--- Log opened Sat Jul 29 00:00:34 2017 00:42 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 00:42 < aeiousomething> hello 00:42 < yoleaux> 28 Jul 2017 15:39Z aeiousomething: isn't provigil pretty cheap in India? 00:42 < aeiousomething> whoa.. thanks yoleaux 00:43 < aeiousomething> it is.. but it's sketchy to buy it 00:43 < aeiousomething> medical store people will sell it to you under the table because usually it doesn't move as fast 00:43 < aeiousomething> but there's a reason it doesn't move as fast 00:43 < aeiousomething> it's only prescribed for narcolepsy and another disease that's even rarer 00:44 < aeiousomething> and they can't sell you large batches.. one strip of 10s for a month is all they can do if you can sweet talk them into it 00:44 < aeiousomething> which is pretty useless 00:44 < aeiousomething> if you want to be functional everyday.. but then again .. I have my own reservations about pills that mask sleep deprivation issues 00:44 < aeiousomething> maybe I'm one of those fitness freaks. 00:45 < aeiousomething> I remember reading some articles on how sleep deprivation can be the most dangerous thing ever. 00:46 < aeiousomething> if you use modvigil/provigil regularly you will never know if you've been having bad/insufficient sleep.. before you know it you will be suceptable to diabetes and other bullshit 00:46 < aeiousomething> '/endwalloftext 00:48 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 00:48 < aeiousomething> is yoleaux a bot that is something that replays messages when someone logs in? if so, that might just be the coolest thing ever. 00:49 < aeiousomething> Everyone hates the movie limitless but it does make it a point to tell you that you need to monitor your sleeping, eating and drinking water.. like literally keep data on it when you decide to use nootropics 00:50 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 276 seconds] 00:50 < aeiousomething> but then again, if we all slept, ate, drank water and worked out regularly... we would probably be performing at a significantly higher percentage of efficiency than we normally are to begin with 00:51 < aeiousomething> '/actualendwalloftext <- I just had my second coffee 00:56 < aeiousomething> If anyone is interested, I'm trying to experiment on myself using quantifiedmind and cambridgebrainsciences. Msg me and I will go into detail 01:00 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.7.1] 01:00 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 01:15 < maaku> aeiousomething: yoleaux is a bot 01:15 < maaku> .tell aeiousomething maaku says hello 01:15 < yoleaux> maaku: I'll pass your message to aeiousomething. 01:16 < aeiousomething> yeh I figured it out 01:16 < yoleaux> 08:15Z aeiousomething: maaku says hello 01:16 < aeiousomething> sweet setup 01:17 < aeiousomething> maaku: do you know how to setup voice prompts in irssi or should I man up and get that "tmux version" you keep talking about 01:17 < maaku> I'm not sure what you mean by voice prompts. Audio bells? There's probably some way to configure that 01:18 < maaku> tmux probably screws with that though. I don't know. 01:52 < aeiousomething> as in .. making a noise when someone mentions my name 01:52 < aeiousomething> I treid to read up on it but most of the documentation is for linux 01:52 < aeiousomething> I'm on a mac 02:25 < archels_> aliexpress search query: "battery sander machine" 02:26 < archels_> AI helpfully suggesting related search terms: "sex machine" 02:28 < maaku> don't leave us in suspense. did you get any results? 02:37 < archels_> I found a cute 12V polisher, yes 02:37 * archels_ runs 02:45 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 260 seconds] 03:20 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:22 < kanzure> hmph 03:24 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 03:38 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:41 < kanzure> "Neuromorphic computing with nanoscale spintronic oscillators" https://www.nature.com/nature/journal/v547/n7664/full/nature23011.html https://twitter.com/nature/status/890938419702005760 03:42 < kanzure> "Competition for a limited supply of synaptic building blocks predicts multiplicative synaptic normalization and heterosynaptic plasticity" http://www.biorxiv.org/content/early/2017/07/21/166819 https://twitter.com/ItsNeuronal/status/890980837784735745 03:50 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 03:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 03:57 -!- emeraldgreen [~user@92.222.68.248] has joined ##hplusroadmap 03:59 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 04:01 < archels_> ah, Jochen Triesch. he's a cool guy, does some really cool work 04:14 -!- emeraldgreen [~user@92.222.68.248] has quit [Quit: Leaving.] 04:19 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-166-215.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 04:30 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 240 seconds] 04:40 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 05:08 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: Malvolio] 05:14 -!- preview_ [~preview@2407:7000:842d:4026:49b:aa53:f0af:a741] has joined ##hplusroadmap 05:15 -!- preview [~quassel@2407:7000:842d:4026:49b:aa53:f0af:a741] has quit [Read error: No route to host] 05:31 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 05:31 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 05:41 -!- preview_ [~preview@2407:7000:842d:4026:49b:aa53:f0af:a741] has quit [Quit: Leaving] 05:53 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 06:01 < aeiousomething> hello 06:38 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds] 06:49 -!- juri_ [~juri@205.166.94.162] has quit [Ping timeout: 248 seconds] 06:56 -!- juri_ [~juri@205.166.94.162] has joined ##hplusroadmap 07:28 -!- esmerelda [~mabel@174-24-228-29.tukw.qwest.net] has quit [Ping timeout: 260 seconds] 07:29 < docl> aeiousomething: modafinil doesn't keep you up as much as coffee does. but you don't want to be taking it late in the day (best to avoid coffee late in the day as well). 07:31 < docl> I usually find my coffee consumption dropping when I take modafinil. 07:31 < aeiousomething> docl: it's complicated 07:32 < aeiousomething> I might sound like a I'm crazy in the coconuts but it feels like I need to have a ritual with any stimulants 07:32 < aeiousomething> including coffee 07:32 < aeiousomething> coffe actually doesn't help me.. 07:32 < aeiousomething> it makes my ADHD worse 07:32 < aeiousomething> but it's all I have when I have nothing.. 07:32 < aeiousomething> modafinil/adderall help .. but they 07:32 < docl> hmm... mix modafinil with a beverage? doesn't taste great 07:32 < aeiousomething> mentally hurt for the lack of a better term 07:33 < aeiousomething> adderall is the worst 07:33 < aeiousomething> If I'm not doing anything it makes me very irritable 07:33 < aeiousomething> it simply doesn't let me relax 07:33 < aeiousomething> what I've found in my case to say the least is I need to have a ritual.. the best way to explain this is by using a lawnmower analogy 07:33 < aeiousomething> it only works for me when I try to do something that requires critical thinking within the first few minutes of ingestion 07:34 < aeiousomething> akin to.. fueling up the lawn mower but pulling the damn cord and pushing it 07:34 < aeiousomething> not just fueling* 07:34 < aeiousomething> so I try to play chess within the first few minutes of taking any stimulant.. it might sound stupid but it seems to explain to my brain how to use the new found "intellect" 07:35 < aeiousomething> I might just be convicing myself this works but it is the only way it works for me 07:35 < aeiousomething> oh and I can never take coffee + adderall .. it puts my mind in a weird state.. I feel detached from my body and my brain goes on hyperdrive... and I'm unable to concentrate on anything.. even simple taks.. 07:36 < aeiousomething> only one stimulant at a time. 07:37 < docl> do you have any math rituals that you do in your head? like walking through the multiplication table or somthing 07:37 < aeiousomething> no.. I just use chess as a way to detect when the adderall has kicked hin.. 07:37 < aeiousomething> I see significant difference.. 07:38 < aeiousomething> without adderall .. my chess.com rating can range between 1200-1400.. 07:38 < aeiousomething> with adderall I beat 1800s and 2000s 07:38 < aeiousomething> I like to make sure I test this all the time because I don't want to be taking stimulants that are not doing anything for me 07:38 < docl> woah, that's a big difference 07:39 < aeiousomething> yeah .. my ADD is very bad.. It was bad all through my life 07:39 < aeiousomething> I never finished my homeworks 07:39 < aeiousomething> but I still managed to pass with good grades.. 07:39 < aeiousomething> I've spent ages in denial about my adhd.. I did not want to take stimulants.. I guess you could say being Indian I come from a different culture 07:39 < aeiousomething> we don't take as many drugs as easily 07:40 < aeiousomething> I only started taking adderall at 27/28... that was when I realized I was going to get fired 07:40 < aeiousomething> after that I got diagnosed.. 07:40 < docl> yeah I'm from a subculture that hates drugs as well 07:40 < aeiousomething> ^ for good reason.. 07:40 < aeiousomething> my grand mother died of ruptured intestines from damage from acidic pain killers over time 07:40 < aeiousomething> she died the most painful death possible 07:40 < aeiousomething> her stomach contents got emptied into her body 07:41 < aeiousomething> I also haven't even smoked pot until 27... 07:41 < aeiousomething> didn't drink coffee until I was 23.. 07:41 < aeiousomething> did drink alcohol. 07:41 < aeiousomething> I guess that's considered less harmful in my culture 07:41 < docl> I was 30 before I tried pot or alcohol 07:41 < aeiousomething> even though they don't encourage it 07:42 < aeiousomething> yeah.. pot was good in most case except it also makes me significantly stupid 07:42 < aeiousomething> esp with my add.. 07:42 < aeiousomething> it's like letting all the horses in my head out of their stable 07:42 < aeiousomething> I think about everything under the sun.. 07:42 < aeiousomething> and I'm unable to "DO" anything.. 07:42 < aeiousomething> I can think of all sorts of abstract things.. but sativa or indica ... I am not getting off the couch 07:42 < docl> yeah that's the problem with it. same with alcohol, although I've found myself doing chores on alcohol that I would procrastinate while sober 07:43 < aeiousomething> alcohol inhibits anxiety 07:43 < docl> that's probably it 07:43 < aeiousomething> but its disadvantages outweigh its benefits in my opinion 07:43 < aeiousomething> my sleep is affected. 07:43 < aeiousomething> regardless of when or hwo much I drink.. 07:43 < aeiousomething> whether it's one drink or 20 07:43 < aeiousomething> I never sleep well 07:43 < aeiousomething> even pot/coffee affects my sleep 07:44 < aeiousomething> I spoke to my doctor about it.. he said people think one drink or pot helps them sleep better but it's not good sleep 07:45 < aeiousomething> one thing I found helps immensely is making my room absolutely dark.. like I can't even see my own hands dark when I sleep.. 07:45 < aeiousomething> this gives me the best sleep 07:45 < docl> have you tried a melatonin supplement? 07:45 < aeiousomething> I've thought about it 07:46 < aeiousomething> but my lack of sleep is not due to some hormonal imbalance 07:46 < aeiousomething> it usually happens when I feel like I haven't accomplished much during the day 07:46 -!- Douhet [~Douhet@unaffiliated/douhet] has quit [Ping timeout: 268 seconds] 07:46 < aeiousomething> physically and mentally 07:46 < aeiousomething> I don't want to address the symptoms without addressing the root cause 07:47 -!- Douhet [~Douhet@unaffiliated/douhet] has joined ##hplusroadmap 07:48 < docl> well, fundamentally your body is physical, so the chemicals kinda are a root cause. your behavior makes your body produce different amounts of chemicals. 07:48 < aeiousomething> indeed. 07:49 < kanzure> "Rapid and scalable characterization of CRISPR technologies using an E. coli cell-free transcription-translation system" http://www.biorxiv.org/content/early/2017/07/28/169441 07:50 < kanzure> "Taming parasites by tailoring them" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498469/ https://twitter.com/CRISPR_papers/status/888702948808704003 07:51 < aeiousomething> kanzure: can you pease help me get that ADHD data dump maaku said you might have? 07:51 < kanzure> "Initial application of CRISPR/Cas9 has already been achieved in Toxoplasma, Plasmodium, Trypanosoma, and Leishmania species (Ghorbal et al., 2014; Lee and Fidock, 2014; Peng et al., 2014; Shen et al., 2014; Sidik et al., 2014; Wagner et al., 2014; Sollelis et al., 2015; Zhang and Matlashewski, 2015). A combination of CRISPR/Cas9 with customary tools has resulted in a significantly efficient ... 07:51 < kanzure> ...production of transgenic strains, as reviewed by Cui and Yu (2016) (Figure ​(Figure4A).4A). " 07:52 < kanzure> aeiousomething: i only have some notes; http://diyhpl.us/~bryan/papers2/nootropics/adderall.txt http://diyhpl.us/~bryan/papers2/neuro/ 08:00 < aeiousomething> kanzure: what do you do for the dysphoria resulting from the comedown 08:03 < kanzure> the what? 08:04 < aeiousomething> you have no issues from when the adderall wears off? 08:04 < kanzure> i have to do different things, and not the same things, which is sort of unfortunate. 08:05 < aeiousomething> http://www.brainprotips.com/adderall-comedown/ 08:05 < aeiousomething> that's a silly website but it does describe most of what happens to me when adderall wears off 08:05 < aeiousomething> happened* 08:05 < aeiousomething> this does not happen to me with modafinil 08:38 < kanzure> time for musics https://www.youtube.com/watch?v=WHoGFB6tsXI&t=5m49s 09:07 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 240 seconds] 09:25 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 09:35 -!- preview [~quassel@2407:7000:842d:4000::3] has quit [Remote host closed the connection] 10:08 < aeiousomething> test 10:17 < nmz787> aeiousomething: modafinil worked OK for my ADHD 10:18 < nmz787> aeiousomething: why not get a Dr to prescribe for you? 10:23 < aeiousomething> they don't prescribe it for ADHD in India 10:23 < aeiousomething> I could try but I'm not sure 10:24 < aeiousomething> I might have to try 10:27 < nmz787> I have a feeling they are much more lax about off-label uses 10:28 < aeiousomething> nmz787: you might be right but I'd still have to go meet a psychiatrist 10:28 < aeiousomething> only medical professionals capable of prescribing that drug 10:28 < aeiousomething> let me find out 10:38 < Qfwfq> Generic provigil (SunPharma etc) is OTC in .in, compare with the blacklist in the appendix of https://web.archive.org/web/20051031023525/http://cdsco.nic.in:80/html/Copy%20of%201.%20D&CAct121.pdf (pp. 612) 10:39 < Qfwfq> (Uh, pp 610; p 612.) 10:40 < Qfwfq> 2006 update https://web.archive.org/web/20070221055138/http://drugscontrol.org/Schedule_H.pdf 10:41 < aeiousomething> Is that the R-Modafinil or the S-modafinil 10:41 < aeiousomething> one of those has higher absorption rate I think 10:43 < Qfwfq> SunPharma brand armodafanil as waklert, modafanil as modalert. 10:43 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 10:44 < Qfwfq> Neither appears to be scheduled. Exports would likely be smaller otherwise. 10:46 < aeiousomething> both wakalert and modalert require prescriptions 10:46 < aeiousomething> I've looked 10:48 < aeiousomething> http://www.netmeds.com/prescriptions/waklert/150mg 10:48 < aeiousomething> http://www.netmeds.com/prescriptions/modalert/200mg 10:48 < aeiousomething> look at the red "prescription needed" sign. 10:49 < aeiousomething> scheduled might mean different things in India.. I just know I need a prescription for it.. and pharmacies can't sell me a whole bunch per month without attracting attention 10:51 -!- augur [~augur@67-207-118-226.static.wiline.com] has joined ##hplusroadmap 10:52 < Qfwfq> you can make this harder for yourself i guess ¯\_(ツ)_/¯ 10:55 < TMA> it looks like there are only illegal amphetamines available in .cz; I was unable to find any in the list of approved medications 10:57 < aeiousomething> how so Qfwfq .. I doubt the exports are sold legally. You would be surprised how lax the laws are with regards to medications in India.. if you know the right people you could buy a bunch of vicodin/xanax/ anything really otc. 10:57 < aeiousomething> it's only bad for people who don't have such connections 10:58 < aeiousomething> I will try walking over to a store and asking for it 10:58 < aeiousomething> will report soon 11:00 -!- Asterion [~Asterion@24.38.131.202] has quit [Quit: Leaving] 11:01 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 11:03 < nmz787> archels_: nice job! your bessel filter page made it to hackaday :) 11:05 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 11:20 -!- ch_screwed [57aa053c@gateway/web/cgi-irc/kiwiirc.com/ip.87.170.5.60] has joined ##hplusroadmap 11:26 -!- augur [~augur@67-207-118-226.static.wiline.com] has quit [Remote host closed the connection] 12:02 -!- Douhet [~Douhet@unaffiliated/douhet] has quit [Ping timeout: 246 seconds] 12:12 -!- tyrosine [~scott@host-128-227-196-212.xlate.ufl.edu] has joined ##hplusroadmap 12:12 -!- tyrosine [~scott@host-128-227-196-212.xlate.ufl.edu] has left ##hplusroadmap [] 12:13 -!- tyrosine [~scott@host-128-227-196-212.xlate.ufl.edu] has joined ##hplusroadmap 12:13 -!- Douhet [~Douhet@unaffiliated/douhet] has joined ##hplusroadmap 12:13 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 12:15 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 240 seconds] 12:15 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 12:17 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 12:17 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 12:17 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 12:18 -!- TC is now known as Guest75407 12:21 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 12:26 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has joined ##hplusroadmap 12:29 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 12:30 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 12:31 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has quit [Ping timeout: 260 seconds] 12:33 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has joined ##hplusroadmap 12:36 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 12:36 -!- cluckj [~cluckj@static-98-114-202-142.phlapa.ftas.verizon.net] has quit [Ping timeout: 268 seconds] 12:44 -!- cluckj [~cluckj@static-98-114-202-142.phlapa.ftas.verizon.net] has joined ##hplusroadmap 12:47 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 12:49 < kanzure> why you guys so boring 12:57 < ch_screwed> i'm a bit shy 12:58 < kanzure> alright but what about everyone else. 12:59 -!- scott__ [~scott@host-128-227-196-212.xlate.ufl.edu] has joined ##hplusroadmap 12:59 < kanzure> literally hours have gone by without a proposal for destroying the planet. 12:59 < ch_screwed> would that come not as a natural byproduct of dna hacking? 13:00 < kanzure> no you usually have to intentionally try to destroy the planet. 13:02 -!- tyrosine [~scott@host-128-227-196-212.xlate.ufl.edu] has quit [Ping timeout: 260 seconds] 13:02 < ch_screwed> i heard a science report on the radio about scientist trying to use a genome scissor (cispr cusp or sth) as a kind of selective self-replicating dna shredder to kill some virus or moscito or the like. sounded a lot like a end of world device 13:02 < kanzure> why would a gene editing technology be a "world ending device"? wtf? 13:03 < ch_screwed> not editing 13:03 < kanzure> crispr is for editing. 13:03 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 13:03 < kanzure> their stock symbol is literally "editas". 13:03 < ch_screwed> editing involves cutting, doesnt it? 13:04 < kanzure> here are various techniques http://diyhpl.us/wiki/gene-editing/ 13:06 < ch_screwed> i found it, they want to fight the zika mosquito 13:06 < ch_screwed> http://edition.cnn.com/2016/03/07/health/zika-virus-gmo-mosquito-dna/index.html 13:07 < ch_screwed> the headline of the german article is literally "the genome-bomb" 13:07 < kanzure> that's not really impressive. we have had proposals in here for replacing 40-60% of the life on the planet with synthetic alternatives (using custom dna). 13:08 < ch_screwed> killing a whole species sounded impressive enought to me 13:08 < kanzure> genocide? meh. 13:11 < ch_screwed> well, replacing something also involves getting rid of the old ones 13:11 < TMA> considering we manage to kill off several whole species a year without even specifically trying, it is probably not that impressive 13:12 < kanzure> that's the spirit :-) 13:12 < JayDugger> One genus at a time. 13:13 < ch_screwed> but what are the mechanisms for that? climate change/ biotope displacement/ chemicals spreading (un)intentionally 13:13 < kanzure> huh? just set the atmosphere on fire. 13:13 < JayDugger> Saturation neutron bombing for small jobs. Kinetic kill for big ones. 13:14 < kanzure> jaydugger has the right idea, he's a team player. 13:14 < ch_screwed> here, setting a bag full of mosquitoes free in one spot kills potentially the whole species, that would count as a "first" 13:14 < JayDugger> We'll get better at it over time. No one much cares about mosquitoes if they don't bite humans or their domesticated species. 13:15 < JayDugger> Aside from ecological management. Don't want a food web to collapse, I admit. 13:15 < TMA> ch_screwed: it's really easy: we managed several with hunting: dodo, aurochs, thylacine 13:15 < JayDugger> Did aurochs get hunted out, or did they get displaced and fail to domesticate? 13:15 < JayDugger> I don't really know, but that ought to have some historical record. 13:16 < streety> I think Editas' stock symbol is EDIT 13:16 < ch_screwed> yeah, but not one guy setting a pack of modified say dodos free killed the species. its indirect, self replicating. another kind of thing in my book 13:16 < kanzure> oops. got the stock symbol wrong. 13:18 < TMA> sheep are reportedly unable to go ferral, the precursor to modern sheep can be thought of as extinct too 13:19 < ch_screwed> i mean, replacing malaria mosquitos with ones that would spread "updated" flu immunity. getting stung once in a while would be a good thing. all those people near the equator would be so thankfull, no longer getting the flu 13:20 < ch_screwed> but good example with the sheep 13:21 < JayDugger> Looks as if aurochs hunted out in Europe, and displaced elsewhere. 13:23 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 13:25 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 14:11 -!- jcluck [~cluckj@static-98-114-202-142.phlapa.ftas.verizon.net] has joined ##hplusroadmap 14:13 -!- cluckj [~cluckj@static-98-114-202-142.phlapa.ftas.verizon.net] has quit [Ping timeout: 260 seconds] 14:37 -!- ch_screwed [57aa053c@gateway/web/cgi-irc/kiwiirc.com/ip.87.170.5.60] has quit [Quit: http://www.kiwiirc.com/ - A hand crafted IRC client] 14:42 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 14:42 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 14:43 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 14:44 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 14:56 < archels_> nmz787: :D thanks for your comment 15:07 < kanzure> what was the objection to igniting the atmosphere, something about not enough nitrogen? streety had a complaint. 15:28 -!- strages [uid11297@gateway/web/irccloud.com/x-tpinhlscgvnmhvyz] has quit [Quit: Connection closed for inactivity] 15:37 -!- jcluck is now known as cluckj 16:22 -!- A93C2952 [~DCA41435@233.23-65-87.adsl-dyn.isp.belgacom.be] has joined ##hplusroadmap 16:26 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has joined ##hplusroadmap 16:29 < fenn> i bet there's a way to re-wild sheep similar to the project breeding aurochs from cows 16:29 < fenn> you might end up with "killer sheep" tho 16:38 < cluckj> that sounds like an adorable problem 16:39 -!- deep-book-gk_ [~1wm_su@177.47.27.242] has joined ##hplusroadmap 16:39 < fenn> personally i think this planet needs more wild roaming genetically modified monsters 16:39 -!- A93C2952 [~DCA41435@233.23-65-87.adsl-dyn.isp.belgacom.be] has quit [Ping timeout: 240 seconds] 16:40 < fenn> there are escaped hogs in the southern US that get really huge and kill dogs and dig up plants and stuff 16:41 -!- deep-book-gk_ [~1wm_su@177.47.27.242] has left ##hplusroadmap [] 16:41 < fenn> you have to hire a pigslayer to go hunt them if they're nearby 16:41 < kanzure> more likely to get genetically modified animolecules than hogs 16:42 < kanzure> (pond-dwelling few-cell organisms) 16:42 < fenn> i'm just tired of all this boring genetic engineering like pesticide resistance or extended shelf life 16:43 < kanzure> would you be satisfied by porting over blue ass monkey pigmentation? 16:43 < fenn> let's see some dragons and wooly baconated milk platypi 16:45 < kanzure> that's.. more difficult. 16:46 < fenn> blue ass monkey isn't very blue 16:47 < fenn> mandrills (blue nosed baboon) is getting there 16:47 < fenn> i guess they have blue asses too 16:47 < kanzure> oh hell i forgot about mandrills. yes. 16:48 < fenn> like that could totally be a GMO monster right there https://www.calgaryzoo.com/mandrill 16:50 < fenn> right so could we splice that coloring gene into a pig? 16:50 < cluckj> one of my bioartist friends wants plaid pigs 16:51 < cluckj> and agrees with your sentiment 16:53 < cluckj> someone needs to put the "horror" back in "genetically modified horror" 16:54 < kanzure> seems that the only monkey pigment research has been regarding scrotal development -_- 16:55 < kanzure> and it's just melanin of course.. 16:55 < cluckj> zzz 16:57 < kanzure> "melanin and hemoglobin" seems kind of like a non-answer to me. 16:57 -!- augur [~augur@c-76-103-28-112.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 16:59 < kanzure> "(D) Transmission electron micrograph of a cross section of a collagen array from the blue facial skin of a mandrill, Mandrillus sphinx. (courtesy of Dr Richard Prum)." 16:59 < kanzure> from http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0749.2006.00360.x/full 17:01 < kanzure> "For many years, it was considered that the prominent blue colors of some primates such as the mandrill (Mandrillus sphinx) that possesses spectacular blue facial skin and a blue rump are the product of incoherent light scatter (Fox, 1976). This conclusion was generally accepted to be true although it was challenged, notably by Findlay (1970) who held that light scatter was unimportant in the ... 17:01 < kanzure> ...generation of blue colors of the skin. Rather, he considered blues to arise from an optical relationship between collagen and melanin leading to a ‘subtractive color mixing’ in the dermis." 17:02 < kanzure> .wik mongolian spot 17:02 < yoleaux> "Mongolian spot (congenital dermal melanocytosis) is a benign, flat, congenital birthmark with wavy borders and irregular shape. In 1883, it was described and named after Mongolians by Erwin Bälz, a German anthropologist based in Japan. It normally disappears three to five years after birth and almost always by puberty." — https://en.wikipedia.org/wiki/Mongolian_spot 17:02 < kanzure> "The most common color is blue, although they can be blue-gray, blue-black or deep brown." 17:04 < kanzure> "The Mongolian spot is referred to in the Japanese idiom shiri ga aoi, meaning "to have a blue butt",[26][27]." 17:06 < kanzure> i think you could induce this with electroporation 17:06 < kanzure> (and some reagents) 17:06 < fenn> sounds like it needs more research to identify the genes responsible 17:07 < kanzure> "The difference in skin color between lightly and darkly pigmented individuals is due not to the number (quantity) of melanocytes in their skin, but to the melanocytes' level of activity (quantity and relative amounts of eumelanin and pheomelanin). This process is under hormonal control, including the MSH and ACTH peptides that are produced from the precursor proopiomelanocortin." 17:07 < kanzure> none of that seems to mention color other than "lightly and darkly pigmented individuals". what happened to all the other colors of the rainbow? 17:07 < fenn> yeah all those blue and green people, where did they go 17:10 < kanzure> what about porting chromatophores instead. 17:11 < kanzure> "Nearly all the vibrant blues in animals and plants are created by structural coloration rather than by pigments. However, some types of mandarinfish do possess vesicles of a cyan biochrome of unknown chemical structure in cells named cyanophores.[11] Although they appear unusual in their limited taxonomic range, there may be cyanophores (as well as further unusual chromatophore types) in ... 17:11 < kanzure> ...other fish and amphibians. For example, brightly coloured chromatophores with undefined pigments are found in both poison dart frogs and glass frogs,[15] and atypical dichromatic chromatophores, named erythro-iridophores have been described in Pseudochromis diadema.[16]" 17:11 < kanzure> uh. 17:12 < kanzure> xanthophores/erythrophores look easier. 17:12 < kanzure> https://en.wikipedia.org/wiki/Chromatophore#Xanthophores_and_erythrophores 17:16 < kanzure> if an octopus has a seizure, does its chromatophores rapidly display nonsense data? 17:16 -!- fltrz [4d6d6745@gateway/web/freenode/ip.77.109.103.69] has joined ##hplusroadmap 17:20 < kanzure> "In fact, if you search for "chromatophores insane in the membrane", you can see a tissue prep where they hooked up the audio output from a mp3 player to some of the descending neurons that control the chromatophores:" 17:20 < kanzure> oh... 17:20 < kanzure> http://blog.backyardbrains.com/2012/08/insane-in-the-chromatophores/ 17:21 < kanzure> "This video contains content from SME, who has blocked it in your country on copyright grounds." 17:21 < kanzure> http://evolver.fm/2012/08/23/squids-can-be-music-apps-apparently/ 17:22 < kanzure> https://www.youtube.com/watch?v=b5F-7Bu8YBQ&list=PLFW6N3rqZXGcS4k6eWG02lGeDRzjGgHeV&index=1 17:26 < fenn> http://fennetic.net/irc/Insane_in_the_Chromatophores-G-OVrI9x8Zs.mp4 (15MB) 17:32 < kanzure> i guess this means the answer to my question is yes. 17:53 < fltrz> what was the question? 17:59 < kanzure> fenn wanted a blue mandrill face 18:04 < fenn> i thought the question was "if an octopus has a seizure, does its chromatophores rapidly display nonsense data?" 18:07 < kanzure> it's so hard to read though 18:14 < kanzure> "and if someone like Peter Thiel wants to live forever, he needs to fund the things in George Church’s lab" hey at least he has jumped from eliezer to george. 18:14 < kanzure> (re the wooly mammoth book interview) 18:15 < kanzure> "doing the anti-malaria mosquitos, working with the Gates foundation, they’re building domes over villages in Africa and releasing mosquitoes that can’t carry malaria" 18:15 < kanzure> domes? 18:15 < kanzure> i guess you need to isolate the mosquito population somehow 18:15 < kanzure> ( http://gizmodo.com/why-bringing-back-a-wooly-mammoth-is-no-longer-science-1797099747 ) 18:16 < kanzure> ".. isn’t the only one working to clone a mammoth. There’s also Hwang Woo-suk’s Korean dog-cloning lab, Soaam Technologies [....] He was the one who claimed to clone human cells, but it turns out he had been forcing his students to donate their eggs, and secondly that his clone cells are fraudulent, so he’s trying to resurrect his reputation by being the first to clone a mammoth." 18:16 < kanzure> makes sense. 18:18 < kanzure> about as much sense as anything else, really. 18:18 < kanzure> dead reputation -> ressurect mammoth, resurrect reputation. got it. 18:23 < kanzure> "(Editor’s Note: This is a speculative idea that Mezrich describes in more detail in the book, in which Pleistocene herbivores might help transition forests and shrub lands into grasslands, which absorb less heat.) The idea is to repopulate the area with mammoths. Church’s goal is 80,000 mammoths, and [he hopes that] you could lower the temperature of the permafrost for generations." 18:23 < kanzure> "Who should play Church in the movie? I love Tom Hanks for that character, Jeff Bridges is my other first choice. Hanks already grew that big beard in Castaway and Jeff Bridges has that great beard, so Hanks or Bridges." 18:28 < cluckj> hahaha 18:30 < kanzure> main problem i see with the domes is you get stuck with all the mosquitoes in the dome with you. 18:34 < cluckj> DEET bath? 18:34 < kanzure> no more than usual, i presume. 18:47 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:51 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 268 seconds] 18:54 < kanzure> "In case Voldemort doesn't want to reveal himself (or give a ℒ-like anonymous remote talk), I've encouraged andytoshi to submit it to Scaling Bitcoin and give the talk on his behalf." 18:54 < kanzure> maaku: hah i had missed that death note reference the first time around 18:55 < kanzure> .title https://news.ycombinator.com/item?id=14883742 18:55 < yoleaux> Confidential Transactions from Basic Principles | Hacker News 18:59 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 19:02 -!- strages [uid11297@gateway/web/irccloud.com/x-tvmtodmzdcuzxais] has joined ##hplusroadmap 20:27 < kanzure> http://blog.otoro.net/2016/09/28/hyper-networks/ https://arxiv.org/abs/1609.09106 20:30 -!- Gurkenglas_ [~Gurkengla@dslb-178-005-166-215.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 20:43 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 21:07 < aeiousomething> test 21:24 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 260 seconds] 21:46 * nmz787 test failed 21:50 < kanzure> that's why you should always have a test test, too. 22:12 < kanzure> hmmmpppph replace-by-fee and nSequence=0 and some other things sent me on a wild goose chase. oh well. 23:14 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 23:16 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:27 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 260 seconds] 23:27 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.7.1] 23:28 -!- aeiousomething [~aeiousome@124.123.15.66] has joined ##hplusroadmap 23:28 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 23:37 -!- aeiousomething [~aeiousome@124.123.15.66] has quit [Ping timeout: 246 seconds] 23:45 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.7.1] 23:45 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap --- Log closed Sun Jul 30 00:00:35 2017