--- Log opened Sat Oct 31 00:00:12 2015
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04:37 < kanzure> "Chondroitinase ABC (ChABC) can reactivate plasticity and affect memory through actions on perineuronal nets. ChABC was injected into the perirhinal cortex and animals were tested for OR memory 1 week later, demonstrating restoration of OR memory to normal levels. Synaptic transmission indicated by fEPSP amplitude was restored to control levels following ChABC treatment. ChABC did not affect the progression of neurodegenerative ...
04:37 < kanzure> ... tauopathy. These findings suggest that increasing plasticity by manipulation of perineuronal nets offers a novel therapeutic approach to the treatment of memory loss in neurodegenerative disorders."
04:37 < kanzure> "Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology" http://www.sciencedirect.com/science/article/pii/S0014488614003835
04:38 < kanzure> "Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice" http://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-015-0233-z
04:39 < kanzure> .wik chondroitinase treatment
04:39 < yoleaux> "Chondroitinase treatment is a treatment of proteoglycans, a protein in the fluid among cells where (among other things) they affect neural activity (communication, plasticity). Chondroitinase treatment has been shown to allow adults vision to be restored as far as ocular dominance is concerned." — https://en.wikipedia.org/wiki/Chondroitinase_treatment
04:41 < kanzure> .title http://curj.columbia.edu/article/tissue-engineered-cartilage/
04:41 < yoleaux> The Effect of Varying Concentrations and Application Periods of Chondroitinase ABC on Tissue-Engineered Cartilage – Columbia Undergraduate Research Journal
04:45 < kanzure> "Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138705
04:45 < kanzure> that's a rather large claim
04:46 < kanzure> "Immobilization of chondroitinase ABC-I and -II on chitosan microbeads improve neurite growth in CSPG-enriched astrocyte culture" http://hub.hku.hk/handle/10722/216630
04:47 < kanzure> .wik chondroitin sulfate proteoglycan
04:47 < yoleaux> "Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage, and also play key roles in neural development and glial scar formation." — https://en.wikipedia.org/wiki/Chondroitin_sulfate_proteoglycan
04:48 < kanzure> "They are known to be involved in certain cell processes, such as cell adhesion, cell growth, receptor binding, cell migration, and interaction with other extracellular matrix constituents.[1] They are also known to interact with laminin, fibronectin, tenascin, and collagen.[1] CSPGs are generally secreted from cells. Importantly, CSPGs are known to inhibit axon regeneration."
04:49 < kanzure> "Here we examined whether ChABC could similarly improve axonal growth of transplanted dopamine neurons in an animal model of PD. Acute delivery of ChABC, into the medial forebrain bundle, degraded CSPGs along the nigrostriatal pathway. Simultaneous homotopic transplantation of dopaminergic progenitors, into the ventral midbrain of ChABC treated PD mice, had no effect on graft survival but resulted in enhanced axonal growth along the ...
04:49 < kanzure> ... nigrostriatal pathway and reinnervation of the striatum, compared to control grafted mice." http://www.sciencedirect.com/science/article/pii/S1044743115300257
04:50 < kanzure> "Enzyme activity enhancement of chondroitinase ABC I from Proteus vulgaris by site-directed mutagenesis" http://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra15220h#!divAbstract
04:50 < kanzure> "Mutating Arg660 to Ala caused a total loss of the enzyme activity either with CS A or CS B as substrate, indicating that Arg660 was one of the active sites of ChSase ABC I. The specific activities of Asn795Ala and Trp818Ala were 1.39 and 1.38 times higher than that of wild type enzyme with CS A as substrate, and 1.85 and 1.71 times higher with CS B as substrate."
04:54 < kanzure> "Plasticity of subcortical pathways promote recovery of skilled hand function in rats after corticospinal and rubrospinal tract injuries"
04:57 < kanzure> "Neuronal growth cones and regeneration: gridlock within the extracellular matrix" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146195/
04:58 < kanzure> http://examine.com/supplements/Glucosamine/
04:59 < kanzure> heh surprisingly weak http://examine.com/supplements/chondroitin/
04:59 < kanzure> ah looks like most people had been looking at chondroitin for joint pain
05:01 < kanzure> "nutritional supplement price comparison shopping" https://www.priceplow.com/
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07:09 < kanzure> "aims to replace cross compiling with native compiling under an emulator (qemu)" http://landley.net/aboriginal/about.html
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10:29 < mgin> this shit again: http://www.dailymail.co.uk/femail/article-3293259/Baby-born-without-brain-amazes-doctors-celebrating-second-birthday-says-Mummy-time.html
10:29 < mgin> what the hell
10:49 < jstanothrspookr> dailymail
10:49 < kanzure> "a very rare health condition known as holoprosencephaly which they said left him 'incompatible with life'.
10:49 < kanzure> Read more: http://www.dailymail.co.uk/femail/article-3293259/Baby-born-without-brain-amazes-doctors-celebrating-second-birthday-says-Mummy-time.html#ixzz3qAXS95PC
10:49 < kanzure> fucking paste spam
10:49 < kanzure> yes dailymail is the worst
10:50 < kanzure> .wik holoprosencephaly
10:50 < yoleaux> "Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species." — https://en.wikipedia.org/wiki/Holoprosencephaly
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12:50 < delinquentme> Anyone in here used alibaba before?
12:51 < delinquentme> whats this ' share express account ' about ?
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13:51 < streety> I think I used alibaba a few years ago but I've only used aliexpress recently
13:54 < chris_99> i use alibaba/aliexpress
13:54 < chris_99> pretty pleased with both
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16:25 < kanzure> .wik leucin zipper
16:25 < yoleaux> "A leucine zipper, aka leucine scissors, is a common three-dimensional structural motif in proteins." — https://en.wikipedia.org/wiki/Leucine_zipper
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18:28 < FourFire> kanzure, I may have asked this before, but what are your thoughts on tDCS ?
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18:34 < kanzure> FourFire: not impressed by resolution and targeting of stimulation
18:35 < FourFire> so it doesn't work, or just not enough for the effort required?
18:36 < kanzure> my tdcs paper collection is rather empty http://diyhpl.us/~bryan/papers2/neuro/tdcs/
18:36 < kanzure> there's been various clinical trials, it works, but what i want is like 1 mm^3 resolution stimulation of any region of brain matter
18:42 < FourFire> thanks for your tips.
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22:34 < barnaby> am I a lobster?
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--- Log closed Sun Nov 01 00:00:12 2015