--- Log opened Sat Oct 22 00:00:28 2016
00:07 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
00:08 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
00:49 -!- drewbot_ [~cinch@ec2-54-87-117-170.compute-1.amazonaws.com] has quit [Remote host closed the connection]
00:50 -!- drewbot [~cinch@ec2-54-162-203-131.compute-1.amazonaws.com] has joined ##hplusroadmap
00:59 -!- nildicit__ [~nildicit@unaffiliated/nildicit] has joined ##hplusroadmap
01:02 -!- nildicit_ [~nildicit@unaffiliated/nildicit] has quit [Ping timeout: 256 seconds]
01:24 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
01:25 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
02:20 -!- Burninate [~Burn@pool-108-56-208-224.washdc.fios.verizon.net] has quit [Ping timeout: 250 seconds]
02:28 < JayDugger> I suspect that's called "reasoning from fictional evidence." Given the author knows more about ML than I do, perhaps his argument has merit. (Yes, that's yielding to argument by authority.)
02:29 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 256 seconds]
02:41 < JayDugger> And Liu Cixin's solution isn't his own, though it might have developed independently. Zebrowski and Pellegrino did it earlier in "The Killing Star."
02:41 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap
02:41 < JayDugger> Hardly an original SF idea, and explored in detail at (where else?) Atomic Rockets. http://www.projectrho.com/public_html/rocket/aliens.php
02:49 < JayDugger> See also https://www.researchgate.net/publication/283986931_The_Dark_Forest_Rule_One_Solution_to_the_Fermi_Paradox
02:50 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-vsyxgrjcsayhbrei] has quit [Quit: Connection closed for inactivity]
02:56 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
02:57 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
03:01 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
03:03 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
03:11 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
03:51 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has joined ##hplusroadmap
04:03 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
04:08 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
04:11 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
04:12 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
04:13 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
04:22 -!- urchin_ [~urchin@89.17.5.71] has quit [Changing host]
04:22 -!- urchin_ [~urchin@unaffiliated/urchin] has joined ##hplusroadmap
04:22 -!- urchin_ is now known as Urchin
04:33 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
05:00 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
05:00 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
05:02 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap
05:08 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
05:15 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap
05:20 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-sllocdfcqblkfsej] has joined ##hplusroadmap
05:22 -!- mf1008 [~mf1008@unaffiliated/mf1008] has quit [Quit: Cave quid dicis, quando, et cui]
05:23 -!- mf1008 [~mf1008@unaffiliated/mf1008] has joined ##hplusroadmap
05:29 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
05:37 -!- ebowden [~ebowden@2001:8003:103d:6200:6593:6eda:ad91:e3f7] has joined ##hplusroadmap
05:37 -!- ebowden [~ebowden@2001:8003:103d:6200:6593:6eda:ad91:e3f7] has quit [Changing host]
05:37 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
05:40 < kanzure> hm.
05:51 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
05:53 -!- ebowden [~ebowden@2001:8003:103d:6200:6593:6eda:ad91:e3f7] has joined ##hplusroadmap
05:53 -!- ebowden [~ebowden@2001:8003:103d:6200:6593:6eda:ad91:e3f7] has quit [Changing host]
05:53 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
06:28 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 265 seconds]
06:36 < kanzure> "Morphological neuron classification using machine learning" http://journal.frontiersin.org/article/10.3389/fnana.2016.00102/abstract
06:37 < kanzure> tractography evaluation tools http://www.tractometer.org/
06:39 < kanzure> "Progress towards mammalian whole-brain cellular connectomics" http://journal.frontiersin.org/article/10.3389/fnana.2016.00062/full
06:43 < kanzure> "mammalian GFP-Reconstitution Across Synaptic Partners (mGRASP)" from http://journal.frontiersin.org/article/10.3389/fnana.2015.00078/full
06:43 < kanzure> "mGRASP is a genetically-controlled, molecular engineering method to detect mammalian synapses using LM (Kim et al., 2011; Feng et al., 2012, 2014; Druckmann et al., 2014). It is based on two complementary split-GFP fragments (called spGFP1-10 and spGFP11), separately non-fluorescent, each tethered to synaptic membranes in each of two neuronal populations. When two neurons, each expressing one of the fragments, are closely opposed across ...
06:43 < kanzure> ... a synaptic cleft, the split fragments unite and fluorescent GFP is reconstituted in that location (Figure 1B). This molecular engineering approach allows the resolution, at nanometer-scale, of synapses viewable by LM."
06:44 < kanzure> "... benefit of mGRASP technology is that it can rapidly and accurately detect nanometer-scale (~20 nm) synapses despite the diffraction limitations of LM: using this technique, fluorescence indicates the locations of mammalian synapses quickly, confidently, and with high spatial resolution. When tested with known synaptic and non-synaptic connections in samples full of axonal contacts, mGRASP was shown to specifically detect actual ...
06:44 < kanzure> ... synapses with very few false positives. When combined with specialized analysis software (Feng et al., 2012, 2014, 2015), mGRASP can relatively quickly reveal the precise locations and numbers of synapses along postsynaptic dendrites, sites responsible for determining many important characteristics of signal processing."
06:45 < kanzure> "The stochastic multicolor labeling of Brainbow combined with mGRASP, for instance, could identify the presynaptic partners of a given neuron; it would require labeling each neuron and preparing dense-reconstructions of synaptic connectivity under LM (Cai et al., 2013). Together with new optical clearing methods (Chung and Deisseroth, 2013; Ke et al., 2013; Renier et al., 2014; Susaki et al., 2014) or the very recently developed ...
06:45 < kanzure> ... expansion imaging method which uses the physical expansion (~4.5-fold) of tissue, resulting in physical magnification (Chen et al., 2015), mGRASPing with multicolored axonal labeling allows mapping connectivity from multiple inputs. Also, mGRASP combined with a new retrograde label virus system (Kato et al., 2011a,b) could help unlock the secrets of disynaptic circuits as well as monosynaptic pairs of cells. Further, a common ...
06:45 < kanzure> ... drawback of all methods for anatomical synaptic mapping, the lack of information about synaptic activity and strength, can be overcome through combinations of techniques including existing activity indicators and optogenetic tools."
06:50 < kanzure> viral techniques for gastrointestinal tract studies http://link.springer.com/article/10.1007/s00418-016-1496-6
06:51 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap
06:51 < kanzure> "Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons" http://journal.frontiersin.org/article/10.3389/fnana.2015.00040/full
06:56 < kanzure> "MAPseq-uencing long-range neuronal projections" http://www.cell.com/neuron/abstract/S0896-6273(16)30522-0
07:00 < kanzure> "Mapping synaptic input fields of neurons with super-resolution imaging" https://www.researchgate.net/profile/Colenso_Speer/publication/282593369_Mapping_Synaptic_Input_Fields_of_Neurons_with_Super-Resolution_Imaging/links/56156e8008ae983c1b41fe7c.pdf
07:01 < kanzure> "Super resolution imaging of genetically labeled synapses in Drosophila brain tissue" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880563/
07:01 < kanzure> "direct stochastic optical reconstruction microscopy (dSTORM)"
07:03 < kanzure> "genetically encoded calcium indicators (GECIs)"
07:03 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
07:04 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
07:05 < kanzure> "Multibow: Digital spectral barcodes for cell tracing" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127822
07:05 < kanzure> "We introduce a multicolor labeling strategy (Multibow) for cell tracing experiments in developmental and regenerative processes. Building on Brainbow-based approaches that produce colors by differential expression levels of different fluorescent proteins, Multibow adds a layer of label diversity by introducing a binary code in which reporters are initially OFF and then probabilistically ON or OFF following Cre recombination. We have ...
07:05 < kanzure> ... developed a library of constructs that contains seven different colors and three different subcellular localizations. Combining constructs from this library in the presence of Cre generates cells labeled with multiple independently expressed colors based on if each construct is ON or OFF following recombination. These labels form a unique "barcode" that allows the tracking of the cell and its clonal progenies in addition to ...
07:05 < kanzure> ... expression level differences of each color. We tested Multibow in zebrafish which validates its design concept and suggests its utility for cell tracing applications in development and regeneration."
07:06 < kanzure> a review of "tyrosine-type site-specific recombinases (T-SSRs)" http://pubs.acs.org/doi/abs/10.1021/acs.chemrev.6b00077
07:07 < kanzure> "A photoactivatable Cre–loxP recombination system for optogenetic genome engineering" http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2205.html
07:07 < kanzure> "Here we develop a highly efficient photoactivatable Cre recombinase (PA-Cre) to optogenetically control genome engineering in vivo. PA-Cre is based on the reassembly of split Cre fragments by light-inducible dimerization of the Magnet system. PA-Cre enables sharp induction (up to 320-fold) of DNA recombination and is efficiently activated even by low-intensity illumination (~0.04 W m−2) or short periods of pulsed illumination (~30 s). ...
07:07 < kanzure> ... We demonstrate that PA-Cre allows for efficient DNA recombination in an internal organ of living mice through noninvasive external illumination using a LED light source. The present PA-Cre provides a powerful tool to greatly facilitate optogenetic genome engineering in vivo."
07:07 < kanzure> yeah i think generically/randomly mutating and varying recombinases to have a variety of properties would be a useful thing to be doing... optical control of recombinases is a useful addition to the toolbox.
07:11 < kanzure> "NIH Blueprint for Neuroscience Research has created several hundreds of Cre driver mouse lines which are currently used by the world-wide neuroscience community."
07:16 < ebowden> Oh THIS is cool.
07:16 < kanzure> "Synthetic recombinase-based state machines in living cells" http://science.sciencemag.org/content/353/6297/aad8559.full?ijkey=wzroPPh1eIu9k&keytype=ref&siteid=sci http://www.scottaaronson.com/blog/?p=2862
07:17 < kanzure> yeah it would seem like "photoactivatable Cre recombinase" could be paired with some sort of viral gene therapy approach where you could use different viruses and light at different time to cause the construction of different DNA molecules.... in a very slow way, that is.
07:18 < kanzure> or, even without viruses, generic dna delivery stuff such as electroporation perhaps
07:18 < ebowden> Hmm, sometimes sci-hub doesn't work with sciencemag.
07:18 < ebowden> (It worked this time.)
07:21 -!- Neuronix [a7725c31@gateway/web/freenode/ip.167.114.92.49] has joined ##hplusroadmap
07:28 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
07:28 -!- ebowden [~ebowden@2001:8003:103d:6200:f941:5774:984f:1ecc] has joined ##hplusroadmap
07:28 -!- ebowden [~ebowden@2001:8003:103d:6200:f941:5774:984f:1ecc] has quit [Changing host]
07:28 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
07:31 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
07:35 -!- ebowden [~ebowden@2001:8003:103d:6200:2d8c:8ff0:6b0c:7372] has joined ##hplusroadmap
07:35 -!- ebowden [~ebowden@2001:8003:103d:6200:2d8c:8ff0:6b0c:7372] has quit [Changing host]
07:35 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
07:36 < kanzure> there should be more papers structured like this (seems like a dump of an email thread) http://journal.frontiersin.org/article/10.3389/fnana.2016.00060/full
07:37 < kanzure> "opsin photoreceptors in the deep brain" http://journal.frontiersin.org/article/10.3389/fnana.2016.00048/full
07:37 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
07:38 -!- ebowden [~ebowden@2001:8003:103d:6200:e15c:e077:1f85:f5a] has joined ##hplusroadmap
07:38 -!- ebowden [~ebowden@2001:8003:103d:6200:e15c:e077:1f85:f5a] has quit [Changing host]
07:38 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
07:38 < kanzure> what "Furthermore, direct illumination through a fiber optic cable into the hypothalamus stimulates testicular growth in blinded ducks (Benoit and Ott, 1944)."
07:45 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
07:47 < kanzure> "Whole brain imaging with serial two-photon tomography" http://journal.frontiersin.org/article/10.3389/fnana.2016.00031/full
07:48 < kanzure> "... Importantly, the discovery of BBB penetrant AAV serotypes presents a unique opportunity for CNS applications, where efficient and specific AAV distribution circumvents the need for highly invasive intracranial injections. However, while the repertoire of AAV serotypes demonstrating BBB penetrance has significantly expanded (Bourdenx et al., 2014), most clinical applications have been limited to the AAV2 (Mingozzi and High, 2011)."
07:52 < kanzure> a review of virus-based materials and virus-functionalized nanoparticles and stuff http://pubs.rsc.org/en/content/articlelanding/2016/cs/c5cs00287g#!divAbstract
07:55 < kanzure> this document proposes solid scaffolds and hydrogels to control the release of viral gene therapy vectors upon implantation http://www.discoverymedicine.com/Magali-Cucchiarini/2016/06/human-gene-therapy-novel-approaches-to-improve-the-current-gene-delivery-systems/ and sponges
07:58 < kanzure> "Flexible AAV-equiped genetic modules for inducible control of gene expression in mammalian brain" http://www.nature.com/mtna/journal/v5/n4/full/mtna201623a.html
07:58 < kanzure> above is using a two-virus system and "tetracycline (tet)-controlled genetic switches for inducible and reversible control of gene expression" and doxycycline
08:01 < kanzure> "Inducible and combinatorial gene manipulation in mouse brain" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404871/   looks like they would have had less problems in this study if they had the photoswitchable recombinase enzyme (something about problems with doxycycline and milk)
08:02 < kanzure> "... The inducible genetic switches in our viruses provide an added advantage over a single virus approach for constitutive Cre recombinase expression; with our approach, Cre/loxP mediated gene recombination can be activated by Dox treatment after a particular biological process, such as memory formation, without causing stress to animals by a surgical intervention for virus injection, thus avoiding potential stress-related effects. ...
08:02 < kanzure> ... Given that targeting selective brain region(s) for gene expression/manipulation is a major hurdle with the traditional transgenic, our virus-based approach can be of a great value for neuroscience research and gene therapy."
08:05 < kanzure> brain vessels and vasculature map and atlas writeup http://journal.frontiersin.org/article/10.3389/fnana.2016.00012/full
08:06 < kanzure> hooray defeated a backlog
08:09 < archels_> how does the anticlimax feel?
08:10 < kanzure> that's not something i am likely to know
08:32 -!- ebowden [~ebowden@2001:8003:103d:6200:e15c:e077:1f85:f5a] has joined ##hplusroadmap
08:32 -!- ebowden [~ebowden@2001:8003:103d:6200:e15c:e077:1f85:f5a] has quit [Changing host]
08:32 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
08:37 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds]
09:04 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap
09:35 -!- crCr62U0 [~crCr62U0@mm-160-186-84-93.dynamic.pppoe.mgts.by] has joined ##hplusroadmap
09:36 -!- crCr62U0 [~crCr62U0@mm-160-186-84-93.dynamic.pppoe.mgts.by] has quit [Client Quit]
09:57 < kanzure> fricatives as seen in speech spectra http://clas.mq.edu.au/speech/acoustics/speech_spectra/fricatives.html
10:07 -!- augur [~augur@2601:645:8100:c347:c0a5:7559:8cef:77ab] has quit [Remote host closed the connection]
10:08 -!- augur [~augur@2601:645:8100:c347:3c97:ffef:b3c1:b8aa] has joined ##hplusroadmap
10:12 -!- augur [~augur@2601:645:8100:c347:3c97:ffef:b3c1:b8aa] has quit [Ping timeout: 256 seconds]
10:33 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
10:50 -!- Regex__ [~Cara@2601:1c0:8501:d159:707a:5351:a3f7:406e] has joined ##hplusroadmap
10:54 -!- Regex_ [~Cara@2601:1c0:8501:d159:cc50:b23c:8928:2a33] has quit [Ping timeout: 256 seconds]
11:06 -!- nildicit_ [~nildicit@unaffiliated/nildicit] has joined ##hplusroadmap
11:10 -!- nildicit__ [~nildicit@unaffiliated/nildicit] has quit [Ping timeout: 256 seconds]
11:14 -!- nildicit__ [~nildicit@unaffiliated/nildicit] has joined ##hplusroadmap
11:18 -!- nildicit_ [~nildicit@unaffiliated/nildicit] has quit [Ping timeout: 245 seconds]
12:18 -!- Urchin[emacs] is now known as JebediahOdysseus
12:35 -!- Qfwfq [~user@unaffiliated/washirving] has joined ##hplusroadmap
12:39 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
12:53 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
12:54 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
12:58 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 244 seconds]
13:04 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
13:08 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds]
13:09 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
13:35 < kanzure> hrm.
13:46 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
13:46 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
13:51 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 265 seconds]
13:56 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
14:00 < nmz787> does pinching the head of a developing fetus cause any disruption to the growth/development of the other organs, such as heart, kidney, liver, etc??? I am thinking in terms of clone organ harvesting and how to make it slightly less murderous.
14:08 < kanzure> perma fetus?
14:18 -!- Burninate [~Burn@pool-108-56-208-224.washdc.fios.verizon.net] has joined ##hplusroadmap
14:32 < adlai> ignoramus question: does mGRASP make bitcoin obsolete? ie, could it someday be used to nonconsentually extract arbitrary information from long-term memory?
14:34 < kanzure> adlai: you can already somewhat extract information using fMRI of e.g. imagined visual scenes into video data
14:34 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
14:34 < adlai> doesn't that require conscious consent?
14:34 < adlai> ie " don't think of a rhinocerous"
14:34 < kanzure> sure blame the victim.. what?
14:35 < adlai> extracting synapse location is qualitatively superior to "think of how a synapse looks while you don't move your head one inch"
14:36 < kanzure> fMRI has also been used to get information about word choice, reliable prediction of unspoken information, etc..
14:36 < adlai> aiui, fMRI reveals synaptic firing, not the location of every single synapse, regardless of activity
14:36 < kanzure> fMRI does not reveal synaptic firing, unfortunately
14:37 < adlai> this ignorance is a much better birthday present. thank you kanzure :)
14:37 < kanzure> (it's blood flow and oxygenated vs non-oxygenated blood)
14:38 < kanzure> and hemoglobin paramagnetism details
14:38 < kanzure> there is a correlation, though.
14:39 < adlai> someday, teachers will be prized  not for providing new information (any shmuck with a modem can do that), but rather for their ability to expose  false assumptions
14:39 < kanzure> re: extraction of arbitrary information, surely you recognize that for some of us the goal is the extraction of all information from a brain for digital reconstruction purposes
14:40 < adlai> of course. i just hope that this becomes possible after people have stopped securing bitcoin with memorized key phrases.
14:42 < kanzure> as i pointed out, fMRI and other methods can recover information from living persons
14:42 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
14:42 < kanzure> for dead people, yes i guess that's a new kind of problem once that starts working
14:46 < kanzure> it might be the case that encoding is different per person, so you would need at least to simulate them and ask them to report on specific information (since you probably can't directly look and get the information out), so... well i guess that might not make you feel better either :). certainly not AlonzoTG.
14:49 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection]
15:05 -!- dpk [~dpk@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap
15:22 < adlai> research topic: is LTM static (or does it require 'simulation' to extract information)
15:22 < adlai> who's AlonzoTG?
15:29 < kanzure> alonzotg is a troubled person (who has been banned from this channel) because he believes that i am part of a secret plot to murder everyone and upload their brains to torture everyone for all eternity
15:30 < kanzure> you probably know him from the bitcoin community though. (i ran into him years earlier pre-bitcoin because of extropians/extropy-chat).
15:31 < kanzure> (his ban wasn't because of his belief; it's because he's annoying as hell and unproductive.)
15:32 < adlai> oh da mn, sorry to reah that. (i only believe that you are the human ambassador of an AI project to upload copies of worthy brains, to enslave for all eternity; quite a different delusion... :)
15:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-sllocdfcqblkfsej] has quit [Quit: Connection closed for inactivity]
15:33 < kanzure> as long as these delusions stay separate and don't comingle.......
15:33 < adlai> speaking of productivity, i should get back to shitting useful bricks.
15:36 < kanzure> adlai: http://diyhpl.us/~bryan/papers2/neuro/Sequencing%20the%20connectome%20-%202012.pdf
15:36 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/Rosetta%20brains:%20A%20strategy%20for%20molecularly-annotated%20connectomics%20-%20Marblestone%20-%20Church%20-%20Boyden%20-%202014.pdf
15:45 -!- Neuronix [a7725c31@gateway/web/freenode/ip.167.114.92.49] has quit [Quit: Page closed]
15:46 -!- JebediahOdysseus is now known as Urchin[emacs]
16:06 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Quit: Leaving...]
16:06 -!- nildicit_ [~nildicit@unaffiliated/nildicit] has joined ##hplusroadmap
16:10 -!- nildicit__ [~nildicit@unaffiliated/nildicit] has quit [Ping timeout: 256 seconds]
16:13 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
16:15 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 265 seconds]
16:16 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.5]
16:18 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds]
16:18 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
16:28 -!- redlegion [~x@gateway/tor-sasl/redlegion] has quit [Remote host closed the connection]
16:29 -!- redlegion [~x@gateway/tor-sasl/redlegion] has joined ##hplusroadmap
17:15 -!- DKordic [~user@93-87-108-199.dynamic.isp.telekom.rs] has joined ##hplusroadmap
17:17 -!- CORDIC [~user@93-87-111-140.dynamic.isp.telekom.rs] has quit [Ping timeout: 250 seconds]
18:07 < justanotheruser> idea: create a miner that operates by issuing sha256 subproblems to mechanical turks
18:08 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
18:08 < kanzure> and then lose money to amazon's fees while you operate asics wired up to mechanical turk?
18:08 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has quit [Remote host closed the connection]
18:13 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds]
18:16 < justanotheruser> cloud mining
18:16 < justanotheruser> 2.0
19:02 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
19:07 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds]
19:17 < kanzure> .title https://www.youtube.com/watch?v=33p-uR5swy0
19:17 < yoleaux> Robust Large-Scale Machine Learning in the Cloud - YouTube
19:40 -!- ebowden [~ebowden@2001:8003:103d:6200:ad97:e3dc:f8a8:9633] has joined ##hplusroadmap
19:40 -!- ebowden [~ebowden@2001:8003:103d:6200:ad97:e3dc:f8a8:9633] has quit [Changing host]
19:40 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
19:59 -!- nildicit_ [~nildicit@unaffiliated/nildicit] has quit [Ping timeout: 245 seconds]
20:22 < adlai> kanzure: thanks for the paperbotting, queued
20:24 -!- nildicit [~nildicit@gateway/vpn/privateinternetaccess/nildicit] has joined ##hplusroadmap
21:12 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
21:13 -!- nildicit_ [~nildicit@gateway/vpn/privateinternetaccess/nildicit] has joined ##hplusroadmap
21:17 -!- nildicit [~nildicit@gateway/vpn/privateinternetaccess/nildicit] has quit [Ping timeout: 260 seconds]
21:32 -!- nildicit__ [~nildicit@gateway/vpn/privateinternetaccess/nildicit] has joined ##hplusroadmap
21:36 -!- nildicit_ [~nildicit@gateway/vpn/privateinternetaccess/nildicit] has quit [Ping timeout: 244 seconds]
21:40 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
21:41 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
21:57 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving]
22:16 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-flckgeyykvgnryxa] has joined ##hplusroadmap
22:26 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds]
22:27 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap
22:49 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap
22:54 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 260 seconds]
22:56 -!- Gurkenglas [~Gurkengla@dslb-178-005-222-194.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap
23:18 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has quit [Quit: Leaving]
23:29 -!- ebowden [~ebowden@2001:8003:103d:6200:ed1f:7377:4f05:1166] has joined ##hplusroadmap
23:29 -!- ebowden [~ebowden@2001:8003:103d:6200:ed1f:7377:4f05:1166] has quit [Changing host]
23:29 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
23:36 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.]
23:37 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap
23:41 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
23:41 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap
23:52 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection]
--- Log closed Sun Oct 23 00:00:29 2016