--- Log opened Mon May 15 00:00:54 2017
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06:23 < kanzure> "Have you ever used cardarine?  It's a PPAR-delta agonist, which should be great.  PPARd increases endurance, and also activates PGC-1a gene expression, which should increase lifespan.  I plan to order some from irc.bio .  I should be able to tell whether it has effects on exercise endurace."
06:23 < kanzure> .wik cardarine
06:23 < yoleaux> "GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol) is a PPAR? receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was  ..." -- https://en.wikipedia.org/wiki/GW501516
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07:14 < thesnark> kanzure: do you have an opinion about zcash?
07:14 < kanzure> so many negative things to say
07:14 < thesnark> I'd like to hear it all
07:14 < thesnark> lay it on me
07:14 < kanzure> snarks are interesting but new crypto so... it's hard to say on that front.
07:15 < kanzure> http://diyhpl.us/~bryan/papers2/bitcoin/snarks/
07:15 < thesnark> right zk proofs are cool
07:15 < thesnark> that's what initially caught my attention, but tbh it seems...poorly implemented?
07:15 < kanzure> as for zcash itself there's a bunch of weird things going on there, like the default transaction type is the non-private type, despite advertising zcash as more anonymous than bitcoin it's essentially fooling unsophisticated users into thinking they have super privacy when they don't, and that really really violates a "do no harm" sort of principle.
07:16 < kanzure> also they require trusted setup for their snarks: https://petertodd.org/2016/cypherpunk-desert-bus-zcash-trusted-setup-ceremony
07:18 < kanzure> thesnark: i would ask Madars for things about snarks and zero-knowledge proof, he's our resident expert in here on that front.
07:18 < thesnark> :) Thanks
07:18 < TMA> let me refresh my memory: zcash has some component of trust in the creators which cannot be verified (there are some hidden parameters that can compromise the scheme if not destroyed as advertised by the creators). do I remember it correctly?
07:18 < kanzure> TMA: see https://petertodd.org/2016/cypherpunk-desert-bus-zcash-trusted-setup-ceremony
07:19 < thesnark> kanzure: I think the reason they default to non-"anonymous" transactions is that the zk proof transactions take a long time
07:19 < thesnark> they don't want to ruin appeal or something?
07:19 < kanzure> yes but that doesn't excuse false advertising
07:19 < thesnark> which doesn't make sense to me
07:19 < thesnark> right
07:19 < TMA> kanzure: yeah, i was not finished writing that before you posted your link before. I ain't a great typist
07:19 < kanzure> i think snarks will get really interesting once we figure out how to avoid the trusted setup requirement
07:20 < kanzure> thesnark: in the mean time there are some interesting privacy-improving upgrades to bitcoin on the horizon, such as confidential transactions, see http://diyhpl.us/wiki/transcripts/gmaxwell-confidential-transactions/
07:21 < thesnark> kanzure: yeah, people might regret giving up on btc just becasue some new features are promised
07:22 < thesnark> dash looks better than zcash imo
07:22 < kanzure> long-term i do expect bitcoin to have more privacy upgrades, such as confidential transactions and signature aggregation (whether schnorr multisig or boneh's BLS scheme or mimblewimble stuff)
07:22 < kanzure> dash is not worth your time don't bother.
07:22 < thesnark> monero?
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07:23 < kanzure> if you're looking for investment advice i am going to have to turn you away... sounds like you want to pick some stuff.
07:23 < thesnark> kanzure: :( I'm sorry I gave that impression
07:23 < thesnark> that's not what I'm looking for
07:23 < kanzure> there were some notes on monero in my last link
07:24 < thesnark> I'm focused on currency that might make darknet transactions easier, or any accompanying practices to use
07:24 < superkuh> I have no expert knowledge but I like Monero. Used it a few times, sitting on a bunch.
07:25 < thesnark> again, not asking which one to buy
07:25 < thesnark> I'm designing a decentralized marketplace
07:25 < thesnark> https://github.com/mgrube/Phage
07:26 < thesnark> will be using bitcoin if nothing else but I'm interested in zk proofs for protection which is why I asked about your opinion on zcash
07:27 < kanzure> look at tumblebit paper, lots of rsa blinding moonmath
07:27 < kanzure> and in meam time there is joinmarket (ask adlai)
07:27 < kanzure> @
07:27 < kanzure> #&x&<';;@*@*&;';eurhbDee w
07:27 < kanzure> uh.. typo.
07:28 < thesnark> cool, thank you
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07:34 < thesnark> joinmarket looks usable right now. awesome
07:38 < kanzure> thesnark: here are some things,
07:38 < kanzure> http://diyhpl.us/~bryan/papers2/bitcoin/Join%20me%20on%20a%20market%20for%20anonymity%20-%20joinmarket%20-%202016.pdf
07:38 < kanzure> http://diyhpl.us/wiki/transcripts/scalingbitcoin/milan/joinmarket/
07:38 < kanzure> http://diyhpl.us/~bryan/papers2/bitcoin/TumbleBit:%20An%20untrusted%20bitcoin-compatible%20anonymous%20payment%20hub%20-%202016.pdf
07:38 < kanzure> http://diyhpl.us/wiki/transcripts/scalingbitcoin/milan/tumblebit/
07:39 < kanzure> https://github.com/JoinMarket-Org/joinmarket
07:39 < kanzure> https://github.com/BUSEC/TumbleBit
07:40 < thesnark> kanzure: much appreciated
07:43 < kanzure> thesnark: generally, bitcoin developers are highly interested in long-term privacy improvements because fungibility is intricately linked to privacy.  if you can "taint" coins then any given $1 isn't necessarily $1.
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08:32 < adlai> kanzure: you forgot to link the parody >_<
08:39 < kanzure> the who what?
08:41 < kanzure> gah i forgot to write down the short/no hair SNPs
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10:34 < kanzure> "SRF has devised a new method for inserting genes into a pre-defined location. In this program, this will be done as a two-step process, in which first CRISPR is used to create a "landing pad" for the gene, and then the gene is inserted using an enzyme that only recognizes the landing pad. SRF has created "maximally modifiable mice" that already have the landing pad, and this project will ...
10:35 < kanzure> ...evaluate how well the insertion step works in different tissues"
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10:39 < thesnark> nice
10:39 < kanzure> thesnark: http://www.vocativ.com/428192/scientists-human-genome-struggle-transparency/
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11:10 < thesnark> kanzure: this is going to sound kind of stupid but I was just thinking yesterday about writing tools for sharing scientific data on Freenet
11:10 < thesnark> kanzure: computing contracts + private publication while still being accessible to the public
11:11 < thesnark> kanzure: specifically aiming at the concept of allowing scientists to work and share without needing to worry about rules that are holding them back
11:12 < thesnark> kanzure: that sounds really irritating though
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11:16 < thesnark> kanzure: I met max ogden at the decentralized web summit last year, he is helping develop a decentralized platform for scientific research and publication(though the network topology makes me die inside)
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11:31 < kanzure> i am in the middle of vermont and my laptop battery has died and i don't know what to do
11:36 < thesnark> Cry?
11:36 < thesnark> no stores around?
11:36 < cevi_> have you tried not being in vermont?
11:48 < cluckj> where in the middle of vermont?
11:51 < cluckj> even in vermont, there has to be a starbucks around...
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11:59 < kanzure> cluckj: brattleboro/putney
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12:01 < cluckj> oh
12:01 < cluckj> that is in the middle of nowhere
12:02 < cluckj> I hear the forest service has been rolling out moose with wifi
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13:15 < kanzure> "put in an extra copy of p53 - with all the same controls, e.g. transcription factor binding site on promotors, enhancers; that seems to work well for whales, they don't get cancer in spite of the enormous numbers of cell divisions they go through to get to their size (and longer telomeres?)"
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14:46 < jrayhawk> speaking of p53 https://en.wikipedia.org/wiki/SV40
14:55 < kanzure> .wik SV40
14:55 < yoleaux> "SV40 is an abbreviation for Simian vacuolating virus 40 or Simian virus 40, a polyomavirus that is found in both monkeys and humans. It was named for the effect it produced on infected green monkey cells, which developed an unusual number of vacuoles." -- https://en.wikipedia.org/wiki/SV40
15:12 < kanzure> fluorescent exonuncleases, "Molecular highly integrated data storage via active control DNA" https://www.google.com/patents/DE102013004584A1
15:14 < kanzure> http://www.nature.com/nature/journal/v494/n7435/abs/nature11875.html#comment-57415
15:14 < kanzure> "We suggest for linking DNA information processing to in silico processing step-by-step in an efficient way light-gated proteins"
15:15 < kanzure> wikipedia cites "Programmable bacterial membranes with active DNA storage" but it was just a presentation at some conference and there's no online slides.   how did that citation get in there? wat?
15:16 < kanzure> "Emerging Technology Final, Dandekar T., Lopez, D"
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15:17 < kanzure> oh i didn't know this was new york genome center.. "In March 2017, scientists at Columbia University and the New York Genome Center published a method known as DNA Fountain which allows perfect retrieval of information from a density of 215 petabytes per gram of DNA"
15:18 < kanzure> from https://en.wikipedia.org/wiki/DNA_digital_data_storage
15:31 < kanzure> why isn't there a chemical DNA synthesis technique that builds the double helix one step at a time instead of a single stranded oligo.
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15:43 < night> kanzure: what would be the advantage
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15:45 < kanzure> well, generally, i don't think that modern chemists have looked at oligonucleotide synthesis or DNA synthesis, so the advantage would be that all the polymer chemistry advances from the last umpteen years would probably get used
15:45 < cluckj> did you make it back to civilization?
15:46 < kanzure> also, if the chemistry turns out to have a higher yield and lower error rate, then synthesizing both strands at the same time would possibly preserve more information in the molecule
15:46 < kanzure> cluckj: no i'll be here for .. a while. i have other devices, though.
15:46 < cluckj> oh :\
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16:25 < kanzure> some metformin stuff http://www.longecity.org/forum/blog/201/entry-3593-geroprotector-review-metformin/
16:26 < cluckj> the "minor" side effects are not that minor
16:27 < cluckj> I've heard that the GI issues with therapeutic doses are pretty terrible
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16:48 < kanzure> thesnark: here is a recent tumblebit presentation https://player.vimeo.com/video/215151763
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18:02 < jrayhawk> http://www.pnas.org/content/early/2017/05/02/1620079114.abstract "Erythritol was shown to be synthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assisted ex vivo blood incubation experiments and through in vivo conversion of erythritol to erythronate in stable isotope-assisted dried blood spot experiments." urrrr?
18:04 < jrayhawk> I wonder if this is an endogenous microbiome control tool like fucose
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--- Log closed Tue May 16 00:00:55 2017