--- Log opened Thu Feb 09 00:00:28 2017 00:28 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has joined ##hplusroadmap 00:47 -!- andytoshi [~apoelstra@unaffiliated/andytoshi] has quit [Ping timeout: 256 seconds] 00:47 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has quit [Ping timeout: 240 seconds] 00:48 -!- andytoshi [~apoelstra@wpsoftware.net] has joined ##hplusroadmap 00:55 -!- esmerelda [~mabel@2601:602:9603:a3f8:626d:c7ff:fe5f:86c7] has quit [Ping timeout: 255 seconds] 01:03 -!- augur [~augur@2601:640:8001:4222:54c0:38ee:3eab:f34a] has quit [Remote host closed the connection] 01:12 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 01:14 -!- andytoshi [~apoelstra@wpsoftware.net] has quit [Ping timeout: 276 seconds] 01:14 -!- andytoshi [~apoelstra@wpsoftware.net] has joined ##hplusroadmap 01:14 -!- duper [~super@ca4.blackcatz.org] has quit [Read error: Connection reset by peer] 01:16 -!- Burn_ [~Burn@pool-108-56-208-224.washdc.fios.verizon.net] has joined ##hplusroadmap 01:19 -!- Burnin8 [~Burn@pool-108-56-208-224.washdc.fios.verizon.net] has quit [Ping timeout: 240 seconds] 01:20 -!- duper [~super@ca4.blackcatz.org] has joined ##hplusroadmap 01:39 -!- andytoshi [~apoelstra@wpsoftware.net] has quit [Ping timeout: 240 seconds] 01:39 -!- andytoshi [~apoelstra@wpsoftware.net] has joined ##hplusroadmap 01:40 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 01:43 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 01:45 < nsh> i need to culture some bacterophages to extract endolysins. what do i need at minimum? 01:56 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 01:58 -!- ebowden [~ebowden@CPE-101-180-233-178.lnse3.cha.bigpond.net.au] has joined ##hplusroadmap 01:58 -!- ebowden [~ebowden@CPE-101-180-233-178.lnse3.cha.bigpond.net.au] has quit [Changing host] 01:58 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 01:59 < nsh> heh, methods canonical since '56 01:59 < nsh> how come nobody told me this would help treat my chronic eczema until yesterday 01:59 < nsh> fuck2humanity 02:11 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 02:29 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 02:38 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Read error: Connection reset by peer] 02:50 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-lcbkjlxqkpusygxi] has joined ##hplusroadmap 03:44 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 04:12 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 04:39 -!- QuadIgni is now known as FourFire 05:03 -!- Gurkenglas__ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 05:04 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 05:04 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Remote host closed the connection] 05:16 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 05:46 < kanzure> you sure you can't buy endolysins? 05:55 -!- Urchin [~urchin@89.17.16.190] has quit [Changing host] 05:55 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 06:01 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 06:09 < kanzure> nsh: anyway if you want to work with bacteriophages i'd be happy to fund some of that 06:13 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Quit: sleeeep] 06:14 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap 06:38 < rkos> https://www.nytimes.com/2017/02/05/health/with-fda-vacancy-trump-sees-chance-to-speed-drugs-to-the-market.html?smprod=nytcore-ipad&smid=nytcore-ipad-share&_r=0 yaness 06:55 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 06:57 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 07:01 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 07:19 -!- JayDugger [~jwdugger@47.185.237.246] has quit [Quit: Leaving.] 07:23 -!- urchin_ [~urchin@89.17.15.211] has joined ##hplusroadmap 07:26 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Ping timeout: 240 seconds] 07:26 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 255 seconds] 07:28 < FourFire> hello kanzure, Did you have a project idea earlier about using benign brain parasites to excrete nootropic substances in the brain? 07:29 < FourFire> can you link me or tell me the details on that? 07:31 < kanzure> FourFire: http://diyhpl.us/~bryan/irc/2017-02-03-beacon.pdf 07:32 < kanzure> also the other important component is that the microbes can migrate to specific brain regions and create cysts to push around brain matter 07:33 < FourFire> push around brain matter is useful for what reason? 07:34 < kanzure> interferes with brain function 07:40 < kanzure> "Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system" http://www.sciencedirect.com/science/article/pii/S0898656817300347 07:41 < kanzure> "European do-it-yourself (DIY) biology: Beyond the hope, hype and horror" http://onlinelibrary.wiley.com/doi/10.1002/bies.201300149/full 07:41 < kanzure> oh that one is old. 07:42 -!- augur [~augur@2601:640:8001:4222:54c0:38ee:3eab:f34a] has joined ##hplusroadmap 07:42 -!- augur [~augur@2601:640:8001:4222:54c0:38ee:3eab:f34a] has quit [Remote host closed the connection] 07:44 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-lcbkjlxqkpusygxi] has quit [Quit: Connection closed for inactivity] 07:47 < kanzure> "Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy" http://stm.sciencemag.org/content/9/374/eaag0481 07:52 -!- augur [~augur@2601:640:8001:4222:54c0:38ee:3eab:f34a] has joined ##hplusroadmap 07:57 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 08:08 -!- Gurkenglas__ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 264 seconds] 08:25 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 240 seconds] 08:26 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 08:34 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Killed (wilhelm.freenode.net (Nickname regained by services))] 08:34 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 08:49 < kanzure> https://github.com/kanzure/culture_shock/blob/master/kvboard.png 08:55 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Read error: Connection reset by peer] 09:11 -!- Regex [~Cara@2601:1c0:8500:5edb:883a:2b38:72e2:edac] has quit [Read error: Connection reset by peer] 09:11 -!- Regex [~Cara@2601:1c0:8500:5edb:883a:2b38:72e2:edac] has joined ##hplusroadmap 09:50 -!- augur [~augur@2601:640:8001:4222:54c0:38ee:3eab:f34a] has quit [Remote host closed the connection] 10:12 < kanzure> grr szabo citing dunbar number http://unenumerated.blogspot.com/2017/02/money-blockchains-and-social-scalability.html 10:12 < kanzure> suck on this, dunbar >:( 10:13 -!- JayDugger [~jwdugger@47.185.237.246] has joined ##hplusroadmap 10:26 -!- nmz787_w1 [~ntmccork@134.134.139.78] has joined ##hplusroadmap 10:28 -!- nmz787_w [~ntmccork@134.134.139.74] has quit [Ping timeout: 252 seconds] 10:30 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 10:30 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 10:40 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 11:13 -!- nnnn20431 [~nnnn20430@plfgr.eu.org] has joined ##hplusroadmap 11:25 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 11:29 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 245 seconds] 11:31 -!- urchin_ [~urchin@89.17.15.211] has quit [Changing host] 11:31 -!- urchin_ [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 11:31 -!- urchin_ is now known as Urchin 11:33 -!- nmz787_w1 [~ntmccork@134.134.139.78] has quit [Quit: Leaving.] 11:47 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 11:54 < kanzure> hmm 12:02 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 12:07 -!- nmz787_w [~ntmccork@134.134.139.83] has joined ##hplusroadmap 12:09 -!- nmz787_w1 [~ntmccork@134.134.139.76] has joined ##hplusroadmap 12:11 -!- nmz787_w [~ntmccork@134.134.139.83] has quit [Ping timeout: 240 seconds] 12:13 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 12:43 -!- iofowekfo [~efkoefk@host243-84-dynamic.1-87-r.retail.telecomitalia.it] has joined ##hplusroadmap 13:13 -!- ekr [~ekr@unaffiliated/ekr] has quit [Quit: leaving] 13:20 -!- sachy [~sachy@2001:67c:2190:c0de:da50:e6ff:feed:cf14] has quit [Quit: Leaving.] 13:21 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 13:23 -!- Guest52475 is now known as abetusk 13:25 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 13:46 -!- balrog [~balrog@unaffiliated/balrog] has quit [Ping timeout: 276 seconds] 13:47 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 13:51 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 13:57 -!- balrog [~balrog@unaffiliated/balrog] has joined ##hplusroadmap 14:02 -!- poppingtonic1 [~brian@105.162.112.79] has joined ##hplusroadmap 14:03 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 245 seconds] 14:16 -!- Regex [~Cara@2601:1c0:8500:5edb:883a:2b38:72e2:edac] has quit [Quit: Leaving] 14:37 < kanzure> boerh0321rar02 14:37 -!- balrog [~balrog@unaffiliated/balrog] has quit [Ping timeout: 240 seconds] 14:44 -!- balrog [~balrog@unaffiliated/balrog] has joined ##hplusroadmap 14:45 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Quit: sleeeep] 14:46 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap 15:05 -!- iofowekfo [~efkoefk@host243-84-dynamic.1-87-r.retail.telecomitalia.it] has quit [Ping timeout: 240 seconds] 15:12 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has quit [Ping timeout: 240 seconds] 15:13 -!- drewbot_ [~cinch@ec2-54-224-18-155.compute-1.amazonaws.com] has quit [Remote host closed the connection] 15:13 -!- iaglium [U2FsdGVkX1@ma.sdf.org] has joined ##hplusroadmap 15:13 -!- drewbot [~cinch@ec2-54-224-31-22.compute-1.amazonaws.com] has joined ##hplusroadmap 15:15 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap 15:20 -!- Gurkenglas__ [~Gurkengla@dslb-178-005-218-116.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 15:20 -!- iofowekfo [~efkoefk@94.161.214.35] has joined ##hplusroadmap 15:24 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has joined ##hplusroadmap 15:41 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:50 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has quit [Ping timeout: 245 seconds] 16:07 < nmz787_w1> .wik boer 16:08 < yoleaux> "Boer (English pronunciation: /'bo?.?r/, /b?:r/ or /b??r/; Afrikaans: [bu:r]) is the Dutch and Afrikaans word for "farmer". As used in South Africa, it was used to denote the descendants of the Dutch-speaking settlers of the eastern Cape frontier in Southern Africa during the 18th century." -- https://en.wikipedia.org/wiki/Boer 16:13 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has joined ##hplusroadmap 16:16 < kanzure> let's blow up australia 16:25 < chris_99> What about the poor Koalas? 16:33 < kanzure> they already have chlamydia 16:34 < nmz787_w1> .g kaola chlamydia 16:34 < yoleaux> http://www.bbc.com/news/magazine-22207442 16:34 < chris_99> awh :( 16:37 -!- sachy [~sachy@nat.brmlab.cz] has joined ##hplusroadmap 16:43 < adlai> heath: that panel you linked has the distracting unfeature of what i shall dub the "debating philosophers" problem, where a panel of N philosophers must share M microphones amongst eachother, but for unknown reasons are unable to keep mental track of whether the next one in line already has a microphone or not 16:50 < eb3c90> I just watched it too, just with the subtitles, so it was less clumsy. I'm with elon on the IA (but I don't think neural links are the priority). 16:59 -!- cosmicroy [~guest@173-198-253-92.static.as40244.net] has quit [Ping timeout: 240 seconds] 17:03 -!- eb3c90 [~kvirc@host86-184-170-176.range86-184.btcentralplus.com] has quit [Ping timeout: 258 seconds] 17:05 -!- cosmicroy [~guest@173-198-253-92.static.as40244.net] has joined ##hplusroadmap 17:14 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 17:25 < kanzure> indiebio demo day already? 17:36 -!- nmz787_w1 [~ntmccork@134.134.139.76] has quit [Ping timeout: 255 seconds] 17:51 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 17:53 < maaku> what's the Elon position on IA? (for those without time to watch a video) 17:59 -!- iofowekfo [~efkoefk@94.161.214.35] has quit [Ping timeout: 245 seconds] 18:04 < kanzure> .title https://www.ncbi.nlm.nih.gov/pubmed/2917954 18:04 < yoleaux> Effect of testosterone on muscle mass and muscle protein synthesis. - PubMed - NCBI 18:06 < docl> http://www-bcf.usc.edu/~ioannou/RobustAdaptiveBook95pdf/Robust_Adaptive_Control.pdf mathy book about automated control systems, seems relevant to self replicating factory design 18:11 < kanzure> https://techcrunch.com/2017/02/09/watch-indiebio-accelerators-demo-day-today/ 18:12 < kanzure> http://www.bioinspira.com/ "BioInspira is harnessing biology to transform modern industry infrastructure by providing remote sensor networks for 24/7 chemical leak detection." 18:12 < kanzure> https://www.animalbiome.com/ "Animalbiome monitors and treats animals with chronic health conditions with a novel microbiome testing service and fecal transplant therapy" 18:13 < kanzure> https://catalogdna.com/ something about data storage in dna 18:13 < kanzure> http://geaenzymes.com/ enzyme optimization stuff 18:14 < kanzure> http://www.neuroqore.com/ rTMS stuff 18:14 < kanzure> http://www.ravatasolutions.com/ fast transgenic animal platform thing? 18:15 < kanzure> http://www.scaledbiolabs.com/ microfludiics platform thing 18:15 -!- iofowekfo [~efkoefk@host82-81-dynamic.19-79-r.retail.telecomitalia.it] has joined ##hplusroadmap 18:27 -!- Lemminkainen [uid2346@gateway/web/irccloud.com/x-vwuutecdxcoubpjh] has joined ##hplusroadmap 18:28 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap 18:33 < kanzure> Lemminkainen: welcome back 18:35 < Lemminkainen> hallo kanzure what a lovely crowd 18:38 < kanzure> agreed and they are almost all here voluntarily! 18:39 < kanzure> Lemminkainen: you might like these recent pages, 18:39 < Lemminkainen> impressive! 18:39 < kanzure> http://diyhpl.us/wiki/gene-editing/ 18:39 < Lemminkainen> raise your hand if you're here under duress 18:39 < kanzure> http://diyhpl.us/wiki/gene-therapy/ 18:39 < kanzure> and the classic has updates http://diyhpl.us/wiki/genetic-modifications/ 18:39 * kanzure raises his hand 18:40 * Lemminkainen raises something else 18:46 -!- iofowekfo [~efkoefk@host82-81-dynamic.19-79-r.retail.telecomitalia.it] has quit [Ping timeout: 252 seconds] 18:52 < kanzure> Lemminkainen: tell me cool things? 18:54 < Lemminkainen> this was cool http://pubs.acs.org/doi/abs/10.1021/acsnano.6b07600 18:55 < Lemminkainen> 90% effective Cas9 recombination in vitro w/ gold-based NP 18:56 < Lemminkainen> I enjoyed this paper a lot http://www.nature.com/nrc/journal/v17/n2/abs/nrc.2016.124.html 18:58 < Lemminkainen> these people are neat http://www.nimbustx.com/approach.html 19:08 < kanzure> .title http://pubs.acs.org/doi/abs/10.1021/acsnano.6b07600 19:08 < yoleaux> kanzure: Sorry, that doesn't appear to be an HTML page. 19:08 < kanzure> "Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing" 19:09 < kanzure> .title http://www.nature.com/nrc/journal/v17/n2/abs/nrc.2016.124.html 19:09 < yoleaux> The recurrent architecture of tumour initiation, progression and drug sensitivity : Nature Reviews Cancer : Nature Research 19:10 < kanzure> Lemminkainen: i recently proposed a way to make some strong nootropics http://diyhpl.us/~bryan/irc/2017-02-03-beacon.pdf#page=15 19:29 < Lemminkainen> will read in a bit 19:37 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 258 seconds] 19:46 < Lemminkainen> how do the $1 genome and AGI evolutionary constraints fit into noops? 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