--- Log opened Thu Apr 13 00:00:25 2017
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04:58 < ki_> I have a question , can I do Deauth Attack on all mac adresses in Acces Point , but exception a specific Mac I don't death it ?
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06:21 < kanzure> hi eudoxia
06:22 < eudoxia> hi kanzu
06:25 < kanzure> greeting process completed
06:28 < eudoxia> ack greeting process completion
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07:17 < kanzure> "Modulation of genome editing outcomes by cell cycle control of cas9 expression" http://biorxiv.org/content/early/2017/04/12/127068
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07:17 < kanzure> "Targeting specific chromosomal sequences for genome modification or regulation during particular phases of the cell cycle may prove useful in creating more precise, predictable genetic changes. Here, we present a system using a fusion protein comprised of a programmable DNA modification protein, Cas9, linked to a cell cycle regulated protein, geminin, as well as green fluorescent protein (GFP...
07:17 < kanzure> ...) for visualization. Despite the large size of Cas9 relative to geminin, cells were observed to express Cas9-GFP-geminin at levels which oscillate with the cell cycle. These fusion proteins are also shown to retain double-strand break (DSB) activity at specific chromosomal sequences to produce both indels and targeted integration of donor ssDNA. Most importantly, the ratio of ssDNA donor integ...
07:17 < kanzure> ...ration to non-homologous end joining (NHEJ) was observed to increase, suggesting that cell cycle control Cas9 expression may be an effective strategy to bias DNA repair outcomes."
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08:46 < kanzure> .wik blindsight (watts novel)
08:46 < yoleaux> "Blindsight is a hard science fiction novel by Canadian writer Peter Watts, published by Tor Books in 2006. It garnered nominations for a Hugo Award for Best Novel, a John W. Campbell Memorial Award for Best Science Fiction Novel, and a Locus Award for Best Science Fiction Novel." -- https://en.wikipedia.org/wiki/Blindsight_(Watts_novel)
08:46 < kanzure> http://www.rifters.com/real/Blindsight.htm
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10:10 < kanzure> "Frequency Therapeutics [...] small molecule drugs to stimulate the regrowth of the sensory hair cells in the inner ear or cochlea that can be damaged by sustained exposure to loud noise"
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10:36 < cluckj> I need some of that
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11:45 < bluebear_> kanzure: ad Blindsight, beware, it's pretty depressing
12:10 < kanzure> synbiobeta conference is upcoming http://sb7.info/
12:10 < kanzure> in singapore.
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13:10 < jcorgan> hmm
13:10 < jcorgan> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944490/
13:11 < jcorgan> read meat consumption correlated with telomere length
13:12 < jcorgan> kinda shitty typical nutrition study relying on self-reported food questionaires
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13:32 < kanzure> satori_: hi.
13:32 < satori_> hiya
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15:05 < kanzure> "Cassini finds molecular hydrogen in the Enceladus plume: Evidence for hydrothermal processes" http://science.sciencemag.org/content/356/6334/155
15:06 < kanzure> .title https://news.ycombinator.com/item?id=14107727
15:06 < yoleaux> Mimicking an impact on Earth's early atmosphere yields all 4 RNA bases | Hacker News
15:08 < cevi_> new plan for diy RNA synthesis: carefully timed asteroid impacts
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15:19 < kanzure> ya, we need to shoot lasers at distant objects and do atmospheric chemistry
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16:45 < kanzure> dingo: hi
17:02 < dingo> hello
17:03 < dingo> i don't normally irc from work but i needed support from #synergy so i thought I'd drop by and say hello while I'm here on freenode
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17:16 < kanzure> "Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244695/
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17:42 < FourFire> kanzure, what methods have been proposed in the direction of breeding bacteria to kill off multi resistant bacterial infections?
17:44 < FourFire> There's ways to evolve a tool organism against a target organism with an uneven ratio of "evolutionary surface area" right?
17:45 < kanzure> there are various next generation antibiotics, do those count?
17:46 < FourFire> do they work?
17:46 < FourFire> All of the antibiotic research graphs I've seen seem pretty gloomy
17:47 < kanzure> i haven't looked in a while.   iirc there was a lot of complaints about bacterial resistance to commercialized antibiotics.
17:48 < FourFire> I've heard bad things like, people with influenza being given antibiotics
17:49 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b0307b96 Bryan Bishop: anti-myopia and mouse memory genetics >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
17:49 < FourFire> Meat industry animals being dosed by default and so on
17:51 < cevi_> I would think (or hope) that multi-resistant bacteria have to pay for the resistance by losing fitness elsewhere
17:51 < cevi_> so maybe just leaving them to compete with non-resistant bacteria would get rid of them
17:51 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2693b24b Bryan Bishop: some more eyesight TODO items >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
17:51 < kanzure> cevi_: the time for that to play out might be longer than your lifespan :)
17:52 < kanzure> e.g. if the advantage is sufficiently tiny then the advantage might show up only over 10^7 generations
17:54 < FourFire> cevi_, I was thinking specifically, actively evolving "bacteria predating bacteria" against multi resistant bacteria
17:55 < cluckj> in 10^7 bacterial generations we will just be filtering them out in our transporter pattern buffers :P
17:55 < FourFire> I thought that if you had, maybe one cell line of multi-resistant bacteria which you leave in a low evolutionary pressure environment, then take multiple consecutive samples, let's call that Gen 1
17:56 < kanzure> FourFire: fwiw there were some predatory bacteria proposals in some igem projects
17:56 < kanzure> like "colon inflammation sensor, and ecoli to attack Clostridium difficile pathogens" http://2012.igem.org/Team:Dundee
17:57 < FourFire> And pit it against your pet/tool bacteria which starts as something benign that lives in or on the human body
17:57 < kanzure> "selective colonization of human wounds by an engineered microorganism to prevent subsequent infection by pathogens" http://2014.igem.org/Team:Auckland_New_Zealand/Project
17:57 < kanzure> "genetic circuit enabling Bacillus subtilis to detect and kill pathogens such as Staphylococcus aureus and Streptococcus pneumoniae" http://2014.igem.org/Team:LMU-Munich/Project/Bakillus
17:57 < FourFire> And then you make successive generations of that compete with repeated samples of the same Gen 1 multiresistant bacteria
17:57 < kanzure> "delivery of a method of silicing of antibiotic resistance genes in pathogens" http://2014.igem.org/Team:Waterloo
17:58 < kanzure> "sensor of high pathogen cell density and release of batericidal alyteserin, including release of a peptide to neutralize the activity of anti-microbial peptides" http://2015.igem.org/Team:IIT_Madras/Description
17:58 < kanzure> "pathogenic bacteria to infect tumors (anaerobic tumor cores) in human bodies" http://2015.igem.org/Team:SPSingapore/Project
17:58 < kanzure> "artificial pathogen against H. pylori ulcers in human stomach" http://2015.igem.org/Team:ATOMS-Turkiye/Project
17:58 < FourFire> kanzure, does the method I suggest make sense and/or is there a much better way to do the same thing?
17:59 < kanzure> see others here http://diyhpl.us/wiki/dna/projects/#igem-2014
18:00 < kanzure> dunno, antibiotic resistance is not necessarily something that a cell would display on its surface. you want a biosensor of resistance ? i mean.. if it's still alive, it's resistant i guess.
18:00 < cluckj> ^
18:00 < cevi_> possible problem: the predator bacteria gets killed off by antibiotics
18:01 < FourFire> Great. I'm meeting with some Biohacking-interested people in Oslo sometime this month to see if they want to join a regular biohacking effort at the local hackerspace
18:01 < cluckj> cevi_, that's kinda how c diff infections happen
18:02 < FourFire> kanzure, nah i don't want a sensor of resistance, that
18:02 < cluckj> something screws up the intestinal environment to make it less favorable to friendly lactobacilli and e coli, and more favorable to c diff
18:02 < FourFire>  is easy enough to detect with medical methods
18:02 < FourFire> I want a weapon of last resort to known resistant infections
18:02 < FourFire> a nuke if you will, for biology gone wrong.
18:03 < kanzure> ok first of all it's resistant by definition, so you can't fight your own definitions
18:03 < cluckj> lol
18:03 < cluckj> and all resistance is not created equal, metabolically speaking
18:03 < FourFire> Accidental Bio X-risk is pretty scary and I'd feel better if I knew there were ways that people were working on to make it less of a prospect.
18:04 < kanzure> if you are specifically interested in human infections that are resistant to currently-commercialized antibiotic medication, then there's a bunch of on-the-horizon antibiotics you could investigate
18:04 < FourFire> ok
18:04 < FourFire> I don't currently have a personal reason to be interested.
18:05 < FourFire> Actually I've got more of a personal interest in antiviral techniques
18:06 < FourFire> if you take a vaccine for a particular viral infection, and then an antiviral drug for that same vector, is there an added benefit, or is there no point?
18:06 < cluckj> kinda redundant
18:06 < FourFire> (or is all added benefit only due to evolutionary driven variations in the virus in question?)
18:07 < cluckj> vaccines are extremely effective because they end up destroying viruses before they have time to evolve
18:08 < cluckj> some of the antibiotic vaccines work the same way
18:09 < FourFire> is there any point in taking a vaccine for an infection you already have?
18:09 < cluckj> yeah
18:09 < FourFire> or are Antiviral drugs the only thing to do then?
18:12 < cluckj> they work in different ways, iirc there was some research about hpv and varicella vaccines being very helpful even after infection
18:12 < cluckj> I think the reasoning was that vaccines make the immune system more effective at fighting the infection
18:13 < FourFire> mhm
18:13 < FourFire> yes, whereas the antiviral is a onetime agent which breaks a bunch of viral particles
18:14 < cluckj> yeah, it will only help destroy an existing infection (and not do a lot for immunity)
18:15 < cluckj> if a pathogen is recognized and destroyed by the immune system before it causes infection, there's less chance of it becoming resistant to the vaccine because if it can't grow there's no selection pressure
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18:17 < FourFire> wait, infection has a formal definition relating to invasion of cells or tissues in particular?
18:18 < FourFire> I just thought it was "bad self replicating thing is inside body and will cause damage"
18:19 < cluckj> in regards to viruses, they have to get inside cells to do any damage
18:20 < kanzure> i dunno if we have an immune system person hanging out in here, i mean maybe derya unutmaz but i haven't seen him in forever
18:21 < FourFire> "will cause damage" as opposed to "has already caused damage"
18:21 < cluckj> antibodies that get produced as a result of vaccines go after the viruses before they get into cells
18:21 < FourFire> yes I was just noticing that I have been using the wrong definition of "infection" until now and asking you to confirm.
18:22 < cluckj> oh
18:23 < cluckj> I think it depends on the infectious agent what the process is
18:25 < cluckj> for viruses it's when the virus gets into a cell, for bacteria it's whenever they get into your body?
18:26 < kanzure> what was the kent kemmish proposal for immune system upgrades and directed evolution.
18:27 < cluckj> the cell-on-chip one?
18:28 < kanzure> the giant factory thing, from a facebook post
18:28 < kanzure> one of those manic "okay here is how you solve everything" posts
18:29 < cluckj> yeah
18:29 < cluckj> lol
18:31 < kanzure> ah, here we go
18:31 < kanzure> https://www.facebook.com/kent.kemmish/posts/10101875737533842
18:31 < kanzure> "I'm pretty sure I've figured out the most direct and likely to work path toward curing all diseases for everyone on earth safely and affordably in the shortest amount of time."
18:32 < kanzure> "Brace yourselves. Here's the plan. It's going to blow your fucking mind."
18:32 < kanzure> "We will build a series of massive largely automated research facilities in which we will guide the evolution of molecular constructs delivered to autologously derived organ systems on chips."
18:32 < kanzure> "We will design our monolithic industrial facilities for a total capacity of trillions of individually addressable and manipulable organ systems, theoretically enabling throughput levels at which every human being on earth would be biomedically represented by hundreds of autologously derived organ systems each grown under different experimental conditions and subjected to continuous massively ...
18:32 < kanzure> ...high-throughput pharmacological engineering guided by comprehensive molecular, cellular, and physiological characterization."
18:32 < kanzure> "The spark that makes it magical to be able to play with trillions of bodies on chips is the idea of iterated molecular evolution. Drugs don't have to be small molecules. Drugs can be things we digitally specify, like DNA molecules. And if your drugs can be linked to a code that produces them, that code can be improved through evolution, blind and/or intelligently directed."
18:33 < cluckj> yeesh
18:34 < cluckj> that might work exceptionally well for certain diseases
18:34 < kanzure> if we had more immune system people in here, they would probably be going on a rant around ~now ish regarding reprogrammable immunity and bone marrow transplants and the more recent magic tricks.
18:34 < cluckj> yes
18:37 < kanzure> someone forgot to renew immunepath's domain name
18:38 < kanzure> oh schloendorn is an advisor to liz now https://bioviva-science.com/advisory-board/
18:39 < kanzure> "Immusoft, a biotech start-up firm that is developing a breakthrough technology that will turn a patient's B cells into miniature drug factories"
18:46 < kanzure> i don't seem to have much on post-antibiotic antibiotics. hrm.
18:48 < cluckj> :<
18:50 < cluckj> what constitutes a post-antibiotic antibiotic?
18:51 < cluckj> like...not-a-medicine?
18:52 < cevi_> faith healing
18:52 < cluckj> crystals?
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20:41 < kanzure> "A systematic review and critical assessment of incentive strategies for discovery and development of novel antibiotics" http://www.nature.com/ja/journal/v69/n2/full/ja201598a.html
20:43 < kanzure> FourFire: https://scholar.google.com/scholar?cites=10939100726716550670&as_sdt=5,44&sciodt=0,44&hl=en
20:44 < kanzure> "Recent advances in the rational design and optimization of antibacterial agents" https://www.researchgate.net/profile/Kirk_Hevener/publication/305077017_Recent_Advances_in_the_Rational_Design_and_Optimization_of_Antibacterial_Agents/links/578cffac08ae7a588ef3d825.pdf
21:26 < kanzure> "narrow-spectrum"
21:27 < kanzure> i wonder if chirality (including our entire food chain, blood, everything in the body, etc.) would be enough to stop infectious bacteria.
21:33 < kanzure> "Novel genetic findings in an extended family pedigree with sleepwalking" http://www.neurology.org/content/76/1/49.short (2010)
21:33 < kanzure> ".. we describe the first genetic locus for sleepwalking at chromosome 20q12-q13.12."
21:39 < kanzure> sleepwalking dog https://www.youtube.com/watch?v=z2BgjH_CtIA
21:48 < kanzure> "In 1959 Michel Jouvet conducted several experiments on cats regarding muscle atonia (paralysis) during REM sleep. Jouvet demonstrated that the generation of REM sleep depends on an intact pontine tegmentum and that REM atonia is due to an inhibition of motor centres in the medulla oblongata. Cats with lesions around the locus coeruleus have less restricted muscle movement during REM sleep, an...
21:48 < kanzure> ...d show a variety of complex behaviours including motor patterns suggesting that they are dreaming of attack, defence and exploration."
21:48 < kanzure> ( https://www.youtube.com/watch?v=Js50Orx94iM )
21:51 < kanzure> "Electrical stimulation of the locus coeruleus area, however, always induced wakefulness."
21:51 < kanzure> jouvet was selectively cooling brain regions? http://www.sciencedirect.com/science/article/pii/0013469482900426
21:53 < kanzure> he also tested methlyphenidate, modafinil and amphetamine on cats and then did brain serial sectioning http://www.pnas.org/content/93/24/14128.short
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22:04 < kanzure> .tw https://twitter.com/RLCscienceboss/status/834083279880015872
22:04 < yoleaux> Scientists are looking to harvest therapeutic proteins from #geneticallyengineered animal slobber http://cen.acs.org/articles/95/web/2017/02/Harvesting-therapeutic-proteins-animal-slobber.html via @cenmag (@RLCscienceboss)
22:16 < kanzure> "Brain mechanisms that control sleep and waking" http://xinbo58.com/UserFiles/files/07_011_Brain%20mechanisms%20that%20control%20sleep%20and%20waking.pdf
22:25 < kanzure> O_O "From Delgado's exercise it is not clear whether caudate stimulation would be effective in inhibiting a strong form of directed behavior, such as attack, without using intensities that would cause motor freezing. My students and I explored this issue, albeit not as exotically as Delgado did. We implanted electrodes into the caudate nucleus and in a region of the hypothalamus that, when e...
22:26 < kanzure> ...lectrically stimulated, produced attack behavior in cats (Wasman and Flynn, 1962)."
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23:48 < jcorgan> kanzure, sometimes your reading interests cause me alarm :-)
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