--- Log opened Sat Sep 09 00:00:13 2017
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05:40 < kanzure> maaku: sounds like other cats are still a problem
05:50 < kanzure> doesn't even have to be 'deficient', i thikn you just need to make the protein fold in a different way
05:54 < kanzure> https://www.nytimes.com/2017/09/08/health/allergan-patent-tribe.html?_r=0
05:55 < kanzure> "The drugmaker Allergan announced Friday that it had transferred its patents on a best-selling eye drug to the Saint Regis Mohawk Tribe in upstate New York — an unusual gambit to protect the drug from a patent dispute. [...] Mr. Bailey and others said the legal theory behind the Mohawk deal stemmed from a decision by the patent-review panel earlier this year involving the University of ...
05:55 < kanzure> ...Florida, which owned a patent being challenged by the medical-device maker Covidien. The university, which was also represented by the Shore Chan DePumpo firm, successfully argued that the challenges should be dismissed because, as an arm of the state of Florida, the university should be granted sovereign immunity."
05:58 < kanzure> http://www.ipwatchdog.com/2017/03/16/ufrf-eleventh-amendment-defense-ptab-creates-ipr-immunity-iprs-public-universities/id=79341/
06:01 < kanzure> "... The APJ panel further found that there was nothing in the record to support Covidien’s claims that the Eleventh Amendment immunity defense would cause harm to the patent system overall."
06:02 < kanzure> "“The risk of invalidity is reduced, so these patents are potentially more valuable as a result.” Gates added that tech transfer offices at state universities across the country should be considering how this PTAB decision could help them leverage their patents for better monetization of their intellectual properties .... noted that the establishment of sovereign immunity as an effective ...
06:02 < kanzure> ...protection against patent validity challenges could significantly improve the value of intellectual properties held by these entities."
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06:26 < kanzure> "Gravitational lensing by spinning black holes astrophysics, and in the movie Intersstellar" http://iopscience.iop.org/article/10.1088/0264-9381/32/6/065001/pdf
07:22 < fenn> https://www.theguardian.com/technology/2017/sep/07/new-artificial-intelligence-can-tell-whether-youre-gay-or-straight-from-a-photograph 80-90% accuracy
07:25 < fenn> .title https://osf.io/zn79k/
07:25 < yoleaux> OSF | Deep neural networks are more accurate than humans at detecting sexual orientation from facial images.
07:26 < fenn> michal kosinski is the same guy that warned about applying machine learning to personalized political messaging in https://motherboard.vice.com/en_us/article/mg9vvn/how-our-likes-helped-trump-win
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07:45 < kanzure> hm.
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11:10 < nmz787> hmm, now I want to try that neural network on myself
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11:15 < kanzure> thikning aout telling gp-write that they should make twist contribute its technology or twist should gtfo
11:15 < kanzure> *about
11:15 < kanzure> *thinking
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11:44 < fltrz> lol The paper suggested that the findings provide “strong support” for the theory that sexual orientation stems from exposure to certain hormones before birth, meaning people are born gay and being queer is not a choice.
11:44 < kanzure> this is getting too close to identity politics. let's leave that alone.
11:44 < fltrz> they also mentioned grooming styles, which aren't birth characteristics,
11:44 < fltrz> ok
11:45 < kanzure> 'cept anti-identity politics. i guess that's okay. have the buddhists started trolling yet?
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12:03 < kanzure> nmz787: we should review that helix.works dna data storage library thing before we show up
12:04 < kanzure> https://openmoss.org/docs/MoSS.pdf
12:04 < kanzure> https://github.com/Helixworks/helix-dnadrive
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12:08 < kanzure> juul: whatcha know about twist's technique? someone tells me they are doing inkjet dna synthesis..
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12:52 < nmz787> kanzure: ok, I'll check it out later... need to get outside and paint my house's siding :(
12:54 < nmz787> kanzure: seems some folks I talked to want to know when proposed DNA technology will be 5 years away from competing with electronics... not sure I found the people who are scared enough that electronics are gonna fail to yield profits... those are the people who probably care less of 5 years vs 10 years, they would just know they need something much much smaller
13:02 < kanzure> oh you mean from a short term data storage interest/perspective?
13:03 < kanzure> e.g. concern aobut market competition on density
13:03 < kanzure> to their other product lines
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16:00 < kanzure> "A high level research and solutions creation initiative is seeking senolytics beyond those listed here: dasatinib/quercetin, fisetin, FOXO4-DRI, piperlongumine. Please advise."
16:00 < kanzure> i dunno what a "high level research and solutions creation initiative" is  but it sounds fake.
16:04 < kanzure> i guess there's isoquercetin
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16:07 < kanzure> maybe also: navitoclax, venetoclax, sulforaphane, BCL-2 protein family inhibitors in general,   based on http://diyhpl.us/~bryan/papers2/longevity/2017-04-11-senolytics.txt
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16:55 < nmz787> kanzure: yeah basically the folks I talked to seemed to only want to put money into research if they could begin making $ in data storage market within 5 years...
16:56 < nmz787> or at least starting to sell at competitive price relative to e-storage
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16:57 < kanzure> i mean.... i guess exabyte writes can be achieved within 5 years, but it's a really tight deadline, and it would probably be a central data storage facility not a data storage product to sit on shelves
16:59 < kanzure> and if it's a central facility, then you have to wonder how does all the data get there? OC-1920 lines?
17:00 < kanzure> reusable hard drives i guess. and then you reuse them for the next data dump. and repeat.
17:06 < kanzure> "1 billion valves" is wrong way to specify the machine requirements.   i think you need to target a write speed.  so 1 GB/sec or something, which will then determine how many billions of valves at what megahertz firing rate you really require.
17:07 < kanzure> and then the pricing is based on cost of GB/sec write bandwidth
17:09 < kanzure> as a simplifying assumption, perhaps everything should go into the same pot and same output-- so each user encrypts their data and all customers get the full set of encrypted data plus information about how to generate the primers to pull out their sequences.
17:12 < kanzure> if you have 1 GB of data to dump, do you use only one spot on the surface and write the (encoded) billion bp to that spot? or do you reserve 1 million spots and write 1k bp to each of those spots, to decrease total time to finish your write?
17:23 < adlai> brujo_biologica: i use dvorak, and have since high school (iirc 9th grade). i can still qwerty although it takes me a doubletake-or-four to switch.
17:25 < adlai> kanzure: how come you're not transcribing paris, am i seriously supposed to watch doubleplusfast video recordings of the talks i slept through?
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17:33 < streety> How are senescent cells measured in vivo? Or are only more indirect outcomes measured?
17:40 < kanzure> adlai: well, tell me which presentations are worth my time. some of them looked sort of boring
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18:21 < kanzure> adlai: no really. show me plz.
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19:47 < Iriez> kanzure: I consume 20mg of sulforaphane weekly. I shall live forever.
19:52 < Iriez> What does FOXO4-DRI do? Does that activate the FOXO4 pathway?
19:54 < Iriez> "The problem is they also kill healthy cells and likely people too." <--- was that in regards to quercetin/sulforaphane or dasatinib, navitoclax ? (or all) ?
19:54 < Iriez> i've not heard of sulforaphane having this effect.
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20:36 < kanzure> that was just me looking at http://diyhpl.us/~bryan/papers2/longevity/2017-04-11-senolytics.txt
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23:16 < adlai> kanzure: how am i supposed to know what's worth your time without a transcript? we
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--- Log closed Sun Sep 10 00:00:14 2017