--- Log opened Wed Mar 01 00:00:46 2017
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02:56 < archels> hrm, what's that website/forum again where people discuss publications?
02:56 < chris_99> researchgate?
03:17 < archels> jrowe47_away: not a tDCS user but I'm designing a tDCS/ACS/RNS device
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03:19 < archels> chris_99: that's not really for discussion though, is it?
03:20 < chris_99> i think it seems to have discussions too, but i've not used it
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03:40 < archels> .title http://journal.frontiersin.org/article/10.3389/fnhum.2017.00077/full
03:40 < yoleaux> Frontiers | Moral Enhancement Using Non-invasive Brain Stimulation | Frontiers in Human Neuroscience
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04:21 < kanzure> archels: pubpeer
04:23 < chris_99> ooh
04:23 < chris_99> that looks handy
04:23 < kanzure> it's a shitposting zone
04:23 < chris_99> oh
04:24 < kanzure> yea, turns out that science sucks under the hood
04:24 < chris_99> heh
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05:50 < kanzure> .title https://news.ycombinator.com/item?id=13756489
05:50 < yoleaux> Deep Voice: Real-Time Neural Text-To-Speech | Hacker News
05:51 < kanzure> http://research.baidu.com/deep-voice-production-quality-text-speech-system-constructed-entirely-deep-neural-networks/
05:52 < kanzure> tensorflow implementation of baidu deepspeech https://github.com/mozilla/DeepSpeech
05:53 < kanzure> https://developer.mozilla.org/en-US/docs/Web/API/SpeechRecognition
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06:27 < archels> kanzure: that's it! cheers
06:29 < archels> hmm, their search function is really bad--no search by author name, just PMID/DOI
06:40 < kanzure> i think pubpeer has a bright future as the 4chan of researcher shitposting
06:52 < adlai> 20:32:03 C0MPAQ: "I wonder if transferrring consciousness into a computer might actually work one day"  <<  what is this 'consciousness' you speak of, sounds interesting
06:58 < kanzure> 404 not found
06:59 < adlai> HTTP 666 UNLANGUAGABLE QUALIUM
07:00 < adlai> btw, i watched arrival. if you haven't yet, don't.
07:00 < adlai> (unless you're a glutton for hollywoodization... they removed everything that was good about the story and just made it an average action/scifi/"mindfuck" movie that DOESN"T EVEN DO THE MAIN MINDFUCK OF THE STORY)
07:01 < adlai> not once in the movie does anybody say the words "fermat", "variational", "stationary", but they did throw in "kanguru" because the target audience is just barely literate enough for a pun
07:03 < kanzure> thanks for being the guinnea pig
07:06 < kanzure> your sacrifice will not be forgotten
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07:50 < JayDugger> Damn, that means he's exempt from being the token viewer for the live-action GitS?
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08:07 < kanzure> i'm sure we will find a victim^W^W^W^Wvolunteer
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08:41 < archels> I acknowledge that use of this tool does not result in article submission for publication and does not guarantee publication in IEEE Xplore(R).
08:41 < archels> I UNDERSTAND
08:41 < archels> via http://publication-recommender.ieee.org/
08:50 < archels> [BThe American Institution of Physics
08:50 < archels> This website is currently unavailable due to technical difficulties, which we are working to fix. We apologize for this downtime and hope to restore access to the site as soon as possible.
08:50 < kanzure> as they say, publish or perish
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09:00 < kanzure> akisoolhando: hello
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10:22 < kanzure> "Holocene selection for variants associated with cognitive ability: Comparing ancient and modern genomes" http://biorxiv.org/content/early/2017/02/20/109678
10:22 < kanzure> "... genetic variants associated with higher general cognitive ability (GCA). Population expansion and replacement has also been proposed as an important source of GCA gene-frequency change during this time period. To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4,557 to 1,208 years of age) with a sample of 503 moder...
10:23 < kanzure> ...n European genomes, using three different cognitive polygenic scores. Significant differences favouring the modern genomes were found for all three polygenic scores (Odds Ratio=0.92, p=0.037; 0.81, p=0.001 and 0.81, p=0.02). Furthermore, a significant increase in positive allele count over 3,249 years was found using a sample of 66 ancient genomes (r=0.217, p one-tailed=0.04). These observatio...
10:23 < kanzure> ...ns are consistent with the expectation that GCA rose during the Holocene."
10:24 < kanzure> "(imagine trying to do nuclear arms control if every single atomic bomb was walking around, having kids, and regularly shed skin cells which could be turned into new atomic bombs)"
10:24 < kanzure> from https://news.ycombinator.com/item?id=13759949
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12:19 < kanzure> igem 2017 team registration is now open http://2017.igem.org/Competition/Registration
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14:14 < kanzure> hrm
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14:22 < redlegion[m]> Great, now I'm trawling "Retraction Watch". Pubpeer is just a gateway drug.
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14:51 < maaku> biocurious is moving to my neighborhood! awesome. i will do what I can to support them
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16:54 < andytoshi> are people here familiar with  https://examine.com/supplements/noopept/  ?
16:55 < andytoshi> someone had suggested i look into Phenylpiracetam but this is no longer sold by liftmode, while this thing is
17:04 < kanzure> https://www.reddit.com/r/Transhuman/comments/5wzkmx/bioviva_is_starting_its_first_gene_therapy_clinic/
17:05 < kanzure> "As you have expressed a prior interest in either participating in potential trials or the availability of our therapies, we kindly ask that you complete a survey we have put together below. This will help inform us and provide us with important information on both demand and procedure."
17:05 < kanzure> https://goo.gl/forms/cbDmrcYDNOOQU6xu1
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17:15 < andytoshi> nice!
17:22 < fenn> i never noticed any effects from noopept at 10-20mg dosage, but then i never noticed any effects from piracetam either, unless it was combined with other drugs
17:23 < andytoshi> jcorgan had some positive things to say about piracetam, i wasn't clear if he'd used it but he said it was one of the few nootropics that i was likely to notice having acute effects
17:23 < fenn> it was easier to say precisely what i meant when on piracetam
17:24 < andytoshi> interesting.
17:24 < fenn> i also started perceiving the status game nature of social interactions by people around me
17:25 < andytoshi> hm, i get this from psychedelics sometimes, i don't really enjoy it
17:26 < fenn> so anyway if you do take noopepet, try it with caffeine or some other stimulant
17:26 < andytoshi> kk. i drink tea every day anyway
17:28 < fenn> there was a study where they restricted blood flow to cat brains to simulate brain trauma in i.e. a vehicle accident
17:28 < fenn> the cats that had received piracetam lasted 10x longer without suffering brain damage
17:29 < fenn> i thought this was enough of a reason to take piracetam
17:30 < andytoshi> heh, liftmode's site 404's on noopept even if you use the search function
17:31 < andytoshi> kanzure also mentioned huperzine "for dreams", what are your thoughts on this fenn ?
17:32 < fenn> i experienced a huge increase in dream retention after eating red palm oil
17:33 < fenn> it's currently not a thing i care about though
17:33 < andytoshi> interesting. i don't know if i care about it, i suspect it may be useful for general creativity to improve my interactions with dreams
17:35 < fenn> huperzine has a straightforward plausible mechanism for boosting memory and recall
17:36 < andytoshi> i'll give it a shot then if i'm going to order stuff from liftmode anyway
17:36 < andytoshi> though i won't until they deal with this 404 on noopept
17:36 < fenn> so if it doesn't do anything at low doses you can try it at higher doses and maybe get an idea of what it does
17:38 < fenn> i have some huperzine, i could try it again and see if i notice anything
17:39 < fenn> it's about bedtime for me
17:39 < andytoshi> that'd be cool. thanks for the help
17:44 < kanzure> how do you not care about dreams? do you just lay there bored for 12 hours a day?
17:44 < fenn> yes
17:45 < andytoshi> lol. i care a lot about dreams but they're not by themselves reason enough to try a new drug that might strain my cardiovascular system
17:45 < fenn> last night i dreamed about tunneling through a grid of blocks
17:46 < kanzure> anyway i am not particularly impressed by any of the available nootropics, nor have i heard any plausible chemical strategies to designing strongly effective nootropics
17:46 < fenn> "Huperzine-A is able to promote proliferation of hippocampal neural stem cells"  sounds useful
17:46 < kanzure> i have very little dream retention without huperzine a :(
17:48 < fenn> also a strategy to prevent quinolinic acid from building up in the first place would probably help a lot of people
17:49 < kanzure> i wonder if anyone has found a lucid dreaming SNP.   i bet people would pay for that one.
17:52 < fenn> beta-carboline suppresses the production of quinolinic acid
17:53 < fenn> "?-carboline is a benzodiazepine receptor inverse agonist and can therefore have convulsive, anxiogenic and memory enhancing effects"
17:54 < kanzure> "As a result of the presence of ?-carbolines in the cuticle of scorpions, their skin is known to fluoresce when exposed to certain wavelengths of ultraviolet light such as that produced by a blacklight."
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17:58 < fenn> you'd want some kind of cybernetic system diagram of the human nervous system, including all the neurotransmitters and neuromodulators
17:58 < fenn> then you'd want some kind of model of what "good function" looks like
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17:59 < kanzure> "then you'd want to remove everything and replace them with more relable components"
17:59 < fenn> and once you can run simulations with this setup you can decide what to try to change with potential new nootropic compounds
17:59 < fenn> yeah i always have to fight the urge to rip everything out and start over from scratch
18:00 < kanzure> we need potent nootropics that only work on specific neurons in specific areas of the brain, none of this "wash the entire brain with choline" shit
18:00 < fenn> agreed
18:00 < kanzure> i think this means some sort of multi-step chemistry where presence of 3 or 4 types of receptors would trigger some other nootropic effect, but not diffuse to the entire brain
18:01 < kanzure> .... probably simpler to put in a genetic regulatory network inside the cell that specifically senses what type of cell it is.   but you lose out on things like sensing the cellular neighborhood. :(
18:01 < fenn> you want something like FRET?
18:01 < kanzure> uhrm..
18:01  * kanzure looks
18:02 < kanzure> oh the fluorophore things
18:02 < kanzure> uhm. for nootropics?
18:02 < fenn> i think those have to actually be in physical contact
18:02 < fenn> 1-10 nm
18:03 < kanzure> i bet we can make a neurotoxic extremely potent dopamine blocker, but i bet it's totally useless when you wash it over the entire brain, there *must* be gating based on cell type or cellular neighborhood
18:04 < kanzure> the "designer drugs made exclusively for designer receptors" stuff is nice, but how many exclusive drugs and exclusive receptors can you really make, given the large quantity of neurons in the brain to target
18:05 < fenn> things like stimulating neurogenesis in various cell types are also available
18:06 < fenn> human glial cells are radically different from chimpanzee glial cells (?)
18:06 < fenn> "Adding human glial cells to mice brains found to improve memory and cognition"
18:06 < kanzure> at least it's not a humpster
18:07 < fenn> oh derp those were astrocyte precursor cells
18:07 < kanzure> yea maybe upregulation/downregulation of receptor types in specific neuron types will be good enough. "give me more serotonin receptors in glutamate neurons please".   but i still think this is insufficiently specific...
18:08 < fenn> getting even that level of control would be a triumph
18:09 < kanzure> .title http://openoptogeneticsblog.org/?tag=fret
18:09 < yoleaux> FRET | OpenOptogenetics
18:09 < kanzure> "Genetically encoded sensors for simultaneous monitoring of Cl- and H+"
18:11  * fenn sleeps
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18:32 < kanzure> RNAi instead of crispr for embryo stuff
18:34 < kanzure> .wik RNA interference
18:34 < yoleaux> "RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules." -- https://en.wikipedia.org/wiki/RNA_interference
18:34 < kanzure> i guess i'm misunderstanding something re: lifecycle of RNAi
18:41 < kanzure> i wonder what the half life really is
18:44 < kanzure> maybe an RNA interference virus.
19:22 < kanzure> .tw https://twitter.com/erowidrecruiter/status/834470320203444225
19:22 < yoleaux> We're looking to create a trading platform for Bitcoin that can last over 24hrs. (@erowidrecruiter)
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19:24 < kanzure> .tw https://twitter.com/erowidrecruiter/status/833744530755117056
19:24 < yoleaux> Seuss creatures in trees, elves, gnomes, dwarves, pixies, demons, golems, all kinds of opportunities would interest you (@erowidrecruiter)
19:24 < kanzure> "A Markov-powered mashup of Erowid trip reports and tech recruiter emails."
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21:34 < superkuh> Probably already in the backlog but I didn't see it on a quick scan, http://stm.sciencemag.org/content/9/379/eaah4586 "Improved tissue cryopreservation using inductive heating of magnetic nanoparticles"
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--- Log closed Thu Mar 02 00:00:47 2017