--- Log opened Sun Feb 05 00:00:24 2017
00:05 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds]
00:09 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
01:09 -!- m4l3z [~m4l3z@2a01cb040226f20038a4f41f7bca54ee.ipv6.abo.wanadoo.fr] has joined ##hplusroadmap
01:21  * archels wonders why MRI+ultrasound heating to remove malignant internal growths isn't more commodity yet
02:59 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap
03:35 -!- m4l3z [~m4l3z@2a01cb040226f20038a4f41f7bca54ee.ipv6.abo.wanadoo.fr] has quit [Quit: Leaving]
03:56 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
04:07 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
04:18 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 260 seconds]
04:21 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap
04:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-nospciojmngdjqhw] has joined ##hplusroadmap
06:24 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap
06:33 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 240 seconds]
06:34 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap
06:39 < JayDugger> Hm.
07:15 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap
07:32 < kanzure> mouse maze thing could be modified for anti-sleep (since we can observe mouse sleeping behavior), and also for hippocampal size (since we can observe hippocampus size).
08:00 -!- augur [~augur@2601:640:8001:4222:4862:fd1c:8836:fef3] has joined ##hplusroadmap
08:01 < kanzure> but dpends on whether size is hippocampally beneficial
08:06 < streety> how do you observe hippocampus size? I might be missing some context
08:07 < JayDugger> X-ray?
08:12 < kanzure> streety: in mice? cut open their brains and look.
08:13 < kanzure> streety: i had proposed a method of designing actually strong nootropics; it uses bacterial populations that infect the brain, then recovering the bacteria from high performing brains, and mutating those strains a bunch of times.
08:14 < kanzure> originally i had made this proposal for maze solving, but it will work for sleep things (such as sleep duration, sleep quality, performance during sleep deprivation) and prooobably for hippocampus size (but i dunno if hippocampus size correlates to memory quantity or memory quality or retrieval performance or such...)
08:17 < kanzure> .wik luzindole
08:17 < yoleaux> "Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist, with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor." -- https://en.wikipedia.org/wiki/Luzindole
08:17 < kanzure> .wik fabomotizole
08:17 < yoleaux> "Fabomotizole (INN) (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions." -- https://en.wikipedia.org/wiki/Fabomotizole
08:31 -!- bsm1175321 [~mcelrath@38.121.165.30] has joined ##hplusroadmap
08:32 -!- bsm1175321 is now known as bsm117532
08:41 < streety> I had assumed you were breeding intelligent mice so would want a fast/cheap way that left them alive for breeding. Makes sense now.
08:42 < kanzure> right, in this case it's bacteria breeding not mouse breeding
08:42 < kanzure> once the bacteria change the mouse brain structure, there's no way to get the mouse back to the way it was, sooo you have to use fresh mice instead
09:25 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
09:45 < kanzure> https://www.fightaging.org/archives/2016/02/an-interview-with-gary-hudson-of-oisin-biotechnologies-senescent-cell-clearance-startup/
09:48 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap
10:02 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
10:36 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap
10:58 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 245 seconds]
11:25 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap
12:42 -!- pompolic [~A@unaffiliated/pompolic] has quit [Read error: Connection reset by peer]
12:42 -!- pompolic [~A@unaffiliated/pompolic] has joined ##hplusroadmap
12:44 < kanzure> "Postmortem changes in the neuroanatomical characteristics of the primate brain: Hippocampal formation" http://onlinelibrary.wiley.com/doi/10.1002/cne.21906/full
12:46 < kanzure> "MRI of postmortem specimens of endangered species for comparative brain anatomy" http://www.nature.com/nprot/journal/v3/n4/abs/nprot.2008.17.html
12:46 -!- bsm117532 [~mcelrath@38.121.165.30] has quit [Remote host closed the connection]
12:47 -!- bsm117532 [~mcelrath@38.121.165.30] has joined ##hplusroadmap
12:52 < kanzure> autoosy of 63 year old mathematician brain http://link.springer.com/article/10.1007/s10803-011-1259-0
12:52 < kanzure> autopsy
13:07 -!- pompolic [~A@unaffiliated/pompolic] has quit [Read error: Connection reset by peer]
13:07 -!- pompolic [~A@unaffiliated/pompolic] has joined ##hplusroadmap
13:08 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Quit: Leaving]
13:47 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap
13:48 -!- drewbot [~cinch@ec2-54-226-223-177.compute-1.amazonaws.com] has quit [Remote host closed the connection]
13:49 -!- drewbot [~cinch@ec2-54-162-19-77.compute-1.amazonaws.com] has joined ##hplusroadmap
14:11 < archels> .wik kopimi
14:11 < yoleaux> "Piratbyr?n  Piratbyr?n (help?info) ("The Pirate Bureau") was a Swedish organization (or think tank) established to support the free sharing of information, culture, and intellectual property. Piratbyr?n provided a counterpoint to lobby groups such as the Swedish Anti-Piracy Bureau." -- https://en.wikipedia.org/wiki/Kopimi
14:32 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
14:32 < kanzure> about rapamycin for dogs:
14:32 < kanzure> http://dogagingproject.com/project-details/
15:01 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
15:02 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Quit: This computer has gone to sleep]
15:05 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap
15:43 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
16:16 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Quit: ERC Version 5.3 (IRC client for Emacs)]
16:33 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
16:35 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds]
16:53 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Quit: Leaving]
17:00 -!- Aurelius [~cpopell@50.35.79.117] has quit [Ping timeout: 252 seconds]
17:08 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Read error: No route to host]
17:08 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap
17:13 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection]
18:07 -!- ExeciN [ExeciN@bnc.stormbit.net] has joined ##hplusroadmap
18:30 < kanzure> blort
18:44 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds]
18:45 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
18:45 < kanzure> modafinil and metabolism, go!
18:46 < kanzure> seems to induce CYP3A4 at least
18:47 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 255 seconds]
19:21 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap
19:25 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds]
19:38 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 258 seconds]
19:38 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap
19:59 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 255 seconds]
20:00 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
20:22 -!- delinquentme [~delinquen@108-77-136-226.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap
20:39 -!- delinquentme [~delinquen@108-77-136-226.lightspeed.sntcca.sbcglobal.net] has quit [Ping timeout: 240 seconds]
21:02 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds]
21:16 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap
21:18 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds]
21:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-nospciojmngdjqhw] has quit [Quit: Connection closed for inactivity]
21:36 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has quit [Quit: Leaving]
21:36 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
21:42 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds]
21:58 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
22:36 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Quit: Leaving]
22:54 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving]
23:12 -!- augur [~augur@2601:640:8001:4222:4862:fd1c:8836:fef3] has quit [Remote host closed the connection]
23:14 < kanzure> https://github.com/kanzure/culture_shock
--- Log closed Mon Feb 06 00:00:25 2017