--- Log opened Sun Sep 10 00:00:14 2017
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01:46 < adlai> kanzure: peter todd's talk about solar mining undermining nakamoto incentivisation was the kind of speculation you may have enjoyed
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03:53 < kanzure> anything else?
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06:44 < kanzure> "MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts" http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30320-X
06:46 < kanzure> uses 'microRNAs miR-9 and miR-124 plus transcription factors ISL1 and LHX3'
06:46 < kanzure> "Another past study from Yoo's team showed that exposure to the same two microRNAs, miR-9 and miR-124, plus a different mix of transcription factors could turn skin cells into a different type of neuron. In that case, the skin cells became striatal medium spiny neurons."
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07:03 < kanzure> photo from breaking bitcoin conference: https://i.redd.it/oizzv405r0lz.jpg
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07:18 < kanzure> "Systemic delivery of factor IX messenger RNA for protein replacement therapy" http://www.pnas.org/content/114/10/E1941.full
07:23 < kanzure> "... Compared with other lipid formulations from industry leaders like DLin-MC3-DMA or MC3 [heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate], LUNAR is five times more efficient. MC3 is the ionizable lipid component of Patisiran, which is currently in clinical trials for treatment of transthyretin-mediated familial amyloid polyneuropathy (FAP)"
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07:26 < kanzure> https://xkcd.com/1883/
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07:46 < kanzure> someone does not understand how water depth works https://lebbeuswoods.files.wordpress.com/2012/03/lowermanhattan.jpg
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08:24 < kanzure> other senolytics: 17-DMAG, ABT-737, ABT263, "Oisin Biotechnologies has a lipid nanoparticle/p16-promoter/caspase DNA "drug" in development. Quercetin and fisetin are probably not usefully senolytic on their own, based on the "people have been taking it and no-one said anything" metric. Piperlongumine and fisetin have only published cell culture studies for senolytic effects, not in vivo ...
08:24 < kanzure> ...studies. ABT-737 has little in vivo data. Are we counting things that aren't pharmaceuticals? If so, Oisin Biotechnologies (DNA construct) and SIWA Therapeutics (antibody)."
08:24 < kanzure> - BCL-2 family inhibitors navitoclax / ABT263 and ABT-737.
08:24 < kanzure> - Some other BCL-2 inhibitors like TW-37 are reported not to be senolytic, though, so it isn't just any old BCL-2 inhibition that works.
08:24 < kanzure> - Whatever Unity Biotechnology is deriving from navitoclax and using in their current studies.
08:24 < kanzure> - BCL-XL inhibitors A1331852 and A1155463.
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09:24 < adlai> kanzure: there were a bunch of good talks today. especially noteworthy was Christian Jeffrey demonstrating an attack that hasn't quite been patched on most nodes, and then getting grief for actually taking the conference name seriously
09:26 < kanzure> report that shit privately and get it fixed first, yo.
09:28 < adlai> he reported it to a bunch of folks (including sipa and jgarzik), and it's been fixed in 0.15
09:28 < adlai> the grief was about the fact that he described the attack on-stage at a conference before it had been fixed for a couple decades
09:34 < sachy> adlai: did right - if the fix is implemented, there is no need to be silent about it
09:36 < adlai> sachy: yeah if you couldn't tell, i think the griefers were being a little childish about it. it's also just a DoS attack, and quite an expensive one too.
09:38 < kanzure> probably the conference should have had a responsible disclosure policy
10:05 < kanzure> awful lot of brains that can be used for comparative neuroanatomy https://en.wikipedia.org/wiki/Old_World_monkey
10:10 < kanzure> also why isn't there more comparative neuroanatomy work done on pygmy marmosets?
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10:32 < nmz787> kanzure: there are two sects in storage... archival (si.e. sarbanes-oxley) and non-archival (maybe they have a flashier term for this)... I think for the latter the semiconductor people aren't going to be interested in droplet printers and such... they will require it to be competitive in all ways with e-storage: bandwidth, capacity, density, $/GB
10:32 < nmz787> kanzure: I will put together the current 'target' numbers before the meeting
10:33 < nmz787> kanzure: also memory hierarchies become important in hiding slower memory accesses, so if r/w DNA is slow, a controller might hide this by storing bits/bytes in a striped manner across multiple physical memories, to take advantage of parallelism
10:43 < kanzure> yes this is archival only really
10:48 < nmz787> not in my opinion
10:48 < nmz787> I see no reason to think it would be
10:48 < nmz787> (limited)
10:48 < nmz787> it's simply a matter of engineering and scheming
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10:53 < kanzure> fltrz: wouldn't you prefer this kind of irc client https://wiki.swiftirc.net/images/e/e4/Irssi.jpg
10:55 < fltrz> i used irssi before, sure was nice
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11:34 < kanzure> "Exploiting off-targeting in guide-RNAs for CRISPR systems for simultaneous editing of multiple genes" http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12835/full
11:34 < kanzure> "... Here, we present a computational workflow to identify promiscuous gRNAs that putatively bind to the region of interest for a defined list of genes in a genome. We experimentally validated two promiscuous gRNA for gene deletion, one targeting FAA1 and FAA4 and one targeting PLB1 and PLB2, thus demonstrating that multiplexed genome editing through design of promiscuous gRNA can be ...
11:34 < kanzure> ...performed in a time and cost-effective manner."
11:35 < kanzure> .tw https://twitter.com/kanzure/status/904345697314639872
11:35 < yoleaux> @AndreasMershin @eboyden3 "wah i can't patent my publicly funded research"? :-) (@kanzure, in reply to tw:904099290632597504)
11:35 < kanzure> .tw https://twitter.com/AndreasMershin/status/906942705632202752
11:35 < yoleaux> @kanzure @eboyden3 This deserves more thought. Grant submissions are not publicy funded work, once funded they become public, rightly so. (@AndreasMershin, in reply to tw:904345697314639872)
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11:55 < sachy> anyone have an idea how to fix *living* small fish (acara) in space for MRI/PET? Im thinking about some net with small holes...
11:56 < kanzure> use restrictive gel cast?
11:56 < kanzure> anesthetize them.
11:58 < sachy> hmm water dopped with isoflurane might be the way
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12:02 < sachy> thanks kanzure :)
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12:52 < juri_> sachy: use 3d printed ninjaflex retainers.
12:57 < kanzure> ninjaflex does not sound real is that real
12:57 < juri_> sure. 3d printable rubber.
12:57 < juri_> comes with a MSDS sheet.
12:57 < juri_> printed hollow, it is really good for retaining.
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12:58 < juri_> I've discussed this with marine biologists before. they wanted to ship a printer to the field, and print retainers to match the size of samples, for measurement.
13:02 < kanzure> don't you need to measure before you print?
13:03 < juri_> there's "general size", then there's imaging.
13:03 < kanzure> also: why isn't anyone hunting for pirate treasure on all the miles of beach surface area that has been revealed by the recent hurricane ocean remodeling. it's prime piracy hunting territory..
13:12 < darsie> There was no hurricane in Austria.
13:12 < darsie> ohh, anyone.
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13:22 < kanzure> perhaps with the right level of geoengineering, i'm sure beachfront can be both added to and removed from austria, sure.
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15:50 < darsie> We have beaches at rivers and lakes.
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16:25 < juul> kanzure: don't know what they're using but i can ask around
16:26 < kanzure> someone told me inkjets soo..
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17:54 < jrayhawk> .title http://www.biorxiv.org/content/early/2017/09/06/184853.1
17:54 < yoleaux> GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence | bioRxiv
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18:10 < kanzure> ZNF638 rs1804020, TMEM89 rs9834639, SLC26A6 rs13324142, BSN rs34762726, CCDC36 rs13068038, C3orf62 rs13077498, MST1 rs3197999, RNF123 rs34823813, TSNARE1 rs79460462
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19:09 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f8d4b074 Bryan Bishop: transcripts about signature aggregation and MAST >> 
19:16 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0ef191e5 Bryan Bishop: better linking >> http://diyhpl.us/diyhpluswiki/transcripts/scalingbitcoin/milan/schnorr-signatures/
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19:58 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f349e3e7 Bryan Bishop: more linkification >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2017-09-07-merkleized-abstract-syntax-trees/
20:01 < kanzure> ayup.
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20:34 < kanzure> https://en.wikipedia.org/wiki/Body_without_organs
20:34 < kanzure> gimme all your organs kthx
20:41 < superkuh> More organs means more human.
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--- Log closed Mon Sep 11 00:00:15 2017