--- Log opened Thu Sep 17 00:00:30 2015 00:41 -!- zadock [~outsider@cthulhu.tuiasi.ro] has joined ##hplusroadmap 01:11 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 01:13 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-lmcyyfhpropaclsi] has quit [Quit: Connection closed for inactivity] 01:16 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-kiwlawdnfgdktuws] has joined ##hplusroadmap 01:17 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 01:51 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Quit: Quit] 02:27 -!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 240 seconds] 02:44 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:02 -!- FourFire [~FourFire@185.7.192.138] has joined ##hplusroadmap 03:14 -!- c0rw|zZz is now known as c0rw1n 03:43 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:8ddd:971b:6728:6dea] has quit [Quit: Leaving] 04:10 < kanzure> http://www.brainpreservation.org/ken-hayworths-personal-response-to-mit-technology-review-article/ 04:10 -!- sheena [~home@S0106c8be196316d1.ok.shawcable.net] has quit [Ping timeout: 252 seconds] 04:11 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-bjdzxlqedflwzdzx] has quit [Quit: Connection closed for inactivity] 04:15 < kanzure> "The hybrid protein combines a photoreceptor protein called cryptochrome 2 (Cry2) from a small, flowering plant Arabidopsis thaliana with the STromal Interaction Molecule 1 (STIM1), a protein found in almost all animals that opens cellular Ca2+ channels. They named the resultant hybrid molecule OptoSTIM1. When they shined blue light on the OptoSTIM1-expressing cells, they were able to coax them to open their Ca2+ channels and allow an ... 04:15 < kanzure> ... influx of 5 to 10 times more Ca2+ than in previous studies." 04:16 < kanzure> .title http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3350.html 04:16 < yoleaux> Optogenetic control of endogenous Ca2+ channels in vivo : Nature Biotechnology : Nature Publishing Group 04:16 < kanzure> http://www.kurzweilai.net/new-optogenetics-process-could-lead-to-neurological-enhancements-and-treatments 04:16 < kanzure> .title http://www.sciencemag.org/content/349/6253/1216 04:16 < yoleaux> Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch 04:17 < kanzure> .title http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002238 04:17 < yoleaux> PLOS Biology: A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior 04:18 < kanzure> igem presentations will be recorded this year for once 05:34 -!- eudoxia [~eudoxia@r167-57-100-78.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 06:09 < kanzure> "Let's say we build a series of large mirrors and possibly Fresnel lenses and send them into space in the direction of a planned ship cruise. Then we send the sail ship, followed by a series of lenses focusing the laser beam on the ship until midway to target, at maximum acceleration, and then switch to the mirrors ahead of it, to effect deceleration. The mirrors eventually crash into the target star or perhaps are left to sail forever ... 06:09 < kanzure> ... but the ship is rapidly slowed down to reach target in the shortest time." 06:09 < kanzure> "This is very similar to the Landis interstellar lightsail model. You use a big sail to accelerate, then detach it and use it as a mirror to slow the payload section that has a smaller center lightsail. The lenses only allow you to accelerate very efficiently for longer, they are unlikely to be helpful near the destination. However, sacrificial lenses and sails make for good SETI targets." 06:09 < kanzure> "In my "spamming the universe" scheme I looked at enormous coilguns, essentially a Dyson sphere with light-second long coilguns (a Dyson urchin?) since they also get around the rocket equation. Eric D pointed out that lasers would be even more effective, and the lens trick could allow focused acceleration for a surprisingly long time." 06:17 -!- drewbot_ [~cinch@ec2-50-16-56-225.compute-1.amazonaws.com] has quit [Remote host closed the connection] 06:18 -!- drewbot [~cinch@ec2-54-158-191-203.compute-1.amazonaws.com] has joined ##hplusroadmap 07:03 < kanzure> someone should test k12 education vs. frontal lobe lobotomies 07:18 -!- zadock [~outsider@cthulhu.tuiasi.ro] has quit [Quit: Leaving] 07:20 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 07:29 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 07:46 < CaptHindsight> lobotomies don't include the social engineering 07:49 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ohvrtgczrwsfsoom] has joined ##hplusroadmap 07:51 -!- eudoxia [~eudoxia@r167-57-100-78.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer] 08:13 -!- sandeepkr [~sandeepkr@111.235.64.135] has joined ##hplusroadmap 08:13 -!- cluckj [~cluckj@pool-108-16-231-242.phlapa.fios.verizon.net] has joined ##hplusroadmap 08:20 -!- andares [~foobar@50.248.212.105] has joined ##hplusroadmap 08:20 < JayDugger> test the effects on students or on the teachers and administrators? 08:21 -!- andares [~foobar@50.248.212.105] has quit [Changing host] 08:21 -!- andares [~foobar@unaffiliated/jacco] has joined ##hplusroadmap 08:25 < chris_99> kanzure, how do i leave a message for someone on 'ere? 08:27 < kanzure> chris_99: use .tell username message 08:27 < chris_99> cheers 08:27 < chris_99> .tell nmz787 http://www.peachyprinter.com/#!peachy-printer-kit/c1uoo 08:27 < yoleaux> chris_99: I'll pass your message to nmz787. 08:39 -!- sheena [~home@S0106c8be196316d1.ok.shawcable.net] has joined ##hplusroadmap 08:39 -!- andares [~foobar@unaffiliated/jacco] has quit [Ping timeout: 244 seconds] 09:05 -!- sheena [~home@S0106c8be196316d1.ok.shawcable.net] has quit [Ping timeout: 252 seconds] 09:20 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:7cc2:95dc:4029:a813] has joined ##hplusroadmap 09:21 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:7cc2:95dc:4029:a813] has quit [Read error: Connection reset by peer] 09:32 -!- Herle [~Herle@217.138.24.130] has joined ##hplusroadmap 10:01 -!- Herle [~Herle@217.138.24.130] has left ##hplusroadmap ["Leaving"] 10:29 -!- _0bitcount [~Big_Byte@2.153.164.116.dyn.user.ono.com] has joined ##hplusroadmap 10:30 -!- andytoshi [~andytoshi@wpsoftware.net] has quit [Changing host] 10:30 -!- andytoshi [~andytoshi@unaffiliated/andytoshi] has joined ##hplusroadmap 10:33 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap 10:43 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-kiwlawdnfgdktuws] has quit [Quit: Connection closed for inactivity] 11:11 -!- FourFire is now known as FourFire|AFK 11:28 -!- nmz787_w [c0373628@gateway/web/freenode/ip.192.55.54.40] has joined ##hplusroadmap 11:58 -!- lpax [~lpax@unaffiliated/lpax] has joined ##hplusroadmap 11:59 -!- fleshtheworld [~fleshthew@108-240-244-194.lightspeed.frsnca.sbcglobal.net] has joined ##hplusroadmap 12:06 -!- lpax [~lpax@unaffiliated/lpax] has quit [Read error: Connection reset by peer] 12:07 -!- lpax [~lpax@unaffiliated/lpax] has joined ##hplusroadmap 12:11 -!- lpax [~lpax@unaffiliated/lpax] has quit [Read error: Connection reset by peer] 12:14 -!- sheena [~home@d99-199-117-38.bchsia.telus.net] has joined ##hplusroadmap 12:29 < juri_> does anyone know what's up with the data science tool kit? 12:37 < erasmus> yes 12:37 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 12:38 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 12:39 -!- drethelin [drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has joined ##hplusroadmap 12:40 < juri_> do they mind telling me? :P 12:40 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has quit [Read error: Connection reset by peer] 12:42 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 12:43 -!- nmz787_w [c0373628@gateway/web/freenode/ip.192.55.54.40] has quit [Ping timeout: 246 seconds] 12:43 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 12:51 -!- FourFire|AFK [~FourFire@185.7.192.138] has quit [Quit: Leaving] 12:51 -!- nmz787_w [86868947@gateway/web/freenode/ip.134.134.137.71] has joined ##hplusroadmap 12:52 < nmz787_w> chris_99: cool! I've seen that before, but too bad they're still only taking pre-orders 12:52 < chris_99> yeah it looks like it was created on kickstarter late 2013 alas 12:52 < chris_99> but looks interesting nonetheless 12:52 -!- _0bitcount [~Big_Byte@2.153.164.116.dyn.user.ono.com] has quit [Quit: Leaving] 12:58 -!- sandeepkr [~sandeepkr@111.235.64.135] has quit [Remote host closed the connection] 13:00 < superkuh> A friend of mine went in for that kickstarter. He'll be happy to see actual progress. 13:00 < chris_99> im awaiting for a spectrometer kickstarter, which also seems very slow in updates 13:03 < kanzure> you mean nmz787's? 13:03 < chris_99> nah, https://www.kickstarter.com/projects/903107259/scio-your-sixth-sense-a-pocket-molecular-sensor-fo 13:03 < chris_99> which is probably a waste of money now i've learned more 13:04 < chris_99> i should have got one like nmz787_w has 13:15 < nmz787_w> seems like the killer spectrometer will be something with optical heterodyning and a variable laser to scan the frequencies of interest 13:18 < chris_99> variable lasers sound nifty i only heard of them not too long ago 13:30 -!- Viper168_ [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 13:30 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-trkhbgjryezutpcr] has joined ##hplusroadmap 13:32 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 13:33 < ryankarason> :o.. a pocket spectrometer would be awesome 13:41 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has quit [Remote host closed the connection] 14:01 < nmz787_w> kanzure: I'm guessing you've heard of this https://www.braintreepayments.com 14:05 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 14:17 < kanzure> i thought they were acquired by paypal 14:18 < kanzure> ah yes. 14:18 < kanzure> anyway, see also stripe 14:21 < nmz787_w> does stripe take bitcoin too? 14:27 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap 14:31 < kanzure> yes stripe has a bitcoin feature 14:35 < nmz787_w> from the quick look at braintree, bitcoin takes more setup with something called coinbase... so it's not ready to use with just signing up for braintree 14:39 < kanzure> coinbase has payment processing things like bitpay 14:39 < kanzure> and a consumer-oriented web wallet 14:51 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Quit: Namaste ] 14:54 < justanotheruser> Do genetic engineers wear designer genes? 14:55 < nmz787_w> justanotheruser: Probably not on purpose... them there genes are expensive... they might spill some genes on themselves once in a while 14:55 * nmz787_w don't spill the beans /or/ genes 14:55 -!- nmz787_w [86868947@gateway/web/freenode/ip.134.134.137.71] has quit [Quit: Page closed] 15:03 -!- altersid [~sid@altersid.net] has quit [Ping timeout: 250 seconds] 15:04 -!- altersid [~sid@altersid.net] has joined ##hplusroadmap 15:04 -!- altersid is now known as Guest19943 15:13 < TMA> justanotheruser: of course they do. If I recall correctly the gene engineer introduces the genes to the target creature using gene gun, that shoots some nanoparticles with genes tacked on. They hold the gun in one hand and the target in the other. Some of the particles miss (or go through) and hit the other hand :) 16:32 -!- sheena [~home@d99-199-117-38.bchsia.telus.net] has quit [Ping timeout: 244 seconds] 16:33 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 16:35 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Ping timeout: 255 seconds] 16:46 -!- Viper168_ [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 16:55 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap 16:57 -!- sheena [~home@d108-180-224-190.bchsia.telus.net] has joined ##hplusroadmap 17:01 < kanzure> http://www.devttys0.com/2015/04/what-the-ridiculous-fuck-d-link/ 17:25 < justanotheruser> why isn't ralph merkle in this channel 17:31 < kanzure> because he's a meanie butthead and is too busy pandering to ethereum 17:35 -!- sheena [~home@d108-180-224-190.bchsia.telus.net] has quit [Ping timeout: 250 seconds] 17:35 < JayDugger> Heh. 17:56 -!- efm [~efm@198.167.166.39] has joined ##hplusroadmap 18:02 -!- crescendo [~mozart@unaffiliated/crescendo] has quit [Quit: leaving] 18:13 -!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:16 < kanzure> yashgaroth: yo 18:16 < yashgaroth> hoi 18:16 < kanzure> sup 18:16 < yashgaroth> put in my 2 weeks' at my job today 18:17 < kanzure> where you headed 18:17 < yashgaroth> nowhere in particular, just free agenting for a little while 18:17 < kanzure> have you finally decided that my nootropics plan is the best idea ever? 18:17 < yashgaroth> is the plan "do a bunch of nootropics"? 18:18 < kanzure> toxo 18:18 < yashgaroth> it's on the list somewhere 18:18 < kanzure> well if you have crazy projects and want more resources hit me up 18:19 < yashgaroth> yeah I can likely do some work on the oligo ligase investigation, and want to write up the follistatic-Fc in yeast project to the point where I can actual start lab work on it 18:20 < kanzure> how do you feel about doing mouse work 18:20 < yashgaroth> how intimate am I being with these mice 18:21 < kanzure> that's at your discretion 18:21 < yashgaroth> keeping mice is one thing, and note that I'd probably be doing it at joseph's lab so I can't be like throwing their brains everywhere 18:22 < kanzure> ah that's unfortunate 18:22 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap 18:22 < yashgaroth> yeah it's really the best part about mice, brain throwin' 18:23 < yashgaroth> the lab is becoming less and less of a reason to remain in san diego since jojack keeps getting rid of equipment, like he's getting into the functional equipment now, I'm worried 18:24 < yashgaroth> I'm fixing up the FPLC for the guy he sold it to, it's bittersweet 18:29 -!- c0rw1n is now known as rw|zZz 18:39 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ohvrtgczrwsfsoom] has quit [Quit: Connection closed for inactivity] 18:39 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Read error: Connection reset by peer] 18:54 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 19:14 < streety> mouse work can be productive, not sure about this brain throwing though 19:16 < yashgaroth> it's optional but entertaining 19:16 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 246 seconds] 19:17 < streety> I prefer other organs. Although I was reading an interesting article today on tissue clearing for microscopy that was in the brain 19:19 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 19:33 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-hezfdkpxdaksmzlg] has joined ##hplusroadmap 19:44 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 256 seconds] 19:48 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 19:50 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Read error: Connection reset by peer] 19:51 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 20:10 -!- rancyd is now known as rancyd[out] 20:32 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 20:38 -!- efm [~efm@198.167.166.39] has quit [Remote host closed the connection] 20:38 -!- efm [~efm@198.167.166.39] has joined ##hplusroadmap 20:43 -!- efm [~efm@198.167.166.39] has quit [Remote host closed the connection] 20:44 -!- efm [~efm@198.167.166.39] has joined ##hplusroadmap 20:50 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 21:11 -!- efm [~efm@198.167.166.39] has quit [Remote host closed the connection] 21:22 -!- rancyd[out] is now known as rancyd 21:31 -!- cluckj [~cluckj@pool-108-16-231-242.phlapa.fios.verizon.net] has quit [Ping timeout: 244 seconds] 21:32 < maaku> pretty confident that it was ethereum / stellar that was pandering to merkle 21:32 < maaku> kanzure: but was there history to the meanie butthead comment? 21:32 -!- proofoflogic [uid65184@gateway/web/irccloud.com/x-ndnmjezpzcnahfpa] has joined ##hplusroadmap 21:36 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 21:41 -!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 21:44 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap 22:33 -!- sheena [~home@S0106c8be196316d1.ok.shawcable.net] has joined ##hplusroadmap 22:34 -!- QuadIngi [~FourFire@185.7.192.138] has joined ##hplusroadmap 22:35 -!- sandeepkr [~sandeepkr@111.235.64.135] has joined ##hplusroadmap 23:53 -!- proofoflogic [uid65184@gateway/web/irccloud.com/x-ndnmjezpzcnahfpa] has quit [Quit: Connection closed for inactivity] --- Log closed Fri Sep 18 00:00:31 2015