--- Log opened Sun Aug 10 00:00:30 2014 00:13 -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has quit [Ping timeout: 260 seconds] 00:29 -!- delinquentme [~dingo@74.61.157.78] has quit [Quit: Leaving] 00:47 -!- ebowden_ [~ebowden@147.69.26.236] has quit [Remote host closed the connection] 01:11 -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap 01:17 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 245 seconds] 01:17 -!- Vutral__ [~ss@176.10.107.229] has quit [Ping timeout: 240 seconds] 01:17 -!- Vutral_ [~ss@176.10.107.229] has quit [Ping timeout: 240 seconds] 01:21 -!- Vutral- [~ss@2a01:198:35a::101] has quit [Excess Flood] 01:24 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 01:25 -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Remote host closed the connection] 01:34 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 01:34 -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has joined ##hplusroadmap 01:38 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] 01:41 -!- sapiosexual [~sapiosexu@d108-180-140-189.bchsia.telus.net] has quit [Ping timeout: 255 seconds] 01:41 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 01:42 < kyknos_> paperbot: http://www.sciencedirect.com/science/article/pii/S0022283668800129 01:42 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/d1a31dad420dfe2b63d22bc489e0c236.txt 01:42 < kyknos_> paperbot: http://www.sciencedirect.com/science/article/pii/0022283670900045 01:42 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/70319e776ddd25010374a4dbbc69d84f.txt 01:48 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 01:48 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 01:49 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-odsoyzonkwkusbcy] has joined ##hplusroadmap 01:51 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 01:52 -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap 01:52 -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] 01:52 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 01:52 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap 01:58 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 01:59 -!- ebowden [~ebowden@147.69.26.236] has quit [Read error: Connection reset by peer] 01:59 -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap 02:00 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 02:01 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 02:19 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] 02:22 < kyknos_> paperbot: http://www.sciencemag.org/content/147/3664/1462.short 02:22 < paperbot> http://libgen.org/scimag/get.php?doi=10.1126%2Fscience.147.3664.1462 02:24 -!- FourFire [~fourfire@2a02:270:2015:b00b:f0fb:c4c9:1920:6d76] has joined ##hplusroadmap 02:29 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 02:32 -!- petrushki [~asakharov@24.60.79.55] has quit [Quit: quit] 02:43 < kyknos_> paperbot: http://link.springer.com/article/10.1007/s10739-009-9184-1 02:45 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/A%20New%20Insight%20into%20Sangers%20Development%20of%20Sequencing%3A%20From%20Proteins%20to%20DNA%2C%2019431977.pdf 02:45 -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has joined ##hplusroadmap 03:03 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] 03:09 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 03:09 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 03:12 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 03:13 -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap 03:13 -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] 03:13 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 03:22 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 03:22 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 03:28 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 03:28 -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap 03:28 -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] 03:28 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 03:33 < kyknos_> paperbot: http://www.nature.com/nature/journal/v485/n7397/abs/nature11117.html 03:33 < paperbot> http://libgen.org/scimag/get.php?doi=10.1038%2Fnature11117 03:36 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] 03:36 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 03:37 -!- gully_foyle_ja [~theghosto@pool-71-116-68-251.snfcca.dsl-w.verizon.net] has quit [Quit: Leaving] 04:22 -!- FourFire is now known as FF_AFK 04:31 -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Remote host closed the connection] 04:39 -!- FF_AFK is now known as FourFire 04:54 -!- comma8 [comma8@gateway/shell/yourbnc/x-nuvxmnyxbokfpyxk] has quit [Ping timeout: 260 seconds] 05:13 -!- comma8 [comma8@gateway/shell/yourbnc/x-mrmckfmcbbtlvcxr] has joined ##hplusroadmap 05:17 -!- ebowden [~ebowden@147.69.26.236] has quit [Remote host closed the connection] 05:22 -!- ebowden [~ebowden@147.69.26.236] has joined ##hplusroadmap 05:27 -!- ebowden 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[comma8@gateway/shell/yourbnc/x-fbndsejgucllfgat] has joined ##hplusroadmap 06:46 -!- comma8 [comma8@gateway/shell/yourbnc/x-fbndsejgucllfgat] has quit [Ping timeout: 250 seconds] 06:46 -!- FourFire [FourFire@2a02:270:2015:b00b:b037:3b3f:3f6f:513a] has joined ##hplusroadmap 06:54 -!- FourFire [FourFire@2a02:270:2015:b00b:b037:3b3f:3f6f:513a] has quit [Quit: Leaving] 06:55 -!- JayDugger [~jwdugger@pool-173-74-79-151.dllstx.fios.verizon.net] has quit [Quit: Leaving.] 07:05 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 240 seconds] 07:20 -!- comma8 [comma8@gateway/shell/yourbnc/x-uphnwexderyirsei] has joined ##hplusroadmap 07:29 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 07:39 -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 07:47 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 08:08 < kyknos> paperbot, http://onlinelibrary.wiley.com/doi/10.1111/mec.12269/abstract 08:08 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/a64d08d68b04488e19d32090d347fb37.txt 08:37 -!- kumavis [~kumavis@107-219-148-42.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap 08:38 < kanzure> ugh i don't know what he wants me to do with this https://github.com/raj12lnm/OpenNurbs-Python 08:52 -!- _0bitcount [~big-byte@81.61.209.223.dyn.user.ono.com] has joined ##hplusroadmap 08:55 -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap 09:06 -!- trotsky [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap 09:10 -!- kumavis [~kumavis@107-219-148-42.lightspeed.sntcca.sbcglobal.net] has quit [Ping timeout: 246 seconds] 09:18 -!- Technicus [~Technicus@166.181.83.221] has joined ##hplusroadmap 09:22 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has joined ##hplusroadmap 09:33 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 10:01 -!- Vutral_ [~ss@31.7.56.131] has joined ##hplusroadmap 10:01 -!- Vutral__ [~ss@31.7.56.131] has joined ##hplusroadmap 10:02 -!- Vutral___ [~ss@31.7.56.131] has joined ##hplusroadmap 10:12 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Read error: Connection reset by peer] 10:13 -!- superkuh [~superkuh@c-24-245-51-196.hsd1.wi.comcast.net] has joined ##hplusroadmap 10:13 -!- superkuh [~superkuh@c-24-245-51-196.hsd1.wi.comcast.net] has quit [Changing host] 10:13 -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap 10:14 -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 272 seconds] 10:20 < ParahSailin> 2146435072 looks like a special number 10:24 -!- _0bitcount [~big-byte@81.61.209.223.dyn.user.ono.com] has quit [Quit: Leaving] 10:25 -!- PoohBear is now known as BearitoEclair 10:35 < ParahSailin> they went retard here https://github.com/rcallahan/UNAFold/blob/c870c55552082c94ae51fbe94cc0e2ff86b7bd4c/src/hybrid-min.c#L1103 10:40 -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap 10:57 < nshlol> paperbot, pap 10:57 < nshlol> paperbot, http://link.springer.com/chapter/10.1007%2F978-3-642-31912-9_16 10:57 < gradstudentbot> Ugh, my clinical trial isn't going so well. 10:57 < nshlol> paperbot, http://dl.acm.org/citation.cfm?id=2363442 10:57 < paperbot> http://libgen.org/scimag/get.php?doi=10.1007%2F978-3-642-31912-9_16 10:57 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/f68b85d8404b29679d352876504abab6.txt 11:05 -!- Technicus [~Technicus@166.181.83.221] has quit [Ping timeout: 250 seconds] 11:06 -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 260 seconds] 11:10 < kanzure> https://github.com/FeepingCreature/autofab/blob/master/recipes.txt 11:13 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap 11:14 -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Quit: Leaving] 11:14 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Read error: Connection reset by peer] 11:15 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap 11:16 -!- augur_ [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap 11:17 -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap 11:18 -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Read error: Connection reset by peer] 11:18 -!- augur__ [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap 11:19 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Ping timeout: 250 seconds] 11:20 -!- nshlol [~xeb@wikipedia/nsh] has joined ##hplusroadmap 11:21 -!- augur_ [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Ping timeout: 272 seconds] 11:21 -!- augur__ is now known as augur 11:30 < dpk> kanzure: pm? 11:33 -!- Technicus [~Technicus@166.181.81.221] has joined ##hplusroadmap 11:34 < kanzure> ok 11:40 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has joined ##hplusroadmap 11:50 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] 11:51 < dingo> http://www.washingtonpost.com/blogs/the-switch/wp/2014/08/06/the-man-who-can-see-the-internet/ <-irssi and python supybot featured on washington post 11:55 -!- Narp [~blargh@unaffiliated/narp] has joined ##hplusroadmap 11:58 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 12:06 < kanzure> the future sure does look a lot like 1997 12:22 -!- top4o [~chatzilla@93.152.162.95] has joined ##hplusroadmap 12:24 -!- poppingtonic [~poppingto@105.230.195.108] has joined ##hplusroadmap 12:38 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 12:39 -!- ElixirVitae [~Shehrazad@88.240.136.12] has joined ##hplusroadmap 12:39 -!- ElixirVitae [~Shehrazad@88.240.136.12] has quit [Changing host] 12:39 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 12:42 -!- Guest54510 [~quassel@50-0-37-37.dsl.static.sonic.net] has quit [Quit: No Ping reply in 180 seconds.] 12:42 -!- maaku [~quassel@50-0-37-37.dsl.static.sonic.net] has joined ##hplusroadmap 12:42 -!- maaku is now known as Guest3970 12:50 -!- Narp [~blargh@unaffiliated/narp] has quit [Quit: http://www.youtube.com/watch?v=20Jcrk6jGfo] 12:53 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Remote host closed the connection] 12:54 -!- nshlol [~xeb@wikipedia/nsh] has quit [Ping timeout: 240 seconds] 12:55 -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap 12:55 -!- xeb [~xeb@31.55.68.123] has quit [Max SendQ exceeded] 13:01 -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap 13:05 < archels> paperbot: http://link.springer.com/chapter/10.1007%2F978-1-4614-2383-6_5 13:06 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/cf5a4ba5c5159d1fb96c0b753c7c84d7.txt 13:07 -!- trotsky [~ruthie@mailhost.polyglotte.fr] has quit [Remote host closed the connection] 13:13 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap 13:31 -!- petrika [~asakharov@24.60.79.55] has joined ##hplusroadmap 13:50 < kanzure> .title http://3dprototypesandmodels.com.au/blog-2/ 13:50 < yoleaux> Low-cost 3D printers and crowdfunding suicide 13:57 -!- xeb [~xeb@31.55.68.123] has quit [Ping timeout: 240 seconds] 14:01 < kanzure> hah "Stretch goals are a quadruple-blow on their bottom line. Kickstarter takes more and more money yet the profit on each printer is the same. The additions themselves cost more money, reducing the profit margin further on each printer and now the printer will take longer to make, using even more funds." 14:13 -!- xeb [~xeb@31.55.68.123] has joined ##hplusroadmap 14:24 < heath> http://12factor.net/ 14:24 < heath> "The twelve-factor app is a methodology for building software-as-a-service apps" 14:26 < kanzure> first one is silly: why use only one repository? 14:26 < kanzure> #3 is also silly: the environment is not persistent, where are you going to develop your config? 14:27 < kanzure> #7 is dumb, everything is already using ports almost everywhere 14:27 -!- xeb [~xeb@31.55.68.123] has quit [Ping timeout: 240 seconds] 14:28 < heath> i had never heard of it 14:29 < heath> referenced in this guy jabbering: https://www.youtube.com/watch?v=f1hSvfDIfbo 14:29 < heath> Baron Schwartz: MySQL, SQL, NoSQL, and Open Source in 2014 and Beyond 14:31 < heath> https://www.youtube.com/watch?v=BUCZJWo9MZo 14:31 < heath> man and computer, from IBM (1965) 14:33 < heath> list of cheap fpgas: http://www.joelw.id.au/FPGA/CheapFPGADevelopmentBoards 14:33 < heath> doesn't mention the cypress boards though 14:33 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Remote host closed the connection] 14:33 < heath> you can get them for less than $5 14:33 < heath> http://www.cypress.com/?mpn=CY7C65211-24LTXI 14:34 < heath> http://www.cypress.com/?rID=92146 14:35 < chris_99> i don't think the psoc4 is an fpga? 14:40 -!- xeb [~xeb@109.144.191.254] has joined ##hplusroadmap 14:44 < heath> oh yeah, it offers cpld instead of fpga 14:47 < heath> http://www.cypress.com/?docID=43232 14:47 * heath walks away from the IRCs for a bit 14:48 < chris_99> oh neat 14:54 -!- xeb [~xeb@109.144.191.254] has quit [Ping timeout: 246 seconds] 14:54 -!- Technicus [~Technicus@166.181.81.221] has quit [Read error: Connection reset by peer] 14:55 -!- Technicus [~Technicus@166.181.83.221] has joined ##hplusroadmap 14:55 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 14:56 -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Remote host closed the connection] 14:57 -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has joined ##hplusroadmap 15:01 -!- augur [~augur@216-164-48-148.c3-0.slvr-ubr1.lnh-slvr.md.cable.rcn.com] has quit [Ping timeout: 260 seconds] 15:02 -!- Technicus [~Technicus@166.181.83.221] has quit [] 15:02 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 15:03 -!- xeb [~xeb@31.55.127.254] has joined ##hplusroadmap 15:23 -!- kyknos_ [~kyknos@89.233.130.143] has joined ##hplusroadmap 15:30 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap 15:35 -!- yorick [~yorick@oftn/member/yorick] has joined ##hplusroadmap 15:40 -!- BearitoEclair is now known as PoohBear 15:48 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Ping timeout: 272 seconds] 15:56 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap 16:00 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 16:01 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] 16:05 -!- Viper168_ is now known as Viper168 16:08 -!- xeb [~xeb@31.55.127.254] has quit [Ping timeout: 272 seconds] 16:19 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] 16:20 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Read error: Connection reset by peer] 16:21 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has joined ##hplusroadmap 16:31 -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap 16:55 -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 260 seconds] 16:57 -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap 16:57 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 16:59 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] 17:01 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] 17:06 -!- poppingtonic [~poppingto@105.230.195.108] has quit [Ping timeout: 246 seconds] 17:08 -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 240 seconds] 17:08 -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap 17:09 -!- xeb [~xeb@109.144.166.154] has quit [Max SendQ exceeded] 17:10 -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap 17:19 < kanzure> .title http://www.nature.com/news/organic-synthesis-the-robo-chemist-1.15661 17:19 < yoleaux> Organic synthesis: The robo-chemist 17:20 < kanzure> hmm "A British project called Dial-a-Molecule is laying the groundwork. Led by Whitby, the £700,000 (US$1.2-million) project began in 2010 and currently runs until May 2015. So far, it has mostly focused on working out what components the machine would need, and building a collaboration of more than 450 researchers and 60 companies to help work on the idea." 17:20 < thundara> Accompanying criticisms: http://pipeline.corante.com/archives/2014/08/07/the_synthesis_machine.php ^^ 17:21 < kanzure> "Jamison, for example, is working on flow chemistry at the Novartis–MIT Center for Continuous Manufacturing in Cambridge, and he is part of a team that last year reported1 the first end-to-end, completely continuous synthesis and formulation of a pharmaceutical: aliskiren hemifumarate, a treatment for high blood pressure. Jamison and his colleagues built a machine (now dismantled) that was more than 7 metres long, and about 2.5 metres high ... 17:21 < kanzure> ... and deep. “It took four years of 'everything that can go wrong, will go wrong',” says Bernhardt Trout, head of the MIT centre and leader of the project. After a lot of trial and error, he says, the researchers got to the point at which they merely had to flip the switch and feed in fresh drums of solvent and raw materials. The machine would hum like a large air-conditioning unit as stirrers whipped up chemicals, pumps whirred, ... 17:21 < kanzure> ... filtration units dripped and squeezed, and a screw conveyer pushed solids through a 2-metre drying tube to be injection-moulded. Finally, after 14 operations and 47 hours, finished tablets dropped down a chute. Batch synthesis would have required 21 operations over 300 hours." 17:22 < kanzure> he is really boring, "My guess is that we're going to see many years of machines that can do some things in very well-defined areas, but which will prove useless (or worse) if you try to push them into unknown territory. And unknown territory is what it's all about." 17:22 < kanzure> no, unknown territory is not what it's "all" about.. 17:23 < kanzure> "The following decade, Corey created software called LHASA (Logic and Heuristics Applied to Synthetic Analysis), which could use these rules to suggest sequences of steps towards a synthesis2. But LHASA and its successors have never taken off, says Grzybowski: either the databases have included too few reactions and too many errors, or the algorithms have not properly assessed whether proposed reactions are compatible with all functional ... 17:23 < kanzure> ... groups in the molecule." 17:23 < kanzure> my hardest problem has been getting access to the relevant databases on sane licensing terms 17:24 < kanzure> it's pretty easy to cull out errorful results if there are 10^60 targets 17:24 -!- ruthie [~ruthie@mailhost.polyglotte.fr] has quit [Ping timeout: 255 seconds] 17:24 < kanzure> "Grzybowski has spent the past decade building a system called Chematica to address those problems. He started by creating a searchable network of about 6 million organic compounds, connected by a similar number of reactions, drawn from one of the main databases behind Reaxys. " 17:24 < kanzure> except reaxys will bleed you dry so why would you bother 17:34 -!- Technicus [~Technicus@166.181.83.166] has joined ##hplusroadmap 17:34 -!- yorick [~yorick@oftn/member/yorick] has quit [Remote host closed the connection] 17:40 -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 246 seconds] 17:40 -!- xeb [~xeb@109.144.166.154] has joined ##hplusroadmap 17:52 -!- xeb [~xeb@109.144.166.154] has quit [Ping timeout: 260 seconds] 18:29 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 18:29 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] 18:32 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 18:32 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] 18:39 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 18:42 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Excess Flood] 18:53 -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap 18:57 -!- augur [~augur@73.163.157.101] has quit [Ping timeout: 250 seconds] 19:09 -!- cpopell [~cpopell@c-76-26-144-132.hsd1.dc.comcast.net] has quit [Ping timeout: 272 seconds] 19:10 -!- cpopell [~cpopell@c-76-26-144-132.hsd1.dc.comcast.net] has joined ##hplusroadmap 19:35 -!- lichen [~lichen@c-50-139-11-6.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 19:36 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 19:38 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 272 seconds] 19:40 -!- Vutral [~ss@mirbsd/special/Vutral] has quit [Ping timeout: 260 seconds] 19:57 -!- Vutral___ [~ss@31.7.56.131] has quit [Ping timeout: 260 seconds] 19:57 -!- Vutral__ [~ss@31.7.56.131] has quit [Ping timeout: 245 seconds] 19:57 -!- Vutral_ [~ss@31.7.56.131] has quit [Ping timeout: 240 seconds] 19:58 -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap 19:58 -!- Vutral [~ss@176.10.107.236] has joined ##hplusroadmap 19:58 -!- Vutral_ [~ss@176.10.107.236] has joined ##hplusroadmap 19:59 -!- Vutral [~ss@176.10.107.236] has quit [Changing host] 19:59 -!- Vutral [~ss@mirbsd/special/Vutral] has joined ##hplusroadmap 19:59 -!- Vutral__ [~ss@176.10.107.236] has joined ##hplusroadmap 19:59 -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has joined ##hplusroadmap 20:04 < kanzure> "Eli Lily actually has something really close to this. It's a completely automated organic synthesis machine. I don't know how many they have but I saw the one in the Indianapolis lab. I don't think people are supposed to know about it though." 20:05 < kanzure> "I just want a robot to run chromatographic columns for me, honestly" huh? 20:15 -!- augur [~augur@73.163.157.101] has quit [Read error: Connection reset by peer] 20:16 -!- augur [~augur@73.163.157.101] has joined ##hplusroadmap 20:19 -!- snuffeluffegus [~snuffeluf@2001:9b0:10:2104:216:3eff:feb7:f845] has quit [Quit: Leaving] 20:22 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-odsoyzonkwkusbcy] has quit [Quit: Connection closed for inactivity] 20:25 -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap 20:31 -!- Vutral- [~ss@2a01:198:35a::101] has quit [Ping timeout: 260 seconds] 21:01 -!- augur [~augur@73.163.157.101] has quit [Remote host closed the connection] 21:05 -!- PoohBear is now known as zombiehands 21:19 -!- sapiosexual [~sapiosexu@d75-156-88-72.bchsia.telus.net] has joined ##hplusroadmap 22:01 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap 22:03 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has quit [Read error: Connection reset by peer] 22:03 -!- augur [~augur@pool-71-191-96-49.washdc.east.verizon.net] has joined ##hplusroadmap 22:09 -!- yashgaroth [~ffffff@cpe-76-167-105-53.san.res.rr.com] has quit [Quit: Leaving] 22:32 -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap 22:32 -!- Vutral- [~ss@2a01:198:35a::101] has quit [Excess Flood] 22:49 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 22:51 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 22:54 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 23:01 -!- Viper168_ is now known as Viper168 23:22 -!- zombiehands is now known as PoohBear 23:31 -!- top4o [~chatzilla@93.152.162.95] has quit [Ping timeout: 240 seconds] 23:32 -!- drewbot [~cinch@ec2-107-21-140-100.compute-1.amazonaws.com] has quit [Remote host closed the connection] 23:32 -!- drewbot [~cinch@ec2-54-242-105-54.compute-1.amazonaws.com] has joined ##hplusroadmap 23:48 -!- Vutral- [~ss@2a01:198:35a::101] has joined ##hplusroadmap 23:52 -!- EnLilaSko [EnLilaSko@unaffiliated/enlilasko] has joined ##hplusroadmap 23:52 -!- Vutral- [~ss@2a01:198:35a::101] has quit [Ping timeout: 260 seconds] --- Log closed Mon Aug 11 00:00:31 2014