--- Log opened Tue Oct 03 00:00:35 2017
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03:58 < archels> A $29 USD Global Livestream event on October 14th in support of paradigm shifting non-profit organizations such as:
03:58 < archels> what, I have to pay $29 to watch a live stream? be serious
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06:14 < kanzure> "PCSK9 inhibitors: A new era of lipid lowering therapy" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329749/
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06:15 < kanzure> "PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide" https://www.ncbi.nlm.nih.gov/pubmed/18675252
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08:21 < kanzure> https://riscv.org/2014/10/why-not-build-on-openrisc/
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09:10 < kanzure> brain modeling toolkit https://github.com/AllenInstitute/bmtk/
09:10 < kanzure> .tw https://twitter.com/BrainiacCostas/status/915191323996577792
09:10 < yoleaux> @Allen_Institute @allenai_org @AllenFrontiers @CompNeuro @neuromusic @NNCN_Germany @HBPBrainSim @HBPCollaborate @HBP_Education https://twitter.com/BrainiacCostas/status/914990203307098112 (@BrainiacCostas)
09:10 < kanzure> .tw https://twitter.com/KriegeskorteLab/status/915152144688467970
09:10 < yoleaux> Videos from Cognitive Computational Neuroscience 2017... #CCN2017 http://ccneuro.org/2017videos/ (@KriegeskorteLab)
09:11 < kanzure> "Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair" https://www.nature.com/articles/s41551-017-0137-2 https://twitter.com/EricTopol/status/914872154256064513
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11:34 < kanzure> .title https://www.youtube.com/watch?v=gDgFbAqdM_c&list=PL8_xPU5epJdctoHdQjpfHmd_z9WvGxK8-
11:34 < yoleaux> Getting Started in Cryo-EM with Professor Grant Jensen - YouTube
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11:58 < CaptHindsight> just logged back on so excuse the possible redundancy here https://www.nature.com/articles/s41551-017-0137-2
11:59 < kanzure> .title
11:59 < yoleaux> Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair | Nature Biomedical Engineering
11:59 < kanzure> redundant, but only by 3 hours
11:59 < kanzure> https://twitter.com/EricTopol/status/914872154256064513
12:00 < CaptHindsight> I forget where you store the logs
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12:01 < kanzure> CaptHindsight: http://gnusha.org/logs/2017-10-03.log and http://gnusha.org/logs/
12:02 < CaptHindsight> easily discovered once you're in the channel
12:04 < CaptHindsight> I have to see which polymer they used for the shell/coating/casing/cloak/shield/disguise
12:15 < CaptHindsight> Diethylenetriamine
12:32 < CaptHindsight> kanzure: why would someone want to help such an agency to rapidly synthesize DNA?
12:37 < CaptHindsight> I'm happy to see that those that attended know so little about the tech involved
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12:42 < kanzure> dunno
12:42 < kanzure> probably because they would help synthetic biology dna production
12:43 < CaptHindsight> at what cost?
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12:52 < CaptHindsight> what is your price?
12:52 < kanzure> hm?
12:52 < kanzure> they are offering to invest $$$ into engineering
12:55 < CaptHindsight> using it for data storage is nonsense
12:56 < CaptHindsight> you can easily make polymer chains for that application
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13:00 < CaptHindsight> something with denser storage and more robust
13:04 < CaptHindsight> why use such giant fragile molecules for bits?
13:06 < CaptHindsight> meant bases
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13:24 < kanzure> polymer chains are more dense than dna polymer chains?
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13:38 < CaptHindsight> sure, all depends on the monomers
13:38 < CaptHindsight> plus then you could choose your structure vs just double helix
13:39 < CaptHindsight> is anyone exploring nudged quanta for this?
13:41 < CaptHindsight> http://trillian.mit.edu/~jc/humor/Ms_fnd_in_a_Lbry.html
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14:22 < kanzure> CaptHindsight: the only person woh has been investigating non-dna polymers in this context is jeanpaul lutz
14:28 < CaptHindsight> heh I told you about this a couple of years ago
14:30 < CaptHindsight> make your own coded polymers
14:34 < kanzure> whoops i mean jeanfrancois lutz
14:34 < kanzure> https://scholar.google.com/citations?hl=en&user=DtEQJvQAAAAJ&view_op=list_works&sortby=pubdate
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14:36 < CaptHindsight> it fits their supposed application so much better
14:37 < kanzure> CaptHindsight: https://scholar.google.com/citations?hl=en&user=DtEQJvQAAAAJ&view_op=list_works&sortby=pubdate
14:38 < CaptHindsight> it's already too easy to make genes and mods
14:38 < kanzure> no we're like cavemen poking at fire with sticks, we need flamethrowers
14:38 < CaptHindsight> no they don't
14:39 < CaptHindsight> it's like handing the keys to nuclear arsenal to the great pumpkin
14:39 < CaptHindsight> oh yeah, too late
14:44 < CaptHindsight> they certainly don't need DNA for storing data
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14:45 < kanzure> DNA is the most easily manipulated sequencable polymer at this point
14:45 < kanzure> we don't have a better system
14:47 < CaptHindsight> I'm happy that you think so
14:53 < kanzure> well what do you gots?
14:56 < kanzure> we don't have it until we do
14:56 < kanzure> but that doesn't mean i can make it happen
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15:06 < nmz787> "why would someone want to help such an agency to rapidly synthesize DNA?
15:06 < nmz787> "
15:07 < nmz787> because we want rapidly synthesized DNA no matter what it takes
15:07 < nmz787> ?
15:08 < nmz787> "using it for data storage is nonsense" well millions and billions of species have found it sensible after billions of stochastic search operations
15:08 < nmz787> iterative advancement, etc
15:12 < CaptHindsight> really?
15:13 < CaptHindsight> that's how you think?
15:17 < nmz787> which point?
15:17 < nmz787> but yeah, pretty much
15:18 < nmz787> I'd like to start producing useful GMOs before I'm old and senile
15:19 < nmz787> maybe my ideas are less clever than some of the crazy, often more indirect stuff people are doing... but nonetheless I want to get it done
15:22 < kanzure> who the hell are these people https://www.plos.org/people
15:22 < kanzure> CaptHindsight: not everyone is familiar with anti-intelligence sentiments.. might be good to say a few words.
15:28 < nmz787> pretty sure this was posted years ago, or maybe it was just a newsmedia article that linked to a photo in it... but I think it is good to post again http://pubs.acs.org/doi/abs/10.1021/nl3039162
15:28 < nmz787> .title
15:28 < yoleaux> nmz787: Sorry, that doesn't appear to be an HTML page.
15:28 < nmz787> (especially since I have a SEM now)
15:28 < nmz787> Direct Imaging of DNA Fibers: The Visage of Double Helix
15:29 < kanzure> CaptHindsight: i think that a lot of people pre-snowden just weren't aware of the scale of what NSA (et al.) have been up to
15:30 < kanzure> CaptHindsight: if these guys are recording all internet packets, then yeah there's a lot of good reason to not give them data storage tech that is 1 million times better
15:30 < nmz787> if you can't beat em, join em
15:31 < nmz787> (and then attempt to influence the system?)
15:36 < CaptHindsight> it's more the lack of maturity, wisdom and ethics
15:37 < CaptHindsight> I'm actually pro intelligence  :)
15:38 < CaptHindsight> maybe after a few decades of breakthroughs in treating mental illness I won't be so worried
15:48 < kanzure> CaptHindsight: please continue. i actually agree with you; however, nobody has made these points in this context, so it's good that someone says it.... (e.g. "maybe using dna to spy on everyone is a bad idea")
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16:10 < kanzure> "This deficit is accelerating such that, by 2020, it is estimated there will be a 7.5 zettabytes (7.5 trillion gigabytes) gap of unstorable data."
16:10 < kanzure> " combining DNA polymer synthesis technology, electronic nano-switches and semiconductor fabrication technologies, Dodo OmniData is developing a highly-parallel format to enable an array of nanomodules with the potential to store data at exceptionally high density"
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16:12 < kanzure> hmm i had not recognized that patents are actually classified into categories https://www.google.com/patents/sitemap/en/Sitemap.html
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16:42 < kanzure> well that escalated quickly... madsen's submarine is now being called a "torture sub": http://www.foxnews.com/world/2017/10/03/suspect-in-death-kim-wall-had-recordings-torture-killings-women-prosecutor-says.html
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--- Log closed Wed Oct 04 00:00:36 2017