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00:36 < fenn> B12 can act as a methyl donor, same as methyl folate
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00:40 < fenn> i think this can affect hormone levels and fatty acid oxidation (in the case of deficiency)
00:41 < fenn> a cheaper source of methyl groups would be choline, TMG, or betaine, though SAMe seems to be popular for some reason: http://www.raysahelian.com/methyl.html
00:42 < fenn> oh TMG is betaine
00:45 < fenn> "The synthesis of SAMe is intimately linked with folate and vitamin B12 metabolism, and deficiencies of both these vitamins have been found to reduce central nervous system SAMe concentrations."
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02:00 < nmz787_> fenn: good diversion
02:00 < nmz787_> kanzure: yeah I forgot about that, what happened to those guys?
02:01 < nmz787_> just got some for of slicing implemented in my BRL-CAD wrapper... and here is a nice animated GIF of slices: https://raw.githubusercontent.com/nmz787/python-brlcad-tcl/master/examples/output/microfluidic_pump_slices_manually_created_animation.gif
02:02 < nmz787_> now to figure out NIRT and getting a raster, to hopefully get g-code (especially if abetusk ever re-appears)
02:02  * nmz787_ sleeps now though
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07:29 < kanzure> https://www.youtube.com/watch?v=MXaONlkQp_E
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08:05 < kanzure> .title http://ai2016.foresight.org/
08:05 < yoleaux> Foresight Institute Artificial Intelligence for Scientific Progress
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09:21 < CaptHindsight> http://lasergen.com/wp-content/uploads/2013/06/Litosh-NAR-January-2011.pdf
09:21 < CaptHindsight> http://lasergen.com/wp-content/uploads/2013/06/Gardner2012Paper.pdf
09:22 < CaptHindsight> they don't see the big picture
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10:10 < kanzure> "Amplification of RNA by an RNA polymerase ribozyme" http://www.pnas.org/content/early/2016/08/10/1610103113
10:10 < kanzure> "Here, we report the in vitro evolution of an improved RNA polymerase ribozyme that is able to synthesize structured functional RNAs, including aptamers and ribozymes, and replicate short RNA sequences in a protein-free form of the PCR. Thus, the replication of RNA and the expression of functional RNA can be accomplished with RNA alone. Combining and improving these activities may enable the self-sustained evolution of RNA and offers a ...
10:10 < kanzure> ... potential route to a synthetic form of RNA life."
10:10 < kanzure> ".. the polymerase can replicate nucleic acids, amplifying short RNA templates by more than 10,000-fold in an RNA-catalyzed form of the PCR"
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11:29 < esmerelda> Holy crap that's amazing.
11:38 < nmz787_> it seems business as usual to me
11:41 < esmerelda> Business as usual is amazing these days. I love the future
11:42 < nmz787_> the problem seems to be the universe is so big/complex... there could be years of this before we get anywhere that isn't akin to "poserville"
11:43 < nmz787_> of course I still reserve myself to be amazed... it is just hard when you see things happening in the world that remind me it could all crumble if politics screw up and some disenfranchised group starts smashing things
11:43 < esmerelda> What? I'm just talking about being excited that RNA world seems even more likely now
11:44 < nmz787_> the RNA world was always as likely though, I guess... it just has some evidence now
11:46 < nmz787_> CaptHindsight: well at least /someone/ is working on better nucleotide chemistry
11:47 < nmz787_> oh, this is the lasergen peole
11:47 < nmz787_> I am stupid for not reading the URL
11:47  * nmz787_ wonders if this means there are other academics in the Houston area, should I desire to pursue PhD in nucleotide chem/applied-chem
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12:00 < CaptHindsight> or move to China and get continual funding as you trickle out new synthesis methods
12:00 < CaptHindsight> China is a lot like Texas
12:07 < nmz787_> I really only consider Texas because I have a friend who might end up being a Medical Doctor around there... and who doesn't need a doctor as a drinking buddy?
12:07 < nmz787_> also, weather in all places but here seems all messed up... Oregon is pretty sweet
12:08  * nmz787_ has told in-laws I'll be driving them to see the blown-out Mt. St. Helens now
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12:35 < kanzure> pasky: how is multi-gpu distributed training supposed to work?
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12:49 < kanzure> "Deep learning with Elastic Averaging SGD" http://arxiv.org/abs/1412.6651
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12:51 < kanzure> well, i don't think i mean placing separate layers on seperate devices (seems like a good way to get bottlenecked on training)
12:51 < kanzure> *during training
12:51 < kanzure> i'm also not sure about "just average the weights once you're done"
12:54 < kanzure> https://github.com/mila-udem/platoon
12:54 < kanzure> welp looks like they really do just "average the weights yo"
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13:12 < kanzure> nope, people are doing literal summing not even averaging https://github.com/fchollet/keras/issues/106#issuecomment-157130117
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13:13 < kanzure> oh that's an average. nevermind.
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13:41 < jcorgan> integration wipes away all sins
13:50 < ybit> http://joss.theoj.org/papers.atom
13:51 < ybit> http://joss.theoj.org/
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15:05 < ybit> anyone have access to
15:05 < ybit> http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b00530?journalCode=nalefd
15:05 < ybit> http://www.nature.com/nature/journal/v523/n7561/full/nature14586.html
15:05 < ybit> http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b05139
15:06 < ybit> someone was nice enough to download a paper for me just now: https://www.reddit.com/r/Scholar/comments/4yrfpw/article_eukaryotic_dna_polymerases/
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15:16 < ybit> guess i'll bundle them into a single request on r/scholar
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15:18 < yashgaroth> is there something wrong with sci-hub
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15:19 < xentrac> nmz787_: congratulations on your slicing!
15:19 < yashgaroth> and the second one is online, no? http://www.hogberglab.net/media/publications/benson2015mc.pdf
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15:26 < ybit> ah, i needed to select "scientific articles" underneath the input form
15:26 < ybit> thanks yashgaroth
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15:38 < maaku> https://www.doc.ic.ac.uk/~mpsha/ECExplained.pdf
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20:24 < kanzure> .title http://www.symmetrymagazine.org/article/the-100-muon-detector
20:24 < yoleaux> The $100 muon detector | symmetry magazine
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22:18 < kanzure> tor is still busy imploding :|
22:18 < ebowden> In what way is tor imploding?
22:19 < anoncicada> :c
22:19 < jcorgan> excess drama
22:19 < superkuh> Lots of members being kicked out, leaving because someone was kicked out, leaving for no stated reason, being replaced in mass.
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23:47 < nmz787_> xentrac: thanks!
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--- Log closed Sun Aug 21 00:00:31 2016