--- Log opened Sat Jan 07 00:00:58 2017 00:02 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 00:19 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 00:20 -!- Solvaring [~solvaring@c-73-158-236-83.hsd1.ca.comcast.net] has quit [Ping timeout: 272 seconds] 00:34 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has joined ##hplusroadmap 00:47 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 00:48 -!- abetusk is now known as Guest76770 01:16 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 01:25 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ltplhkplisxwpyxx] has joined ##hplusroadmap 01:57 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has joined ##hplusroadmap 02:15 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Ping timeout: 255 seconds] 02:16 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 02:22 < fenn> .wik memacs 02:22 < yoleaux> "MicroEMACS is a small, portable Emacs-like text editor originally written by Dave Conroy in 1985, and further developed by Daniel M. Lawrence (1958-2010) and was maintained by him. MicroEMACS has been ported to many operating systems, including MS-DOS, Microsoft Windows, VAX/VMS, Atari ST, AmigaOS and various Unix-like operating systems." -- https://en.wikipedia.org/wiki/MicroEMACS 02:22 < fenn> i'm guessing instead they meant https://github.com/novoid/Memacs 02:23 < fenn> " 02:23 < fenn> What did I do on February 14th 2007? Visualize your (digital) life in Org-mode" 03:04 < fenn> this seems pretty reasonable (from the author? of memacs) http://karl-voit.at/managing-digital-photographs/ 03:07 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:10 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has joined ##hplusroadmap 03:25 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has quit [Remote host closed the connection] 03:26 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has joined ##hplusroadmap 03:31 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has quit [Ping timeout: 255 seconds] 04:05 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Remote host closed the connection] 04:05 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 04:11 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 04:15 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Ping timeout: 272 seconds] 04:36 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has quit [Ping timeout: 272 seconds] 05:00 -!- Gurkenglas [~Gurkengla@dslb-178-000-182-233.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 05:12 -!- Lemminkainen [uid2346@gateway/web/irccloud.com/x-zuislyapbkwmvfzj] has quit [Quit: Connection closed for inactivity] 05:22 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ltplhkplisxwpyxx] has quit [Quit: Connection closed for inactivity] 05:47 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 06:05 -!- Gurkenglas_ [~Gurkengla@dslb-178-000-181-186.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 06:07 -!- Gurkenglas [~Gurkengla@dslb-178-000-182-233.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 06:42 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 06:52 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 07:11 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has quit [Read error: Connection reset by peer] 07:12 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 08:21 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Quit: Leaving] 08:25 -!- Guest76770 [~abe@68.175.143.22] has quit [Ping timeout: 255 seconds] 08:27 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has joined ##hplusroadmap 08:31 -!- augur [~augur@2601:640:8001:4222:e8b6:22b0:5117:6bef] has quit [Ping timeout: 255 seconds] 08:35 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 08:42 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has joined ##hplusroadmap 08:45 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 09:11 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has quit [Ping timeout: 245 seconds] 09:44 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has joined ##hplusroadmap 09:58 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 09:59 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 10:03 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Ping timeout: 255 seconds] 10:12 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:f066:d391:ecc8:2d20] has joined ##hplusroadmap 10:12 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:f066:d391:ecc8:2d20] has quit [Changing host] 10:12 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 10:16 < kanzure> .wik WWC1 10:16 < yoleaux> "Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene." -- https://en.wikipedia.org/wiki/WWC1 10:16 < kanzure> " single nucleotide polymorphism (rs17070145) [6] in the gene has been associated with human memory performance in one 2006 study.[7] No significant support for association with memory was found in a study with 584 subjects.[8] However it was replicated in a smaller study of the elderly.[9] A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetti... 10:16 < kanzure> ...ng of non-semantic material.[10] ... KIBRA has at least 10 interaction partners, including synaptopodin, PKC? and Dendrin, most of which modify synaptic plasticity. For instance, dendrin is a post-synaptic protein with expression regulated by sleep deprivation.[12] KIBRA has been shown to interact with Protein kinase M?.[13]" 10:18 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oqrcmazbaiwpazvr] has joined ##hplusroadmap 10:46 -!- JenElizabeth [~Jen@cpc76806-brmb10-2-0-cust240.1-3.cable.virginm.net] has joined ##hplusroadmap 10:57 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has quit [Ping timeout: 248 seconds] 10:58 -!- Gurkenglas_ is now known as Gurkenglas 11:00 -!- Solvaring [~solvaring@c-73-158-236-83.hsd1.ca.comcast.net] has joined ##hplusroadmap 11:04 < pasky> kanzure: do you have a few example pairs that ought to be scored correct but didn't match the gold standard? i wonder if it's mstly single-word error (or us/uk spelling errors?) or something more complex 11:22 < kanzure> Truth: saint aubert's manner towards him was affectionate though grave and emily was serious though she made frequent efforts to appear cheerful 11:22 < kanzure> Prediction: send overs mannertowards him was apfectionite though greave and emily was sorious though she maye frequent afforits to appear cheerful 11:22 < kanzure> Loss/CTC cost: [ 38.93444061] 11:22 < kanzure> Truth: and they all three sat in a row on a stone bench and began to eat sandwiches and cake and pickles and cheese 11:23 < kanzure> Prediction: and they all gre sat ina ro on a ston bench and begain to ea somiwiches and cate and pickles ands ches fom wo 11:23 < kanzure> Loss/CTC cost: [ 48.43120956] 11:24 < kanzure> i dunno, it's hard to show in just single samples, it's more like... something i observed while i was watching the train log scroll by. 11:24 < kanzure> it's also interesting that "fom we" and "from we" end up tacked on the end of the predictions, it's a sign of overtraining and CTC isn't really able to nix that 11:25 < kanzure> pasky: ^ 11:47 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 11:47 -!- abetusk is now known as Guest56868 11:47 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 11:49 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 12:03 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has quit [Remote host closed the connection] 12:04 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 12:04 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has quit [Max SendQ exceeded] 12:05 < kanzure> "Impact of Genetic Variation in SORCS1 on Memory Retention" Impact of Genetic Variation in SORCS1 on Memory Retention 12:06 < kanzure> .wik dysbindin 12:06 < yoleaux> "Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1." -- https://en.wikipedia.org/wiki/Dysbindin 12:08 < kanzure> "PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals." https://www.ncbi.nlm.nih.gov/pubmed/24842701 12:09 < kanzure> "Genome-wide analyses of working memory ability: A review" https://pdfs.semanticscholar.org/c8ea/de6196e27e7ec7030d3af54eba9e93c00f17.pdf (2014) 12:11 < kanzure> "A genome-wide survey of human short-term memory" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030750/ (2011) 12:16 < kanzure> "The sorting receptor SorCS1 regulates trafficking of neurexin and AMPA receptors" https://www.ncbi.nlm.nih.gov/pubmed/26291160 (2015) 12:16 < pasky> kanzure: well but these *are* real mistakes, aren't they? that "fom we" is interesting.. 12:17 < pasky> this seems like something longer training and/or more training data should just fix 12:18 < kanzure> "mannertowards" is fine but it gets downscored 12:20 < pasky> that's just 2 of the 30 mistakes it made though 12:21 < pasky> and ultimately you don't want that mistake either i think 12:21 < pasky> i support your idea 00:30 < kanzure> i need to make a "language model" 12:22 < kanzure> "Identification of common variants associated with human hippocampal and intracranial volumes" https://www.ncbi.nlm.nih.gov/pubmed/22504417/ (2012) 12:23 < kanzure> er, i mean https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635491/ 12:25 -!- drewbot [~cinch@ec2-54-226-200-41.compute-1.amazonaws.com] has quit [Remote host closed the connection] 12:26 < kanzure> "Common genetic variation and performance on standardized cognitive tests." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987367/ 12:26 -!- drewbot [~cinch@ec2-54-159-161-220.compute-1.amazonaws.com] has joined ##hplusroadmap 12:29 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has joined ##hplusroadmap 12:29 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has quit [Client Quit] 12:29 < kanzure> .wik FADS2 12:29 < yoleaux> "Fatty acid desaturase 2 (FADS2) also known as delta(6) fatty acid desaturase (D6D) is an enzyme that in humans is encoded by the FADS2 gene." -- https://en.wikipedia.org/wiki/FADS2 12:30 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has joined ##hplusroadmap 12:31 -!- UnknownRogue [~UnknownRo@2601:194:0:b872:8913:75dc:4c3:79d] has joined ##hplusroadmap 12:37 < kanzure> .wik NRXN3 12:37 < yoleaux> "Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene." -- https://en.wikipedia.org/wiki/NRXN3 12:40 < kanzure> .wik IMMP2L 12:40 < yoleaux> "Inner mitochondrial membrane peptidase subunit 2 (IMMP2L) is an enzyme that in humans is encoded by the IMMP2L gene on chromosome 7." -- https://en.wikipedia.org/wiki/IMMP2L 12:43 < kanzure> .wik neurocalcin 12:43 < yoleaux> "Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains. It possesses a Ca2+/myristoyl switch" -- https://en.wikipedia.org/wiki/Neurocalcin 12:44 < kanzure> .wik CHRM2 12:44 < yoleaux> "The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene. Multiple alternatively spliced transcript variants have been described for this gene." -- https://en.wikipedia.org/wiki/CHRM2 12:45 < kanzure> .wik GRIN2B 12:45 < yoleaux> "Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene." -- https://en.wikipedia.org/wiki/GRIN2B 12:45 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] 12:48 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has quit [Ping timeout: 246 seconds] 12:49 < kanzure> "Genome-wide studies of verbal declarative memory in nondemented older people" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513651/ (2015) 12:49 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 12:51 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 13:22 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 13:22 < cluckj> anyone have access to: http://jamanetwork.com/journals/jama/article-abstract/289716 13:22 < cluckj> .title 13:22 < yoleaux> BLOOD SUGAR VERSUS URINE SUGAR | JAMA | The JAMA Network 13:23 < kanzure> urine sugar, are you really that desperate? 13:24 < cluckj> I need to feed my sweet tooth somehow 13:26 < cluckj> I'm putting together a project proposal and my otherwise surprisingly great university library doesn't give me access to that article 13:26 < kanzure> use scihub. 13:27 < cluckj> oh right 13:27 < cluckj> thanks 13:28 * cluckj facepalms 13:28 < kanzure> you're not a very good pirate, are you 13:28 < cluckj> I was so spoiled by the good library that I forgot that journal piracy existed 13:29 < cluckj> my shame will be forever written in the logs 13:30 < kanzure> that's okay, nobody reads those 13:36 < cluckj> if anyone does, this is probably the thing I am least concerned about... 13:56 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 13:56 -!- q4_ [~q4@user-94-254-167-54.play-internet.pl] has joined ##hplusroadmap 13:58 -!- q4 [~q4@user-94-254-167-54.play-internet.pl] has quit [Ping timeout: 245 seconds] 14:00 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 14:24 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 14:33 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 14:36 -!- UnknownRogue [~UnknownRo@2601:194:0:b872:8913:75dc:4c3:79d] has quit [Read error: Connection reset by peer] 14:36 -!- UnknownRogue [~UnknownRo@2601:194:0:b872:8913:75dc:4c3:79d] has joined ##hplusroadmap 15:32 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oqrcmazbaiwpazvr] has quit [Quit: Connection closed for inactivity] 15:44 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 15:46 -!- Gurkenglas_ [~Gurkengla@dslb-178-012-150-130.178.012.pools.vodafone-ip.de] has joined ##hplusroadmap 15:47 -!- Gurkenglas [~Gurkengla@dslb-178-000-181-186.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 15:50 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 16:20 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:21 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 16:28 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 16:30 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:30 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 16:36 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 16:39 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:44 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 16:45 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] 16:48 < kanzure> "Rs11074779 is located at 302 kilobase from HS3ST4, which is strongly expressed in the hippocampus and is thought to play a role in herpes simplex virus (HSV)-1 pathogenesis (29); it is intriguing that HSV-1 infection of the brain (herpes simplex encephalitis) preferentially affects the hippocampus and can result in profound memory loss" 16:49 < kanzure> "Further, AD-related plaques and tangles were shown to be enriched in HSV-1 binding proteins (30), and although controversial, a possible role of HSV-1 has been suggested in AD occurrence (31-33)." 16:51 < kanzure> neat little gene network explorer thingy http://129.125.135.180:8080/GeneNetwork/?gene=NRXN3 16:51 < kanzure> er, http://genenetwork.nl 16:52 < kanzure> .wik SEMA5A 16:52 < yoleaux> "Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene." -- https://en.wikipedia.org/wiki/SEMA5A 16:52 < kanzure> "Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][6] Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016)." 16:56 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:81a8:ef0:77b9:93ad] has joined ##hplusroadmap 16:56 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:81a8:ef0:77b9:93ad] has quit [Changing host] 16:56 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 16:58 < kanzure> .wik CTNNBL1 16:58 < yoleaux> "Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene." -- https://en.wikipedia.org/wiki/CTNNBL1 17:00 < kanzure> .wik TOMM40 17:00 < yoleaux> "Translocase of outer mitochondrial membrane 40 homolog (yeast), also known as TOMM40, is a protein which in humans is encoded by the TOMM40 gene." -- https://en.wikipedia.org/wiki/TOMM40 17:01 < kanzure> .wik FASTKD2 17:01 < yoleaux> "FAST kinase domain-containing protein 2 (FASTKD2) is a protein that in humans is encoded by the FASTKD2 gene on chromosome 2. This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress. FASTKD2 has been implicated in mitochondrial encephalomyopathy, breast cancer, and prostate cancer." -- https://en.wikipedia.org/wiki/FASTKD2 17:02 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 17:14 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d55ddcf2 Bryan Bishop: a bunch of genes and SNPs for brain and memory >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 17:15 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 17:20 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 17:31 -!- q4_ [~q4@user-94-254-167-54.play-internet.pl] has quit [Ping timeout: 240 seconds] 17:31 -!- FourFire [~fourfire@81.4.122.176] has joined ##hplusroadmap 17:33 < FourFire> Greetings all, Is there a recommended list of Life extensionist literature? 17:34 < FourFire> I ask this distinct from transhumanist literature 17:37 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ppbbwzjdhhvvtyrm] has joined ##hplusroadmap 17:38 < kanzure> FourFire: http://diyhpl.us/~bryan/papers2/longevity/ 17:43 < FourFire> kanzure, why does that list have fewer and fewer papers for each successive year, have you been more and more busy since 2010 and since you manually add them there are fewer? 17:43 < kanzure> you've caught me 17:46 < kanzure> feel free to feed me new longevity research 17:50 < FourFire> will do, I'm helping to gather some technical and some nontechnical but interested longevity researchers on the Slack clone Discord, here: https://discord.gg/ftSbffu 17:51 < FourFire> It's early days yet, but we have one of the MMTP people and a cryonicist 17:51 < kanzure> tell them to read 2 papers/day else they get kickbanned 18:17 -!- augur_ [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:17 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 240 seconds] 18:23 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 18:30 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 18:45 < kanzure> https://www.reddit.com/r/9M9H9E9/wiki/narrative 18:47 < kanzure> http://www.scp-wiki.net/scp-173 18:51 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 18:55 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 18:58 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 19:24 < kanzure> .wik selegiline 19:24 < yoleaux> "Selegiline, also known as L-deprenyl, is a substituted phenethylamine. At normal clinical doses, it is a selective irreversible MAO-B inhibitor. In larger doses it loses its specificity and also inhibits MAO-A." -- https://en.wikipedia.org/wiki/Selegiline 19:55 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:58 -!- OfficialLeibniz [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 20:07 -!- UnknownRogue [~UnknownRo@2601:194:0:b872:8913:75dc:4c3:79d] has quit [Quit: Leaving] 20:22 -!- Aurelius [~cpopell@50.35.79.117] has quit [Quit: Aurelius] 20:25 -!- Aurelius [~cpopell@50.35.79.117] has joined ##hplusroadmap 20:31 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 20:42 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 20:42 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ppbbwzjdhhvvtyrm] has quit [Quit: Connection closed for inactivity] 20:47 -!- Gurkenglas_ [~Gurkengla@dslb-178-012-150-130.178.012.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 21:10 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Remote host closed the connection] 21:14 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap 21:19 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit [Ping timeout: 255 seconds] 21:43 < jcorgan> what a Trojan horse molecule. It looks so much like a monoamine that MAO thinks it's about to have a tasty meal, but instead it gets a alkyl through the heart and taken out 22:17 -!- augur_ [~augur@noisebridge130.static.monkeybrains.net] has quit [Quit: Leaving...] 22:29 -!- Solvaring [~solvaring@c-73-158-236-83.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer] --- Log closed Sun Jan 08 00:00:59 2017