--- Log opened Sun Sep 11 00:00:51 2016
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03:40 < kanzure> oh it's probably because targeting memory consolidation pathways/neurons is difficult with viruses
03:41 < kanzure> or er, with stereotaxic stuff. because poking through lots of brain matter, and such. (viral targeting is probably more possible, to be fair)
03:44 < fenn> neither of those are good reasons
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03:55 < kanzure> why would that not be a good reason?
03:55 < kanzure> they probably break all the other brain parts if they try to inject neurons near those targets
03:55 < kanzure> http://www.academia.edu/download/39731675/Upgrading_the_sleeping_brain_with_target20151105-18157-51ku9k.pdf
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04:05 < kanzure> mirror tracing task and dream recall http://onlinelibrary.wiley.com/doi/10.1111/jsr.12286/full
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06:00 < abetusk> psa: pstoedit is an excellent tool.  Worth looking into if you want to convert between formats.  It even goes from postscript to gcode
06:09 < JayDugger> Thank you for posting the link to the HSAM paper, kanzure.
06:10 < JayDugger> And I'll guess "no," but would be interested in knowing whether the head-mounted refrigerator works.
06:12 < JayDugger> Not super-impressed that the HSAM paper relies so much on "can you keep a mental perpetual calendar," though.
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07:25 < abetusk> .title http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-s079-nanomaker-spring-2013/videos/
07:25 < yoleaux> Videos | Nanomaker | Electrical Engineering and Computer Science | MIT OpenCourseWare
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09:38 < justanotheruser> .title https://youtu.be/plVk4NVIUh8
09:38 < yoleaux> The Evolution of Bacteria on a “Mega-Plate” Petri Dish - YouTube
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09:43 < justanotheruser> Is this a common technique? If so, what other evolutionary experiments have been done
09:48 < CaptHindsight> the problem is sourcing the 4ft square petri dishes
09:50 < kanzure> justanotheruser: surely you know about the 20 year 40,000 generation ecoli experiments?
09:51 < justanotheruser> I do not
09:51 < kanzure> justanotheruser: https://en.wikipedia.org/wiki/E._coli_long-term_evolution_experiment
09:51 < justanotheruser> by this technique I mean specifically the large petri dish
09:51 < CaptHindsight> Chipotle has been open for 20 years?
09:51 < justanotheruser> but that is in my interest too
09:52 < kanzure> so that link is a good place to start
09:52 < kanzure> but also things like https://en.wikipedia.org/wiki/In_vitro_compartmentalization
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10:06 < justanotheruser> Would be interesting if they had a database mapping DNAs to the attributes o fthe growth medium it has survived
10:25 < kanzure> justanotheruser: http://diyhpl.us/wiki/transcripts/montclare-protein-engineering/directed-evolution/
10:36 < justanotheruser> very interesting
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11:53 < pasky> justanotheruser: there is also a similar experiment with fruit flies
11:59 < kanzure> and dogs, foxes, tomato, lots of stuff.
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12:41 < kanzure> probably there's a thing that selects events for memory consolidation. that's probably an ideal target for enhancement. consolidation probably works well enough, and maybe it's the set of things that need to get consolidated that is too fuzzy.
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13:10 < justanotheruser> kanzure: where do I go when sci-hub.la is down
13:10 < kanzure> to the motherland https://vk.com/sci_hub
13:11 < justanotheruser> how does this even work
13:11 < justanotheruser> I don't speak russian
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13:12 < kanzure> over-annunciate your v's and you'll be fine
13:12 < justanotheruser> srsly though, is there supposed to be a mirror link here or something
13:12 < kanzure> http://sci-hub.cc/
13:13 < justanotheruser> danke
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13:56 < kanzure> "A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain" http://www.sciencedirect.com/science/article/pii/S0014488616301492
13:57 < kanzure> oh it is berger. that is okay with me.
13:58 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/memory/A%20cognitive%20prosthesis%20for%20memory%20facilitation%20by%20closed-loop%20functional%20ensemble%20stimulation%20of%20hippocampal%20neurons%20in%20primate%20brain%20-%20Berger%20-%202016.pdf
14:00 < kanzure> page 29 (marked 28) has a diagram of their circuit. those wires sure do seem to go through a lot of important brain matter....
14:03 < kanzure> "Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity" http://diyhpl.us/~bryan/papers2/neuro/memory/Morphometric%20and%20histologic%20substrates%20of%20cingulate%20integrity%20in%20elders%20with%20exceptional%20memory%20capacity%20-%202015.pdf
14:03 < kanzure> "These findings suggest that reduced vulnerability to the age-related emergence of Alzheimer pathology and higher von Economo neuron density in anterior cingulate cortex may represent biological correlates of high memory capacity in advanced old age."
14:06 < kanzure> "Sparse generalized volterra model of human hippocampal spike train transformation for memory prostheses"
14:06 < kanzure> "Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses"
14:08 < kanzure> "Neurons and networks organizing and sequencing memories" https://www.researchgate.net/profile/Dong_Song2/publication/270288519_Neurons_and_Networks_Organizing_and_Sequencing_Memories/links/551d805d0cf213ef063e6149.pdf
14:10 < kanzure> "Distributed encoding of spatial and object categories in primate hippocampal microcircuits" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594006/
14:12 < kanzure> "A million-plus neuron model of the hippocampal dentate gyrus: Dependency of spatio-temporal network dynamics on topography" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878386/
14:20 < kanzure> "Hamani et al. (2008) describe a case where a patient was implanted with a deep brain stimulation (DBS) device targeted at the hypothalamus to treat morbid obesity. Through post-operative CT scans, the researchers estimated that the electrodes were located in the hypothalamus, but two were notably proximal to the fornix. Initial stimulation of one electrode evoked an autobiographical memory from decades prior. Of particular relevance, ...
14:20 < kanzure> ... the patient developed enhanced memory function. Hamani et al. found that DBS led to greater activation in the patient's hippocampus and parahippocampal gyrus. Suthana et al. (2012) implanted DBS electrodes in the entorhinal cortex of epilepsy patients and found enhanced spatial memory. "
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21:10 < kanzure> "bored george church" https://twitter.com/BoredSynBio
21:11 < kanzure> .tw https://twitter.com/BoredSynBio/status/673338190846128128
21:11 < yoleaux> Garden DNA sequencers that survey soil microbes and are disguised as George Church garden gnomes. (@BoredSynBio)
21:13 < kanzure> .tw https://twitter.com/BoredSynBio/status/620966652545511424
21:14 < yoleaux> A human appendix engineered to do something, anything. (@BoredSynBio)
21:14 < kanzure> .tw https://twitter.com/BoredSynBio/status/617389703227162625
21:14 < yoleaux> Fungal spores that are sprinkled onto your yard and grow into a Slip n Slide. #GeorgeDoesThe4th (@BoredSynBio)
21:14 < kanzure> .tw https://twitter.com/BoredSynBio/status/616654871022989312
21:14 < yoleaux> Mandatory microbiome tests for presidential candidates to quantify how full of shit they are, and what kind. (@BoredSynBio)
21:14 < kanzure> .tw https://twitter.com/BoredSynBio/status/616287838825484288
21:14 < yoleaux> Worms that don't succumb to the early bird. (@BoredSynBio)
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21:15 < kanzure> .tw https://twitter.com/BoredSynBio/status/609384867646697472
21:15 < yoleaux> Gene circuit to selectively regulate dihydrotestosterone stimulation of hair follicles so that my beard is always the perfect length. (@BoredSynBio)
21:16 < kanzure> .tw https://twitter.com/BoredSynBio/status/609196064445497344
21:16 < yoleaux> Zoo full of synthetic (and de-extincted) animals, including mammoths and dinosaurs. All profits go to next-gen conservation efforts. (@BoredSynBio)
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--- Log closed Mon Sep 12 00:00:52 2016