--- Log opened Fri Apr 03 00:00:41 2015
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01:36 < nickjohnson> This should be interesting: http://pid.codes/
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02:07 < fenn_> i didn't realize stereos and lights were illegal
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02:08 < fenn> apparently "bike party" is every second friday
02:09 < fenn> lots of stereos and lights on bikes
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06:30 < kanzure> carboat http://www.smbc-comics.com/index.php?id=3692
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06:32 < mosasaur> that's why hoovercraft are cool
06:32 < kanzure> why would you turn a president into a vehicle?
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06:49 < chris_99> does anyone know when people experiment with lasers and mirrors on a table thing, what do you call the mechanical parts they use to hold and align the laser or mirrors
06:49 < yoleaux> 06:00Z <nmz787> chris_99: seems the alibaba user either doesn't use alibaba anymore, or my messages don't go back far enough in their history... you could try emailing the address in the headers of the email I forwarded you
06:49 < chris_99> oh cheers nmz787
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06:55 < kanzure> chris_99: thorlabs
06:56 < chris_99> ooh cheers :)
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07:12 < FourFire> chris_99, pizeoelectric actuators?
07:14 < chris_99> pizeoelectric actuators? nah i was looking for things like optical mounts, like what kanzure pointed too
07:40 < kanzure> "Mergers: Commission approves joint venture between Holtzbrinck and Springer Science + Business in publishing sector"
07:40 < kanzure> "More information is available on the Commission's competition website, in the public case register under the case number M.7476"
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09:54 < kanzure> 09:46 <+xentrac> http://pid.codes/ looks really useful for open-source USB hardware
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10:43 < CaptHindsight> "they obtained the Vendor ID before the USB-IF changed their licensing terms to prohibit transfers or subassignments." the USB-IF made sure to close that loophole
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11:30 < jackybgood> paperbot http://www.ncbi.nlm.nih.gov/pubmed/18457504
11:30 < paperbot> http://libgen.info/scimag/get.php?doi=10.1162%2Fjocn.2008.20151
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11:46 < jackybgood> paperbot http://www.mitpressjournals.org/doi/pdf/10.1162/jocn.2008.20151
11:46 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/2eb174b87517d592429087713401dda1.pdf
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12:19 < thetester> hi does anyone know about the bot that downloads papers? https://www.ncbi.nlm.nih.gov/pubmed/21471392
12:21 < kanzure> paperbot: https://www.ncbi.nlm.nih.gov/pubmed/21471392
12:21 < paperbot> http://libgen.info/scimag/get.php?doi=10.1152%2Fjn.00287.2010
12:24 < thetester> thanks for the instructions, that file doesn't appear to be there. i am going to tes tanotyher one
12:25 < thetester> paperbot: http://www.nature.com/nature/journal/v483/n7389_supp/full/483S32a.html
12:25 < paperbot> http://libgen.info/scimag/get.php?doi=10.1038%2F483S32a
12:27 < thetester> doesn't appear to be working for me :(
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12:44 < kanzure> thetester: paperbot is not omnipotent and does not always find your paper
12:45 < chris_99> theoretically i should be able to use a metallurgical microscope as a biological microscope too right, if i added a light below the platform
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13:30 < kanzure> fenn: i told jgarzik that you will build him a space habitat i hope that's okay
13:35 < thetester> @kanzure those papers exist on libgen though
13:38 < kanzure> not always by doi number
13:38 < kanzure> libraries are hard, man
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13:42 < kanzure> 13:40 <kanzure> i told fenn that you will pay him for a space habitat i hope that's okay
13:42 < kanzure> 13:41 <jgarzik> thumbs up :)
13:42 < kanzure> oh he joined, shit
13:42 < kanzure> my lies will have to become more clever now
13:43 < jgarzik> Opening troll RE transhumanism:  going inorganic->inorganic is easy & obvious, organic->organic will be possible in the future.  everybody wants organic<->inorganic but it will continue to be a unicorn
13:44 < kanzure> how is that a troll
13:44 < jgarzik> RE space:  DSS mission is to build physical, virtual & financial infrastructure to enable space settlement.  physical - satellites & drones.  virtual - spacecraft & ops software.  financial:  instruments of extraordinary tradability.
13:44 < jgarzik> be back in an hour :)
14:05 < chris_99> nmz787_i, i was just wondering how you aligned the grating out of interest
14:12 < justanotheruser> we already have a satelite natural satelite to build on
14:12 < justanotheruser> why not send bitcoin to the moon
14:13 < kanzure> er i believe we have many natural satellites
14:13 < justanotheruser> we do?
14:13 < justanotheruser> they haven't been sucked up by the moon?
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14:15 < kanzure> paperbot: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14288.html#figures
14:15 < paperbot> http://libgen.info/scimag/get.php?doi=10.1038%2Fnature14288
14:15 < kanzure> .title
14:15 < yoleaux> 404 Not Found
14:15 < kanzure> .title http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14288.html#figures
14:15 < yoleaux> Reducing the energy cost of human walking using an unpowered exoskeleton : Nature : Nature Publishing Group
14:16 < kanzure> paperbot: http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14288.pdf
14:17 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/53a8bcc3d137e154870998493867df2.pdf
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14:42 < kanzure> same https://www.cmu.edu/me/news/archive/2015/collins-clutch.html
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15:36 < delinquentme> kanzure: Ideas on whats the best way to parse a string to ensure its properly formatted SQL ... *without* executing a query?
15:37 < kanzure> database transaction
15:37 < kanzure> failing that, database subtransaction
15:37 < kanzure> finally, rip out the sql parser from your database of choice and write custom bindings
15:37 < t12> explain it
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15:38 < kanzure> t12: "executing a query" is vague and does not really reference any of the existing database capabilities. execution can mean many things.
15:38 < t12> no i mean
15:38 < kanzure> execution within an uncommitted transaction is probably fine and not his problem
15:38 < t12> sql EXPLAIN the query
15:38 < t12> will parse it
15:38 < t12> without running it
15:39 < t12> dunno if explain is standard or not it appears to be standard enough
15:39 < kanzure> sure.
15:41 < delinquentme> when I say 'execute' I mean actually go hit the database and ask it for information or passit information
15:41 < delinquentme> I just want to feed a string in a get a True or False if its valid SQL or not.
15:45 < kanzure> https://www.kickstarter.com/projects/1971282701/edible-optics
15:47 < delinquentme> aww dem bubbles.  Need dat degassing stuff !
15:48 < delinquentme> much optical abberation... sux
16:00 < kanzure> optics smchoptiks https://www.zemax.com/home
16:00 < kanzure> schmoptiks
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17:01 < kanzure> "Yes, I step on any snail that I see. I do this because I want to do my part in selecting snails that have increasingly impossible to break shells."
17:01 < kanzure> uhrm... seems like there are more scientific or productive ways to do that.
17:06 < cluckj> that's more cruel than scientific
17:07 < kanzure> i was trying to find whether anyone has used their shell as a (living) bioreactor
17:07 < kanzure> you could mill holes in the upper shell and tap them if you wanted
17:07 < kanzure> there's at least one species that produces a dye, but it's just excreted with all the other mucus
17:08 < cluckj> snail milking?
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17:15 < kanzure> *secreted
17:15 < kanzure> .title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565753/
17:15 < yoleaux> Cone Snail milked venom dynamics – A quantitative study of Conus purpurascens
17:16 < kanzure> "Cone snails represent a highly valuable natural resource for drug-lead discovery programs. With an estimated >75,000 individual bioactive peptides within the genus of some +500 species (Olivera, 2002), the venom peptides from these carnivorous marine predators have provided numerous highly selective ligands that target a myriad of ion channels (as reviewed in Terlau and Olivera, 2004)."
17:17 < kanzure> "One peptide in particular, ω-conotoxin MVIIA, also cited as SNX-111 or Ziconotide has received US Food and Drug Administration approval as Prialt™ (Primary Alternative to morphine), a potent neuropathic pain analgesic, specifically targeting N-type voltage-gated calcium channels (Miljanich, 2004). Other conopeptides have now transitioned into clinical trials (see Han et al., 2008), providing a clear indication attesting to their ...
17:17 < kanzure> ... pharmaceutical and therapeutic worth."
17:18 < kanzure> "Conus purpurascens (the purple cone; Fig. 1) represents a unique research candidate within the cone snail genus. Being an Eastern Pacific piscivore (fishing eating species), its mammalian bioactive peptides have been well described. What differentiates these studies from previous conopeptide research is the source of material; the majority of these conopeptides have been isolated directly from the pooled milked venom (see Table 1) and ...
17:18 < kanzure> ... not from the crude dissected venom duct gland. C. purpurascens presently represents the species with the best-characterized milked venom of the genus."
17:19 < kanzure> hmm.
17:21 < kanzure> what? "A number of observations were made during long-term C. purpurascens captivity: (i) Snails were able to consume fish equal to their own shell size and had ability to feed weekly; (ii) If snails were not fed regularly or did not discharge their pre-loaded radula harpoons from the proboscis (<2 times/month), they would singularly lose the ability to penetrate the receptacle membrane, resulting in loss of milked venom – recovery ...
17:21 < kanzure> ... occurred naturally with ‘spent’ radula harpoon expulsion and then re-arming; (iii) Specimens seem to be sturdy and resilient to captive conditions, as illustrated by the ability to produce viable veliger upon mating – a situation that occurred twice during 48 months of captivity. No specimen mortalities were recorded during these experiments, until specimens were terminated for duct venom extracts."
17:22 < kanzure> eh, sounds like hairy root cultures are more productive
17:23 < kanzure> method: http://i.ytimg.com/vi/85J94PtO1Ok/maxresdefault.jpg
17:38 < kanzure> "Milk, egg white, blood, urine, seminal plasma and silk worm cocoon from transgenic animals are candidates to be the source of recombinant proteins at an industrial scale."
17:38 < kanzure> do we really have nothing better yet?
17:40 < kanzure> "Fish eggs as bioreactors: the production of bioactive luteinizing hormone in transgenic trout embryos" http://staff.unak.is/not/oddurv/slt1103/morita.pdf
17:40 < kanzure> what happened to transgenic milk
17:43 < kanzure> phasmid milking http://www.phasmatodea.com/web/guest/milking
17:45 < kanzure> aphid honeydew http://en.wikipedia.org/wiki/Aphid#Ant_mutualism
17:50 < kanzure> tsetse flies are another candidate, although they only lactate.. internally? or something.
17:55 < kanzure> "Noticeably, for a small- or medium-sized facility, the rabbit system is ideal to produce up to 50 kg of protein per year, considering both economical and hygienic aspects; rabbits are attractive candidates for the mammary-gland-specific expression of recombinant proteins."
17:56 < FourFire> was the silk cow a failure?
17:58 < kanzure> "Foreign proteins are commonly reported to be produced in transgenic milk at rates of several grams per liter. Based on the assumption of average expression levels, daily milk volumes, and purification efficiencies, 5.400 cows would be needed to produce the 100.000 kg of human serum albumin that are required per year worldwide, 4.500 sheep would be required for the production of 5000 kg α-antitrypsin (α-AT), 100 goats for 100 kg ...
17:58 < kanzure> ... of monoclonal antibodies (mAbs), 75 goats for 75 kg of antithrombin III, and two pigs to produce 2 kg of human clotting factor IX [15]."
17:59 < kanzure> "The use of transgenic eggs for large-scale production of recombinant proteins is another method being contemplated. Interest in this system is driven by the fact that a single hen can produce an impressive number of eggs (up to 330 eggs/year) and egg white naturally contains approximately 4 g of protein [22–24]. Transgenic chicken stably produced a human erythropoietin fusion protein not only in their serum and egg white but also in ...
17:59 < kanzure> ... the egg yolk, as was expected [25]. However, the egg system has been hampered by the lack of an efficient transgenesis system in poultry [7]."
17:59 < kanzure> what? we don't have transgenic chickens?
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18:21 < cluckj> kanzure, there aren't any? seriously?
18:22 < kanzure> according to whatever paper that was...
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19:19 < kanzure> "Evolution of a novel function: nutritive milk in the viviparous cockroach, Diploptera punctata"
19:19 < kanzure> paperbot: http://onlinelibrary.wiley.com/doi/10.1111/j.1525-142X.2004.04012.x/abstract
19:19 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/8d2263bd6b95790f3e12fc4e52f7df6.txt
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--- Log closed Sat Apr 04 00:00:42 2015