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[EnLilaSko@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 08:46 -!- ParahSailin [~parahsail@unaffiliated/parahsailin] has quit [Ping timeout: 260 seconds] 08:48 -!- ParahSailin [~parahsail@unaffiliated/parahsailin] has joined ##hplusroadmap 09:12 -!- TeMPOraL [~user@89-68-70-120.dynamic.chello.pl] has joined ##hplusroadmap 09:27 -!- catern [~catern@catern.com] has quit [Ping timeout: 276 seconds] 09:29 -!- catern [~catern@catern.com] has joined ##hplusroadmap 09:31 -!- ElixirVitae [~Shehrazad@95.5.110.202] has joined ##hplusroadmap 09:31 -!- ElixirVitae [~Shehrazad@95.5.110.202] has quit [Changing host] 09:31 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 09:34 < jrayhawk_> http://en.wikipedia.org/wiki/McLaren_MP4-25#F-duct outstanding 09:45 -!- joepie91_ [5064fe45@gateway/web/freenode/ip.80.100.254.69] has joined ##hplusroadmap 09:49 -!- TeMPOraL [~user@89-68-70-120.dynamic.chello.pl] has quit [Quit: ERC Version 5.3 (IRC client for Emacs)] 10:11 -!- Jaakko911 [~Jaakko@cpc13-newc15-2-0-cust64.16-2.cable.virginm.net] has joined ##hplusroadmap 10:11 -!- Jaakko910 [~Jaakko@cpc13-newc15-2-0-cust64.16-2.cable.virginm.net] has quit [Ping timeout: 244 seconds] 10:21 -!- petrush [~asakharov@24.60.79.55] has joined ##hplusroadmap 10:36 < kanzure> hrm 10:49 -!- catern [~catern@catern.com] has quit [Ping timeout: 255 seconds] 10:56 -!- catern [~catern@catern.com] has joined ##hplusroadmap 11:02 -!- nshlike [~unf@wikipedia/nsh] has joined ##hplusroadmap 11:23 -!- eudoxia [~eudoxia@179.26.171.123] has quit [Quit: Lost terminal] 11:59 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Read error: Connection reset by peer] 12:01 -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap 12:02 -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has joined ##hplusroadmap 12:08 -!- nsh [~nsh@host217-43-193-138.range217-43.btcentralplus.com] has joined ##hplusroadmap 12:19 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap 12:27 -!- delinquentme [~dingo@74.61.157.78] has quit [Ping timeout: 240 seconds] 12:48 -!- ruphos [~ruphos@biofag.com] has quit [Ping timeout: 240 seconds] 12:48 -!- ruphos [~ruphos@biofag.com] has joined ##hplusroadmap 12:48 -!- d3vz3r0 [~d3vz3r0@jsr.6502.ws] has quit [Ping timeout: 252 seconds] 12:57 -!- ||0_-_0|| [uid34064@gateway/web/irccloud.com/x-tpkllsgpohsupnru] has joined ##hplusroadmap 12:58 < ||0_-_0||> paperbot http://www.nature.com/nbt/journal/v32/n1/full/nbt.2786.html 12:58 < paperbot> http://libgen.org/scimag/get.php?doi=10.1038%2Fnbt.2786 13:00 < kanzure> .title http://www.nature.com/nbt/journal/v32/n1/full/nbt.2786.html 13:00 < yoleaux> Clinical development success rates for investigational drugs 13:02 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 240 seconds] 13:02 -!- d3vz3r0 [~d3vz3r0@jsr.6502.ws] has joined ##hplusroadmap 13:04 -!- abetusk [~abe@208.184.72.78] has quit [Ping timeout: 240 seconds] 13:05 -!- abetusk [~abe@208.184.72.78] has joined ##hplusroadmap 13:05 -!- abetusk is now known as Guest91421 13:06 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Ping timeout: 240 seconds] 13:06 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 13:10 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 13:13 < ||0_-_0||> I'm building an axe, kanzure 13:13 -!- catern [~catern@catern.com] has quit [Ping timeout: 240 seconds] 13:14 < ||0_-_0||> seeking to quantify the pattern by which pharma R&D is getting steadily worsening returns and in doing so figure out the R&D investment::clinical advancement limit 13:15 < kanzure> ||0_-_0||: i suggest going the opposite direction, presenting a question like "if our target is 1 new drug per $1 million, what would have to change to make the system this efficient?" 13:17 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has joined ##hplusroadmap 13:18 -!- catern [~catern@catern.com] has joined ##hplusroadmap 13:24 < FourFire> ||0_-_0||, kanzure's suggestion sounds like an admirable goal 13:24 < ||0_-_0||> FourFire + kanzure you've hit the other part of the analysis spot-on; the above is about determining total opportunity size 13:25 < FourFire> alright 13:28 -!- FourFire [~fourfire@49-27-15.connect.netcom.no] has quit [Quit: Leaving] 13:47 < kanzure> what does "total opportunity size" have to do with "how would we achieve a goal of a $1 million pipeline?" ? 13:49 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 14:04 -!- nsh [~nsh@host217-43-193-138.range217-43.btcentralplus.com] has quit [Quit: Leaving] 14:04 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 14:04 -!- nsh [~nsh@wikipedia/nsh] has quit [Excess Flood] 14:05 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 14:05 -!- nsh [~nsh@wikipedia/nsh] has quit [Max SendQ exceeded] 14:27 -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has quit [Ping timeout: 244 seconds] 14:29 -!- nmz787_i [~nmccorkx@134.134.139.76] has quit [Quit: Leaving.] 14:48 -!- Guest91421 is now known as abetusk 14:48 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Remote host closed the connection] 15:01 -!- nmz787_i [~nmccorkx@134.134.137.73] has joined ##hplusroadmap 15:03 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 15:11 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 15:49 -!- Miriam1 [~Miriam@CPEbcc8100d0e56-CMbcc8100d0e53.cpe.net.cable.rogers.com] has left ##hplusroadmap [] 15:49 < kanzure> various photoresist datasheets http://diyhpl.us/~bryan/papers2/curing/datasheets/ 16:23 -!- joepie91_ [5064fe45@gateway/web/freenode/ip.80.100.254.69] has quit [Ping timeout: 246 seconds] 16:45 -!- ielo [~ielo@unaffiliated/lumos] has quit [Read error: Connection reset by peer] 16:51 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 16:51 -!- nsh [~nsh@wikipedia/nsh] has quit [Excess Flood] 16:51 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 16:51 -!- nsh [~nsh@wikipedia/nsh] has quit [Max SendQ exceeded] 16:52 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 16:52 -!- nsh [~nsh@wikipedia/nsh] has quit [Max SendQ exceeded] 16:53 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 16:54 -!- nsh [~nsh@wikipedia/nsh] has quit [Max SendQ exceeded] 16:54 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 16:54 -!- nsh [~nsh@wikipedia/nsh] has quit [Max SendQ exceeded] 16:55 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has joined ##hplusroadmap 16:57 -!- nsh [~nsh@wikipedia/nsh] has joined ##hplusroadmap 17:05 -!- nmz787_i [~nmccorkx@134.134.137.73] has quit [Quit: Leaving.] 17:06 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has quit [Ping timeout: 264 seconds] 17:07 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has joined ##hplusroadmap 17:07 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has quit [Client Quit] 17:16 -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] 17:18 < kanzure> .title https://www.youtube.com/watch?v=8SkdfdXWYaI#t=558 17:18 < yoleaux> Using Python to Code by Voice 17:19 -!- nmz787_i [~nmccorkx@192.55.54.38] has joined ##hplusroadmap 17:19 -!- nmz787_i [~nmccorkx@192.55.54.38] has quit [Client Quit] 17:24 < nsh> because what software needs most is more ways to misinterpret your intentions 17:26 < kanzure> well, everyone else does that anyway 17:44 -!- TeMPOraL [~user@89-68-70-120.dynamic.chello.pl] has joined ##hplusroadmap 17:51 -!- seba- [~hel1@cpe-90-157-233-7.static.amis.net] has quit [Read error: Connection reset by peer] 17:51 -!- seba- [~hel1@cpe-90-157-233-7.static.amis.net] has joined ##hplusroadmap 17:56 -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has joined ##hplusroadmap 18:02 -!- seba-- [~hel1@cpe-90-157-233-7.static.amis.net] has joined ##hplusroadmap 18:02 -!- seba- [~hel1@cpe-90-157-233-7.static.amis.net] has quit [Read error: Connection reset by peer] 18:08 -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has joined ##hplusroadmap 19:08 -!- ||0_-_0|| [uid34064@gateway/web/irccloud.com/x-tpkllsgpohsupnru] has quit [Quit: Connection closed for inactivity] 19:15 -!- sapiosexual [~sapiosexu@d50-92-48-8.bchsia.telus.net] has joined ##hplusroadmap 19:25 -!- delinquentme [~dingo@74.61.157.78] has joined ##hplusroadmap 19:36 -!- TeMPOraL [~user@89-68-70-120.dynamic.chello.pl] has quit [Quit: ERC Version 5.3 (IRC client for Emacs)] 19:37 -!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has quit [Quit: Leaving.] 19:55 < kanzure> not sure what this is: "Esterline Instrument Corp 201CE" 19:55 < kanzure> "Made by Esterline Instrument Corp for Bio-Rad. Part Number 201CE. Unit consists of a Deuterium Lamp, Beam splitter, Lens that couples to sample chamber, (not included). and stepper motor driven mirror assembly which balances the sample output to the reference output and produces a measurable value" 19:55 < kanzure> something about light.. but then there's a chamber because ?? 19:55 < kanzure> and then you are measuring something because why not? 20:41 -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has quit [Remote host closed the connection] 20:53 < kanzure> ugh microscope adapters http://www.microscopy-uk.org.uk/mag/artmar13/gm-digital.pdf 21:09 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] 21:09 -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has joined ##hplusroadmap 21:13 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 244 seconds] 21:21 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 21:31 -!- AshleyWaffle [~waffle@gateway/tor-sasl/anastasiawyatt] has joined ##hplusroadmap 21:48 -!- Guest14473 is now known as maaku 21:57 < kanzure> an okay list: http://en.wikipedia.org/wiki/Genetically_modified_crops#Examples_of_genetically_modified_crops 21:59 < dingo> i turned 0x1f earlier this week 21:59 < dingo> happy birthday me! 22:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0c5aa24a Bryan Bishop: things that have been done with custom DNA >> http://diyhpl.us/diyhpluswiki/dna/projects/ 22:06 < kanzure> i was asked what could be done with custom dna, so i thought i should at least write down a list 22:06 < kanzure> ParahSailin: i know i am forgetting lots of really important stuff, perhaps you could recommend a few.. 22:08 < kanzure> especially non-commercial non-implemented stuff 22:13 < kanzure> gah, i forgot about all the igem projects 22:14 < kanzure> and i forgot how awful their site is for figuring out which ones did any gene stuff: 22:14 < kanzure> http://igem.org/Results?year=2012®ion=All&division=igem 22:14 < ebowden> Oh, kanzure, I heard something about rare codons, if the start of a sequence that codes for a protein has a rare codon, endpoint protein production was increased. Have you heard about this? 22:14 < kanzure> "spider silk gfp fusion protein" http://2012.igem.org/Team:Utah_State 22:17 < kanzure> "arachnicoli" with someone dressed up in a spiderman suit holding a petri dish :shakes head: 22:24 < ebowden> Damn it. I can only find the press release. 22:24 < ebowden> http://wyss.harvard.edu/viewpressrelease/125/a-hidden-genetic-code-for-better-designer-genes- 22:24 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has quit [Quit: Leaving] 22:33 < ebowden> paperbot http://link.springer.com/article/10.1007%2Fs10969-013-9163-9 22:33 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/New%20LIC%20vectors%20for%20production%20of%20proteins%20from%20genes%20containing%20rare%20codons.pdf 22:36 < ebowden> God damn it I love you paperbot. 22:43 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f92a78ff Bryan Bishop: various igem projects >> http://diyhpl.us/diyhpluswiki/dna/projects/ 22:57 < kanzure> https://ia801509.us.archive.org/18/items/al_saleel_4/SaleelSawarim.mp4 22:59 -!- drewbot [~cinch@ec2-54-227-159-52.compute-1.amazonaws.com] has quit [Remote host closed the connection] 22:59 -!- drewbot [~cinch@ec2-54-197-83-154.compute-1.amazonaws.com] has joined ##hplusroadmap 23:28 -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap 23:31 -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has quit [Ping timeout: 244 seconds] 23:31 -!- kyknos [~kyknos@89.233.130.143] has quit [Ping timeout: 260 seconds] 23:34 -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has quit [Remote host closed the connection] 23:34 -!- kumavis [~kumavis@24-196-137-155.static.ftbg.wi.charter.com] has joined ##hplusroadmap 23:35 -!- ebowden [~ebowden@CPE-60-231-182-1.lns4.dav.bigpond.net.au] has joined ##hplusroadmap --- Log closed Sat Jun 14 00:00:34 2014