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02:44 < prim0> hello
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06:20 < kanzure> hrmph
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06:33 < JayDugger> Morning.
06:36 < kanzure> did you try the nasa music? http://ice1.somafm.com/missioncontrol-128-mp3
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06:51 < archels> http://www.demilked.com/needle-free-blood-drawing-hemolink-tasso/
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06:56 < FourFire> `"They're back now, after all-- raised from the grave with the voodoo of paleogenetics, stitched together from junk genes and fossil marrow steeped in the blood of sociopaths and high-functioning autistics." wat`
06:56 < FourFire> heh kanzure I enjoyed all the hilarious quotes from blindsight
06:59 < JayDugger> Isn't CES a hypernym of tXCS?
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07:06 < kanzure> "A sight on the current nanoparticle-based gene delivery vectors" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/ (2014)
07:06 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=03bbbae0 Bryan Bishop: some gene therapy delivery methods >> http://diyhpl.us/diyhpluswiki/gene-therapy/
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07:23 < kanzure> sent a reply to someone asking about TdT for DNA synthesis, https://groups.google.com/d/msg/diybio/FXaT-MjJQYI/ZcwBV0CYEwAJ
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08:59 < kanzure> " "We do have data from the parabiosis experiments that suggests that yes, this would reverse the aging process,"  "But to what degree, we don't know." Craig S. Atwood CEO of JangoBio"
08:59 < kanzure> https://www.jango-bio.com/our-solution/
08:59 < kanzure> "Our strategy is to develop cell-based therapeutics capable of correcting the imbalance of circulating reproductive hormones that occurs as a result of disease, or progressively as we age"
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09:01 < kanzure> man, we should have laws against not citing actual mechanisms of action
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10:59 < kanzure> "The Multilayer Connectome of Caenorhabditis elegans" http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005283
11:00 < kanzure> "Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function and occurs primarily outside the synaptic connectome. We have mapped the putative monoamine connections, as well as a subset of neuropeptide connections, in C. elegan...
11:00 < kanzure> ...s based on new and published gene expression data."
11:00 < kanzure> .title https://github.com/openworm/PyOpenWorm/issues/281
11:00 < yoleaux> Method to get potential extrasynaptic connectivity ? Issue #281 ? openworm/PyOpenWorm ? GitHub
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16:19 < kanzure> bloop
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17:55 < kanzure> "Optimization of PAMAM-gold nanoparticle conjugation for gene therapy" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906732/
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18:02 < kanzure> "Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells" http://www.sciencedirect.com/science/article/pii/S1549963416301319
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18:14 < kanzure> "Non-viral nucleic acid delivery strategies to the central nervous system" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088201/
18:24 < kanzure> "The transferrin receptor is frequently targeted for BBB transcytosis. After binding the transferrin receptor carrier protein, the transferrin-iron complex is internalized at the apical side of the brain endothelium and is eventually exocytosed at the opposite basal surface. Since transferrin receptor is expressed on the BBB and transcytoses transferrin, it can be utilized as an uptake pathway...
18:24 < kanzure> ... into the brain by nucleic acid vehicles functionalized with transferrin. In one example, polyamidoamine (PAMAM) dendrimers were decorated with transferrin by a PEG linker and showed a ~2-fold higher brain uptake and gene transfer compared to PEGylated dendrimers alone (Huang et al., 2007). In another example, transferrin antibodies were used to decorate liposomes that hid plasmid DNA. This sy...
18:25 < kanzure> ...stem was able to show a 10-fold greater ?-glucuronidase enzyme activity in murine brains deficient of the protein (Zhang et al., 2008)."
18:26 < kanzure> "Another BBB transcytosis moiety is the rabies viral glycoprotein (RVG) peptide, a 29-amino acid peptide which binds to nicotinic acetylcholine receptors. Modifying the peptide sequence to include nine arginines on the C-terminus allows for complexation with nucleic acids (Kumar et al., 2007). Upon systemic intravenous administration, these complexes were able to transvascularly deliver siRNA ...
18:26 < kanzure> ...to the brain through clathrin- and caveolae-mediated endocytosis by endothelial cells, which lead to extended lives of encephalitic mice. The RVG peptide can also modulate the accumulation of larger vehicles and has delivered macro-structures such as PAMAM dendrimers (Liu et al., 2009), liposomes (Pulford et al., 2010), chitosan nanoparticles (Gao et al., 2014), poly(mannitol-co-PEI) complexes...
18:26 < kanzure> ... (Park et al., 2015) and exosomes (Alvarez-Erviti et al., 2011) across the BBB and into the brain parenchyma."
18:27 < kanzure> "Other targeting agents have included: angiopep, a peptide that binds to low-density lipoprotein receptor-related protein-1 (Ke et al., 2009); lactoferrin, an iron-binding protein of the transferrin family (Huang et al., 2008, 2010); leptin, a peptide that binds to leptin receptor in different parts of the brain (Liu et al., 2010); chlorotoxin, a scorpion-derived venom that is a specific marke...
18:27 < kanzure> ...r for gliomas (Costa et al., 2013); TGN peptide, a BBB targeting peptide isolated by phage display (Qian et al., 2013); and LIMK2 NoLs peptide, a nucleolar translocation signal sequence derived from the LIM Kinase 2 protein (Yao et al., 2015). Collectively, these targeting agents have shown to facilitate the accumulation of PEGylated PAMAM dendrimers, lysine dendrimers, liposomes, and polymeri...
18:27 < kanzure> ...c polyplexes in the brain."
18:27 < kanzure> oh neat:
18:27 < kanzure> "More recently microbubbles, or gas-filled microspheres, have been coupled with ultrasound as a method to temporarily disrupt the BBB (Meairs and Alonso, 2007; Panje et al., 2013; Rychak and Klibanov, 2014; Figure Figure2).2). This process, called sonoporation, creates micropores, permeabilizes cell membranes and breaks up tight junctions as microbubbles act as local enhancers of the ultras...
18:27 < kanzure> ...ound acoustic energy and cavitate causing local shear flow, microstreams and microjets (Greenleaf et al., 1998; Zhou et al., 2012; Panje et al., 2013). These BBB openings are large enough to allow for the permeation of macromolecules into the brain such as immunoglobulin G and 70 kDa dextran (Sheikov et al., 2004; Choi et al., 2007, 2010, 2011; Xie et al., 2008). The safety of microbubble-medi...
18:28 < kanzure> ...ated BBB disruption has been evaluated in rats and macaque monkeys with no or limited damage to brain tissue and no behavioral or visual deficits (McDannold et al., 2012; Kobus et al., 2015). Microbubble-mediated disruption of the BBB has been used to increase anti-Huntingtin siRNA delivery into the murine brain to reduce Huntingtin protein levels in animal disease models (Burgess et al., 2012)."
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19:07 < superkuh> Somehow I don't see that one ever getting medical use in humans.
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19:07 < superkuh> (sonoporation)
19:18 < kanzure> use your imagination! :D
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19:45 < kanzure> at least with ultrasound you could do localization
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20:52 -!- mode/##hplusroadmap [+o kanzure] by ChanServ
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20:53 -!- Regex was kicked from ##hplusroadmap by kanzure [Regex]
20:54 -!- mode/##hplusroadmap [-o kanzure] by kanzure
20:54 < kanzure> hmph
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22:04 -!- justanotheruser is now known as OfficialLeibniz
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--- Log closed Wed Jan 11 00:00:02 2017