--- Log opened Sat May 06 00:00:46 2017 00:44 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 01:27 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 01:32 -!- augur [~augur@2601:640:8001:4222:901d:44a4:29c0:f378] has joined ##hplusroadmap 01:35 -!- augur [~augur@2601:640:8001:4222:901d:44a4:29c0:f378] has quit [Remote host closed the connection] 01:38 -!- augur [~augur@2601:640:8001:4222:901d:44a4:29c0:f378] has joined ##hplusroadmap 02:04 -!- augur_ [~augur@2601:640:8001:4222:acf3:688a:43fe:5edb] has joined ##hplusroadmap 02:07 -!- augur [~augur@2601:640:8001:4222:901d:44a4:29c0:f378] has quit [Ping timeout: 240 seconds] 02:31 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 02:52 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:05 -!- augur_ [~augur@2601:640:8001:4222:acf3:688a:43fe:5edb] has quit [Remote host closed the connection] 03:22 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 03:26 -!- augur [~augur@2601:640:8001:4222:acf3:688a:43fe:5edb] has joined ##hplusroadmap 03:31 -!- augur [~augur@2601:640:8001:4222:acf3:688a:43fe:5edb] has quit [Ping timeout: 260 seconds] 03:33 -!- augur [~augur@2601:640:8001:4222:d0ed:46f3:13fd:9190] has joined ##hplusroadmap 03:37 -!- augur [~augur@2601:640:8001:4222:d0ed:46f3:13fd:9190] has quit [Ping timeout: 245 seconds] 03:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 04:11 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 04:22 -!- darsie [~darsie@84.113.55.42] has joined ##hplusroadmap 04:55 < kanzure> nmz787_: okay let's buy it; but you do the bidding. 04:58 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 05:31 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 05:34 -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap 05:44 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 05:50 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 05:54 -!- Guest79448 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 258 seconds] 06:00 -!- drewbot [~cinch@50.16.110.180] has quit [Remote host closed the connection] 06:01 -!- drewbot [~cinch@54.196.17.145] has joined ##hplusroadmap 06:50 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 260 seconds] 06:55 -!- jtimon [~quassel@37.134.31.9] has joined ##hplusroadmap 07:25 -!- bsm1175321 [~mcelrath@2604:2000:7055:c900:c6a:701e:eef9:7e6f] has joined ##hplusroadmap 07:42 -!- bsm1175321 [~mcelrath@2604:2000:7055:c900:c6a:701e:eef9:7e6f] has quit [Ping timeout: 246 seconds] 07:52 < kanzure> andytoshi: https://github.com/kanzure/diyhpluswiki/commit/ce12664da2c8732bd98c6a4339d0b36e4406e9ba#commitcomment-22042721 07:54 < kanzure> jrayhawk: https://github.com/kanzure/diyhpluswiki/issues/9 07:58 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 08:07 -!- Reventlov [~reventlov@unaffiliated/reventlov] has quit [Quit: WeeChat 1.7.1] 08:09 -!- Reventlov [~reventlov@unaffiliated/reventlov] has joined ##hplusroadmap 08:16 < juri_> a group of hackers treating SEMs the way we treat 3d printers. 08:27 < kanzure> with total disrespect and disdain? 08:32 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 08:32 < kanzure> yashgaroth: ready? 08:32 < yashgaroth> hell yeah mostly 08:35 < juri_> maybe a bit. ;) 08:35 < juri_> i was more thinking "document / open source/ re-engineer all of the things!" 08:36 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has quit [Quit: ZNC - 1.6.0 - http://znc.in] 08:37 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has joined ##hplusroadmap 08:38 < kanzure> juri_: that doesn't sound negative at all. i don't understand the analogy to 3d printers? 08:39 < juri_> we are all 3d printer builders / tinkerers. thus, using printers and the skills we gain by building them on SEMs. 08:41 -!- razzy [~razzy@labka.stud.slu.cz] has quit [Ping timeout: 240 seconds] 09:32 < streety> Does anyone know a better way to scrape a website with aggressive rate limiting other than a few dozen ec2 instances? 09:32 < kanzure> hack the planet 09:33 < kanzure> you only need one ec2 instance, just multiple network bindings 09:39 < streety> thanks, investigating now 09:51 < anthk_> streety: wget paralell connections 09:51 < anthk_> or httrack 09:57 < streety> I don't think those solutions will work. The site seems to be actively messing with the page contents if I make too many requests 10:15 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 10:54 -!- anachronick [~kvirc@a85-138-147-224.cpe.netcabo.pt] has joined ##hplusroadmap 10:54 -!- razzy [~razzy@labka.stud.slu.cz] has joined ##hplusroadmap 11:20 < kanzure> yashgaroth: let's replace your presentation with a reading of a fanfic script of "pinky and the brain" featuring george church. 11:20 < yashgaroth> way ahead of you' 11:23 < darsie> streety: wget? 11:24 < nmz787_> kanzure: ok, I will wait to hear back from the seller until Monday... just asked them a few more questions for the shippers 11:25 < nmz787_> kanzure: there are 3 days left for the auction 11:30 < streety> wget is still going to be tied to a single ip address and will get throttled. 11:30 < kanzure> use containers, assign different network connections to each cgroup 11:30 < kanzure> http://docs.aws.amazon.com/AWSEC2/latest/UserGuide/MultipleIP.html 11:30 < streety> the multiple network bindings suggestion would work as it will appear that fewer requests are coming from any single source 11:32 < streety> yeah I found that, thanks. I'm not entirely sure there is a big advantage over multiple servers. The numbers are limited and would only save a little money 11:32 < streety> numbers of additional IPs that is 11:33 < streety> it looks like only the data from the previous year is throttled so I'm focusing on the archives for the moment 11:59 -!- abcc9 [2ec432db@gateway/web/freenode/ip.46.196.50.219] has joined ##hplusroadmap 12:02 -!- augur [~augur@74-95-6-5-SFBA.hfc.comcastbusiness.net] has joined ##hplusroadmap 12:05 -!- razzy [~razzy@labka.stud.slu.cz] has quit [Ping timeout: 240 seconds] 12:07 -!- augur [~augur@74-95-6-5-SFBA.hfc.comcastbusiness.net] has quit [Ping timeout: 240 seconds] 12:07 -!- razzy [~razzy@labka.stud.slu.cz] has joined ##hplusroadmap 12:17 -!- abcc9 [2ec432db@gateway/web/freenode/ip.46.196.50.219] has quit [Quit: Page closed] 13:26 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] 13:59 -!- jtimon [~quassel@37.134.31.9] has quit [Ping timeout: 240 seconds] 14:02 < kanzure> Twitter: @GP_write hashtag: #GPwrite 14:28 -!- emeraldgreen [~user@178.70.245.40] has joined ##hplusroadmap 14:29 -!- emeraldgreen is now known as kirka 14:31 < kirka> hi, great to see that the channel is alive and well 14:33 < kanzure> welcome back 14:38 < kirka> kanzure I'm glad you still remember me 14:38 < kirka> I'll try to stick around here from now on 14:40 < kanzure> i belive we last talked 2013-05-21 14:40 < anthk_> hello kanzure, I am doing progresses 14:40 < anthk_> linear algebra seems easy 14:40 < anthk_> btw, wget had rate limits 14:43 < kirka> kanzure I don't have lots of news, I'm a fullstack js dev now (currently mostly doing frontend lol). I will try to do some interesting projects though. 14:44 < kirka> In last years I was mostly interested in ML, deep learning and UAI (AIXI approximations). But it was just a hobby. 14:44 < kanzure> getting your react/redux on? 14:45 < kirka> kanzure I'd like to, but my current job uses Angular 2. I don't like it that much, but the working conditions are nice and the job pays relatively well. 14:48 < kirka> Also I had a cool idea about using asm.js/WASM with webworkers for large scale grid computing in the browser 14:49 < kirka> Anyone with a PC or a smartphone would be able to contribute compute power by opening the page in the browser 14:52 -!- NixCipher [~NixCipher@173.254.222.146] has joined ##hplusroadmap 14:58 < kirka> also, fun stuff: there was this decade long idea about self-optimizing algorithms, mostly discussed by futurists; I was really sceptical about it. My main objections were: * no "recursively self-improving" algorithm has been demonstrated ever * "self improving" is really learning, and it isn't possible in a closed mode, without new external data about the world the agent lives in 14:59 < kirka> both objections are now wrong: there are at least 2 demonstrations: http://people.idsia.ch/~juergen/oops.html http://people.idsia.ch/~juergen/metalearner.html and a more recent one: https://arxiv.org/abs/1611.05763 https://arxiv.org/abs/1611.02779 15:00 < kirka> So, now I cannot deny the theoretical possibility of that one discussed-to-death scenario (^: 15:00 < kirka> > this decade long idea 15:00 < kirka> decades old, I mean 15:01 < kanzure> narcolepsy + gwas http://www.nature.com/ng/journal/v42/n9/abs/ng.647.html 15:03 -!- NixCipher [~NixCipher@173.254.222.146] has left ##hplusroadmap ["Read error: Erection reset by beer"] 15:05 < kirka> I read this list http://diyhpl.us/wiki/genetic-modifications/ it's fascinating 15:06 < kanzure> https://www.ebi.ac.uk/gwas/search?query=memory 15:06 < kanzure> ah. 15:07 < kirka> kanzure would be cool to try to validate these mods on mice 15:08 < kanzure> some of them have been. not all of them are mouse-relevant, some of them are human-only. 15:08 < kirka> Also I'd like to validate this one on mice https://www.elysiumhealth.com/basis/in-depth to see if it's worth it to take it myself 15:09 < kirka> Also, do you think this one http://dogagingproject.com/ is really a large-mammal life extension trial in disguise? PR'ed in pet-friendly language 15:10 < kanzure> jojack want to feed lots of metformin to dogs 15:10 < kanzure> joejack? i forget. 15:11 < kirka> kanzure Do you think some of those memory-related mutations could work if delivered via gene therapy ? 15:12 < kirka> If they control brain development they wouldn't... 15:12 < kanzure> senolytics are popular this year http://diyhpl.us/~bryan/papers2/longevity/The%20fountain%20of%20youth%20by%20targeting%20senescent%20cells%3f%20-%202017.pdf 15:12 < kanzure> yeah it's not clear if the WWC1 stuff would effect adult working memory 15:12 < kanzure> but i think it's worth a shot. 15:14 < kirka> I wonder if mouse experiments could be automated. If I had unlimited funding I'd build a standard infrastructure for handling mice and logging their behavior, scaled it to thousands of cells and ran batches of "gene/environment => phenotype" experiments 15:15 < kirka> there is transcriptic and emerald cloud lab for bacteria now, maybe one day there will be similar service for mice 15:16 < kanzure> there is a transcript-like company that does mouse studies 15:16 < kanzure> *transcriptic 15:16 < kirka> wow 15:16 < kanzure> yeah trying to remember the name.. 15:19 < kanzure> it's in the logs somewhere. 15:19 < kirka> ok, I'll find 15:20 < kanzure> 16:46 < kanzure> hmm these people seem to be doing standardized mouse studies using fancypants cage setups? http://www.vium.com/technology/ 15:21 < kanzure> from 2017-02-23 15:22 < kanzure> https://www.bloomberg.com/news/articles/2016-06-02/vium-automates-the-testing-of-drugs-on-mice 15:25 -!- pent [~pent@138.197.129.246] has quit [Ping timeout: 240 seconds] 15:34 -!- pent [~pent@138.197.129.246] has joined ##hplusroadmap 15:38 -!- pent [~pent@138.197.129.246] has quit [Ping timeout: 258 seconds] 15:44 < kanzure> https://www.ebi.ac.uk/gwas/search/traits 15:46 < kanzure> "Brain structure (temporal lobe volume)" 15:52 -!- pent [~pent@138.197.129.246] has joined ##hplusroadmap 16:16 -!- ExeciN [ExeciN@bnc.stormbit.net] has quit [Excess Flood] 16:26 < kanzure> https://www.ebi.ac.uk/gwas/search?query=Longevity 16:27 -!- ExeciN [ExeciN@bnc.stormbit.net] has joined ##hplusroadmap 16:35 < kanzure> those p values https://www.ebi.ac.uk/gwas/search?query=freckles 16:38 < kanzure> and what's goin on with these p values https://www.ebi.ac.uk/gwas/search?query=fasting 16:47 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e9050c05 Bryan Bishop: anti-acne SNPs >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 16:47 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5194150e Bryan Bishop: various gwas traits >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 17:25 -!- c0rw1n_ [~c0rw1n@132.90-242-81.adsl-dyn.isp.belgacom.be] has joined ##hplusroadmap 17:27 -!- augur [~augur@50.254.147.77] has joined ##hplusroadmap 17:38 -!- c0rw1n_ [~c0rw1n@132.90-242-81.adsl-dyn.isp.belgacom.be] has quit [Quit: Leaving] 17:54 -!- jtimon [~quassel@9.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 18:25 -!- augur [~augur@50.254.147.77] has quit [Remote host closed the connection] 18:30 -!- kirka [~user@178.70.245.40] has left ##hplusroadmap [] 18:30 -!- emeraldgreen [~user@178.70.245.40] has joined ##hplusroadmap 18:32 -!- emeraldgreen [~user@178.70.245.40] has left ##hplusroadmap [] 18:48 -!- darsie [~darsie@84.113.55.42] has quit [Ping timeout: 240 seconds] 18:57 -!- augur [~augur@50.254.147.77] has joined ##hplusroadmap 19:01 -!- augur [~augur@50.254.147.77] has quit [Remote host closed the connection] 19:08 -!- augur [~augur@50-254-147-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 19:24 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 19:41 < nmz787_> "I couldn't sleep so I checked on my baby and it's just moved to Pore Group 2...of 4. Currently sitting at 14 MILLION reads at 3000bp or less and then a few million at 10kbp and beyond. The amount of data this thing has generated is ENORMOUS and this was, for all intents and purposes, a very poor performance run. Sub-optimal conditions still gave us a treasure trove of novel sequences. Kinda like do 19:41 < nmz787_> ing 14 million random primer PCR runs ... 19:41 < nmz787_> ... with subsequent Sanger sequencing. This IS the future and it is GLORIOUS. Can't wait to pack it all in a nice bow (torrent) and share it with all of you. Yay, actual science!" 20:10 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 20:11 * nmz787_ going to test the electroporator 20:11 < nmz787_> hopefully I get a result by the time I leave for my flight 20:55 -!- cluckj [~cluckj@pool-108-52-166-30.phlapa.fios.verizon.net] has quit [Ping timeout: 260 seconds] 22:06 < nmz787_> welp, gopro battery died on me, just as I was about to electroporate :/ but I got a good amount of the prep work 22:07 -!- augur [~augur@50-254-147-77-static.hfc.comcastbusiness.net] has quit [Remote host closed the connection] 22:11 -!- augur [~augur@50-254-147-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 22:16 -!- augur [~augur@50-254-147-77-static.hfc.comcastbusiness.net] has quit [Ping timeout: 240 seconds] 22:25 -!- preview__ [~preview@2407:7000:842d:4009:bb98:6906:19d5:2639] has joined ##hplusroadmap 22:25 -!- preview_ [~preview@2407:7000:842d:4009:bb98:6906:19d5:2639] has quit [Remote host closed the connection] 23:03 -!- jtimon [~quassel@9.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 260 seconds] 23:15 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 23:18 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:22 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 23:27 -!- chickenhawk [~chickenha@174-22-7-14.eugn.qwest.net] has joined ##hplusroadmap 23:36 -!- chickenhawk [~chickenha@174-22-7-14.eugn.qwest.net] has quit [Quit: Leaving] --- Log closed Sun May 07 00:00:47 2017