--- Log opened Tue Nov 17 00:00:27 2015
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03:57 < jrayhawk> Updated, though it'll be broken for some browsers until the OCSP server updates.
03:58 < jrayhawk> Which can take a day with startcom.
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04:51 < kanzure> thanks
05:07 < fenn> it's difficult to measure executive function loss due to temporal lobe damage vs "i can't see" or "i can't move my left arm" so the side effects of surgery magically go away :D
05:19 < kanzure> gah who taught you neurosurgery
05:20 < kanzure> wha? https://github.com/bitcoin/bips/pull/242/files
05:37 < archels> might not be so difficult, there's probably not many standardised tasks for it though
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05:58 < kanzure> http://vknight.org/unpeudemath/code/2015/11/15/Visualising-markov-chains/
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06:24 < kanzure> jrayhawk: "A new piny account ``newuser'' has been created"
06:24 < kanzure> dunno if this is a hole
06:24 < kanzure> eh probably not
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08:27 < justanotheruser> http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b03764
08:27 < justanotheruser> .title
08:27 < yoleaux> An Error Occurred Setting Your User Cookie
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08:58 < fenn> "Biologists Announce They’re All Done With Rodents ‘There Is Nothing About Them That Requires Further Scientific Inquiry,’ Say Scientists"
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09:04 < kanzure> "Mouse Biologist Says Disregard Last Statement"
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09:32 < kanzure> what's the correct name for "microphone"?
09:33 < chris_99> whatcha mean? i guess it's a type of transducer
09:33 < kanzure> micro-phone is a pretty bad name heh
09:33 < chris_99> heh
09:34 < kanzure> "acoustic sensor" or "acousto-electric transducer" or "sound recorder" or something.. any of those would be better.
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09:54 < FourFire> "Phonon moderator"
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10:47 < jrayhawk> oh, i think i send out that email regardless of whether or not the creation was successful because i am actually a moron
10:47 < jrayhawk> there is one legitimate hole i should really take care of
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11:46 < jrayhawk> Stskeeps: Is there a comparison of the feature scope of libhybris and ARC somewhere?
11:46 < Stskeeps> jrayhawk: they're not really related. sortof.
11:47 < Stskeeps> jrayhawk: ARC actually implements the entire bionic library using NaCL from what i can tell
11:47 < jrayhawk> That's ambitious.
11:47 < Stskeeps> but only for NDK stuff
11:47 < Stskeeps> i think
11:47 < Stskeeps> libhybris has to use insane android drivers and their weird bits like TLS slots, so .. :)
11:47 < Stskeeps> bit different audience
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11:54 < jrayhawk> Like at this point if someone tells me "I want to run Android apps on my computer" I have no idea whether to attempt to set up libhybris, ARC, or an Android VM for them because I don't really understand the tradeoffs.
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11:55 < ButaTine> jrayhawk, perhaps just ask what the application is and suggest an easier to impliment soluton to the problem
11:57 < jrayhawk> What's good for development? What's good for speed? What's good for security? What's good for weird hardware integration like GPS and accelerometers and such? No idea!
11:58 < andares> How do people map all these complex gene regulatory networks and model their interactions?
11:58 < andares> Just millions of hours in the lab?
11:59 < Stskeeps> jrayhawk: a virtual machine is usually the sanest
11:59 < Stskeeps> jrayhawk: ARC is emerging but not generic
12:01 < kanzure> my life improved dramatically when i started using android-x86 vm for development reasons
12:01 < kanzure> andares: yep, plus lots and lots of inference. and modeling. and speculation.
12:01 < andares> I can't even begin to imagine a computational approach
12:02 < andares> Given all the different ways genes can interact
12:03 < kanzure> it's important to build islands of stability and repeatable stuff that you can use, and then hopefully ignore all the noise
12:03 < kanzure> for example, molecular nanostructures made out of proteins or related byproducts
12:04 < jrayhawk> http://scholar.google.com/scholar?q=measuring+transcription is a big start, but, yeah, we're still quantifying means by which genes are expressed
12:04 < kanzure> not just regulatory network interaction but also protein-protein interaction too
12:04 < jrayhawk> we're still discovering new DNA bases
12:04 < kanzure> protein-protein or cofactor stuff or whatever the hell antibiotics often do to ribosomes
12:05 < andares> Bases? You mean like SNPs or new genes?
12:05 < kanzure> nucleotides
12:05 < nmz787_i> nucleotides?
12:05 < jrayhawk> 5-formyl cytosine was discovered in, what, 2014?
12:05 < nmz787_i> are these just epigenetically different?
12:05 < kanzure> nucleobases
12:06 < andares> Besides agtc? Whoa
12:06 < nmz787_i> oh, yeah, seems epigenetically related
12:06 < nmz787_i> nah it's just a modified C
12:06 < kanzure> "adenosine, BUT WITH A METHYL TAG"
12:06 < andares> Ah
12:06 < andares> Are all nucleotides methylatable?
12:06 < ButaTine> kanzure, why weren't all of these variants hypotheasized in 1952?
12:07 < kanzure> that's more of a question for jrayhawk at the moment, i am too deep in socket programming to know my snd from my recv's
12:08 < nmz787_i> ButaTine: that's like asking why all the different computer science datatypes weren't hypothesized in 1900 or something
12:08 < nmz787_i> "and some day, we'll need a thing called a qubit"
12:08 < nmz787_i> and a uint_8_t
12:08 < kanzure> all two of them? pointer and pointer pointer?
12:09 < jrayhawk> andares: At least for eukaryotes, we've got a g t c 5mc 5hmc 5cac and 5fc as "normal" bases, quite a lot of others considered "damaged" by "abnormal" processes, and a lot of others besides in prokaryotes.
12:09 < kanzure> and then various artificial synthesized nucleobases and backbone substitutes
12:09 < nmz787_i> and then the synthetic analogues
12:09 < nmz787_i> XNA and such
12:09 < nmz787_i> damnit kanzure
12:09 < nmz787_i> quit winning at typing my thoughts
12:09 < andares> Hehe
12:09 < kanzure> http://diyhpl.us/~bryan/papers2/DNA/
12:11 < jrayhawk> I don't actually pay much attention to non-tet-mediated base mutations, so I couldn't tell you what sorts of things can happen to stuff other than cytosine.
12:12 < jrayhawk> I fined it entirely plausible that "abnormal" "damage" and "repair" will wind up having genetic semantics for legitimate adaptive purposes in a lot of cases.
12:12 < jrayhawk> So the field is still wide open.
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12:25 < kanzure> we should really get around to making mutantpedia happen
12:25 < jrayhawk> andares: another fun fact: we still haven't sequenced the human genome
12:26 < jrayhawk> PCR can only do short segments and even using extremely sophisticated statistical trickery we just can't fill in the gaps of repeating sections.
12:26 < jrayhawk> SMRT is getting pretty close, though.
12:26 < jrayhawk> We'll probably be able to sequence it in the next five years.
12:32 < jrayhawk> I suppose there's a much better way to answer the question "11:58 < andares> How do people map all these complex gene regulatory networks and model their interactions?"
12:33 < jrayhawk> "Badly."
12:38 < jrayhawk> https://en.wikipedia.org/wiki/File:Genome_sequencing_costs,_May_2012.jpg this chart is often thrown around; the precipitous drop is where we gave up on any sort of accuracy standard and just assumed we could correct everything in statistics.
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13:13 < kanzure> "Observation of thermal Hawking radiation and its entanglement in an analogue black hole" http://arxiv.org/abs/1510.00621
13:13 < kanzure> "Realization of a Sonic Black Hole Analog in a Bose-Einstein Condensate" http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.105.240401
13:14 < kanzure> "Observation of Dirac monopoles in a synthetic magnetic field" http://www.nature.com/nature/journal/v505/n7485/full/nature12954.html
13:14 < kanzure> from https://news.ycombinator.com/item?id=10573138 about gravity
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13:40 < kanzure> .title http://lists.linuxfoundation.org/pipermail/lightning-dev/2015-November/000309.html
13:40 < yoleaux> [Lightning-dev] Better privacy with SNARKs
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13:50 < kanzure> https://en.wikipedia.org/wiki/Grandiose_delusions
13:51 < kanzure> "Other common grandiose delusions in schizophrenia include religious delusions such as the belief that one is Jesus Christ.[24]"
13:51 < kanzure> "For example, the person may possibly declare to own IBM and kindly offer to write a hospital staff member a check for $5 million if they would only help them escape from the hospital.[23]"
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15:44 < nmz787_i> .title http://www.explainshell.com/
15:45 < yoleaux> explainshell.com - match command-line arguments to their help text
15:45 < nmz787_i> "This site contains 29761 parsed manpages from sections 1 and 8 found in Ubuntu's manpage repository. A lot of heuristics were used to extract the arguments of each program, and there are errors here and there, especially in manpages that have a non-standard layout."
16:24 < kanzure> https://github.com/BBBSnowball/python-solvespace
16:25 < kanzure> http://www.mattkeeter.com/projects/constraints/
16:25 < kanzure> .title https://www.youtube.com/watch?v=2r8Y4tOeYZQ
16:25 < yoleaux> Using SolveSpace to draw Sonex flap detent - YouTube
16:25 < kanzure> .title https://github.com/ruevs/solvespace/commit/9963d9bb25d1e17ed5d5bbe8cd42fc73c8326f7c
16:25 < yoleaux> Added a new constraint "Length Difference" · ruevs/solvespace@9963d9b · GitHub
16:28 < nmz787_i> huh, neat
16:29 < nmz787_i> I wonder what benefit I could gain from using this with BRLCAD
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17:34 < kanzure> what was the nature/nurture stuff about, again? that you could only optimize in one of the two dimensions ? or what
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18:46 < kanzure> beep boop
18:47 < kanzure> "a more technical explanation of constraint solving in sketchflat (solvespace’s predecessor)" http://cq.cx/dl/sketchflat-internals.pdf
19:07 < kanzure> http://www.japanesebugfights.com/
19:08 < kanzure> uh, nevermind
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--- Log closed Wed Nov 18 00:00:28 2015