--- Log opened Mon Dec 12 00:00:36 2016 00:21 -!- jjjjjj [uid189425@gateway/web/irccloud.com/x-sbssriihhztmccku] has left ##hplusroadmap [] 00:32 -!- augur [~augur@2602:304:cdac:e260:65d3:30d5:6bc7:9881] has joined ##hplusroadmap 00:36 -!- augur [~augur@2602:304:cdac:e260:65d3:30d5:6bc7:9881] has quit [Ping timeout: 258 seconds] 00:40 -!- augur [~augur@76-218-206-38.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap 00:44 -!- augur [~augur@76-218-206-38.lightspeed.sntcca.sbcglobal.net] has quit [Remote host closed the connection] 00:55 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has joined ##hplusroadmap 01:40 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-tpxgseflyjtcftzv] has joined ##hplusroadmap 02:28 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 02:51 -!- anachronick [~kvirc@a81-84-40-93.cpe.netcabo.pt] has joined ##hplusroadmap 02:52 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:a52f:3259:588e:ac59] has quit [Read error: Connection reset by peer] 03:07 -!- sandeepkr [~sandeepkr@103.49.155.114] has joined ##hplusroadmap 03:30 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:52 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-tpxgseflyjtcftzv] has quit [Quit: Connection closed for inactivity] 04:17 < nsh> -- 04:17 < nsh> Human neocortex expansion likely contributed to the remarkable cognitive abilities of humans. This expansion is thought to primarily reflect differences in proliferation versus differentiation of neural progenitors during cortical development. Here, we have searched for such differences by analysing cerebral organoids from human and chimpanzees using immunohistofluorescence, live imaging, and single-cell transcriptomics. We find that the cytoarchitecture, 04:17 < nsh> cell type composition, and neurogenic gene expression programs of humans and chimpanzees are remarkably similar. Notably, however, live imaging of apical progenitor mitosis uncovered a lengthening of prometaphase-metaphase in humans compared to chimpanzees that is specific to proliferating progenitors and not observed in non-neural cells. Consistent with this, the small set of genes more highly expressed in human apical progenitors points to increased 04:17 < nsh> proliferative capacity, and the proportion of neurogenic basal progenitors is lower in humans. These subtle differences in cortical progenitors between humans and chimpanzees may have consequences for human neocortex evolution. 04:17 < nsh> -- https://elifesciences.org/content/5/e18683 04:23 -!- drewbot [~cinch@ec2-54-161-142-157.compute-1.amazonaws.com] has quit [Remote host closed the connection] 04:23 -!- drewbot [~cinch@ec2-54-147-26-57.compute-1.amazonaws.com] has joined ##hplusroadmap 04:24 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-khrjcobspyxlffuv] has joined ##hplusroadmap 04:39 < bluebear_> nsh: nice catch, this article :-) 04:40 < bluebear_> nsh: but for me personally, the most interesting part is the organoid they used for comparison :-) although observing the differences and showing how subtle they are is also an important step 05:14 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has quit [Quit: Leaving] 05:17 -!- m4l3z [~m4l3z@2a01cb040226f2008895c74f09faac7c.ipv6.abo.wanadoo.fr] has joined ##hplusroadmap 05:48 -!- proofoflogic [sid65184@gateway/web/irccloud.com/x-lixlqwcavkubqghv] has quit [] 05:48 -!- proofoflogic [sid65184@gateway/web/irccloud.com/x-sjiodraedqiilvlf] has joined ##hplusroadmap 06:28 < kanzure> nsh: http://fennetic.net/irc/human_chimpanzee_brain_differences.png 06:41 -!- pompolic [~A@unaffiliated/pompolic] has quit [Read error: Connection reset by peer] 06:41 -!- pompolic [~A@unaffiliated/pompolic] has joined ##hplusroadmap 07:02 < kanzure> http://docs.ceph.com/docs/jewel/rados/api/librados-intro/ 07:07 -!- wrldpc1 [~ben@p352135-ipngn200606kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 07:16 -!- wrldpc1 [~ben@p352135-ipngn200606kyoto.kyoto.ocn.ne.jp] has quit [Quit: wrldpc1] 07:20 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-szhpmpfwhidhrxxg] has quit [] 07:20 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-mpuxfkqjwtdvqark] has joined ##hplusroadmap 07:32 -!- TinKode [~TinKode@unaffiliated/tinkode] has quit [Quit: Practicing escapism.] 07:33 -!- TinKode 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10:27 -!- nmz787_w [~ntmccork@134.134.139.76] has quit [Ping timeout: 252 seconds] 10:53 < kanzure> http://spectrum.ieee.org/the-human-os/biomedical/devices/tiny-implantable-microcoils-in-the-brain-activate-neurons-via-magnetic-fields 10:54 < kanzure> "In October, the company Second Sight implanted a stimulator in a blind person's visual cortex in a first-of-its-kind experiment" http://investors.secondsight.com/releasedetail.cfm?ReleaseID=995211 10:54 < kanzure> "Implantable microcoils for intracortical magnetic stimulation" http://advances.sciencemag.org/content/2/12/e1600889 10:58 < kanzure> "Electric-field-stimulated protein mechanics." https://www.ncbi.nlm.nih.gov/pubmed/27926732 10:58 < kanzure> "Rapidly evolving homing CRISPR barcodes" http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4108.html (previously on biorxiv.org) 11:03 < nmz787_w1> kanzure: my idea years ago was a short-lived drug that would act as a nano/micro antenna 11:04 < nmz787_w1> specifically an inhalant 11:05 < kanzure> how would you get it to the right place? 11:05 < nmz787_w1> molecular structure was my thought 11:06 < nmz787_w1> or if you had fine spatial control of the electronics exterior to the skull, then maybe it could just target any neuron 11:06 < kanzure> oh like targting specific receptors etc 11:07 -!- cluckj [~cluckj@pool-173-49-237-221.phlapa.fios.verizon.net] has quit [Ping timeout: 258 seconds] 11:07 < kanzure> beamshaping could get you the rest of the way 11:07 < nmz787_w1> i just was thinking hard about how to get a BCI without nasty through-skin implants 11:09 -!- cluckj [~cluckj@pool-173-49-237-221.phlapa.fios.verizon.net] has joined ##hplusroadmap 11:12 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 11:12 -!- jtimon [~quassel@77.224.94.35] has joined ##hplusroadmap 11:22 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-yklbjnexlxwitnni] has quit [Quit: Connection closed for inactivity] 11:26 -!- darsie is now known as bad 11:28 -!- bad is now known as good 11:31 -!- Qfwfq_ [uid187767@gateway/web/irccloud.com/x-dutovpolwvknxccf] has quit [Quit: Connection closed for inactivity] 11:55 < chris_99> is ultrasound any better than eeg out of interest, i'm curious how it compares 12:22 -!- malez_ [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has quit [Quit: Leaving] 12:24 -!- m4l3z [~m4l3z@2a01cb040226f2008895c74f09faac7c.ipv6.abo.wanadoo.fr] has quit [Quit: Leaving] 12:26 < kanzure> for stimulation, eeg doesn't work-- you need tdcs or electroshock. ultrasound can do stimulation. 12:26 < chris_99> sorry i was wondering specifically for imaging 12:26 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 12:27 < kanzure> "The hallmarks of aging" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ 12:44 -!- sandeepkr [~sandeepkr@103.49.155.114] has quit [Ping timeout: 268 seconds] 13:03 -!- saturn2 [~visitant@unaffiliated/clone-of-saturn/x-2509460] has joined ##hplusroadmap 13:19 < kanzure> .title https://www.youtube.com/watch?v=opChLhLMFmU 13:19 < yoleaux> IceDream: The Iceberg project - YouTube 13:44 -!- Gurkenglas [~Gurkengla@dslb-178-008-183-012.178.008.pools.vodafone-ip.de] has quit [Ping timeout: 258 seconds] 14:02 -!- urchin_ [~urchin@89.17.9.17] has joined ##hplusroadmap 14:05 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 240 seconds] 14:38 -!- good is now known as darsie 14:47 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-bmkpmcrjsapfidmj] has joined ##hplusroadmap 14:50 -!- helleshin [~talinck@66-161-138-110.ubr1.dyn.lebanon-oh.fuse.net] has joined ##hplusroadmap 15:06 -!- urchin_ [~urchin@89.17.9.17] has quit [Changing host] 15:06 -!- urchin_ [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 15:06 -!- urchin_ is now known as Urchin 15:16 -!- nmz787_w1 [~ntmccork@134.134.137.73] has quit [Ping timeout: 246 seconds] 15:23 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:28 < kanzure> bloop 15:31 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:37 -!- jtimon [~quassel@77.224.94.35] has quit [Ping timeout: 264 seconds] 15:45 -!- jtimon [~quassel@77.224.94.35] has joined ##hplusroadmap 15:50 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 16:03 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:c901:b2a7:df38:9620] has joined ##hplusroadmap 16:39 -!- nmz787_w [ntmccork@nat/intel/x-vwknazplkezzrijd] has joined ##hplusroadmap 17:05 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 17:31 -!- crescendo [~mozart@unaffiliated/crescendo] has quit [Ping timeout: 246 seconds] 18:09 -!- Fausta [47ee9284@gateway/web/freenode/ip.71.238.146.132] has joined ##hplusroadmap 18:10 < Fausta> so here is something odd 18:10 < Fausta> I took part in a psych experiment in collij where they hooked me up to electrodes while I did some task involving words 18:11 < Fausta> the experiment said I had odd brainwaves in that although I was awake, alpha, beta, delta etc. were all present in equal quantities 18:11 < Fausta> experimenter* 18:12 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-bmkpmcrjsapfidmj] has quit [Quit: Connection closed for inactivity] 18:13 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:14 -!- abetusk [~abe@68.175.143.22] has quit [Ping timeout: 250 seconds] 18:17 < kanzure> because 'brainwaves' is ancient pseudoscience 18:23 < __mz_o> explain 18:26 < kanzure> low resolution recordings of neural activity 18:27 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 18:27 -!- abetusk is now known as Guest47207 18:28 < __mz_o> hows it been proved otherwise? whats the alternative theory 18:29 < kanzure> electrophysiology 18:30 < __mz_o> hows that related to (eeg?) resolution? 18:31 < __mz_o> in vivo? 18:31 -!- jtimon [~quassel@77.224.94.35] has quit [Ping timeout: 252 seconds] 18:32 < kanzure> what? 18:34 < __mz_o> why and how are brainwaves ancient psuedoscience 18:35 < nmz787_w> Fausta: basically it's like saying something about a full-length movie based on the trailer 18:35 < nmz787_w> err, I guess __mz_o 18:36 < __mz_o> kanzure: are you discrediting the method of examination? 18:36 < nmz787_w> or rather, what if you were listening to a symphony, but only heard something for a moment once every 2 seconds, and maybe it was only a single instrument you heard 18:36 < nmz787_w> maybe you'd notice some pattern, but would it really represent the true audio composition? 18:36 < __mz_o> or the theory of alpha, beta, theta, waves etc? if so on what basis? 18:37 < nmz787_w> __mz_o: do you know the sample rate of EEG? 18:37 < nmz787_w> do you know how many MBPS netflix requires? or streaming audio, or what a self-driving car's systems transfer between them and the RAM and CPU??? 18:38 < nmz787_w> hint, EEG is miniscule in comparison... so something must obviously be missing 18:38 < __mz_o> i know our silicon is inferior to our wetware 18:38 < __mz_o> but how is it pseudoscience 18:38 < nmz787_w> exactly, so it's doing things faster and with more parallelism probably 18:39 < nmz787_w> so low-sample rate hardware is kind of bogus 18:40 < __mz_o> but why dismiss it when there's no alternative lol? 18:40 < nmz787_w> go try doing a study on peoples' movie habits based on 1% of the data stream of their netflix video history (and not full-segments of video, for all time, toss out 99% of that moment's data) 18:40 < nmz787_w> there is alternatives, which is my argument 18:40 < nmz787_w> idk kanzure's 18:41 < __mz_o> ok. intoxicated, it seemed silly and i just wanted an explanation is all 18:41 < nmz787_w> I have a 1GSPS oscilloscope, it was $400 18:41 < __mz_o> makes sense 18:41 < nmz787_w> it has 4 channels 18:41 < __mz_o> right 18:41 < nmz787_w> a few kHz is a joke 18:41 < __mz_o> i know what youre saying 18:42 < nmz787_w> I literally want to see a study that takes like 16 of my o-scope, and hooks them to EEG pads 18:42 < nmz787_w> and then lets talk experiments and data mining 18:42 < nmz787_w> like, play an audio file to the person, then after the audio ends, have them 'replay' it in their head 18:42 < nmz787_w> and try to find data corellation 18:43 < __mz_o> i dont know the technical specifics but itd be interesting to see a study on high frequency eeg, and reaction to stimuli 18:43 < __mz_o> and its observations 18:43 < nmz787_w> or something like that... display the word 0xbeef... and try finding that in the data 18:43 < __mz_o> yes, what you just said 18:44 < __mz_o> lol program portion of our brain by assembly 18:44 < __mz_o> via pneumonic keys 18:45 < Fausta> your nicks are very confusing 18:45 < __mz_o> so is life 18:45 < Fausta> this could be fixed though 18:45 < __mz_o> by whos choice though? 18:45 < nmz787_w> Fausta: part of the puzzle of personalities 18:45 < __mz_o> just underscore underscore tab 18:46 < __mz_o> and its me 18:46 < Fausta> I think brain waves as measured by electrodes are too coarse 18:46 < kanzure> "brain waves" 18:47 < kanzure> .wik brain wave 18:47 < yoleaux> "Neural oscillation is rhythmic or repetitive neural activity in the central nervous system. Neural tissue can generate oscillatory activity in many ways, driven either by mechanisms within individual neurons or by interactions between neurons." -- https://en.wikipedia.org/wiki/Brain_wave 18:47 < Fausta> but it isn't total nonsense as there are apparently some clearly distinct patterns associated with different mental states 18:47 < Fausta> like deep sleep versus working on an exam 18:48 < nmz787_w> corellation != causation 18:48 < nmz787_w> Fausta: I'd be happier if they just bumped up the analog-to-digital converter sample rate by about 40 years 18:49 < kanzure> "Fast fMRI can detect oscillatory neural activity in humans" http://www.pnas.org/content/113/43/E6679.full 18:49 < __mz_o> isnt there a flaw in fmri? 18:49 < __mz_o> or a manufacturing flaw? 18:49 < nmz787_w> that was just a programming/math CONSTANT error, I thought 18:50 < Fausta> so I was reading about general anaesthesia 18:50 < __mz_o> didnt it render all previous data useless? 18:50 < __mz_o> i lol'd when id read it 18:50 < nmz787_w> __mz_o: I think only because they didn't store the raw data 18:50 < Fausta> and they found that it doesn't stop neural firing from occurring but rather stops coordinated activity among different brain regions 18:50 < __mz_o> ah thats funny and i guess it cant be corrected mathmatically 18:51 < Fausta> so it basically takes out the conductor and random instruments playing is not enough to give rise to an ego 18:51 < kanzure> Fausta: "Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia" lice.btc.calendar.opentimestamps.org 18:51 < kanzure> oops 18:51 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/sleep/Electrical%20stimulation%20of%20the%20parabrachial%20nucleus%20induces%20reanimation%20from%20isoflurane%20general%20anesthesia%20-%202016.pdf 18:51 < Fausta> wow 18:55 < Fausta> maybe this PBN is the conductor 18:55 < kanzure> "Towards an executive without a homunculus: computational models of the prefrontal cortex basal ganglia system" http://diyhpl.us/~bryan/papers2/neuro/Towards%20an%20executive%20without%20a%20homunculus:%20computational%20models%20of%20the%20prefrontal%20cortex%20basal%20ganglia%20system.pdf 18:56 < __mz_o> thats a trippy title 18:58 < Fausta> Francis Crick I think wrote a book called the Astonishing Hypothesis where he basically said that the seat of volition was some particular brain region 18:58 < Fausta> not the prefrontal cortex, I can't remember what 18:58 < __mz_o> pineal gland 18:58 < Fausta> you could be aware without it but "wouldn't want to do anything" 18:59 < Fausta> no 19:00 < nmz787_w> read this recently: http://www.sciencealert.com/harvard-scientists-think-they-ve-pinpointed-the-neural-source-of-consciousness 19:00 < nmz787_w> has refs 19:00 < nmz787_w> http://www.neurology.org/content/early/2016/11/04/WNL.0000000000003404.short 19:00 < nmz787_w> .title 19:00 < Fausta> lol I have a feeling that headline is misleading 19:00 < yoleaux> A human brain network derived from coma-causing brainstem lesions 19:01 < nmz787_w> https://en.wikipedia.org/wiki/Pontine_tegmentum https://en.wikipedia.org/wiki/Insular_cortex https://en.wikipedia.org/wiki/Anterior_cingulate_cortex 19:01 < nmz787_w> are mentioned specifically 19:03 < Fausta> maybe GA interrupts this network 19:03 < Fausta> that should be their next thing to do 19:04 < nmz787_w> GA? 19:04 < nmz787_w> ! genetic algorithms 19:04 < nmz787_w> ? 19:04 < Fausta> general anaesthesia 19:05 < nmz787_w> basically we need hyperparticle imaging tomography of the brain, I think 19:05 < Fausta> they should take animals and put them in a coma before doing experiments on them 19:05 < nmz787_w> idk if I just invented that word 19:06 < nmz787_w> but like hyperspectral imaging (all EM freqs), and also particle monitoring like free electrons maybe 19:06 < Fausta> btw that piracetam is really having a major impact 19:07 < nmz787_w> I guess free-electron detection wouldn't be needed, since your head isn't in a vacuum 19:07 < Fausta> I felt like my IQ was up by 10 pts today 19:07 < nmz787_w> and electrodes placed on-skin would do the same at catching those electrons 19:09 * Fausta wonders if anyone has tried to do brain augmentation 19:09 < cluckj> I have a calendar in my cell phone, and a notepad 19:09 < Fausta> like, take an animal and expand its skull (make more room) and see if you can put in stem cells and if they'll fill up the rea 19:09 < cluckj> works grerat 19:09 < cluckj> err great 19:09 < nmz787_w> hah 19:10 < __mz_o> nmz787_w: hyperspectral/hyperparticle imaging makes sense 19:11 < __mz_o> to know the exact substance across each nueron as well as voltage, liquid volume, blood flow etc 19:11 < __mz_o> in an ideal world obviously 19:11 < Fausta> that stuff isn't important 19:11 < nmz787_w> Fausta: that stuff /is/ the state of matter though 19:11 < __mz_o> maybe not for consiousness 19:12 < Fausta> they need to do a big data treatment on firing patterns and find the underlying order 19:12 < nmz787_w> in the system of biobrains 19:12 < Fausta> you are like "let's keep track of each particle in this watch to figure out how watches work" 19:12 < __mz_o> it would do wonders for psychopharmocology 19:12 < nmz787_w> obv if the 'brain' was in-silico, the state of matter would be different 19:12 < __mz_o> right 19:12 < kanzure> nmz787_w: some of the neuroimaging techniques that russell hanson likes are the ones where they put a brain in front of particle sources like accelerators etc 19:13 < nmz787_w> kanzure: my deal is, then you're modifying the system... and maybe damaging or altering pathways as result of the system noticing 19:13 < nmz787_w> not quite the quantum observer effect, but sort of a control system version of that 19:14 < kanzure> http://www.anl.gov/articles/adventures-first-neuroscientist-argonne 19:14 < nmz787_w> Fausta: firing patterns are detectable via EM signatures 19:14 < kanzure> from http://gnusha.org/logs/2016-03-28.log 19:14 < nmz787_w> Fausta: that is EEG 19:14 < kanzure> ""We're testing at the APS, and we think it will let us map the entire brain without having to cut it or slice it or deform it -- and to possibly do it very fast -- which is crazy," Kasthuri said. "With a method like that we could do multiple brains, so that we could see the variance between them."" 19:14 < nmz787_w> Fausta: I'm saying we need to expand the frequency range significantly, and the resolution 19:14 < Fausta> no I mean something less crude than that 19:15 < nmz787_w> Fausta: heard of biophotons? 19:15 < kanzure> https://www.anl.gov/nst/person/narayanan-bobby-kasthuri 19:15 < nmz787_w> even photons are EM 19:15 < Fausta> yeah I have nmz787_w that is some weird stuff 19:15 < kanzure> https://www.neuroscience.mcknight.org//newsroom/neuroscience-news/2016-tech-awards 19:16 < kanzure> "Brain-X: Nanoscale maps of entire brains using synchrotron-based high-energy x-rays" 19:16 < kanzure> "Dr. Kasthuri's lab is using high energy X-rays to create complete and comprehensive maps of the brain. The stacks of images generated result in staggering amounts of data that can be segmented to identify the location of every neuron, blood vessel, and component of the brain. By generating maps of healthy mice and human brains, scientists can compare them to pathological samples to better u... 19:16 < kanzure> ...nderstand cellular and ultimately synaptic differences in diseased brains affected by autism, diabetes and stroke, among other diseases." 19:16 < nmz787_w> it used to be thought of as crazy talk, but then lots of reports of 'autoflourescense' turned into connecting the ideas to lots of evidence (at least as I recall) 19:16 < Fausta> that is amazing kanzure 19:17 < kanzure> "Quantifying mesoscale neuroanatomy using X-ray microtomography" https://arxiv.org/abs/1604.03629 19:17 < kanzure> "Methods for resolving the 3D microstructure of the brain typically start by thinly slicing and staining the brain, and then imaging each individual section with visible light photons or electrons. In contrast, X-rays can be used to image thick samples, providing a rapid approach for producing large 3D brain maps without sectioning. Here we demonstrate the use of synchrotron X-ray microtomogra... 19:17 < kanzure> ...phy (?CT) for producing mesoscale (1 ?m3) resolution brain maps from millimeter-scale volumes of mouse brain. We introduce a pipeline for ?CT-based brain mapping that combines methods for sample preparation, imaging, automated segmentation of image volumes into cells and blood vessels, and statistical analysis of the resulting brain structures. Our results demonstrate that X-ray tomography ... 19:17 < kanzure> ...promises rapid quantification of large brain volumes, complementing other brain mapping and connectomics efforts." 19:17 < nmz787_w> the only thing that seems to be missing is the state of EM waves 19:18 < nmz787_w> I'd guess action potentials may be derived 19:18 < nmz787_w> based simply on molecular dispersion 19:18 < nmz787_w> oh, 1 micron res 19:18 < nmz787_w> not quite atomic 19:18 < Fausta> well 19:18 < Fausta> the only problem with this is that it's not safe 19:19 < anachronick> who wants to listen to my radioshow? 19:19 < nmz787_w> I'd say more like, it isn't sustainable 19:19 < kanzure> nanoCT is under investigation by russell hanson's group 19:19 < nmz787_w> also not done with live brains 19:19 < nmz787_w> or not in-skull 19:20 < kanzure> 19:16 < kanzure> here's russell hanson talking about nanoCT and gold nanoparticles for synapse-resolution scanning http://gnusha.org/logs/2014-11-28.log 19:20 < kanzure> from http://gnusha.org/logs/2015-12-16.log 19:20 < nmz787_w> but now I may be drinfting to thinking about things from a BCI standpoint too 19:20 < kanzure> nmz787_w: for BCI things you should read http://diyhpl.us/~bryan/papers2/neuro/Physical%20principles%20for%20scalable%20neural%20recording%20-%20Marblestone.pdf 19:21 < nmz787_w> it might be interesting to think about pausing brain state somehow... seems like general anesthesia is not the trick 19:21 < nmz787_w> but maybe close to it, or related to sleep? 19:22 < nmz787_w> if you can't grab everything in parallel, maybe we can dump things serially in a stream (of time) somehow 19:22 < nmz787_w> flush it out like JTAG 19:22 < kanzure> in the above paper, marblestone proposes molecular ticker tape based on recordings from dna polymerase in each cell 19:22 < kanzure> then recover dna from bloodstream using an array of nanopore sequencers in the human heart 19:23 < nmz787_w> nano-drug DNA-compute-interface to read out the state during sleep, then clear the cache 19:24 < nmz787_w> i hate things dealing with inputting or outputting related to blod 19:24 < nmz787_w> blood* 19:24 < nmz787_w> unless maybe a dissection 19:25 < kanzure> well it ain't going to show up in stool samples 19:25 < nmz787_w> well, this wireless methods 19:26 < nmz787_w> thus* 19:26 < nmz787_w> or maybe we change the pattern in the eyes 19:26 < nmz787_w> and image it daily 19:27 < nmz787_w> there was a movie with Arnold Schwarzenneger for research on that one 19:32 < nmz787_w> hmm, that last paper gets me wondering more about MRI, I really have never studied it 19:32 < nmz787_w> maybe MRI can just get a lot better and this all goes away? 19:32 < cluckj> sixth day? 19:33 < kanzure> no, the one where arnold owns a helicopter tourism company 19:33 < cluckj> yeah 19:33 < cluckj> with the cloning 19:34 < cluckj> and the clones have the dots depending on what number clone they are... 19:36 < Fausta> some group actually kept an isolated animal brain alive for some time in a liquid bath 19:37 < kanzure> tissue culture? 19:38 < Fausta> I mean a full brain 19:38 < Fausta> I think it was an Italian group 19:39 < Fausta> llinas, survived for a few days wikipedia says 19:40 < nmz787_w> hmm, hyperspectral MRI? 19:41 < Fausta> I wonder if you could do some kind of imaging on such a brain and not have the obstruction of a skull etc 19:41 < nmz787_w> and when I read scattering, I think radon transform 19:41 < kanzure> well there's skull windows 19:43 < Fausta> creepy lol 19:45 < nmz787_w> kanzure: you find DNA in urine ;) 19:46 < nmz787_w> not sure how fragmented it would be though 19:46 < nmz787_w> and certainly hope my brain DNA isn't getting dumped out my pee too often/at all 19:47 * kanzure adds this to the list of things to be paranoid about 19:47 < nmz787_w> I guess if it was engineered to ship out, that'd be better 19:47 < kanzure> .tw https://twitter.com/kanzure/status/808518356886286336 19:47 < yoleaux> Client-side validation #bitcoin design, no txns/updates/deltas in blocks only a merkle root: http://gnusha.org/bitcoin-wizards/2016-12-11.log @petertoddbtc (@kanzure) 19:47 < Fausta> I thought there was a blood brain barrier 19:47 < cluckj> better start keeping it in jars, dude 19:47 < Fausta> how is brain dna getting into the bloodstream 19:47 < nmz787_w> cluckj: lol 19:47 < Fausta> is it small enough to pass through 19:47 < nmz787_w> Fausta: lotsa stuff makes it past the BBB 19:48 < nmz787_w> idk in this case 19:48 -!- c0rw1n_ [~c0rw1n@184.155-201-80.adsl-dyn.isp.belgacom.be] has joined ##hplusroadmap 19:48 < cluckj> poop is probably a better place to look, but there's lots of noise there 19:49 < kanzure> i don't think cluckj knows how anatomy works 19:49 < kanzure> he might not have normal human anatomy, though 19:49 < cluckj> lol 19:50 < Fausta> lol 19:50 < kanzure> (you're forgetting that kidneys don't generally dump things from the blood into the intestines) 19:50 < cluckj> I definitely don't, but stuff from the blood does make it into the intestines 19:50 < Fausta> it has to go into the liver and from there get excreted in bile 19:51 < cluckj> ^ 19:51 < kanzure> ehhh. 19:51 < Fausta> most of what is in the poop though just failed to get absorbed 19:52 -!- c0rw1n [~c0rw1n@91.180.156.194] has quit [Ping timeout: 260 seconds] 19:52 * kanzure nods 19:53 < cluckj> snot? make it change color for low-bandwidth signaling 19:55 < cluckj> lol 19:59 < Fausta> they need to splice a fluorescence gene into an embryo 20:00 < Fausta> so that all neurons will be tagged and manipulable in the grown organism 20:02 < yashgaroth> what, like brainbow? 20:02 < kanzure> brainbow is too old these days 20:02 < Fausta> another idea someone else thought of first I see 20:03 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 20:03 < kanzure> "In-vivo RGB marking and multicolour single-cell tracking in the adult brain" http://www.nature.com/articles/srep07520 20:03 < kanzure> there was also a crispr lineage tracing method that was introduced recently 20:04 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/mouse-embryo-immunostained-for-axons-iDISCO.png 20:04 < kanzure> "Improved tools for the brainbow toolbox" http://diyhpl.us/~bryan/papers2/neuro/Improved%20tools%20for%20the%20brainbow%20toolbox%20-%202013.pdf 20:05 < Fausta> I am worried about futuristic torture methods which create horrific qualia 20:06 < Fausta> not to be a whiner 20:06 < kanzure> eh it will be offset by horific amounts of other 'qualia' (whatever that is) 20:06 < Fausta> speaking of which 20:06 < Fausta> I wonder if there is anything special about the firing patterns involved in unpleasant experiences 20:06 < Fausta> pain 20:14 -!- ebowden [~ebowden@2001:8003:1179:f000:c8f8:deb2:6f04:e238] has joined ##hplusroadmap 20:14 -!- ebowden [~ebowden@2001:8003:1179:f000:c8f8:deb2:6f04:e238] has quit [Changing host] 20:14 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 20:18 < nmz787_w> Fausta: I recently thought of using pain as a tracer/signal of some sort 20:19 < nmz787_w> I didn't really develop the idea... just a passing thought 20:20 < nmz787_w> also, people can seemingly develop an enjoyment of pain (self mutilation, tattoos, insane exercise, boxing, etc) 20:22 < Fausta> I think they are enjoying the endorphins sent to the rescue in response to the pain 20:22 < Fausta> certainly that is the case with the insane exercise 20:23 -!- yash [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 20:24 -!- yash is now known as Guest97161 20:24 -!- Guest47207 [~abe@68.175.143.22] has quit [Ping timeout: 264 seconds] 20:26 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Ping timeout: 240 seconds] 20:26 < nmz787_w> so maybe neural plasticity can rewire some synthetically-driven data-laden pain signals into processing centers 20:27 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 20:30 -!- Guest97161 [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Ping timeout: 240 seconds] 20:35 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has joined ##hplusroadmap 20:36 < nmz787_w> fenn: what kind of magnesium supplement is the best for my old cranky dad? 20:36 < nmz787_w> I feel like i could grep this in the logs if there was a webgrep of them 20:37 < Fausta> no I don't think it is getting rewired 20:37 < Fausta> rather, it is just that those people are into what follows the pain signals, namely the endorphins 20:37 < nmz787_w> but at least they tolerate it 20:37 < Fausta> I doubt they are enjoying the pain itself but since the endorphins show up soon it gets conflated 20:37 < Fausta> yes 20:37 < nmz787_w> maybe 20:38 < nmz787_w> wire up a baby, quick! 20:38 -!- Gurkenglas [~Gurkengla@178.8.183.12] has joined ##hplusroadmap 20:39 * Fausta hangs Gurkenglas on her tree 20:47 < __mz_o> i agree with Fausta, not necessarily rewired, rather tolerated and the downstream effects are favored 20:47 < __mz_o> as in with the above mentioned examples 20:48 < __mz_o> in all aspects of life. humans can look past pain 20:54 < Fausta> I wonder if other animals exercise "courage" 20:55 < Fausta> by which I mean, in contests there is a balance between rage and fear 20:55 < Fausta> I wonder if animals other than humans ever use executive functioning to force themselves to be aggressive even when afraid 20:57 < Fausta> this is one way in which we are different from other animals; you don't have "war" among animals as far I know 20:57 < Fausta> it is just dominance contest skirmishes 21:01 < __mz_o> exact;y 21:01 < __mz_o> ignorance is bliss 21:02 < __mz_o> monkeys have subcultures cliques, and "rival" societies i believe 21:12 < nmz787_w> war seems pretty much like a resource battle in most cases... seems to me that humans just have complex/weird value systems 21:13 < nmz787_w> so what I mean is, it seems like the most 'animalistic' trait we still have 21:28 -!- Gurkenglas [~Gurkengla@178.8.183.12] has quit [Ping timeout: 268 seconds] 21:39 -!- Fausta [47ee9284@gateway/web/freenode/ip.71.238.146.132] has quit [Quit: Page closed] 21:59 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 22:01 -!- nmz787_w [ntmccork@nat/intel/x-vwknazplkezzrijd] has quit [Quit: Leaving.] 22:07 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 22:15 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 22:15 -!- abetusk is now known as Guest70702 22:17 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 252 seconds] 22:37 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:41 < jcorgan> war, racism, and nationalism all have roots in the fact that during evolutionary times, we lived in fairly small, isolated groups, and if you saw someone that wasn't familiar to you, or didn't look like your group, it probably meant they were going to try to kill you 22:42 < jcorgan> of course that is vestigial today, and takes effort during formitive stages to override 22:42 -!- anachronick [~kvirc@a81-84-40-93.cpe.netcabo.pt] has quit [Ping timeout: 260 seconds] 22:44 < jcorgan> *formative 22:50 < Malvolio> they're still trying to kill you 22:54 < jcorgan> heh 22:55 < jcorgan> if that were the case, i would not have married someone of a different race and who grew up just about 12 time zones away from me 22:56 < Malvolio> oo 22:57 < jcorgan> but where i live, that describes most of the population, from all over the world, from every different race, and the diversity is so much that it fades into the background and nobody cares 23:06 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:20 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has quit [Remote host closed the connection] 23:32 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:c901:b2a7:df38:9620] has quit [Quit: Leaving] 23:47 -!- augur [~augur@2602:304:cdac:e260:4995:6a08:abef:9bd] has joined ##hplusroadmap 23:49 -!- Guest70702 [~abe@68.175.143.22] has quit [Ping timeout: 260 seconds] --- Log closed Tue Dec 13 00:00:37 2016