--- Log opened Thu Jan 19 00:00:09 2017
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06:08 < JayDugger> Good morning.
06:22 < kanzure> docl: yes well, let me know when the high skill people start showing up to actually help
06:27 < kanzure> Connectomics. April 22-26, 2017. Neuroscience School of Advanced Studies; Siena, Italy. Coordinator: Sean Hill (Switzerland). "
06:27 < kanzure> This Advanced Course will focus on multi-scale aspects of the connectome and will cover the cellular basis of connectivity; large-scale data gathering and data analysis of whole brain connectivity across scales; data integration of multimodal connectome data; data-driven computational modeling and simulation at different scales of brain circuitry; the development of the connectome and its link...
06:28 < kanzure> ... to behavior and neurological disorders;  predicting whole brain dynamics from the connectome; the relationship between the connectome and the diversity of brain states and experiences."
06:28 < kanzure> http://www.nsas.it/courses-workshops/advanced-courses/connectomics/
06:30 < kanzure> archels: you should go to that one and record the lectures (or transcribe them)
06:59 < JayDugger> David Gelernter for science advisor? (https://twitter.com/iowahawkblog/status/822061865358528512)
07:00 < JayDugger> What's next? Privatizing section 8 housing to Linden Labs?
07:00 < JayDugger> Yes, yes, yes. 20 microBTC for the off-topic jar.
07:02 < kanzure> (music) https://www.youtube.com/watch?v=hAnGHhITS8c
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07:09 < kanzure> JayDugger: do you mean langton labs?
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07:27 < archels> kanzure: I might need sponsoring
07:28 < kanzure> archels: do the math and then let me know. maybe airbnb or something.  also maybe we have an hplusroadmapper in the area..
07:30 < kanzure> at best maybe we have someone in florence, but i kind of doubt it. maybe a bitcoiner or two.. but that's the wrong demographic.
07:34 < archels> kanzure: oh, never mind, it's silly expensive. The course registration fee alone is EUR830
07:34 < kanzure> so?
07:35 < archels> that's just silly, we should not stand for this
07:37 < kanzure> archels: i haven't been able to find good/recent/modern lectures on similar topics on youtube. do people just not record lectures anymore, or is it supposed to be a secret..?
07:40 < kanzure> er, nevermind. i have been using the wrong keywords.
07:41 < kanzure> .title https://www.youtube.com/watch?v=w40pVPR4l9c
07:41 < yoleaux> Ken Hayworth - Interview - Part 1 - YouTube
07:41 < kanzure> .title https://www.youtube.com/watch?v=Z63tKv6xcKM
07:41 < yoleaux> Ken Hayworth - the Connectome - Neuroscience part 2 - YouTube
07:44 < kanzure> berger transcript http://gf2045.com/read/269/ on his prostheses
07:45 < kanzure> george church transcript http://gf2045.com/read/269/
07:45 < kanzure> boyden transcript http://gf2045.com/read/266/
07:45 < kanzure> randal koene transcript http://gf2045.com/read/268/
07:46 < kanzure> ken hayworth transcript http://gf2045.com/read/274/ (cc nmz787)
07:48 < kanzure> .title https://www.youtube.com/watch?v=GbRZWVUVX-A
07:48 < yoleaux> BIL2015 - Todd Huffman - The Frontlines of Geek Imperialism - YouTube
07:55 < archels> kanzure: to be frank, I think my main hangup is that this whole concept of "connectomics" is pretty vague and seems to want to be a model of everything at the same time
07:56 < archels> euphemistically calling it "multiscale"
07:58 < JayDugger> kanzure, no, I meant Linden Lab, makers of Second Life, as a joke on Gelernter
07:58 < JayDugger>  and his book "Mirror Worlds," in which he calls virtual spaces the new public and civic spaces.
08:00 < kanzure> archels: sure, i mean, it's not worth any of our time if they are just waving their hands. but if they are discussing recent techniques that we wouldn't otherwise hear about, i think it might be worthwhile.
08:01 < poppingtonic> And you don't expect them to record?
08:04 < kanzure> no
08:14 < archels> kanzure: agreed. part of me thinks that the HBP guys are going to be rather reticent though
08:14 < archels> the HBP story strikes me as possibly the most interesting one
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08:28 < archels> other than that I'm interested in advances in EM scanning and reconstruction
08:29 < kanzure> did you see the recent neural barcoding paper from the other day?
08:30 < kanzure> "Using high-throughput barcode sequencing to efficiently map connectomes" http://biorxiv.org/content/early/2017/01/09/099093
08:30 < archels> but there's not really any EM stuff in that course, unfortunately
08:30 < kanzure> this is back to the "use DNA sequencing instead of optical imaging of connectomes"
08:30 < kanzure> method.
08:35 < archels> cute, the speedup could be massive
08:36 < kanzure> other refs available; thought i had shown this to you before.
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08:37 < archels> I wonder how quantitative they can make it; can they decode synaptic strength?
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08:38 < kanzure> archels: FISSEQ can help decode synaptic strength
08:38 < kanzure> but it's not an in vivo method, it's more of a tissue microscopy method
08:39 < archels> EM is also not quite in vivo ;)
08:39 < kanzure> for synaptic strength you need to record and measure the mRNAs floating around
08:41 < kanzure> archels: http://gnusha.org/logs/2016-07-14.log
08:41 < kanzure> near 09:04
08:42 < kanzure> and http://gnusha.org/logs/2016-08-19.log
08:45 < kanzure> "in summary, random barcodes give you a unique "color" for each cell body, and aptamers give you a unique "color" for each receptor type or other proteins of interest"
08:46 < kanzure>  09:18 < fenn> you could label each receptor with aptamers and then sequence all the aptamers in-situ to get 120 or more "colors" in your microscope image
08:47 < archels> do we have more info on 3Scan's high-throughput microscope yet?
08:50 < kanzure> um, we probably have a bunch of random details spread out in our logs... fenn lived with the guy or something, too.
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13:59 < kanzure> http://www.cmegroup.com/trading/energy/crude-oil/light-sweet-crude_contractSpecs_futures.html
13:59 < kanzure> "Delivery shall be made free-on-board ("F.O.B.") at any pipeline or storage facility in Cushing, Oklahoma with pipeline access to Enterprise, Cushing storage or Enbridge, Cushing storage. Delivery shall be made in accordance with all applicable Federal executive orders and all applicable Federal, State and local laws and regulations."
13:59 < kanzure> " At buyer's option, delivery shall be made by any of the following methods: (1) by interfacility transfer ("pumpover") into a designated pipeline or storage facility with access to seller's incoming pipeline or storage facility; (2) by in-line (or in-system) transfer, or book-out of title to the buyer; or (3) if the seller agrees to such transfer and if the facility used by the seller allows ...
13:59 < kanzure> ...for such transfer, without physical movement of product, by in-tank transfer of title to the buyer."
14:03 < kanzure> http://seawaypipeline.com/
14:06 < archels> .title https://www.youtube.com/watch?v=ffvu6Mr1SVc
14:06 < yoleaux> Davos 2017 - An Insight, An Idea with Sergey Brin - YouTube
14:11 < kanzure> https://www.google.com/maps/@35.9426246,-96.7481384,2448m/data=!3m1!1e3?hl=en
14:15 < kanzure> https://en.wikipedia.org/wiki/Cushing,_Oklahoma
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14:24 < kanzure> "Nullpunktsenergie" https://www.shadertoy.com/view/4dfGzS
14:32 < kanzure> "In 2015, global capacity for oil storage was out-paced by global oil production and an oil glut occurred. Crude oil storage space became a tradable commodity with CME Group-- which owns NYMEX-- offering oil-storage futures contracts in March 2015.[3] Traders and producers can buy and sell the right to store certain types of oil.[3]"
14:43 < JayDugger> Good night.
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17:08 < fenn> creative commons "non-commercial" clause strikes again! (shadertoy default license)
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17:41 < kanzure> "Homologous recombination is important in facilitating viral evolution.[79][81] For example, if the genomes of two viruses with different disadvantageous mutations undergo recombination, then they may be able to regenerate a fully functional genome. Alternatively, if two similar viruses have infected the same host cell, homologous recombination can allow those two viruses to swap genes and the...
17:41 < kanzure> ...reby evolve more potent variations of themselves.[81]"
17:41 < kanzure> combining that with phage-assisted continuous evolution would probably be irresponsibly cool
17:42 < kanzure> er i guess i should call that a cell-virus co-culture for evolution.. technique, thing.
18:08 < kanzure> culture collapse tho from viruses, so..
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18:43 < kanzure> http://www.the-scientist.com/?articles.view/articleNo/47996/title/Opinion--Reuse-and-Reduce/
18:43 < kanzure> " Recognizing that there are often significant amounts of tissue after scientists have completed animal studies, my colleagues and I sought to determine whether these experimental "leftovers" might be of use to the wider research community. A survey of U.K.-based biomedical scientists from a range of disciplines revealed a strong desire to make leftover animal material available to other g...
18:43 < kanzure> ...roups. Thus, our concept of "sharing experimental animal resources, coordinating holdings," or SEARCH, was born."
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20:09 < kanzure> "This year, for the first time, the US government office that oversees federally funded climate studies is formally recommending geoengineering research. The move has the backing of President Barack Obama's former science adviser John Holdren, who has said that geoengineering has "got to be looked at." Last year, 11 climate scientists declared that the Paris agreement had actually set ba...
20:09 < kanzure> ...ck the fight against climate change, saying that, "Our backs are against the wall and we must now start the process of preparing for geoengineering.""
20:09 < kanzure> http://www.sciencemag.org/news/2017/01/us-should-pursue-controversial-geoengineering-research-federal-scientists-say-first
20:10 < kanzure> "The crucial benefit of investigating geoengineering is that it offers the only way to reduce the global temperature quickly." hooray, this might even stop all the climate change squawking
20:12 < kanzure> "To be clear, I am not advocating that we should start geoengineering today or even in this decade." alright the author turned completely lame
20:12 < kanzure> "The most cost-effective and least invasive approach is probably a process called marine cloud whitening, whereby seawater droplets are sprayed into marine clouds to make them slightly whiter and reflect more sunlight. This augments the naturally occurring process by which salt from the oceans provides the condensation particles for water vapor, creating and boosting the whiteness of clouds. "
20:13 < kanzure> http://www.copenhagenconsensus.com/publication/fix-climate-climate-engineering-assessment-bickel-lane " ... spending just $9 billion on 1,900 seawater-spraying boats could prevent all of the global warming set to occur this century"
20:13 < kanzure> from https://www.project-syndicate.org/commentary/geoengineering-climate-change-by-bjorn-lomborg-2017-01
20:16 < adlai> 02:53:02         kanzure | docl: i'm not buying the disaster porn, sorry. << fwiw, rough paraphrase-from-memory (Hry2002,isbn:0072226013): "battery life will make the robot uprising the shortest revolution to ever fail"
20:17 < kanzure> i'm not saying disaster is impossble, simply that it is not too exciting or motivating.  so far i just see people spreading propaganda, not so many people sitting down to build highly relevant tech.
20:18 < kanzure> why can't propaganda inspire people to make ridiculously cool tech, instead of inspiring them to timewaste squabblegobble?
20:18 < adlai> obviously the people are either waiting in line for food stamps or sipping pina coladas while their robots build the next gen tech
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--- Log closed Fri Jan 20 00:00:10 2017