--- Log opened Sat Jul 04 00:00:00 2015 00:01 < wrldpc1> I post a comment on one of Danaylov’s facebook posts promoting his Singularity 101 podcast with Michio Kaku asking whether or not Kaku has answered for the claims that he appropriated the Kardashev scale and was proferring it as his own idea without proper attribution and Danaylov deleted the comment. 00:01 -!- ebowden [~ebowden@147.69.32.113] has joined ##hplusroadmap 00:06 -!- zzubzzub [~chatzilla@117.199.32.31] has joined ##hplusroadmap 00:06 -!- ant4t [~s3an@50.141.79.18] has joined ##hplusroadmap 00:21 -!- DarmokAndJalad [~Porbus@CPE-110-149-122-114.vwl9.win.bigpond.net.au] has joined ##hplusroadmap 00:29 -!- JayDugger [~jwdugger@108.19.186.58] has joined ##hplusroadmap 00:44 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Quit: Leaving] 00:47 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 01:25 -!- Acty [uid89656@gateway/web/irccloud.com/x-mbdohuieuqmwxrsx] has joined ##hplusroadmap 01:37 -!- wrldpc1 [~ben@hcc3d73d032.bai.ne.jp] has quit [Quit: wrldpc1] 01:49 -!- ant4t [~s3an@50.141.79.18] has quit [Ping timeout: 252 seconds] 01:52 -!- ebowden [~ebowden@147.69.32.113] has quit [Read error: Connection reset by peer] 01:52 -!- ebowden [~ebowden@147.69.32.113] has joined ##hplusroadmap 02:01 -!- justinzero [~justinzer@c-98-238-36-45.hsd1.fl.comcast.net] has quit [Remote host closed the connection] 03:12 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-kpafsdrbhvhfqwku] has quit [Quit: Connection closed for inactivity] 03:24 -!- zadock [~outsider@81.180.210.87] has joined ##hplusroadmap 03:30 -!- zadock [~outsider@81.180.210.87] has quit [Remote host closed the connection] 03:42 -!- wrldpc1 [~ben@hcc3d73d032.bai.ne.jp] has joined ##hplusroadmap 03:51 -!- wrldpc1 [~ben@hcc3d73d032.bai.ne.jp] has quit [Quit: wrldpc1] 04:02 -!- justinzero [~justinzer@c-98-238-36-45.hsd1.fl.comcast.net] has joined ##hplusroadmap 04:07 -!- justinzero [~justinzer@c-98-238-36-45.hsd1.fl.comcast.net] has quit [Ping timeout: 255 seconds] 04:45 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 05:01 -!- ebowden [~ebowden@147.69.32.113] has quit [Read error: Connection reset by peer] 05:02 -!- ebowden [~ebowden@147.69.32.113] has joined ##hplusroadmap 05:26 -!- wrldpc1 [~ben@hcc3d73d032.bai.ne.jp] has joined ##hplusroadmap 05:28 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-muzuisbipeqedjmr] has joined ##hplusroadmap 05:33 -!- ebowden [~ebowden@147.69.32.113] has quit [Remote host closed the connection] 05:36 -!- Beatzebub [~beatzebub@d172-218-176-59.bchsia.telus.net] has quit [Quit: Beatzebub] 05:48 < kanzure> "The presence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3" http://www.cell.com/neuron/abstract/S0896-6273(15)00428-6 05:49 < kanzure> "Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular substrates, is poorly ... 05:49 < kanzure> ... understood. Here we find that both memory storage and its underlying synaptic plasticity are mediated by the increase in level and in the aggregation of the prion-like translational regulator CPEB3 (cytoplasmic polyadenylation element-binding protein). Genetic ablation of CPEB3 impairs the maintenance of both hippocampal long-term potentiation and hippocampus-dependent spatial memory. We propose a model whereby persistence of ... 05:49 < kanzure> ... long-term memory results from the assembly of CPEB3 into aggregates. These aggregates serve as functional prions and regulate local protein synthesis necessary for the maintenance of long-term memory." 05:49 < kanzure> "CPEB3 forms aggregates after synaptic activity in the hippocampus. After aggregation, CPEB3 promotes the translation of AMPA receptors. CPEB3 conditional knockout mice have impaired long-term memory and LTP. CPEB3 mediates the persistence of memory through a prion-like mechanism." 05:50 < kanzure> "SUMOylation is an inhibitory constraint that regulates the prion-like aggregation and activity of CPEB3" http://www.cell.com/cell-reports/abstract/S2211-1247(15)00493-3 05:51 < kanzure> "The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton" http://www.cell.com/cell-reports/abstract/S2211-1247(15)00492-1 05:51 < kanzure> "... Interestingly, deletion analysis of the CPEB3 prion domain uncovered a tripartite organization: two aggregation-promoting domains surround a regulatory module that affects interaction with the actin cytoskeleton." 05:54 < kanzure> hm. but what about the methylation stuff. 06:00 < kanzure> the dna methylation neuron stuff was primarily about memory formation, not memory persistence.. hm. 06:01 -!- Acty [uid89656@gateway/web/irccloud.com/x-mbdohuieuqmwxrsx] has quit [Quit: Connection closed for inactivity] 06:02 < kanzure> specifically http://diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation%20-%20emerging%20insights%20-%202015.pdf 06:02 -!- ebowden [~ebowden@147.69.32.113] has joined ##hplusroadmap 06:03 -!- justinzero [~justinzer@2601:6c0:c100:e233:240d:e55a:f422:6426] has joined ##hplusroadmap 06:07 -!- justinzero [~justinzer@2601:6c0:c100:e233:240d:e55a:f422:6426] has quit [Ping timeout: 248 seconds] 06:08 < kanzure> los angeles biohackers ad for 3d printing stuff http://i.imgur.com/Xr5xdvg.png 06:11 -!- ebowden [~ebowden@147.69.32.113] has quit [Ping timeout: 252 seconds] 06:13 -!- wrldpc1 [~ben@hcc3d73d032.bai.ne.jp] has quit [Ping timeout: 255 seconds] 06:18 -!- wrldpc1 [~ben@baicb85c75e.bai.ne.jp] has joined ##hplusroadmap 06:22 -!- ebowden [~ebowden@147.69.32.113] has joined ##hplusroadmap 06:50 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 255 seconds] 06:53 -!- streety [streety@2a01:7e00::f03c:91ff:feae:ded6] has quit [Ping timeout: 252 seconds] 06:56 < kanzure> .wik NEURL 06:56 < yoleaux> "Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene." — https://en.wikipedia.org/wiki/NEURL 06:56 < kanzure> bah 06:58 -!- crescendo [~mozart@unaffiliated/crescendo] has quit [Ping timeout: 256 seconds] 06:58 -!- crescendo [~mozart@unaffiliated/crescendo] has joined ##hplusroadmap 06:58 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 07:01 -!- streety [streety@2a01:7e00::f03c:91ff:feae:ded6] has joined ##hplusroadmap 07:02 < kanzure> neuralized1 overexpression in mice (which influences CPEB3) shows memory improvements http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442370/ 07:03 < kanzure> and also increases the number of synapses 07:18 -!- JayDugger [~jwdugger@108.19.186.58] has quit [Read error: Connection reset by peer] 07:24 -!- JayDugger [~jwdugger@108.19.186.58] has joined ##hplusroadmap 07:57 -!- wrldpc1 [~ben@baicb85c75e.bai.ne.jp] has quit [Ping timeout: 246 seconds] 07:57 -!- AmbulatoryCortex [~Ambulator@173-31-9-188.client.mchsi.com] has joined ##hplusroadmap 08:04 -!- justinzero [~justinzer@2601:6c0:c100:e233:34de:c7c4:989e:ed36] has joined ##hplusroadmap 08:04 -!- wrldpc1 [~ben@153.131.169.216.client.dyn.strong-sf94.as22781.net] has joined ##hplusroadmap 08:08 -!- justinzero [~justinzer@2601:6c0:c100:e233:34de:c7c4:989e:ed36] has quit [Ping timeout: 248 seconds] 08:10 -!- CheckDavid 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justinzero [~justinzer@2601:6c0:c100:e233:ec00:3e6:2967:ab41] has joined ##hplusroadmap 15:51 -!- namespace [~user@50-35-177-83.evrt.wa.frontiernet.net] has quit [Quit: leaving] 15:53 -!- justinzero [~justinzer@2601:6c0:c100:e233:ec00:3e6:2967:ab41] has quit [Remote host closed the connection] 16:09 < kanzure> some unusual and dumb attempts at music notation https://www.youtube.com/watch?v=8F2Dv27CSuI 16:17 -!- justinzero [~justinzer@c-98-238-36-45.hsd1.fl.comcast.net] has joined ##hplusroadmap 16:34 -!- drewbot [~cinch@ec2-54-83-94-27.compute-1.amazonaws.com] has quit [Remote host closed the connection] 16:35 -!- drewbot [~cinch@ec2-23-20-146-177.compute-1.amazonaws.com] has joined ##hplusroadmap 17:04 -!- rigel [~yourmom@c-24-21-52-83.hsd1.or.comcast.net] has joined ##hplusroadmap 17:26 < JayDugger> Yup. 17:38 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 17:38 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 250 seconds] 17:46 -!- wrldpc1 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