--- Log opened Sun Aug 16 00:00:42 2015
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01:01 < kish> what's the use of that
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01:51 < erasmus> use of what?
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05:34 < kanzure> bloop
05:36 < c0rw1n> bleep
05:41  * Adlai burps
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06:00 < kanzure> "A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice." http://www.jimmunol.org/content/147/10/3501.short
06:03 < kanzure> http://www.jbc.org/content/276/26/24223.short "Early during infection (1–2 h), <1% of all genes show a significant change in the abundance of their transcripts. Of the 63 known genes in this group, 27 encode proteins associated with the immune response. These genes are also up-regulated by secreted, soluble factors from extracellular parasites indicating that the early response does not require parasite invasion. Later during ...
06:03 < kanzure> ... infection, genes involved in numerous host cell processes, including glucose and mevalonate metabolism, are modulated. Many of these late genes are dependent on the direct presence of the parasite;i.e. secreted products from either the parasite or infected cells are insufficient to induce these changes."
06:03 < kanzure> "A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii" https://scholar.google.com/scholar?cites=8272812233483743158&as_sdt=5,44&sciodt=0,44&hl=en
06:04 < kanzure> .title http://www.nature.com/mp/journal/v13/n5/abs/mp20085a.html
06:04 < yoleaux> Molecular Psychiatry - Abstract of article: Are some cases of psychosis caused by microbial agents? A review of the evidence
06:09 < kanzure> http://www.sciencedirect.com/science/article/pii/S0889159113005436 "We examined neuroanatomical cyst distribution (53 forebrain regions) in infected rats after predator odor aversion behavior and anxiety-related behavior in the elevated plus maze and open field arena, across a 6-week time course. ... Our findings demonstrate that while cysts are randomly distributed throughout the forebrain, individual variation in cyst localization, ...
06:09 < kanzure> ... beginning 3 weeks post-infection, can explain individual variation in the effects of T. gondii on behavior. Additionally, not all infected rats develop cysts in the forebrain, and attenuation of predator odor aversion and changes in anxiety-related behavior are linked with cyst presence in specific forebrain areas."
06:10 < kanzure> .wik synaptophysin
06:10 < yoleaux> "Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene." — https://en.wikipedia.org/wiki/Synaptophysin
06:11 < kanzure> evidence of influence on neural connectivity even away from cysts http://dmm.biologists.org/content/7/4/459.short
06:12 < kanzure> mice + toxo testing showed poor performance in spatial memory recall but enhanced performance in reversal learning tasks http://www.sciencedirect.com/science/article/pii/S1383576914001135
06:13 < kanzure> welp there you go
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06:18 < kanzure> also note the complete absence of zombies from that study, despite youse guys's claims
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06:20 < kanzure> selecting for better performance might only select for enhanced immunity either to toxo itself or to its effects. not sure how to get around this.
06:22 < kanzure> because making a toxo that just happens to be ineffective might be shorter distance on the landscape than the distance to something that provides an order-of-magnitude benefit
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06:49 < kanzure> http://academia.stackexchange.com/questions/51305/grant-fraud-should-i-bust-my-phd-advisor
06:56 < Adlai> best thing about that (if it's true), there are now dozens of fraudsters sweating bullets
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07:01 < kanzure> i would expect there to be a few layers of indirection or protection
07:02  * Adlai includes the other grant recipients potentially in the same position as OP in "fraudsters"
07:03 < Adlai> maybe a bit too loose with the word
07:07 < kanzure> https://www.reddit.com/r/mechanical_gifs/
07:08 < kanzure> "syringes as pneumatic actuators" http://imgur.com/LWmJTL0
07:09 < kanzure> actual video: https://www.youtube.com/watch?v=m5WuIUWlNvg
07:20 < kanzure> they hide inside neurons http://www.researchgate.net/profile/Ildiko_Dunay/publication/267875630_Toxoplasma_gondii_induced_neuronal_alterations/links/54df5e910cf2953c22b1eee2.pdf
07:22 < kanzure> "In 2001, the first report on the potential impact of T. gondii on psychomotor performance suggested that individuals with latent infection exhibited increased reaction times, scored more poorly on a standard computerized test, and appeared to lose their concentration more quickly (43)."
07:23 < kanzure> "More recently, Beste et al. (44) investigated the possible modulatory role of latent T. gondii infection on cognitive functions in elderly individuals. When confronted with an auditory deviant stimulus, elderly individuals with positive IgG Toxoplasma serum concentrations revealed delaying processes of attentional allocation and disengagement."
07:24 < kanzure> "However, a recent study by Stock et al. revealed a paradoxical improvement of cognitive control process in T. gondii-infected healthy individuals, arguing therefore for a rather positive effect of infection on cognitive capacities than the commonly held view that latent infection is detrimental for the host (50, 51)."
07:27 < kanzure> ref 50 is "Latent toxoplasma gondii infection leads to improved action control" http://www.researchgate.net/profile/Christian_Beste/publication/258526409_Latent_Toxoplasma_gondii_infection_leads_to_improved_action_control/links/5433e29d0cf2dc341dae0ee3.pdf
07:29 < kanzure> "Summing up our findings, individuals with latent toxoplasmosis display an improvement in action control which contradicts the commonly held view that parasitic manipulation is always to the detriment of the host. A potential explanation for this contradiction is provided by the fact that humans are dead-end hosts to the parasite so that no direct negative consequences (like predation) arise from dopamine-triggered changes in action ...
07:29 < kanzure> ... control (or exploratory behavior)."
07:29 < kanzure> what? that's their explanation? what about "positive influences may lead infected brained mammals to be eaten, moreso than certain other possible negative consequences"?
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07:38 < kanzure> "A lower IQ of Toxoplasma-positive subjects was also observed in children with subclinical congenital toxoplasmosis in the early seventies (Saxon et al., 1973; Alford et al., 1974). "
07:40 < kanzure> Saxon, S.A., Knight, W., Reynolds, D.W., Stagno, S., Alford, C.A., 1973. Intellectual deficits in children born with subclinical congenital toxoplasmosis: a preliminary report. Journal of Pediatrics 72, 792-797.
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07:51 < kanzure> "Toxoplasma upregulates [testosterone] synthesis by increasing the number of luteinizing hormone receptors on Leydig cells, that is the receptors that regulate the synthesis of testosterone in testes (Lim et al. 2013). This explains why Toxoplasma increases testosterone level only in men but not women (Flegr et al. 2008) and why neither the increase of testosterone, nor associated behavioural changes, exist in castrated male rats (Lim et ...
07:51 < kanzure> ... al. 2013)."
07:51 < kanzure> from http://web.natur.cuni.cz/flegr/pdf/toxoepigenet.pdf
07:52 < kanzure> and "The Toxoplasma genome contains two enzymes catalysing the key step in the synthesis of dopamine (Gaskell et al. 2009). A large amount of this important neurotransmitter is produced in Toxoplasma cysts in the infected host’s brain and is exported to surrounding tissue in rodents and likely in humans as well (Prandovszky et al. 2011). This increased concentration of dopamine could be responsible for the observed close association ...
07:52 < kanzure> ... between toxoplasmosis and more severe forms of schizophrenia (Holub et al. 2013)."
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07:53 < kanzure> hehe "Similarly, infected male students rate the smell of diluted cat urine as relatively more pleasant (Flegr et al. 2011)."
07:55 < kanzure> "They also show that the fear of cat smell can be restored by a systemic hypermethylation (by systemic administration of L-methionine) in infected animals. Most importantly, the ‘fatal attraction phenomenon’ can be induced in noninfected rats by intracerebral delivery of methylation inhibitor into the medial amygdala. Using immunohistochemistry (measuring the number of AVP and Fos colabelling cells in several parts of the brain) and ...
07:55 < kanzure> ... proper controls, authors have shown that cat odour increases the neuronal activation of vasopressinergic neurons in the medial amygdala only in the infected rats."
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09:24 < kanzure> rhd-negative toxoplasma-infected men displayed higher intelligence than their toxoplasma-free peers http://web.natur.cuni.cz/flegr/pdf/iq.pdf
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10:30 < kanzure> http://www.nature.com/news/octopus-genome-holds-clues-to-uncanny-intelligence-1.18177
10:32 < kanzure> .wik protocadherin
10:32 < yoleaux> "Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family." — https://en.wikipedia.org/wiki/Protocadherin
10:32 < gradstudentbot> Uh, interesting question.
10:33 < kanzure> "This has led to speculation and further to the proposal that Pcdhs may provide a synaptic-address code for neuronal connectivity or a single-cell barcode for self-recognition/self-avoidance similar to that ascribed to DSCAM proteins of invertebrates"
10:33 < kanzure> .wik neuronal self-avoidance
10:33 < yoleaux> "Neuronal self-avoidance, or isoneural avoidance, is an important property of neurons which consists in the tendency of branches (dendrites and axons) arising from a single soma (also called isoneuronal or sister branches) to turn away from one another." — https://en.wikipedia.org/wiki/Neuronal_self-avoidance
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10:39 < kanzure> https://en.wikipedia.org/wiki/Role_of_cell_adhesions_in_neural_development
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13:18 < kanzure> hi sh
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14:58 < kanzure> 14:53 <+deltab> http://i.imgur.com/FQhtJ3N.png
14:58 < kanzure> 14:53 <+saxo> deltab: <sbp> 'My boss told me to put a "no need to calibrate" sticker on everything in our lab. I put one on a ruler.' — CaribouNuggets, imgur
14:58 < kanzure> 14:58 <+kanzure> false; you need to calibrate your visual system when reading the ruler.
14:59 < kanzure> .wik PDE4B
14:59 < yoleaux> "cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene." — https://en.wikipedia.org/wiki/PDE4B
14:59 < kanzure> -_-
14:59 < kanzure> "The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP."
15:00 < kanzure> .title http://www.nature.com/npp/journal/vaop/naam/abs/npp2015240a.html
15:00 < yoleaux> Neuropsychopharmacology - Abstract of article: Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition
15:01 < kanzure> "To define the effects of specific inhibition of the PDE4B subtype, we generated mice with a catalytic domain mutant form of PDE4B (Y358C) that has decreased ability to hydrolyze cAMP. Structural modelling predictions of decreased function and impaired binding with DISC1 were confirmed in cell assays. Phenotypic characterization of the PDE4BY358C mice revealed facilitated phosphorylation of CREB, decreased binding to DISC1, and ...
15:01 < kanzure> ... upregulation of DISC1 and β-Arrestin in hippocampus and amygdala. In behavioural assays, PDE4BY358C mice displayed decreased anxiety and increased exploration, as well as cognitive enhancement across several tests of learning and memory, consistent with synaptic changes including enhanced long-term potentiation and impaired depotentiation ex vivo. PDE4BY358C mice also demonstrated enhanced neurogenesis."
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15:11 < kanzure> something something toxoplasmosis vaccine http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014057
15:19 < kanzure> journal of experimental biology issue on "neural parasitology" http://jeb.biologists.org/content/216/1.toc
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18:39 < kanzure> bleep bloop
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18:50 < mgin> MOO
18:50 < mgin> ...moooo
18:50 < mgin> i'm really lonely
18:51 < souljack> daww
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18:55 < souljack> Don't have your DBS implant yet?
18:58 < gradstudentbot> Protip: I wouldn't go to the far end of the lab alone.
19:00 < mgin> ?
19:05 < justanotheruser> mgin: perhaps you should import a russian bride
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21:42 < kanzure> bloop
21:56 < fenn> just stepped outside and saw the ISS go overhead
22:10 < kanzure> it tends to do that :-)
22:25 < kanzure> the navy has a posix-compatible api for large-scale network simulation.. stuff? http://www.robgjansen.com/talks/shadowbitcoin-cset-20150810.pdf
22:35 < kanzure> fenn: https://www.youtube.com/user/thang010146/videos
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22:46 < fenn> these are all things you would have learned had you paid attention in school
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--- Log closed Mon Aug 17 00:00:43 2015