--- Log opened Sun Jun 25 00:00:31 2017
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07:16 < kanzure> "Perineuronal nets in the adult sensory cortex are necessary for fear learning" http://www.cell.com/neuron/fulltext/S0896-6273(17)30505-6 https://twitter.com/neuroecology/status/877924991391674368
07:16 < kanzure> "The experimental design and data interpretation in 'Unexpected mutations after CRISPR Cas9 editing in vivo' by Schaefer et al. are insufficient to support the conclusions drawn by the authors" http://biorxiv.org/content/early/2017/06/21/153338 https://twitter.com/GaetanBurgio/status/877649245595029504
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07:21 < kanzure> https://scholar.google.com/citations?view_op=list_classic_articles&hl=en&by=2006
07:21 < kanzure> .tw https://twitter.com/KordingLab/status/877943067755429888
07:21 < yoleaux> google classic papers (https://scholar.googleblog.com/2017/06/classic-papers-articles-that-have-stood.html) has no neuroscience or machine learning but does have wood science. #TaxonomyFailure (@KordingLab)
07:22 < kanzure> .tw https://twitter.com/antonioregalado/status/877226907808522240
07:22 < yoleaux> more weirdness: The Woolly Mammoth resurrection project at Harvard is funded by Peter Thiel. (@antonioregalado)
07:22 < kanzure> not sure why they think that's weird.
07:24 < kanzure> "A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve" http://iopscience.iop.org/article/10.1088/1741-2552/aa7a42 https://twitter.com/eboyden3/status/876859877490118658
07:30 < kanzure> maybe 2006 was a bad year but none of these papers look particularly classic.
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10:04 < maaku> Expanding on "bad fee estimation" -- most wallets set fees for their transaction to get into the very next block or two, which causes their estimators to be very unstable
10:05 < maaku> It's entirely expected IMHO that fees will be >$100 at some point in time. Bitcoin can only really survive as a high-value settlement network.
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10:55 < streety> thanks maaku
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13:24 < kanzure> jrayhawk: why not coma wards for people who want to skip keto adaptation
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13:57 < jrayhawk> Being in a coma is not particularly healthy, either.
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14:46 < streety> is keto adaptation that big a deal?
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15:53 < jrayhawk> streety: Is the question about cost, or about benefit?
16:02 < kanzure> streety is asking whether people would be annoyed enough by keto adaptation to want to go into a coma
16:02 < kanzure> aren't comas recommended for some types of (drug) withdrawals?
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18:41 < jrayhawk> Yeah, but some drug withdrawals have actual risk of death.
18:41 < jrayhawk> i.e. the cost/benefit tradeoff is actually reasonable.
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19:00 < kanzure> what i'm hearng is "tell them to get life-ending addictions first" :P
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19:28 < streety> yeah I was questioning whether the annoyance/discomfort of the transition was sufficiently bad that anyone would consider an induced coma as a desirable approach
19:29 < streety> although cost is an interesting question. I had not considered that a ketogenic diet would cost much more than most other diets
19:30 < streety> or were you talking about the cost of medical supervision for an induced coma?
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19:37 < kanzure> cost/benefit was re: medical coma vs dying due to addiction withdrawal
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19:43 < kanzure> cost presumably being death risk
19:43 < jrayhawk> Adapting to ketone metabolism involves a period of lethargy and brain fog, similar to a chronic exercise burden.
19:47 < streety> is adaptation success gauged subjectively (brain fog clears) or are there more objective measures? I know there are ketone measurements but is adaptation more than just elevated ketones?
19:50 < jrayhawk> Fasting blood sugar levels are what's typically used, AFAIK
19:52 < streety> interesting, I would not have thought that would be the case
19:56 < jrayhawk> The body will maintain via gluconeogenesis whatever blood sugar levels it thinks it needs to survive; the expectation is to push that number downward as more mitochondria come online to process fatty acids and ketone bodies.
19:57 < jrayhawk> If the signalling milieu is generally broken by e.g. diabetes or what have you, then you're going to need some actual performance measurement as well.
19:57 < jrayhawk> But subjective measures are certainly adequate.
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20:07 < streety> thanks
20:08 < streety> are there any studies pulling this all together? Would be interesting to see time series in blood glucose, ketone bodies, expression of different mitochondrial proteins etc
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--- Log closed Mon Jun 26 00:00:32 2017