258 seconds]
12:15 -!- heath [quassel@unaffiliated/ybit] has joined ##hplusroadmap
12:21 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap
12:22 < delinquentme> paperbot, http://pubs.acs.org/doi/abs/10.1021/nn405097u
12:22 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/Compartmental%20Genomics%20in%20Living%20Cells%20Revealed%20by%20Single-Cell%20Nanobiopsy.txt
12:24 -!- Shehrazad [~Shehrazad@unaffiliated/shehrazad] has quit [Quit: Leaving]
12:24 -!- ElixirVitae [~Shehrazad@95.5.71.250] has joined ##hplusroadmap
12:24 -!- ElixirVitae [~Shehrazad@95.5.71.250] has quit [Changing host]
12:24 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap
12:26 -!- sheena1 [~home@d75-155-198-81.bchsia.telus.net] has joined ##hplusroadmap
12:28 -!- sheena [~home@d75-155-198-81.bchsia.telus.net] has quit [Ping timeout: 265 seconds]
12:49 <@kanzure> paperbot: http://www.cell.com/cell/abstract/S0092-8674(14)00418-8
12:49 <@kanzure> "Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis"
12:50 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/Whole-Brain%20Imaging%20with%20Single-Cell%20Resolution%20Using%20Chemical%20Cocktails%20and%20Computational%20Analysis.pdf
12:50 <@kanzure> "Systems-level identification and analysis of cellular circuits in the brain will require the development of whole-brain imaging with single-cell resolution. To this end, we performed comprehensive chemical screening to develop a whole-brain clearing and imaging method, termed CUBIC (clear, unobstructed brain imaging cocktails and computational analysis). CUBIC is a simple and efficient method involving the immersion of brain samples in ...
12:51 <@kanzure> ... chemical mixtures containing aminoalcohols, which enables rapid whole-brain imaging with single-photon excitation microscopy. CUBIC is applicable to multicolor imaging of fluorescent proteins or immunostained samples in adult brains and is scalable from a primate brain to subcellular structures. We also developed a whole-brain cell-nuclear counterstaining protocol and a computational image analysis pipeline that, together with CUBIC ...
12:51 <@kanzure> ... reagents, enable the visualization and quantification of neural activities induced by environmental stimulation. CUBIC enables time-course expression profiling of whole adult brains with single-cell resolution."
12:51 <@kanzure> paperbot: http://www.sciencedirect.com/science/article/pii/S0092867414004188
12:51 < nsh> .wa number of cells in human brain
12:51 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/2165fbbd0371142b5576fec4d49135c9.txt
12:51 < yoleaux> nsh: Sorry, no result!
12:51 < nsh> (lots)
13:05 <@kanzure> ParahSailin: i "solved" the problem by doing a custom build of nodejs :(
13:05 < ParahSailin> yeah, recompiling always solves these things
13:09 < ParahSailin> do you have any assets at illumina?
13:15 <@kanzure> not to my knowledge?
13:15 <@kanzure> oh wait, hm
13:16 <@kanzure> no
13:16 <@kanzure> i keep forgetting that lifetech was acquired by thermo fisher
13:18 < cpopell> Life is weird sometimes. I just found out the mother of one of my friends growing up went back to school in her late forties for a degree in CS and is getting into predictive analytics.
13:20 -!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap
13:20 -!- nsh [~nsh@wikipedia/nsh] has quit [Disconnected by services]
13:20 -!- nsh_ is now known as nsh
13:28 <@kanzure> http://www.consul.io/intro/index.html
13:28 <@kanzure> http://www.consul.io/docs/internals/architecture.html
13:28 <@kanzure> http://www.consul.io/intro/vs/serf.html
13:34 -!- bertm [~bertm@remote.pacificlighttech.com] has joined ##hplusroadmap
13:39 -!- FourFire [~fourfire@191-219-15.connect.netcom.no] has left ##hplusroadmap ["Leaving"]
13:43 -!- eudoxia [~eudoxia@r186-53-74-21.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
13:47 < delinquentme> https://www.youtube.com/watch?v=uL6e3co4Qqc
13:49 < delinquentme> THIS is awesome
13:49 < delinquentme> and I need to pee
13:49 < delinquentme> TTYL!
13:49  * delinquentme licks ParahSailin 
13:49 -!- delinquentme [~dingo@74.61.157.78] has quit [Quit: Leaving]
13:49 < eudoxia> wow licking people on IRC, how rude is that
13:52 -!- ielo [~ielo@129-2-129-26.wireless.umd.edu] has joined ##hplusroadmap
14:03 -!- kardan [~kardan@199.254.238.183] has joined ##hplusroadmap
14:06 < jrayhawk> kanzure: did you meet delinquentme in real life and, if so, did delinquentmy at any point attempt to lick you?
14:06 < jrayhawk> s/my/me
14:12 -!- devrando1 is now known as devrandom
14:20 -!- ielo [~ielo@129-2-129-26.wireless.umd.edu] has quit [Ping timeout: 245 seconds]
14:26 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap
14:39 -!- _Sol_ [SolGr@c-50-166-90-49.hsd1.nj.comcast.net] has joined ##hplusroadmap
14:40 -!- kardan [~kardan@199.254.238.183] has quit [Quit: Ciao!]
14:41 <@kanzure> "Human Somatic Cell Nuclear Transfer Using Adult Cells" http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00137-4
14:41 <@kanzure> "•Adult cell reprogramming via SCNT is not successful via the conventional protocol"
14:41 <@kanzure> "•Improved success was achieved with a recently developed approach"
14:41 <@kanzure> "•hESCs were derived via SCNT from 35- and 75-year-old males"
14:41 <@kanzure> "Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant somatic cells. In this study, we describe the application of a recently developed methodology for the generation of human ESCs via SCNT ...
14:41 <@kanzure> ... using dermal fibroblasts from 35- and 75-year-old males. Our study therefore demonstrates the applicability of SCNT for adult human cells and supports further investigation of SCNT as a strategy for regenerative medicine."
14:43 -!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has quit [Excess Flood]
14:45 -!- eudoxia [~eudoxia@r186-53-74-21.dialup.adsl.anteldata.net.uy] has quit [Quit: leaving]
14:46 < delinquentme> Theres some nordic fashion designer whos spending money in the bahamas or jamaca or someplace warm to bring about research in SCNT
14:46 < delinquentme> good news for him
14:46 <@kanzure> http://opensslrampage.org/
14:46 < delinquentme> Blahhhhhh kanzure should I work for academia.edu
14:47 <@kanzure> “So the OpenSSL codebase does “get the time, add it as a random seed” in a bunch of places inside the TLS engine, to try to keep entropy high. I wonder if their moto is “If you can’t solve a problem, at least try to do it badly”.”
14:47 <@kanzure> hahaha no
14:47 <@kanzure> no way man
14:47 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap
14:47 < delinquentme> I mean its could be good connections and the money would be solid.
14:47 <@kanzure> good connections with what
14:48 < delinquentme> kanzure, I also just realized that with the right circuitry the research in fishingline muscles could be REALLY handy in quad copters / the work being done w 3drobotics
14:48 < delinquentme> I mean I'd quickly be able to vet tons of people within academic circles
14:58 -!- Auctus [~Auctus@unaffiliated/auctus] has joined ##hplusroadmap
15:00 -!- Auctwo [~Auctus@122-57-138-207.jetstream.xtra.co.nz] has quit [Ping timeout: 258 seconds]
15:01 -!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap
15:02 -!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 258 seconds]
15:08 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Remote host closed the connection]
15:11 -!- nsh_ is now known as nsh
15:28 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]
15:28 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap
15:33 -!- trotsky [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap
15:33 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Ping timeout: 265 seconds]
15:43 -!- ielo [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has joined ##hplusroadmap
15:43 -!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 252 seconds]
16:07 -!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer]
16:19 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap
16:20 -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap
16:22 -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection]
16:24 -!- trotsky [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]
16:24 <@kanzure> http://www.nlm.nih.gov/news/welcome_library_agreement.html "NLM and Wellcome Library Establish Agreement to Make 150 Years of Biomedical Journals Freely Available Online"
16:24 <@kanzure> "Representatives of the US National Library of Medicine (NLM), a component of the National Institutes of Health, and the Wellcome Trust recently signed a memorandum of understanding to work together to make thousands of complete back issues of historically-significant biomedical journals freely available online. The terms of the MOU include a donation of £750,000 ($1.2 million) to the NLM that will support coordination of the three-year ...
16:24 <@kanzure> ... project to scan original materials from NLM's collection at the article level, and Wellcome's work to secure copyright clearances and permissions for electronic deposit from publishers. NLM will undertake conservation of the original material to ensure its preservation for future generations."
16:24 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap
16:24 <@kanzure> um... "and Wellcome's work to secure copyright clearances and permissions for electronic deposit from publishers."
16:24 <@kanzure> copyright permissions for 100 year-old papers?
16:26 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap
16:29 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Ping timeout: 258 seconds]
16:33 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]
16:36 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap
16:37 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]
16:41 -!- nmz787_i [~nmccorkx@192.55.55.37] has quit [Quit: Leaving.]
16:44 -!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has joined ##hplusroadmap
16:47 <@kanzure> performance of hashing in javascript crypto libraries http://dominictarr.github.io/crypto-bench/
16:53 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-wepzhlvcwayqijmt] has joined ##hplusroadmap
16:54 <@kanzure> yahoo mail emails are breaking mailman with DMARC p=reject http://www.dmarc.org/pipermail/dmarc-discuss/2014-April/002445.html
17:06 -!- entelechios [~elysium@181.194.129.122] has joined ##hplusroadmap
17:09 -!- entelech1os [~elysium@181.194.129.122] has joined ##hplusroadmap
17:10 -!- entelech1os [~elysium@181.194.129.122] has quit [Client Quit]
17:13 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has joined ##hplusroadmap
17:14 -!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 258 seconds]
17:18 -!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has quit [Ping timeout: 250 seconds]
17:26 -!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap
17:28 -!- nsh [~nsh@wikipedia/nsh] has quit [Ping timeout: 258 seconds]
17:31 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has joined ##hplusroadmap
18:03 -!- ielo is now known as amillers_boyfrie
18:03 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has joined ##hplusroadmap
18:03 -!- amillers_boyfrie is now known as jamesz
18:05 -!- cpopell [~cpopell@pool-71-255-241-91.washdc.fios.verizon.net] has joined ##hplusroadmap
18:06 < cpopell> http://scholar.google.com/scholar?hl=en&q=a+fundamental+study+and+modeling+of+the+micro-droplet+formation+process+in+near-field+electrohydrodynamic+jet+printing&btnG=&as_sdt=1%2C47&as_sdtp=
18:08 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
18:10 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 276 seconds]
18:15 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap
18:17 -!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has quit [Ping timeout: 245 seconds]
18:21 < ParahSailin> http://www.state.gov/j/drl/p/224863.htm
18:22 -!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 258 seconds]
18:27 <@kanzure> ParahSailin: i don't think they will particularly accept the "let's send lots of open source molecular biology equipment to north korea" proposal
18:28 < entelechios> lol
18:29 < entelechios> http://www.koryogroup.com/ north korea vacations
18:29 -!- ruthie [~ruthie@dhcp-130-58-198-65.swarthmore.edu] has quit [Remote host closed the connection]
18:30 < entelechios> i saw some bearded gringo with a sorta angry look on his face wearing a red tshirt that said 'COMMUNIST' on it walking out of a cuban bar the other day and all i could do was lol
18:30 < ParahSailin> dangit
18:31 < ParahSailin> how about design the freedom virus?
18:31 <@kanzure> only if it's sexually transmitted
18:32 < entelechios> http://cdn.pophangover.com/wp-content/uploads/2013/04/kim-jong-un-fx_o_1241392.gif
18:32 -!- drewbot [~cinch@ec2-54-205-5-34.compute-1.amazonaws.com] has quit [Remote host closed the connection]
18:32 -!- drewbot [~cinch@ec2-50-17-42-27.compute-1.amazonaws.com] has joined ##hplusroadmap
18:33 < ParahSailin> oh god
18:37 -!- delinquentme [~dingo@131.107.200.34] has joined ##hplusroadmap
18:42 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Quit: Leaving.]
18:42 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap
18:45 <@kanzure> "Kepler-186f is an exoplanet orbiting the red dwarf Kepler-186, 500 light-years from the Earth. It is the first planet with a radius similar to Earth's discovered in the habitable zone of another star." https://en.wikipedia.org/wiki/Kepler_186f
18:50 <@kanzure> 18:29 < justanot1eruser> Looking at the scrollback for the interplanetary Bitcoin, is there a way to prove you're on a certain planet that is cryptographically verifiable?
18:51 <@kanzure> "how fast would the fastest human run 100m?" http://freakonometrics.hypotheses.org/13880
18:55 < dingo> lol
18:57 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection]
19:00 -!- delinquentme [~dingo@131.107.200.34] has quit [Read error: No route to host]
19:02 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-wepzhlvcwayqijmt] has quit [Quit: Connection closed for inactivity]
19:03 -!- ruthie [~ruthie@c-98-225-143-81.hsd1.pa.comcast.net] has joined ##hplusroadmap
19:05 -!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has joined ##hplusroadmap
19:21 -!- Qfwfq [~Qfwfq@cm113.kappa36.maxonline.com.sg] has joined ##hplusroadmap
19:21 -!- Qfwfq [~Qfwfq@cm113.kappa36.maxonline.com.sg] has quit [Client Quit]
19:28 -!- jamesz [~ielo@c-69-255-193-198.hsd1.md.comcast.net] has quit [Ping timeout: 258 seconds]
19:31 -!- HashNuke [uid12117@gateway/web/irccloud.com/x-ivjfzfqxytqfxlww] has joined ##hplusroadmap
19:47 -!- Adifex|zzz is now known as Adifex
19:52 < heath> where is biologik located?
19:57 <@kanzure> his smile is annoying
19:57 <@kanzure> "He would like nothing more than to become a master of manipulating DNA through complexity science"
19:57 <@kanzure> he's also apparently an idiot about dna
19:59 < entelechios> imma mad scientist, watch me style my hair like einstein put on a lab coat and spout off bullshit
20:00 < entelechios> hey look i have a flask with green koolaid in it and googly eyes
20:01 <@kanzure> your own eyes are googly?
20:01 < entelechios> and i have a german accent
20:03 < cluckj> wat
20:08 <@kanzure> 'parently it's fucked up o'clock in here
20:11 < heath> fig is pretty great
20:12 < heath> i've been using packer for about two weeks now
20:12  * heath was rereading the logs, just saw your fig stuff kanzure
20:15 < heath> i havent' used docker though
20:16 < heath> and subsequently fig
20:16 <@kanzure> the major downside with fig is service discovery
20:17 <@kanzure> it forces you to do a lot of service discovery stuff upfront
20:17 <@kanzure> instead of ignoring it until your infrastructure is breaking
20:17 < heath> fig looks a lot like ansible, which we've been using
20:19 < heath> i don't know that i'll have much use for it unless i use docker
20:19 <@kanzure> probably not
20:21 < heath> oh yeah, i've been working remotely for awhile :)
20:21 < heath> and i don't plan on changing this
20:22 < heath> not a fan of cubicle culture
20:24 < heath> kanzure: you've been working away on the pokemon disassembly for awhile, where are you heading with this?
20:24 < heath> please say you're making google's april fool's joke a reality
20:24 < heath> juri_: why haven't you been all over osvehicle?
20:24 <@kanzure> i didn't see their latest thing. something about a map and pokemon?
20:24 <@kanzure> in which case, no
20:26 <@kanzure> when i was 11 i was doing lots of trial-and-error gamesharking on pokemon
20:26 <@kanzure> the disassembly is my way of squashing my inner child
20:27 <@kanzure> violently
20:27 <@kanzure> instead of trial and error you can look at things like reality! and make progress on things!
20:28 <@kanzure> but also if you're asking for TODOs it's mostly related to removing the dependency on baserom.gbc
20:34 < xmj> good morning
20:35 < xmj> kanzure: does disassembling and looking at the inner plumbing feel more 'fun' ?
20:37 <@kanzure> more fun than what?
20:38 < xmj> trial/error
20:38 <@kanzure> i've been able to think about stuff like asm injection and stack busting
20:39 <@kanzure> jrayhawk: was there ever any "real-time" non-turn-based interactive fiction?
20:45 < juri_> heath: there's a link to it on my wiki page.
20:45 -!- Qfwfq [~Qfwfq@unaffiliated/washirving] has joined ##hplusroadmap
20:45 < juri_> it looked way too not-printable, to me.
20:47 < xmj> kanzure: that doesn't answer my question
20:48 <@kanzure> i haven't really evaluated it on the spectrum of fun, ever
20:48 <@kanzure> i guess i've forgotten to
20:49 < xmj> ah
20:49 < xmj> how sad
20:50 <@kanzure> if you say so
21:02 -!- Qfwfq [~Qfwfq@unaffiliated/washirving] has quit [Ping timeout: 276 seconds]
21:05 -!- cluckj [~cluckj@cpe-24-92-63-104.nycap.res.rr.com] has quit [Ping timeout: 245 seconds]
21:06 < jrayhawk> kanzure: you'll have to be a bit more specific in your definition of "interactive fiction" and "real time"
21:07 -!- cluckj [~cluckj@cpe-24-92-63-104.nycap.res.rr.com] has joined ##hplusroadmap
21:08 < jrayhawk> the stanley parable probably matches most of the definitions you could come up with
21:09 -!- petora [~asakharov@24.60.79.55] has joined ##hplusroadmap
21:10 < jrayhawk> if "real time" means "matches the flow of time outside the game" then a fair number of mmorpgs might qualify, though usually narratives can only be loosely guided through those
21:10 < jrayhawk> early Ultima Online and Matrix Online had lots of real-time narrative elements.
21:12 <@kanzure> "real time" as in, if you don't type an action, stuff is happening on your screen
21:12 <@kanzure> do MUDs count? or do things only happen in MUDs once you enter a command
21:15 < jrayhawk> MUDs don't usually have much plot to speak of; they're usually stereotypical "RPG" hedonic treadmills.
21:15 < yashgaroth> a kobold arrives from the north
21:15 < jrayhawk> And/or player-driven dramas.
21:15 <@kanzure> that's disappointing. glad i never bothered.
21:15 < yashgaroth> aww c'mon the discworld mud was pretty good
21:15 < jrayhawk> player-invented dramas can get fairly entertaining, as seen with EVE
21:16 < jrayhawk> the forces of recursive tribal power concentration versus space nihilists
21:17 < jrayhawk> most of the game industry consists of products that are not turn based and contain a narrative, so you'll probably want to be more specific
21:18 <@kanzure> "a kobold arrives from the north" while you're typing "north"
21:18 < yashgaroth> and begins to attack you; anyway yes stuff happens in MUDs without you entering commands
21:19 <@kanzure> i've only seen MUDs that send me text after i hit enter
21:19 < jrayhawk> That does not sound like a good multi-user interaction model.
21:20 < yashgaroth> by necessity in a multi-user environment, at the least another player's actions will appear
21:20 <@kanzure> well, i was thinking single-player originally, but i suppose multi-user counts as interactive fiction too
21:20 < jrayhawk> what exactly do you think "MUD" stands for
21:20 <@kanzure> i don't know who you're asking anymore
21:21 <@kanzure> i know that the server game state is updating in that scenario, but i'm talking about async updates on the user's screen
21:21 -!- snuffeluffegus [~John@homie-vserver314.dreamhost.com] has quit [Remote host closed the connection]
21:22 < jrayhawk> Yeah, MUDs did that even back in, like, 1990, though how often that feature was relevant was a matter of game dynamics.
21:22 <@kanzure> was it.. a good dynamic?
21:22 <@kanzure> or just annoying
21:23 < jrayhawk> I never played MUDs in the internet era where multiplayer was somewhat more meaningful, so I couldn't tell you.
21:23 < jrayhawk> I think I know a guy who can recommend some if you want to give them a whirl.
21:23 <@kanzure> well i was pondering a text-based dinoslaughter onslaught
21:24 < jrayhawk> violetland/crimsonland aren't good enough for you, huh?
21:24 <@kanzure> no sorry
21:25 <@kanzure> (i'm not sorry)
21:27 < jrayhawk> http://www.topmudsites.com/
21:27 < jrayhawk> i am told aardwolf is pretty good
21:29 < jrayhawk> in that it is a large community and has active development
21:30 -!- nsh_ [~nsh@wikipedia/nsh] has quit [Ping timeout: 252 seconds]
21:35 < jrayhawk> dwarf fortress is a single player sandbox game with anomalously strong procedurally/emergently generated narrative elements
21:35 < jrayhawk> i think you get to stop time whenever, though
21:35 < jrayhawk> it's just a particularly outstanding example of how to do unstructured narratives
21:38 < jrayhawk> Space Station 13 is also pretty innovative
21:39 <@kanzure> yes, dwarf fortress counts, although they rely a lot on ascii art
21:39 <@kanzure> "interactive fiction" at one point referred almost exclusively to infocom i think
21:40 < jrayhawk> ah, okay
21:42 < jrayhawk> yeah, that's not really my area of expertise. There's a big community focused around http://www.ifwiki.org/index.php/Main_Page at least.
21:42 <@kanzure> got it, so you have dominion over arcade games, but not anything earlier :p
21:43 -!- nsh_ [~nsh@wikipedia/nsh] has joined ##hplusroadmap
21:59 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has quit [Quit: Leaving]
22:05 < petora> jrayhawk  Someone really needs to build a GUI frontend to dwarf fortress
22:05 < petora> I mean one with mouse click windows
22:07 <@kanzure> p. sure that exists somewhere
22:09 < petora> it doesnt really exist actually
22:09 < petora> still have to keyboard everything
22:10 < petora> and then ESC-ESC-ESC-ESC to get back to the top of the  keypress tree
22:15 < petora> people have only been troubled enough to build GUIs "on top of" the underlying mechanics
22:22 < cpopell> petora: not as advanced, but you could play Gnomoria
22:23 <@kanzure> that sounds like the name of ParahSailin's freedom virus
23:13 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal]
23:13 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has joined ##hplusroadmap
23:21 -!- nsh_ [~nsh@wikipedia/nsh] has quit [Ping timeout: 240 seconds]
23:23 < JayDugger> Good morning, everyone.
23:28 -!- kuldeepdhaka [~kuldeepdh@unaffiliated/kuldeepdhaka] has joined ##hplusroadmap
23:58 -!- kyknos__ [~kyknos@89.233.130.143] has joined ##hplusroadmap
--- Log closed Fri Apr 18 00:00:43 2014