--- Log opened Sat Jun 17 00:00:24 2017 00:08 -!- sbodin [~sbodin@91.226.140.2] has quit [Ping timeout: 255 seconds] 00:31 -!- nmz787_i [~ntmccork@134.134.139.82] has quit [Quit: Leaving.] 00:47 < JayDugger> biography of Haber http://a.co/gqF1DmF 00:53 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 00:54 -!- JayDugger [~jwdugger@47.185.237.246] has quit [Quit: Leaving.] 01:05 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 01:24 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Remote host closed the connection] 02:32 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 02:36 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 02:40 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 02:41 -!- ebowden [~ebowden@110.141.79.110] has joined ##hplusroadmap 02:41 -!- ebowden [~ebowden@110.141.79.110] has quit [Changing host] 02:41 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 02:41 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 258 seconds] 02:53 -!- emeraldgreen [~user@188.227.115.178] has joined ##hplusroadmap 03:16 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 03:17 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 03:30 -!- emeraldgreen [~user@188.227.115.178] has left ##hplusroadmap [] 03:32 -!- emeraldgreen [~user@188.227.115.178] has joined ##hplusroadmap 05:22 -!- yorick_ [~yorick@oftn/oswg-member/yorick] has joined ##hplusroadmap 05:38 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 05:42 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 246 seconds] 05:53 -!- preview [~preview@118-92-220-128.dsl.dyn.ihug.co.nz] has quit [Remote host closed the connection] 05:55 -!- preview [~preview@2407:7000:842d:4000::3] has joined ##hplusroadmap 06:05 -!- yorick_ is now known as yorick 06:08 -!- emeraldgreen [~user@188.227.115.178] has quit [Quit: Leaving.] 06:08 -!- preview [~preview@2407:7000:842d:4000::3] has quit [Remote host closed the connection] 06:09 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has quit [Read error: Connection reset by peer] 06:10 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 06:10 -!- preview [~preview@118-92-220-128.dsl.dyn.ihug.co.nz] has joined ##hplusroadmap 06:28 -!- preview [~preview@118-92-220-128.dsl.dyn.ihug.co.nz] has quit [Read error: Connection reset by peer] 06:35 -!- preview [~preview@118-92-220-128.dsl.dyn.ihug.co.nz] has joined ##hplusroadmap 07:08 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 07:13 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 246 seconds] 07:31 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 08:13 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 08:32 -!- strangewarp_ [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 08:34 -!- thundara [~thundara@104.236.109.149] has quit [Ping timeout: 246 seconds] 08:34 -!- rancyd [stryfe@unaffiliated/rancyd] has quit [Ping timeout: 246 seconds] 08:35 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has quit [Ping timeout: 255 seconds] 08:36 -!- thundara [~thundara@104.236.109.149] has joined ##hplusroadmap 08:45 -!- rancyd [stryfe@unaffiliated/rancyd] has joined ##hplusroadmap 09:08 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 09:10 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 09:15 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 255 seconds] 09:18 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 09:19 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 09:25 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 09:38 < kanzure> yashgaroth: that email from jeff is weird. 09:45 < yashgaroth> at least he kept the $1 genome in there, but yeah 09:47 < yashgaroth> I get that he hasn't done synthesis or w/e, but the spreadsheet doesn't really look like genome synthesis 09:47 < kanzure> the only salient items are "better DNA synthesis" and "$1/genome" seems sort of pointless 09:48 < kanzure> i can get on the phone and be an asshole about this, but i'm not sure what it would accomplish 09:48 < yashgaroth> I mean there's 1) identifying mutations/changes to make, 2) cheaper DNA synthesis, 3) more reliable assembly, and 4) getting large fragment into cells without them shearing 09:49 < kanzure> biologists will figure out the delivery problems if you hand them a magic DNA synthesis machine 09:49 < kanzure> biologists will claw their eyes out to get access to that 09:50 < yashgaroth> yeah I feel like, though people were adamant on delivery, no one's really worked on it that much; versus assembly, where we could see real progress and it'd even benefit other projects 09:50 < kanzure> i want to see them get more serious about synthesis/assembly and have a plan that is more involved than "write a sentence that says we need better synthesis/assembly tech" 09:51 < yashgaroth> the budget only allows speculation 09:53 < kanzure> maybe we can get them to find some chemists and provide some overviews of current chemistry tech and whether chemical dna synthesis is completely outdated 09:54 < kanzure> lotta polymer chemistry stuff out there 09:54 < yashgaroth> I do wonder if twist is moving beyond pamidites for their ultra-cheap DNA, though I'm almost certain it's just tinier and massively parallel reactions 09:55 < kanzure> enzymatic dna synthesis stuff is probably more relatable to these guys, since they presumably understand how enzymes work, so we could suggest they think about protein engineering efforts 09:56 < yashgaroth> improvements in the first 3 steps (identifying deletions to make, DNA synthesis, assembly) are useful in general 09:57 < yashgaroth> and I do think my recombinase-mediated assembly has some promise there, just sayin' 09:58 < kanzure> yes they should find room to fit their own pilot projects into whatever plan gets created 10:01 < yashgaroth> anyway the spreadsheet is terrible 10:03 < kanzure> thomas jefferson (or someone) was notorious for showing up to meetings with better plans and prep work than the meeting organizers 10:04 < kanzure> https://www.johndcook.com/blog/2011/03/03/thomas-jefferson-meetings/ 10:05 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 10:11 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 10:15 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 246 seconds] 10:39 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 10:42 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 10:50 -!- strangewarp_ [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has quit [Read error: Connection reset by peer] 10:52 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 11:31 < nmz787_> well it was ThermoFisher and that French company that presented on enzymatic ideas, not twist or anyone else 11:31 < nmz787_> yashgaroth: heard back re pilot project? 11:31 < yashgaroth> nnnope 11:32 < yashgaroth> thermo? that was molecular assemblies, no? 11:32 < nmz787_> hmm 11:33 < nmz787_> I thought it was some company that was bought by Thermo... maybe I was dreaming 11:33 < nmz787_> I'm sure kanzure has records 11:33 < yashgaroth> the founders also founded applied biosystems back in the day 11:34 < yashgaroth> "Helge Bastian, ThermoFisher Scientific | Engineering Nucleic Acids to Support Building Genomes" I forget what that one was about 11:35 < nmz787_> that was him 11:35 < nmz787_> the enzymatic stuff 11:35 < nmz787_> I remember because he didn't have an american accent 11:35 < nmz787_> and his name also sounded swedish or something 11:37 < yashgaroth> was he talking about how great TALENs are or was that someone else 11:41 < nmz787_> hrmm, I don't really remember anything about TALENs from that conf 11:42 < yashgaroth> someone did a presentation on how TALENs are better than CRISPR in many regards, which they are 11:42 < yashgaroth> and I'm p sure it was corporate 11:45 < kanzure> thomas ybert 11:45 < yashgaroth> that's the french guy 11:47 < nmz787_> remember that Atari game Qbert? 11:48 < nmz787_> way more interesting than ybert's talk 11:48 < yashgaroth> and substantial 11:48 -!- Netsplit *.net <-> *.split quits: balrog, Taek, marciogm, nickjohnson, nanotube 11:49 -!- Netsplit over, joins: marciogm 11:49 -!- Netsplit over, joins: balrog 11:49 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-okhmxozqxavtspjd] has joined ##hplusroadmap 11:50 -!- Netsplit over, joins: Taek 11:51 -!- pent [~pent@138.197.129.246] has quit [Ping timeout: 260 seconds] 11:54 -!- pent [~pent@138.197.129.246] has joined ##hplusroadmap 11:55 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 240 seconds] 11:56 -!- nanotube [~nanotube@unaffiliated/nanotube] has joined ##hplusroadmap 12:38 -!- preview [~preview@118-92-220-128.dsl.dyn.ihug.co.nz] has quit [Ping timeout: 268 seconds] 12:39 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 13:19 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-lbmmxunclhuaipvt] has joined ##hplusroadmap 13:39 -!- mxflagship_ [~textual@212.252.97.45] has joined ##hplusroadmap 13:59 -!- mxflagship_ [~textual@212.252.97.45] has quit [Quit: Textual IRC Client: www.textualapp.com] 14:22 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:03 -!- emeraldgreen [~user@188.227.115.178] has joined ##hplusroadmap 15:24 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.7.1] 15:26 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:28 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 15:28 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:39 -!- sbodin [~sbodin@91.226.140.2] has joined ##hplusroadmap 15:59 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-lbmmxunclhuaipvt] has quit [Quit: Connection closed for inactivity] 15:59 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 16:23 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 16:23 -!- TC is now known as Guest37847 16:26 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 17:22 -!- nmz787_i [~ntmccork@134.134.139.83] has joined ##hplusroadmap 17:24 -!- yorick [~yorick@oftn/oswg-member/yorick] has quit [Ping timeout: 260 seconds] 17:31 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 17:46 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 17:55 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: Malvolio] 18:06 -!- emeraldgreen [~user@188.227.115.178] has left ##hplusroadmap [] 18:07 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 18:25 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 18:27 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 18:35 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 18:36 -!- Guest37847 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 18:47 -!- bkero [~bkero@osuosl/staff/bkero] has quit [Ping timeout: 240 seconds] 18:48 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 18:55 -!- preview [~preview@2407:7000:842d:4078:ab39:1b65:59a7:cd65] has joined ##hplusroadmap 20:10 -!- bkero [~bkero@bke.ro] has joined ##hplusroadmap 20:11 -!- bkero [~bkero@bke.ro] has quit [Changing host] 20:11 -!- bkero [~bkero@osuosl/staff/bkero] has joined ##hplusroadmap 20:32 -!- jaboja [~jaboja@jaboja.pl] has quit [Remote host closed the connection] 20:32 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has quit [Read error: Connection timed out] 20:33 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 20:40 -!- strangewarp_ [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 20:44 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has quit [Ping timeout: 240 seconds] 21:03 -!- drewbot [~cinch@54.160.145.74] has joined ##hplusroadmap 21:22 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 21:26 -!- WashIrving [Qfwfq@gateway/shell/suchznc/x-eovykilfzxfboseb] has joined ##hplusroadmap 21:27 -!- Qfwfq [Qfwfq@gateway/shell/suchznc/x-kndgvetcrhdeienm] has quit [Remote host closed the connection] 21:27 -!- WashIrving is now known as Qfwfq 21:29 -!- ebowden [~ebowden@110.141.40.86] has joined ##hplusroadmap 21:29 -!- ebowden [~ebowden@110.141.40.86] has quit [Changing host] 21:29 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 21:33 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 260 seconds] 21:39 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 21:41 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 21:44 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 21:51 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Remote host closed the connection] 22:13 -!- sbodin [~sbodin@91.226.140.2] has quit [Ping timeout: 240 seconds] 22:29 < kanzure> timestamping service thing https://twitter.com/otsproofbot 22:45 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 22:52 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 23:09 -!- esmerelda [~mabel@71-212-79-193.tukw.qwest.net] has joined ##hplusroadmap 23:09 -!- esmerelda [~mabel@71-212-79-193.tukw.qwest.net] has quit [Changing host] 23:09 -!- esmerelda [~mabel@unaffiliated/jacco] has joined ##hplusroadmap 23:22 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has joined ##hplusroadmap 23:26 -!- augur [~augur@2601:643:8400:9b9b:e578:9944:2001:7689] has quit [Ping timeout: 246 seconds] --- Log closed Sun Jun 18 00:00:25 2017