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02:39 < archels> .title https://www.ncbi.nlm.nih.gov/pubmed/27773582
02:40 < yoleaux> Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals. - PubMed - NCBI
02:45 < archels> (there's videos)
02:47  * adlai sends kanzure a PR
02:48 < adlai> your one-line-per-paragraph format makes it rather tricky to see what exactly was changed
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04:57 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7b9b3357 Adlai Chandrasekhar: fix wild/Weil typo, add link >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/pairing-cryptography/
04:57 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c5112c4d Bryan Bishop: Merge pull request #8 from adlai/master >> http://diyhpl.us/diyhpluswiki/
04:57 < kanzure> adlai: thanks
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05:13 < kanzure> "Activity-dependent spatially localized miRNA maturation in neuronal dendrites" http://science.sciencemag.org/content/355/6325/634 https://medicalxpress.com/news/2017-02-witnessing-birth-tiny-rna-brain.html https://twitter.com/medical_xpress/status/831091426993774592
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05:25 < kanzure> "Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167293/
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05:28 < kanzure> hrm no pdf link there.
05:28 < kanzure> http://www.cell.com/neuron/pdf/S0896-6273%2816%2930703-6.pdf
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05:32 < kanzure> "Understanding neural computation requires methods such as 3D acousto-optical (AO) scanning that can simultaneously read out neural activity on both the somatic and dendritic scales. AO point scanning can increase measurement speed and signal-to-noise ratio (SNR) by several orders of magnitude, but high optical resolution requires long point-to-point switching time, which limits imaging capabi...
05:32 < kanzure> ...lity. Here we present a novel technology, 3D DRIFT AO scanning, which can extend each scanning point to small 3D lines, surfaces, or volume elements for flexible and fast imaging of complex structures simultaneously in multiple locations. Our method was demonstrated by fast 3D recording of over 150 dendritic spines with 3D lines, over 100 somata with squares and cubes, or multiple spiny dendri...
05:32 < kanzure> ...tic segments with surface and volume elements, including in behaving animals. Finally, a 4-fold improvement in total excitation efficiency resulted in about 500 x 500 x 650 ?m scanning volume with genetically encoded calcium indicators (GECIs)."
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05:37 < kanzure> "Communication between viruses guides lysis-lysogeny decisions" http://www.nature.com/nature/journal/v541/n7638/full/nature21049.html
05:37 < kanzure> aka some peptides that phages use to communicate with each other
05:39 < kanzure> "A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers" http://www.nature.com/nrmicro/journal/v15/n3/abs/nrmicro.2016.178.html
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05:44 < kanzure> "Flexible near-field wireless optoelectronics as subdermal implants for broad applications in optogenetics" http://www.cell.com/neuron/fulltext/S0896-6273%2816%2931004-2
05:51 < kanzure> "Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2" http://www.nature.com/articles/ncomms14127
05:51 < kanzure> cc cluckj
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06:35 < cluckj> cool
06:35 < cluckj> iirc there are already some therapies in clinical trial that put pancreatic islet cells into human livers
06:46 < kanzure> "Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation" http://www.nature.com/articles/s41551-016-0025
06:46 < kanzure> not sure what's going on there
06:48 < kanzure> "Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin" http://stm.sciencemag.org/content/9/376/eaak9537
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07:47 < bluebear_> kanzure: extremely interesting, thanks! :-)
07:50 < kanzure> hi what
07:50 < bluebear_> kanzure: more or less all links you posted in last 2 hours :-)
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11:15 < kanzure> hm https://github.com/bramcohen/MerkleSet/commit/eda28ad6e672d0412e74c2a0a92719b4cfe624be
11:16 < kanzure> .title https://github.com/fchollet/keras/issues/5090
11:16 < yoleaux> Different results from max pooling layer when using theano and tensorflow ? Issue #5090 ? fchollet/keras ? GitHub
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12:15 < sumie-dh> 2/win18
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12:21 < nmz787_w> seeing an opentrons ad on some Japanese blog site
12:24 < kanzure> the ads are targeted based on your browser
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12:51 < chris_99> nmz787_w, you ever used a fully differential amplifier per chance?
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13:07 < kanzure> "Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput" http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4179.html
13:08 < kanzure> "Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED" http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4178.html
13:08 < kanzure> 'serial femtosecond crystallography'
13:14 < kanzure> "Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes" http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3806.html
13:16 < kanzure> an organic chemistry AMA https://www.reddit.com/r/science/comments/5tsr50/science_ama_series_im_phil_baran_and_im_here_to/
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13:19 < heath> .title https://www.youtube.com/watch?v=giS41utjlbU
13:19 < yoleaux> Boston Dynamics "nightmare inducing" wheeled robot "Handle", presentation video close-up | 2017 - YouTube
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13:31 < kanzure> fda workshop on regulating non-invasive brain stimulation devices http://www.fda.gov/downloads/MedicalDevices/NewsEvents/WorkshopsConferences/UCM480906.pdf
13:32 < kanzure> australian government infosheet for patients seeking off-shore stem cell medical tourism https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/rm001a_stem_cell_treatments_faq_131220.pdf
13:33 < kanzure> "The regulation of consumer tDCS: engaging a community of creative self-experimenters" https://academic.oup.com/jlb/article/3/2/304/1751225/The-regulation-of-consumer-tDCS-engaging-a
13:36 < nmz787_w> chris_99: I've played with them in op-amps
13:38 < chris_99> nmz787_w, as in differential output you mean?
13:38 < nmz787_w> yeah
13:39 < nmz787_w> kanzure: that video inducing nightmares must be in the context of steampunk people or something
13:39 < kanzure> that was ybit not me
13:40 < nmz787_w> actually wasn't it heath?
13:40 < kanzure> heath was ybit
13:40 < chris_99> ah cool, i'm just looking at http://uk.farnell.com/texas-instruments/ths4521idgkt/very-low-power-r-r-fully-diff/dp/1755708 i'm thinking of using it with an ADC, to provide amplified differential input to one, what did you use them for?
13:41 < nmz787_w> I think it was in context of trying to build an xray detector based on a PIN photodiode... and needing lots of high SNR amplification
13:41 < chris_99> ahh neat
13:42 < nmz787_w> I mostly just played with some cheap op-amps and was injecting stimulus and watching the output on my o-scope
13:43 < nmz787_w> these horses look really really dumb: https://www.facebook.com/BillyGoBoy/videos/985015321621564/
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13:47 < kanzure> fenn: i had no idea that chris rasch coauthored a paper with eleitl
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15:06 < genehacker> http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2016.305.html\
15:06 < genehacker> http://www.nature.com/news/elusive-triangulene-created-by-moving-atoms-one-at-a-time-1.21462
15:07 < kanzure> genehacker: thanks
15:07 < genehacker> baby steps towards atomically precise manufacturing
15:07 < kanzure> "Synthesis and characterization of triangulene"
15:07 < kanzure> "The tip of a combined scanning tunnelling and atomic force microscope (STM/AFM) was used to dehydrogenate precursor molecules."
15:12 < genehacker> they've made something that has yet to be made with solution chemistry
15:21 < kanzure> cool.
15:22 < kanzure> genehacker: what else is up
15:22 < genehacker> not much
15:22 < genehacker> trying to do monte-carlo tree search on the space of molecules
15:23 < kanzure> any problems?
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15:28 < genehacker> gets fixated when it finds a terminal solution
15:34 < kanzure> oh that's a pretty typical problem
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15:35 < kanzure> genehacker: my recommendation is to throw out the molecule search aspect, and do something much faster (something that solves instantly), so that you can test an algorthm to get "unstuck". otherwise you have to wait for molecular dynamics or whatever your scoring method is, i assume it takes a while.....
15:35 < kanzure> *algorithm
15:35 < kanzure> and once you figure out a way you like for it to get unstuck, then add the molecule evaluation back into it
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15:43 < nmz787_w> so is Pieter@Waag.org a troll?
15:44 < nmz787_w> I have held off on saying more on the recent diybio thread... cause maybe he's travelling or busy or something
15:45 < kanzure> yes it's trolly
15:45 < kanzure> even if he isn't a troll himself
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15:55 < cluckj> I've held off saying anything in that thread
15:56 < kanzure> good
15:56 < cluckj> yes
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15:59 < cluckj> I haven't seen any evidence of it in the US, but that doesn't mean anything
15:59 < cluckj> I checked with some other researchers in the EU and they haven't seen anything
16:02 < genehacker> it is hard finding an equivalent test problem
16:03 < genehacker> I am running a simpler molecule test problem though
16:03 < genehacker> MD run time isn't too bad
16:04 < kanzure> ah.
16:21 < kanzure> fenn: rasch/eleitl paper was "Vitrification enhancement by synthetic ice blocking agents" (1999) http://www.sciencedirect.com/science/article/pii/S0011224000922430
16:25 < kanzure> genehacker: some hypertelescope stuff "Self-deployed extremely large low mass space structures" http://www.niac.usra.edu/files/library/meetings/fellows/mar07/1314Crowe.pdf
16:25 < kanzure> (2007)
16:29 < nmz787_w> cluckj: I was thinking that he in fact might be trying to start this meme...
16:29 < nmz787_w> cluckj: meaning he himself is the hijacker
16:45 < superkuh> https://www.youtube.com/watch?v=AsCgcyq7GN8 - The new GITS trailer confirms they went and ruined it with a crappy "victim complex"/robocop storyline.
16:46 < kanzure> maybe there will be a fan cut later
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17:10 < streety> on the subject of large and light space structures has anyone seen http://www.nature.com/news/what-it-would-take-to-reach-the-stars-1.21402
17:10 < streety> not very large, but certainly light for what they want to do
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17:15 < superkuh> I've wondered how they plan on receiving the signal sent back by such a device.
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17:30 < streety> "Starshot leaders acknowledge that they are counting on breakthroughs from the laser industry." ?
17:30 < streety> does seem unlikely that a <1 g nuclear battery will be able to power much of a return signal
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18:39 < cluckj> nmz787, lol really?
18:40 < cluckj> it sounded like he was just worried unnecessarily
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18:51 < fenn> huh i knew chris rasch was into cryonics but i didn't realize he actually did research
18:52 < kanzure> didn't you live with the guy
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18:53 < fenn> yes for a short while
18:53 < fenn> we had a little warehouse next door to hacker dojo
18:56 < kanzure> meetlog is theoretically supposed to prevent situations like this
18:56 < kanzure> maybe i should turn it into a game of 20 questions to identify mutual interests
18:56 < kanzure> and then i can proactively inflict this as a weapon on everyone i know in n**2 rounds
18:57 < kanzure> also this would have prevented the robert mcintyre disaster
19:00 < fenn> "disaster"
19:00 < kanzure> i talked with him about pokemon in 2012 instead of cryonics and vitrification
19:00 < heath> today i found out a friend of ours from this channel was born and raised in a labor camp
19:01 < fenn> what is a labor camp?
19:01 < heath> prison camp
19:01 < kanzure> and then actually talked with him december 2015 about relevant things
19:01 < kanzure> if it's the korean, he's just lying to you to get money
19:01 < kanzure> long-term stalker yo
19:01 < heath> it's not
19:04 < kanzure> old name
19:04 < kanzure> haven't heard that name in a long time
19:07 < kanzure> i think greg proposed some sort of "20 questions" game
19:07 < kanzure> based on previous tags from my data set
19:07 < fenn> anti-pigeonholing protocol
19:08 < kanzure> if i am okay with the selection bias from the following proposal, i could have it a self-fill webform that folks could voluntarily fill out :P
19:09 < fenn> ideally we'd all have compatible microformat interests and preferences listed on our home pages
19:09 < kanzure> actually i never really processed my notes from that conversation...
19:10 < cluckj> hah
19:10 < kanzure> "meetlog for having someone having a perfect knowledge;  so decompose it into an orthogonal basis of collected knowledge.  which topics synergize well in multiple people.  wave mechanics and non-linear resonators at the same time."
19:11 < fenn> i think it would take me some number of years just to get a complete list of interests written down
19:11 < kanzure> .title https://www.vahala.caltech.edu/Research/Nonlinear
19:11 < yoleaux> Nonlinear Resonators: Introduction - Caltech Vahala Research Group
19:11 < kanzure> the problem with vague broad tags is that it hides all the relevant things
19:11 < kanzure> "biology" is meaningless but it's super helpful to tell someone about induced pluripotency
19:12 < fenn> you heartless robot how can you say biology is meaningless
19:12 < kanzure> now what is a non-linear resonator and why did it come up in conversation with greg
19:13 < fenn> it's a vague and broad label
19:13 < kanzure> he also gets excited about phased-lock loops
19:13 < kanzure> *phase-locked loops
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19:14 < kanzure> yeah i am not finding anything about nonlinear resonators on google
19:15 < fenn> i imagine it's something like a laser with frequency doubling
19:15 < kanzure> "if we both know the exact same things, there's no purpose to communicate. you want a graph structure that has good fan out properties and people can have base pieces of knowledge, and they overlap with other people who they talk to, who have common pieces and different pieces, and the graph rapidly fans out and mixes with only a few hops. expander graph."
19:16 < kanzure> "20 questions intro.  what are the information maximizing questions to ask. sum of entropy over tag set."
19:17 < kanzure> "extracting english language embeddings, map words into a 300 dimensional space, compute analogies with vector arithmetic, word pairs and word co-occurence, then minimize the words into some vector space where the words occur at their co-occurrence levels, then you can solve analogies with very high accuracy"
19:17 < fenn> that sounds like a painful process because the information maximizing questions are ideally 50% "don't care"
19:17 < fenn> because you're bisecting
19:17 < kanzure> yes i don't expect my victims to just sit there answering stupid questions; i guess i could be OK with a bias where i only talk with people that are okay with stupid questions :).
19:18 < cluckj> it's also insanely impossible, not even accounting for apathy
19:18 < kanzure> hm?
19:18 < fenn> the curse of the corners i think it's called
19:18 < fenn> high dimensional cubes have long diagonal dimensions
19:19 < cluckj> it's easy to fool a tree of 20 questions :P
19:19 < cluckj> but yeah, what fenn said
19:19 < kanzure> well, the tree can be rendered in real-time ish
19:19 < kanzure> doesn't have to be statically generated tree
19:20 < kanzure> or rather, question 2 can be picked based on answers to question 1
19:20 < fenn> "when the dimensionality increases, the volume of the space increases so fast that the available data become sparse. This sparsity is problematic for any method that requires statistical significance. In order to obtain a statistically sound and reliable result, the amount of data needed to support the result often grows exponentially with the dimensionality"
19:20 < kanzure> maybe a quick ranking tool would be easier: a user is given a list of tags, they are then asked to rank them 1 to 100 in some rapid UI as to their interest level.
19:21 < fenn> realistically i expect people will cluster naturally into a small number of clusters once you find the right projection
19:21 < kanzure> yes but that's only because people are boring
19:21 < kanzure> and awful
19:22 < kanzure> (if they weren't awful, then they would have a better sense of entropy and they wouldn't cluster so much...)
19:22 < cluckj> those tags are also going to be too vague to gather any statistically significant meaning
19:22 < kanzure> i have been trying to not write down general tags lately, it's difficult though
19:23 < fenn> i still think general tags are better than no tags
19:23 < kanzure> for example i'll try to write down "impact of alleles on population fitness" instead of only "population genetics"
19:23 < cluckj> ^
19:24 < kanzure> or "different selection strategies in evolutionary search algorithms" (e.g. more phrases than just simple tags)
19:24 < fenn> title, abstract, and keywords are solutions to different problems
19:24 < kanzure> i forgot what the problem is
19:25 < cluckj> remembering what people talk about and are interested in?
19:25 < fenn> not being able to model other peoples' states of knowledge
19:26 < kanzure> yeah it was definitely something about state/persistence i think
19:26 < cluckj> I try to think of my field notes (which do this) as a device to remind myself of conversations I've had
19:26 < cluckj> it works....okay
19:26 < fenn> you should do graduated interval repetition of reading your field notes
19:27 < cluckj> of course
19:27 < fenn> "of course" but nobody actually does that
19:27 < fenn> even though it would be super useful
19:27 < kanzure> your field notes aren't that long, just re-read the whole thing every 3 months
19:28 < cluckj> my field notes aren't that long, per se, but the stuff they index is enormous
19:28 < kanzure> my yaml file is 5.4 MB but only 544,000 words including all markup
19:28 < fenn> it's more important to re-read recent stuff
19:28 < kanzure> 566,000 words
19:28 < cluckj> fenn, it's a pretty standard practice to re-read field notes when writing them up
19:28 < fenn> in a systematic way?
19:28 < cluckj> yep
19:29 < fenn> what's the system?
19:29 < kanzure> i don't believe that.   we would see people reading each other's field notes, instead of reading their own field notes.
19:29 < cluckj> reading someone else's field notes is an exercise in futility because they're a triggering system for memories
19:33 < fenn> "Crystallization of ice on borosilicate glass in contact with cryoprotectant solutions was inhibited by only 1 ppm of PVA copolymer."   that's pretty impressive
19:33 < cluckj> fenn, mine is: write quick notes by hand in the book, type notes into the computer and annotate (add other interesting things I remember), sleep, annotate again, repeat until you figure something out:[compare with other notes about similar things, write connections between observations in the notes, connect to social theory]
19:34 < fenn> cluckj: how do you end up reading something months and years later though?
19:35 < cluckj> like in the handwritten part?
19:36 < fenn> i'm proposing that there's a system that algorithmically reminds you at the right time for maximum memory retention
19:36 < cluckj> ah
19:36 < fenn> you said people actually do this (i think we are miscommunicating though)
19:36 < cluckj> I think so too
19:36 < kanzure> with the right brain lesion you might be able to stop forgetting, would that be sufficient
19:37 < fenn> no, i'd prefer to have some small amount of control over what gets forgotten
19:37 < kanzure> i emailed some of the hyperthymesia researchers the other evening, one of them replied "why would you suspect that dna sequencing would reveal anything?" in a lengthy email
19:37 < kanzure> and another replied "Genetic studies have begun" in a super short email :)
19:38 < fenn> ffs everything is genetic when you get down to it
19:38 < kanzure> hyperthymesia might not be inherited, tho, she has a point
19:38 < cluckj> I do look at my notes frequently when I'm working on a particular project, or going back to one, or get towards the end (to 'prove' what I'm suggesting I saw was actually there and not a construction of the process itself)
19:38 < kanzure> .wik hyperthymesia
19:38 < yoleaux> "Hyperthymesia is the condition of possessing an extremely detailed autobiographical memory. People with hyperthymesia remember an abnormally vast number of their life experiences." -- https://en.wikipedia.org/wiki/Hyperthymesia
19:39 < fenn> if you don't dump a piece of knowledge into your graduated interval reminder system, you'll be more likely to forget it
19:39 < fenn> vs one you are intentionally reminded of multiple times
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19:39 < kanzure> to me, hyperthymesia looks like some sort of compulsion to recall dates and autobiographic detail
19:39 < cluckj> yeah, I've had that happen to me from when I was first figuring out field notes
19:40 < kanzure> and the compulsion seems to be constantly executing in the background
19:40 < fenn> not from what i've read
19:40 < fenn> they remember all sorts of crap like the texture of the paint on the sign while entering a building
19:41 < kanzure> the date/day stuff seems a little weird to me; i often go for weeks without knowing what day it is. how do these people remember that?
19:41 < fenn> it's just that dates are easy for other people to cross check
19:42 < kanzure> so there are other people walking around with good memories, but it's harder to check because no dates, thus they are less reported?
19:42 < cluckj> it would be interesting to see how folks with hyperthymesia index their memories without dates
19:43 < fenn> no i'm saying that dates are used as anecdotal information because it's easier to verify that january 28 1985 was a tuesday than it is to verify that a particular sign had a paint chip missing on the lower left hand corner
19:43 < kanzure> hyperthymesia people should be given body cams and the footage should only be viewable to the researchers
19:43 < kanzure> wait why aren't there hyperthymesia/bodycam studies
19:43 < cluckj> lol
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19:44 < kanzure> you can even let them turn off the bodycam whenever they want
19:44 < fenn> i doubt there are enough of them to do studies on
19:44 < cluckj> that hasn't stopped science before!
19:44 < fenn> "25 cases of hyperthymesia have been confirmed in peer-reviewed articles"
19:44 < kanzure> well... shit.
19:45 < cluckj> call it a pilot study
19:46 < fenn> it seems to happen at around age 12-15
19:46 < cluckj> sample size of 30 is pretty good for anthropology, with 2-3 hour interviews each
19:48 < fenn> i find it strange that hyperthymesia was 'discovered' only recently
19:49 < kanzure> what about that synesthesia remembering person from a long while back
19:49 < kanzure> shesesekektehevo or whatever
19:50 < kanzure> shestakov
19:50 < fenn> shesek is loquat in hebrew :P
19:50 < fenn> .wik shestakov
19:50 < yoleaux> "Shestakov (Russian: ?????????, ?????????) is a Russian surname, and it may refer to:" -- https://en.wikipedia.org/wiki/Shestakov
19:50 < kanzure> no... hrm.
19:51 < kanzure> .wik solomon shereshevsky
19:51 < yoleaux> "Solomon Veniaminovich Shereshevsky (Russian: ??????? ???????????? ???????????; 1886-1958), also known simply as '?' ('Sh'), 'S.', or Luria's S was a Russian journalist and mnemonist active in the 1920s." -- https://en.wikipedia.org/wiki/Solomon_Shereshevsky
19:53 < fenn> "ivefold synaesthesia, in which the stimulation of one of his senses produced a reaction in every other. For example, if Shereshevsky heard a musical tone played he would immediately see a colour, touch would trigger a taste sensation, and so on for each of the senses"
19:54 < docl> it would be cool to find a way to remember/efficiently absorb all these math and science books I try to photoread.
19:56 < fenn> i wouldn't want to be like shereshevsky
19:59 < docl> are there drugs/halucinogens that produce effects close to synesthesia?
20:00 < kanzure> maybe the genome data from "long life family study" is publicly available, we could go hunting i guess
20:01 < kanzure> "Number of study subjects that have individual level data available through Authorized Access: 4835"
20:01 < kanzure> wtf is "authorized access"
20:02 < kanzure> ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000397/phs000397.v1.p1/
20:03 < kanzure> ftp://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000397/phs000397.v1.p1/release_notes/Release_Notes.phs000397.CIDR_LLFS.v1.p1.MULTI.pdf
20:05 < kanzure> so basically no public data
20:14 < kanzure> oh here's a good study:
20:14 < kanzure> "The cingulate cortex of older adults with excellent memory capacity" http://www.sciencedirect.com/science/article/pii/S0010945216303239
20:14 < kanzure> "Some older adults, known as "Supernormals", maintain excellent memory. This study examined relationships between cerebral amyloid deposition and functional connectivity (FC) within the cingulate cortex (CC) and between CC and other regions involved in memory maintenance between Supernormals, healthy controls (HC), and those at risk for AD (amnestic mild cognitive impairment [MCI]). Supern...
20:14 < kanzure> ...ormals had significantly stronger FC between anterior CC and R-hippocampus, middle CC (MCC) and L-superior temporal gyrus, and posterior CC (PCC) and R-precuneus, while weaker FC between MCC and R-middle frontal gyrus and MCC and R-thalamus than other groups. All of these FC were significantly related to memory and global cognition in all participants. Supernormals had less amyloid deposition ...
20:14 < kanzure> ...than other groups. Relationships between global cognition and FC were stronger among amyloid positive participants. Relationships between memory and FC remained regardless of amyloid level. This revealed how CC-related neural function participates in cognitive maintenance in the presence of amyloid deposition, potentially explaining excellent cognitive function among Supernormals."
20:17 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/memory/The%20cingulate%20cortex%20of%20older%20adults%20with%20excellent%20memory%20capacity%20-%202016.pdf
20:22 < kanzure> oh this is just more MRI >:(
20:23 < kanzure> what do people have against collecting and analyzing dead brains?
20:26 < kanzure> probably that document is more useful for its references :(
20:33 < kanzure> http://www.mpi.nl/departments/language-and-genetics/projects/decoding-the-genetics-of-synaesthesia/genetics-of-synaesthesia
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20:43 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=721a50e4 Bryan Bishop: more longevity mutations, particularly in OBFC1 >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
20:44 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8af72cab Bryan Bishop: fix formatting >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
20:45 < kanzure> human OBFC1 http://www.proteopedia.org/wiki/index.php/4jqf
20:46 < kanzure> "Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolis...
20:46 < kanzure> ...m at non-telomeric sites."
20:51 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=03acf5f4 Bryan Bishop: also KLOTHO of course >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
20:56 < kanzure> what's weird about genetic-modifications.mdwn is that these are only natural variants, and not much thought has been put into optimizing these mutations or looking at what they actually do on a mechanistic level
20:57 < kanzure> dna binding pockets are very very optimizable
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