--- Log opened Thu Mar 02 00:00:47 2017
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01:53 < archels> .title www.sci-hub.cc
01:53 < yoleaux> Sci-Hub: removing barriers in the way of science
01:53 < archels> oh, works now
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04:43 < kanzure> oh because you need to have even heating/thawing of cryopreserved tissue
04:43 < kanzure> mike darwin's suggestion was something about rapid heat transfer using gas
04:43 < kanzure> "Organ transplantation is limited by the availability of viable donor organs. Although storage at very low temperatures (cryopreservation) could extend the time between organ harvest and transplant, the current gold standard for rewarming (convection) leads to cracking and crystallization in samples larger than a few milliliters. Manuchehrabadi et al. demonstrate the rewarming of cells and tis...
04:43 < kanzure> ...sues by radiofrequency inductive heating using magnetic nanoparticles suspended in a cryoprotectant solution. This nanowarming technique rapidly and uniformly rewarmed cryopreserved fibroblasts, porcine arteries, and porcine heart tissues in systems up to 50 ml in volume, yielding tissues with higher viability than convective rewarming."
04:43 < kanzure> "Vitrification, a kinetic process of liquid solidification into glass, poses many potential benefits for tissue cryopreservation including indefinite storage, banking, and facilitation of tissue matching for transplantation. To date, however, successful rewarming of tissues vitrified in VS55, a cryoprotectant solution, can only be achieved by convective warming of small volumes on the order of...
04:44 < kanzure> ... 1 ml. Successful rewarming requires both uniform and fast rates to reduce thermal mechanical stress and cracks, and to prevent rewarming phase crystallization. We present a scalable nanowarming technology for 1- to 80-ml samples using radiofrequency-excited mesoporous silica-coated iron oxide nanoparticles in VS55."
04:44 < kanzure> "Nanowarming was then used to demonstrate uniform and rapid rewarming at >130?C/min in both physical (1 to 80 ml) and biological systems including human dermal fibroblast cells, porcine arteries and porcine aortic heart valve leaflet tissues (1 to 50 ml). Nanowarming yielded viability that matched control and/or exceeded gold standard convective warming in 1- to 50-ml systems, and improved vi...
04:44 < kanzure> ...ability compared to slow-warmed (crystallized) samples. Last, biomechanical testing displayed no significant biomechanical property changes in blood vessel length or elastic modulus after nanowarming compared to untreated fresh control porcine arteries. In aggregate, these results demonstrate new physical and biological evidence that nanowarming can improve the outcome of vitrified cryogenic s...
04:44 < kanzure> ...torage of tissues in larger sample volumes."
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06:34 < kanzure> http://www.wired.co.uk/article/human-genome-synthesise-dna
06:35 < kanzure> " Autodesk has pledged $250,000, but organisers want to secure $10 million by the end of 2017."
06:40 < kanzure> .tw https://twitter.com/MolochChan/status/580930500451274752
06:40 < yoleaux> Desiring To Immanentize The Eschaton. (@MolochChan)
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08:49 < kanzure> ugh more diybio spam
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09:04 < JayDugger> Hm...
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09:26 < kanzure> https://techcrunch.com/2017/03/01/how-synthegos-founders-went-from-a-mission-to-mars-to-a-mission-to-cure-disease/
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10:28 < cluckj> oh no bioethicists talking about diybio
10:28 < cluckj> oh noooooo
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10:37 < kanzure> kill em all
10:38 < cluckj> can't, I wasn't invited
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16:08 < kanzure> bloops
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19:01 < streety> bioethicists can be useful to have around. I've been at meetings where it has been the bioethicists arguing to take risks
19:01 < streety> not always the case but on occasion can be useful
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21:04 < kanzure> bloop
21:04 < kanzure> i don't want the ones that believe things should be quantiifed as risk
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22:13 < nmz787_> sup
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--- Log closed Fri Mar 03 00:00:48 2017