--- Log opened Sun Feb 12 00:00:31 2017
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00:37 < adlai> JayDugger: thank you for reminding me about Severian, it's probably time I reread those (Book of the New Sun)
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03:11 < kanzure> ah.
03:12 < rkos> anyone know about nmda positive allosteric modulators? can they replace current neurolepts?
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03:16 < kanzure> fenn was recently asking about some, bug him about it
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03:18 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b5ad94e8 Bryan Bishop: link to dan boneh pairing crypto slides >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/pairing-cryptography/
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03:35 < adlai> kanzure: typo in 1st paragraph, i'm pretty sure 'wild' should be 'Weil"
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06:18 < kanzure> adlai: fix it yourslef :P
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06:39 < kanzure> "Optogenetic control of cellular forces and mechanotransduction" http://www.nature.com/articles/ncomms14396
06:39 < kanzure> "Contractile forces are the end effectors of cell migration, division, morphogenesis, wound healing and cancer invasion. Here we report optogenetic tools to upregulate and downregulate such forces with high spatiotemporal accuracy. The technology relies on controlling the subcellular activation of RhoA using the CRY2/CIBN light-gated dimerizer system. We fused the catalytic domain (DHPH domain...
06:39 < kanzure> ...) of the RhoA activator ARHGEF11 to CRY2-mCherry (optoGEF-RhoA) and engineered its binding partner CIBN to bind either to the plasma membrane or to the mitochondrial membrane. Translocation of optoGEF-RhoA to the plasma membrane causes a rapid and local increase in cellular traction, intercellular tension and tissue compaction. By contrast, translocation of optoGEF-RhoA to mitochondria results...
06:39 < kanzure> ... in opposite changes in these physical properties. Cellular changes in contractility are paralleled by modifications in the nuclear localization of the transcriptional regulator YAP, thus showing the ability of our approach to control mechanotransductory signalling pathways in time and space."
06:40 < kanzure> .tw https://twitter.com/fchollet/status/830499993450450944
06:40 < yoleaux> Time for an update: what does the deep learning library landscape look like, seen from GitHub? https://pbs.twimg.com/media/C4aHRWvVYAEXDQ6.jpg https://pbs.twimg.com/media/C4aHSvsUcAE0EnY.jpg (@fchollet)
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08:46 < kanzure> i need some suggestions for twitter anti-aging research feeds
08:46 < kanzure> or longevity stuff
08:52 < JayDugger> That aren't just ad streams?
08:52 < JayDugger> You're welcome, adlai.
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09:30 < kanzure> JayDugger: no? https://twitter.com/kanzure/lists/science1
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10:12 < kanzure> nmz787_w: darpa has a "radio bio" program http://www.darpa.mil/news-events/2017-02-07
10:19 < kanzure> .title https://www.fbo.gov/index?s=opportunity&mode=form&id=8d7980f7ad846f51c385f17f96cf93d2&tab=core&_cview=0
10:19 < yoleaux> RadioBio Proposers Day, February 21, 2017. - Federal Business Opportunities: Opportunities
10:19 < kanzure> "The RadioBio program aims to definitively establish whether purposeful signaling via electromagnetic waves between biological systems exists and, if it does, determine the mechanisms involved and the information being transferred.  If electromagnetic communications between bio-systems exist, then systematic study of the phenomenon may reveal new knowledge.  The program will determine the vali...
10:19 < kanzure> ...dity of electromagnetic biosignaling claims and, where evidence exists, learn how the structure and function of these natural "antennae" are capable of generating and receiving information in a noisy background."
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10:24  * superkuh rolls eyes.
10:24 < TMA> does sign language count as "purposeful signaling via electromagnetic waves"?
10:24 < kanzure> does channlelrhodopsin count?
10:24 < superkuh> I assume they only mean long, macroscopic+ wavelengths.
10:25 < superkuh> That's surely going to drag all the crackpots out of the woodwork though.
10:26 < superkuh> About as legit as the research in to "remote presence" psychics.
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10:55 < kanzure> "Designing novel protein backbones through digital evolution" http://www.foresight.org/nanodot/?p=7202
10:55 < kanzure> "Design of structurally distinct proteins using strategies inspired by evolution" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934125/
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10:59 < kanzure> "Peptoid nanosheets exhibit a new secondary-structure motif" http://www.nature.com/nature/journal/v526/n7573/full/nature15363.html
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12:54 < nmz787> kanzure: awesome, thanks
12:55 < nmz787> maybe I need to get some electric eels and an SDR
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13:19 < kanzure> https://www.researchgate.net/profile/Ralph_Merkle/publication/2595891_Two_Types_Of_Mechanical_Reversible_Logic/links/00b4953a224ff0537b000000.pdf
13:22 < kanzure> 13:22 <+xentrac> eliminating sliding contact is quite crucial for reducing scale
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14:41 < kanzure> is society for neuroscience happening right now? >:(
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15:10 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=9227e2ba Bryan Bishop: add helpful reference about pairings for bitcoin >> http://diyhpl.us/diyhpluswiki/transcripts/2016-july-bitcoin-developers-miners-meeting/dan-boneh/
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16:09 < kanzure> http://www.telegraph.co.uk/news/2017/02/11/anxious-chinese-parents-fuel-gene-testing-boom-try-discover/
16:10 < kanzure> hehe genetic testing instead of sports testing
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17:20 -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by lobsters everywhere, banned by the Federal Death Administration (5 times) | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church
17:20 -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Wed May 20 12:46:25 2015]
17:20 [Users ##hplusroadmap]
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17:20 -!- Irssi: ##hplusroadmap: Total of 96 nicks [0 ops, 0 halfops, 0 voices, 96 normal]
17:20 -!- Channel ##hplusroadmap created Thu Feb 25 23:40:30 2010
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17:41 < kanzure> "Exome sequencing of three cases of familial exceptional longevity" https://www.researchgate.net/profile/Nuria_Garatachea2/publication/264710474_Exome_sequencing_of_three_cases_of_familial_exceptional_longevity/links/5469bfb80cf2397f782d8a8e.pdf (2014)
17:43 < kanzure> oh that's an interesting point, they filtered out mutations that are frequent in other sequencing data sets, because long lifespan is not frequent in the general population anyway
17:44 < fenn> by definition
17:44 < kanzure> https://en.wikipedia.org/wiki/Apolipoprotein_B
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17:52 < kanzure> .wik hypobetalipoproteinemia
17:52 < yoleaux> "Hypobetalipoproteinemia is a disorder consisting of low levels of LDL cholesterol or apolipoprotein B, below the 5th percentile. The patient can have hypobetalipoproteinemia and simultaneously have high levels of HDL cholesterol." -- https://en.wikipedia.org/wiki/Hypobetalipoproteinemia
17:55 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e1743394 Bryan Bishop: some questionable longevity mutations >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
17:57 < kanzure> "Autophagy-mediated longevity is modulated by lipoprotein biogenesis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836030/
18:14 < kanzure> "Both TET2 and DNMT3A are factors [28,29] and are thought to silence hematopoietic stem cell self-renewal to permit efficient hematopoietic differentiation [30,31]. Therefore, loss of functionality in these genes is likely to underlie an enhanced self-renewal leading to the observed age-related myeloid lineage bias. This skewing towards the myeloid lineage is assumed to have adverse effects on...
18:14 < kanzure> ... immune functionality in normal healthy individuals, but in the oldest old the increase of the myeloid compartment might be compensative for the age-related decrease in naive T-cells, known as immuno-senescence. Hence on condition that the enhanced self-renewal, instigated by somatic disruptive mutations in TET2 and DNMT3A, leads to increased levels of competent immune cells, be it of the myel...
18:14 < kanzure> ...oid lineage though, might partly compensate for the age-related loss of immuno-capacity of the lymphoid compartment."
18:14 < kanzure> from "Germ line and somatic characteristics of the long-lived genome"
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18:37 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=40b4f238 Bryan Bishop: some alleles for exceptional episodic memory >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
18:39 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b04db830 Bryan Bishop: fix typo >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
19:26 < kanzure> .title https://www.youtube.com/watch?v=LdNu113Ep2U
19:26 < yoleaux> Mercedes Benz Mono Wiper Animation - YouTube
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--- Log closed Mon Feb 13 00:00:20 2017