--- Log opened Tue Aug 01 00:00:37 2017
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00:24 < maaku> https://www.forbes.com/sites/tonybradley/2017/07/31/facebook-ai-creates-its-own-language-in-creepy-preview-of-our-potential-future/#707aca65292c
00:24 < maaku> .title
00:24 < yoleaux> Facebook AI Creates Its Own Language In Creepy Preview Of Our Potential Future
00:24 < maaku> I dont know why it is creepy or why they shut it down. It sounds like very interesting linguistic research.
00:24 < maaku> Maybe they can evolve a better human language.
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00:57 < mrdata> they shut it dowen because the AIs were supposed to be learning english, and this wasnt english and couldnt be audited
01:06 < kanzure> i sort of doubt it was anything intereting. journalists are notorious for getting everything wrong about a story.
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04:55 < FourFire> maaku, it's creepy because the control problem is being thrown in researchers' faces when they just want to make money
04:57 < kanzure> ehh there's no way to know how their systems actually work.
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05:06 < kanzure> hmph
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05:58 < kanzure> funding and venture capital in synthetic biology companies in 2017 https://synbiobeta.com/synthetic-biology-funding-2017/
05:58 < kanzure> from https://twitter.com/johncumbers/status/892015755406876672
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09:19 < nmz787> fenn: because medical devices and medical data processing is big bucks
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09:29 < nmz787> fenn: they are also involved in some scientific crunching, I saw one of his colleagues at the PNW microscopy symposium, advertising servers/datacenters... and talking about optimizing cryo TEM tomography data processing pipelines
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10:30 < kanzure> a company working on "worlds smallest qPCR machine" https://news.ycombinator.com/item?id=14901862
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10:49 < kanzure> "Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals" http://www.biorxiv.org/content/early/2017/07/31/170712
10:51 < kanzure> "Photographic image synthesis with cascaded refinement networks" https://arxiv.org/abs/1707.09405
10:51 < kanzure> "1% of the population are affected by intellectual disability"  only 1%? that's kind of impressive.
10:51 < kanzure> "Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses ...
10:51 < kanzure> ...for neuroscience experiments using model systems."
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11:51 < fltrz> to me the 1% is hardly impressive, I would also estimate about 1% with a lung disability, or 1% with a muscle disability etc
11:51 < fltrz> darwinism spreads the good genes very quickly in terms of generations
11:53 < fltrz> most people we consider "dumb" can still learn lyrics of their favourite song... so our perception of their "dumbness" is mostly just our disapproval of how they use their capacities
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11:59 < kanzure> yes a lot of "dumb" people are way more brilliant than the common pet rock. it's quite interesting.
12:02 < kanzure> this is probably a semantics argument about what "affected by intellectual disability" really means.
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12:52 < fltrz> that "photographic image synthesis ..." paper you linked is amazing
12:56 < kanzure> there was a paper that did something similar starting from simple text descriptions of scenes, and then it would generate a photo-realistic image that matches the scene.
12:58 < kanzure> it may have had the word "caption" in the title.
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13:23 < kanzure> "Parsing natural scenes and natural language with recursive neural networks" http://nlp.stanford.edu/pubs/SocherLinNgManning_ICML2011.pdf
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13:23 < kanzure> .title https://www.youtube.com/watch?v=xKt21ucdBY0
13:23 < yoleaux> Automated Image Captioning with ConvNets and Recurrent Nets - YouTube
13:24 < kanzure> okay that is the wrong direction.
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13:25 < kanzure> h here we go,
13:25 < kanzure> https://github.com/paarthneekhara/text-to-image
13:25 < kanzure> "StackGAN: Text to photo-realistic image synthesis with stacked generative adversarial networks" https://arxiv.org/abs/1612.03242 https://arxiv.org/pdf/1612.03242.pdf
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13:27 < kanzure> "Generative adversarial text to image synthesis" https://arxiv.org/abs/1605.05396 https://arxiv.org/pdf/1605.05396.pdf
13:29 < kanzure> this one uses a human pose database as additional augmentation https://arxiv.org/pdf/1703.06676.pdf
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14:11 < nmz787> that qPCR may be the world's smallest commercial device... but it doesn't seem like the world's smallest in general. Unless their case is massive because of the battery and other support gizmos
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17:48 < kanzure> mozilla deepspeech stuff https://research.mozilla.org/machine-learning/ https://news.ycombinator.com/item?id=14903071
17:52 < streety> nmz787: by smallest are you talking about reaction volume? The total size of the instrument needed to go from reaction mixture to result seems like a reasonable measure of size
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17:58 < kanzure> cevi_: not quite the highest quality math discussion but here you go https://news.ycombinator.com/item?id=14903333 (automatic theorem proving complaints, i guess)
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18:15 < nmz787> streety: when it's iPod sized, I'll hoot and holler
18:16 < nmz787> that was like single-soda can cooler size
18:17 < nmz787> I guess it might almost be 10X smaller in device volume (the gizmo's box) than the qPCR machine I last used
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18:46 < ybit> a search for "Instability and decay of the primary structure of DNA" on google scholar results in the link on gnusha :)
18:48 < kanzure> ybit: relatedly,
18:48 < kanzure> here is a fun query: https://scholar.google.com/scholar?q=-site%3Adiyhpl.us+%22diyhpl.us%22&btnG=&hl=en&as_sdt=0%2C44
18:48 < kanzure> like why the hell is "Characterization of zygotic and nucellar embryo of six indonesian mango cultivars using molecular markers" citing hplusroadmap's file server?
18:50 < kanzure> this one cites one of my transcripts  (which is a little more reasonable i guess) "The FBI and biohackers: an unusual relationship" http://embor.embopress.org/content/17/6/793
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18:54 < kanzure> we are also cited in a patent (somehow they picked us as the best host of "Guerrilla Guide to CNC Machining, vol. 1") https://www.google.com/patents/US9117300
18:55 < kanzure> "Effect of Mars Conditions on Growth of Halobacterium sp. NRC-1"  cites "The Biocatalytic Potential of Extremophiles and Extremozymes. Retrieved March 23, 2011, from diyhpl: http://..."
18:56 < kanzure> also cited in "Biomedical Enhancements as Justice"
18:56 < kanzure> "Simulation of the machining of a workpiece" https://www.google.com/patents/US9524583
18:59 < ybit> 👍
18:59 < kanzure> a lot of papers seem to have a line like "We used TFSearch version 1.3 for transcription factor binding sites (http://diyhpl.us/∼bryan/irc/protocol-online/protocol-cache/TFSEARCH.html)" but that page has literally never worked. it's cited multiple times in many different papers.
19:01 < kanzure> "A simple approach to numerical simulation with trimmed CAD surfaces" https://arxiv.org/pdf/1501.06741.pdf  cites the hplusroadmap server for the IGES standard
19:02 < kanzure> "The epistemology of cognitive enhancement" https://philpapers.org/archive/CARTEO-58.pdf cites us :-)
19:02 < kanzure> huh this is actually a somewhat high signal way to find reading material.
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19:05 < streety> For the qPCR it seems like there are quite severe diminishing returns. Just how useful is a machine that can take only 3 samples? Beyond the marketing claim would there be any advantage to going smaller?
19:05 < kanzure> cited also in "Helicopter stabilizer optimization considering rotor downwash in forward-flight"
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19:19 < kanzure> if they are so cheap that they could be one use and disposable then that might be useful.. dunno.
19:44 < ybit> https://en.wikipedia.org/wiki/Reed%E2%80%93Solomon_error_correction
19:45 < kanzure> ybit: have you read this one yet https://groups.google.com/d/msg/enzymaticsynthesis/WvDidIldm7c/q7aQTnmkAAAJ
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19:49 < ybit> yeah, it definitely came to mind when hearing someone talk about this
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20:56 < nmz787> kanzure: I don't see any hits for diyhpl.us for the indonesian mango paper
21:00 < nmz787> huh, all the citations are pretty recent
21:00 < nmz787> err
21:00 < nmz787> s/recent/interesting/
21:01 < nmz787> kanzure: nevermind, I see the citation on the mango paper... I thought you meant something else
21:02 < kanzure> there's a lot of weird places we're showing up
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21:42 < maaku> n/win 9
21:43 < kanzure> yep.
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23:22 < kanzure> "Implications of human genetic variation in CRISPR-based therapeutic genome editing" https://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4377.html
23:22 < kanzure> ".. we provide a compendium of guide RNAs predicted to have high efficacy in diverse patient populations."
23:24 < kanzure> .tw https://twitter.com/antonioregalado/status/892399466069848064
23:24 < yoleaux> George Church says idea to use patent pool to enforce good behavior on gene drives still an active plan. Background: https://www.technologyreview.com/s/602633/stop-gene-spills-before-they-happen/ (@antonioregalado)
23:26 < kanzure> maaku: i really don't have the bandwidth to completely fight the crispr-mpeg patent pool stuff.
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23:28 < fenn> gene drives are scary and one of the few things that actually needs regulation
23:29 < kanzure> i don't trust anyone to correctly regulate biotech; they will end up cutting off their hands because "it turns out that everyone is a bioterrorist for attempting to exert influence on their own biology in any conceivable way"
23:29 < fenn> i am surprised how little discussion there has been about gene drives in the media
23:29 < kanzure> in this case i would say the only ethical regulation that could be imposed would be significant funding for biodefense research
23:30 < kanzure> (and biodefense development)
23:30 < fenn> but gene drives aren't for affecting your own biology, it's for affecting large swathes of existing populations
23:30 < kanzure> yes there's lots of running code out there and it should be patched for many different problems- including basic things like aging
23:31 < fenn> i don't want to be "patched" by J random hacker
23:31 < kanzure> well you certainly don't want to not be able to choose to do that.
23:32 < kanzure> it would be absurd to mandate that computer users could no longer get rid of the malware infesting their own personal computers
23:32 < kanzure> and you're certainly welcome to keep running the malware... but you'd be dead.
23:33 < kanzure> attack surface area is superhuge; asking regulators to stop all the biotech equipment isn't going to secure the surface area; only hard actual biodefense work will do this.
23:33 < fenn> look i'm not talking about biotech in general, just gene drives
23:34 < kanzure> i hypertired generality thing am doing my
23:34 < fenn> ah so
23:34 < fenn> go to sleep
23:35 < kanzure> for all you know, i already am. i have been working on the sleeptype thing-- don't have all the bugs kinked out though.
23:36 < Qfwfq> Is this an actual thing?
23:36 < fenn> yes there are hilarious dream transcripts
23:36 < kanzure> yes i started typing in my sleep a while back after hearing about sign language users signing in their sleep and so i wondered if it would work with typing
23:37 < kanzure> always.be.typing
23:47 < kanzure> Qfwfq: http://diyhpl.us/~bryan/sleeptypes/2016-04-24-sleeptypes.excerpts.txt
23:49 < Qfwfq> I enjoy your brain very much.
23:50 < kanzure> https://www.youtube.com/watch?v=nXARrMadTKk
--- Log closed Wed Aug 02 00:00:38 2017