--- Log opened Sun Apr 23 00:00:34 2017
00:16 < fenn> charlie manion
00:20 < fenn> "Carriers of a single Tay-Sachs allele do not exhibit symptoms of the disease but appear to be protected to some extent against tuberculosis. This accounts for the persistence of the allele"
00:20 < fenn> if tay-sachs weren't a neurodegenerative disorder i doubt that anyone would suggest it was responsible for intelligence
00:21 < fenn> that future pundit page doesn't say anything about tuberculosis
00:22 < fenn> it would be really bad to give people tay-sachs genes if it doesn't actually help
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01:04 < fenn> i can't say that i really understand this paper, but it seems relevant
01:04 < fenn> .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180346/
01:04 < yoleaux> Geographic Distribution of Disease Mutations in the Ashkenazi Jewish Population Supports Genetic Drift over Selection
01:06 < fenn> "The extreme localization--both in time and space--observed for the TSD 1421 mutation, as compared with the primary TSD 1277 mutation, along with the other data reported above, provides compelling evidence for genetic drift and not selection as the explanation for the observed frequency of [lysosomal storage diseases (tay-sachs, gaucher, niemann-pick, mucolipidosis iv)] mutations in the
01:06 < fenn> Ashkenazi population."
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01:11 < fenn> hm maybe they are just talking about the origin of the mutation
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05:04 < hojuruku> http://vid.me/ozzieslovepedos - OR https://www.youtube.com/watch?v=X5z_8Lh5UM0 Exposes how Australian government leaders say YOU - YES YOU MUST LOVE THE RELIGION OF GAY BABY FUCKING AND BOY MURDER OTOAustralia.org.au OR GO TO JAIL for "religious vilification" of Satanic gay pedophile cult - video brought to you by 911scholars.org Jim Fetzer PhD who's a doctorate/professor in a IT field among others.
05:04 < hojuruku> <hojuruku> <hojuruku> Satanism must be respected by law I shit you not.. all the sources are here: https://johnsunol.blogspot.com/2017/04/censorship-repost-x3-act-human-rights.html#gpluscomments Government letterhead / case law galore!
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06:55 < fenn> well at least it's different from the usual spam
06:59 < fenn> his blog reads like markov chain output. unfortunately it's a human doing the writing
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07:36 < kanzure> opentrons talk transcript http://blog.opentrons.com/opentrons-at-sbbuk17/ https://twitter.com/mnlimas/status/855686863763406848
07:41 < kanzure> .tw https://twitter.com/mirikramer/status/855789914985820160
07:41 < yoleaux> It's a brain hat! #marchforscience #ScienceMarch https://pbs.twimg.com/media/C-BgX0OVoAA9Pkh.jpg (@mirikramer)
07:41 < kanzure> this is not neuroanatomically accurate >:(
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09:32 < kanzure> .wik piperlongumine
09:32 < yoleaux> "Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum), a pepper plant found in southern India and southeast Asia." -- https://en.wikipedia.org/wiki/Piperlongumine
09:32 < kanzure> .wik fisetin
09:32 < yoleaux> "Fisetin (3, 7, 3?, 4?-tetrahydroxyflavone) is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers." -- https://en.wikipedia.org/wiki/Fisetin
09:32 < kanzure> .wik navitoclax
09:32 < yoleaux> "Navitoclax (previously ABT-263) is an experimental orally active anti-cancer drug, which is similar in action to obatoclax, except that unlike obatoclax, it does not have off-target effects." -- https://en.wikipedia.org/wiki/Navitoclax
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09:33 < kanzure> "No, she spent $200K to actually develop two CRISPR gene therapies from stratch in essentially a home-based lab"
09:35 < kanzure> https://www.fightaging.org/archives/2017/04/transfusion-of-young-blood-associates-timp2-with-aging-and-cognitive-function/
09:36 < kanzure> https://www.fightaging.org/archives/2017/04/reviewing-the-state-of-biomarkers-of-aging/
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11:08 < nmz787_> if biohackers were getting married inan amazing big-hollywood biohacker movie, what would their awesome wedding feature?
11:12 < jrayhawk> http://www.gregadunn.com/self-reflected/self-reflected-gallery/
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13:30 < kanzure> "Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience" https://link.springer.com/article/10.1007/s10827-016-0623-7
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16:33 < kanzure> bloooooop
16:34 < kanzure> CoOlCyrus: whodis?
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16:54 < kanzure> further evidence that fMRI can be a waste of time http://biorxiv.org/content/biorxiv/early/2017/04/15/127571.full.pdf
17:03 < kanzure> "Novel genetic loci associated with hippocampal volume" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632/
17:03 < kanzure> "To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that...
17:03 < kanzure> ... a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155)."
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17:09 < kanzure> rs11979341 (7q36.3) 200 kb upstream of SHH (sonic hedgehog) crucial for neural tube formation, rs7020341 (9q33.1) in ASTN2 (astrotactin 2), rs2268894 (2q24.2) in an intron of DPP4, rs2289881 (5q12.3) in an intron of MAST4 which modules microtubule scaffolding, rs7492919, rs17178006.
17:09 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f77272f3 Bryan Bishop: more alleles for hippocampus volume >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
17:15 < kanzure> "AKAP6 is highly expressed in various brain regions and cardiac and skeletal muscle where it binds to the regulatory subunit of protein kinase A (PKA) and anchors PKA to the nuclear membrane or sarcoplasmic reticulum. The cAMP-dependent PKA signalling pathway, in turn has been shown to be involved in short- and long-term memory and working memory (Bernabeu et al. 1997; Taylor et al. 1999)."
17:16 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=34845bc3 Bryan Bishop: add AKAP6 rs17522122 and MIR211 rs10457441 >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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18:09 < kanzure> "... carriers of an APOE ?4 allele who also harbored TOMM40 risk alleles (rs11556505 and rs2075650) relied more heavily on hippocampal volume for episodic memory performance" from https://openarchive.ki.se/xmlui/bitstream/handle/10616/45506/Thesis_Beata_Ferencz.pdf
18:12 < kanzure> "Although there was no relation between inflammatory cytokines and brain volume, high levels of IL-12p40 in individuals who were physically inactive were associated with smaller lateral prefrontal cortex and hippocampal volumes, as well as with global cognitive decline over 6 years."
18:12 < kanzure> cc jrayhawk
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18:21 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7623a0fd Bryan Bishop: TMEM106B and GRN alleles for cognitive aging >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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18:27 < kanzure> .wik copy-numer variation
18:27 < yoleaux> "?-Amylase is a protein enzyme EC 3.2.1.1 that hydrolyses alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen, yielding glucose and maltose. It is the major form of amylase found in humans and other mammals. It is also present in seeds containing starch as a food reserve, and is secreted by many fungi." -- https://en.wikipedia.org/wiki/Alpha-amylase
18:27 < kanzure> O_O
18:27 < kanzure> .wik copy-number variation
18:27 < yoleaux> "Copy number variation (CNVs) is a relatively new field in genomics and it is defined as a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals in the human population." -- https://en.wikipedia.org/wiki/Copy-number_variation
18:40 < kanzure> MC1R is associated with non-youthful skin aging appearance.. and there's an MC1R variant associated with alzheimer's ( http://content.iospress.com/articles/journal-of-alzheimers-disease/jad161113 )
18:50 < kanzure> something about sortilin-related receptor SORL1 rs2070045 and APOE ?4 risk allele   and hippocampus connectivity to the precuneus/posterior cingulate cortex, subgenual anterior cingulate cortex, sensorimotor cortex, middle temporal gyrus, and inferior frontal gyrus https://link.springer.com/article/10.1007/s00429-017-1377-3
18:56 < kanzure> not really sure what to do with that.
18:59 < kanzure> "ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults" https://www.researchgate.net/profile/Qiang_Xu28/publication/312302193_ZNF804A_rs1344706_interacts_with_COMT_rs4680_to_affect_prefrontal_volume_in_healthy_adults/links/5879cdd508aed3826ae222b8.pdf
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19:14 < kanzure> "High levels of neuroticism are associated with decreased cortical folding of the dorsolateral prefrontal cortex" https://link.springer.com/article/10.1007/s00406-017-0795-9
19:18 < kanzure> "Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population" https://www.researchgate.net/profile/Shih_Jen_Tsai2/publication/314254395_Effects_of_circadian_clock_genes_and_environmental_factors_on_cognitive_aging_in_old_adults_in_a_Taiwanese_population/links/58c5ea40a6fdcce648e8b820/Effects-of-circadian-clock-genes-and-environmental-fa...
19:18 < kanzure> ...ctors-on-cognitive-aging-in-old-adults-in-a-Taiwanese-population.pdf
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20:12 < jrayhawk> Huh, I would've expected some sort of cytokines->thyroid downregulation->inactivity->catabolism association
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20:17 < jrayhawk> And there's all sorts of interesting relationships between different interleukins and IGF-1 receptivity.
20:49 < kanzure> "DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores" https://link.springer.com/article/10.1007/s00439-014-1489-2 (2015)
20:49 < kanzure> .. and also schizophrenia risk factor. bleh.
20:54 < kanzure> "No relative expansion of the number of prefrontal neurons in primate and human evolution" http://www.pnas.org/content/113/34/9617.abstract (2016) ".. We thus propose that the most distinctive feature of the human prefrontal cortex is its absolute number of neurons, not its relative volume."
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21:09 < kanzure> this seems to be bgi's intelligence project site (no updates in quite a few years...) https://www.cog-genomics.org/
21:10 < kanzure> https://www.cog-genomics.org/plink/2.0/ also seems to be doing projects with human longevity inc.
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21:24 < kanzure> hrmph.
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21:59 < nmz787_> yup
22:00 < nmz787_> kanzure: any more thoughts on FIB? I am thinking an OSHpark model may be interesting
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22:01 < nmz787_> and even of the possibility of bolting my SEM column to it, to make a dual-beam
22:02 < nmz787_> or visa-versa, if the SEM chamber is somehow better
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23:02 < nmz787_> http://iranarze.ir/wp-content/uploads/2016/11/E537.pdf
23:02 < nmz787_> Compact implicit surface reconstruction via low-rank tensor approximation
23:02 < nmz787_> "We start with fitting an algebraic spline surface defined on a box that bounds the given point set. We split the box into eight sub-cells if the fitting error is greater than a given threshold. For each cell over which the fitting error is larger than the given threshold, a local offset function represented by an algebraic spline function is computed to reduce the fitting error. In order to obtain
23:02 < nmz787_> a compact representation, a low-rank ...
23:02 < nmz787_> ... regularization term is introduced in the fitting model, and the optimization problem is solved locally based on the alternating direction method of multipliers together with the CP decomposition of tensors. The above procedure terminates when the fitting error over each cell is less than a user-specified threshold or the maximum subdivision level reaches."
23:03 < nmz787_> I guess I should have posted the DOI instead of the PDF: http://dx.doi.org/10.1016/j.cad.2016.05.007
23:03 < nmz787_> .title
23:03 < yoleaux> Compact implicit surface reconstruction via low-rank tensor approximation
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