--- Log opened Thu Nov 02 00:00:03 2017
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01:10 < kanzure> maybe they should also commit to removing some of the older satellits in orbit
01:14 < kanzure> seems like a bunch of entire cateories of proposed project types are missin from http://engineeringbiologycenter.org/pilotprojects/
01:14 < kanzure> like direct full-lenth whole chromosme synthesis thins
01:14 < kanzure> *things
01:14 < kanzure> and shouldn't that be alarming or something
01:15 < kanzure> the "DNA fountain" person proposed a project... but it doesn't seem to be a proposal, just an abstract? http://engineeringbiologycenter.org/wp-content/uploads/2017/10/Erlich-Pilot-Project.pdf
01:16 < kanzure> so er.. maybe i should send in a dna data storage approach.
01:18 < kanzure> and these guys seem to be talking about >50 fragments of dna and assembling inside of a single host, http://engineeringbiologycenter.org/wp-content/uploads/2017/10/Tsuge-Pilot-Project.pdf   but they don't talk about directed evolution or optimization, seems like they just want to repeat old results? wat?
01:24 < kanzure> .to cluckj these guys are probably going to fund all sorts of silly ethics projects, you should send in your proposals now. e.g. maybe one about the ethics of withholding important technologies from amateur communities. http://engineeringbiologycenter.org/pilotprojects/
01:24 < yoleaux> kanzure: I'll pass your message to cluckj.
01:26 < kanzure> also, i think they are reviewing the unreviewed projects on monday
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01:34 < kanzure> "hrnnjijieqjreojfdahrnnehrqjhrnnjj has subscribed to you on youtube!"
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05:07 < kanzure> "Be selfish and avoid dilemmas: Fork after withholding (FAW) attacks on bitcoin" https://acmccs.github.io/papers/p195-kwonA.pdf
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05:59 < archels> suddenly there are 7 people I have to supervise on this hackathon project
06:00 < archels> I just wanted to do some hacking, not people management!
06:01 < kanzure> hack the people out of management
06:01 < kanzure> https://xkcd.com/356/
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06:17 < kanzure> i am do gp-write proposal for inkjet dna synthesizer, is here: http://diyhpl.us/~bryan/irc/hgp-write/Proposal:%20Gigaprinter%20-%20Development%20of%20a%20large-scale%20inkjet%20DNA%20synthesizer.pdf
06:21 < kanzure> also here is a backup of the unreviewed pilot projects http://diyhpl.us/~bryan/irc/hgp-write/pilot-projects-2017-11-02/
06:21 < kanzure> (e.g. the not-yet-accepted ones)
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06:56 < hopner> Hello sir
06:57 < hopner> Bryan
06:59 < hopner> ok
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08:40 < nmz787> are there any hplus communities that are focused on new human child training/mods/upgrades?
08:40 < nmz787> i.e. matrix-style information training
08:40 < nmz787> or other things
08:41 < nmz787> I've seen some stuff recently about training with 'baby' sign language (or maybe it was real sign language, I don't know)
08:43 < nmz787> but I'm thinking more like neural network training session type stuff... flashing all of wikipedia (or english dictionary) on a baby's face, combined with text-to-speech of the body/definition , along with images of the item
08:43 < nmz787> sort of like in "a clockwork orange"
08:43 < nmz787> except not holding the eyelids open
09:15 < kanzure> i think you should focus on the academic literature on parenting instead
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10:09 < CaptHindsight> http://www.pnas.org/content/early/2017/10/25/1618854114
10:10 < CaptHindsight> Intercellular competition and the inevitability of multicellular aging
10:17 < kanzure> yeah but senolytics and young blood at least
10:39 < nmz787> not what I was talking about: https://boingboing.net/2012/12/08/clockwork-orange-babies.html
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10:56 < kanzure> nmz787: you should do 1-page writeup for gp-write of a dna synthesis proposal
10:56 < kanzure> nmz787: use their form http://engineeringbiologycenter.org/pilotprojects/
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11:16 < nmz787> ok, can it wait til later in the evening?
11:20 < kanzure> prolly
11:24 < nmz787> ok, yeah I've got something that seems like they'd be able to parse easily and is an easy experiment
11:25 < nmz787> is there a patentbot?
11:25 < nmz787> something that we can just start defensively filing in a very fast manner?
11:26 < nmz787> milliseconds before submitting anything to gnusha, it could be defensively filed, for example
11:27 < CaptHindsight> tied to a Paypal account (or similar) to pay the filing fees?
11:27 < nmz787> like, it seems kinda stupid potentially novel stuff is now online (not just me being selfish, but also i.e. max's)  when it might be the only published version of such an idea... and
11:27 < nmz787> and not protected
11:27 < nmz787> (from corporate shananigans)
11:29 < nmz787> I mean, not that we want to become ultramegaoverlords... but if we have good ideas and the resilience/motivation/energy to pull them off (eventually), we should be the ones to own and benefit... obviously we want to continue to reinvest in our other more important ideas
11:29 < nmz787> so don't want to lose any profit/etc
11:30 < nmz787> CaptHindsight: tied to paypal I guess, sure... if this was a webpage it could just use the oauth API for PayPal
11:30 < nmz787> then the user would have to pay themselves
11:31 < nmz787> I guess I was asking if such a website existed, where you could easily file patents if you had the body of knowledge assembled and ready to cut-and-paste
11:31 < nmz787> or rather, which site to use of the many that might exist
11:32 < maaku> nmz787: patent applications aren't really automatable. but maybe provisional patents
11:33 < CaptHindsight> if they were automatable then you wouldn't need a lawyer  :)
11:33 < maaku> nmz787: having actually raised a baby, I think the fastest thing is basically best practice -- lots of play time, care and attention
11:34 < maaku> matrix-style information dumps don't work on human cognition very well. are brains are not convolutional networks
11:34 < CaptHindsight> heh speak for yourself
11:35 < CaptHindsight> nmz787: the system is there for a reason, it's gamed
11:35 < maaku> well.. we're not. human brains don't work that way
11:36 < kanzure> you have always been an "ultramegaoverlord"
11:36 < kanzure> information dumps are what i eat for breakfast
11:37 < CaptHindsight> real ultramegaoverlords only do things for money and power
11:37 < maaku> motivation is orthogonal, no?
11:37 < CaptHindsight> that only a fraction of ever gets used, it's like frozen power
11:37 < kanzure> superior ability breeds superior motivation
11:38 < kanzure> .g superior ability breeds superior ambition
11:38 < yoleaux> http://ipv6.google.com/sorry/index?continue=http://www.google.com/search%3F%26q%3Dsuperior%2520ability%2520breeds%2520superior%2520ambition%26btnI%3D&q=EhAqAQT4AgFyMAAAAAAACGrnGKrM7c8FIhkA8aeDS_gay86bEyXxEtORyuE-KeeEipf7MgFy
11:38 < kanzure> bah
11:39 < maaku> anyway all I'm trying to say is that there are in fact very interesting things to say about more efficient eductational techniques that leverage what we know about learning generally and human brains specifically
11:39 < maaku> but they tend to overlap with the state of the art in educational research, for obvious reasons
11:39 < CaptHindsight> maaku: how does this enhance my money and power?  :)
11:39 < kanzure> maaku: seems to me that marginally better parenting (which might mean, doing nothing) might have larger educational impacts than baby language training or whatever.
11:40 < CaptHindsight> or rather, feed my obsession
11:40 < maaku> but there's also a lot of junk science in education that is obvious if you know even a little neuroscience or bio-inspired AI. getting rid of that is the low hanging fruit
11:40 < maaku> kanzure: agreed 100%
11:41 < maaku> the one place you do get a convolutional-net like approach is probably some aspects of foreign language learning, and -- no surprise -- the state of the art there is spaced repetition systems
11:42 < CaptHindsight> isn't it easier to publish ideas so that they can't be patented
11:42 < kanzure> unfortunately that's not how patents work
11:42 < kanzure> you'd have better luck prosecuting patent clerks for bias
11:42 < CaptHindsight> still won't stop an examiner that looks the other way
11:45 < CaptHindsight> or move to China, get funded, hear everyone whine about how the Chinese messed up patenting things
11:45 < CaptHindsight> left out getting funded by their government
11:46 < CaptHindsight> so the courts lean your direction
11:52 < kanzure> nmz787: heath: ready for the meeting?
11:57 < nmz787> almost
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13:11 < adlai> nmz787: re 'patentbot', wouldn't a better approach be timestamping such mentions and/or a fuller writeup of the idea, so the timestamp can be used in future troll battles? at the very least, this saves filing fees.
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13:45 < kanzure> adlai: if you are in court for patent litigation then you have already lost (probably)
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13:48 < adlai> the patent field seems further out of my comprehension than even those of higgs or yukawa
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13:53 < kanzure> nmz787: http://www.microspectra.com/support/learn/what-is-a-microspectrophotometer
13:59 < yumbox> a thing to measure my penis size?
14:05 < kanzure> .title https://news.ycombinator.com/item?id=15610489
14:05 < yoleaux> The Exercise Pill | Hacker News
14:06 < kanzure> "The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men" http://www.nejm.org/doi/full/10.1056/NEJM199607043350101
14:07 < kanzure> "Tavassoli came across his drug, Compound 14, more or less by chance, while designing a way to screen a new class of cancer drug, and he still seems somewhat bemused by the fact that his lab is now a front-runner in the race to develop an exercise pill. In a recent paper, he and his colleagues showed that Compound 14 caused the blood-glucose levels of obese, sedentary mice on a high-fat diet ...
14:07 < kanzure> ...to approach normal levels in just a week, while melting away five per cent of their body weight. It works, he explained, by fooling cells into thinking that they are running out of energy, causing them to burn through more of the body’s fuel reserves."
14:07 < kanzure> .wik irisin
14:07 < yoleaux> "Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris." — https://en.wikipedia.org/wiki/Irisin
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16:05 < heath> http://cellmanufacturingusa.org/
16:05 < heath> http://cellmanufacturing.gatech.edu/
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16:26 < heath> roadmaps at http://cellmanufacturingusa.org/national-cell-manufacturing-consortium
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16:31 < kanzure> .wik manchester code
16:31 < yoleaux> "In telecommunication and data storage, Manchester code (also known as phase encoding, or PE) is a line code in which the encoding of each data bit is either low then high, or high then low, for equal time. It is a self-clocking signal with no DC bias. As a result, electrical connections using a Manchester code are easily galvanically isolated." — https://en.wikipedia.org/wiki/Manchester_code
16:43 < kanzure> .wik run length encoding
16:43 < yoleaux> "Run-length encoding (RLE) is a very simple form of lossless data compression in which runs of data (that is, sequences in which the same data value occurs in many consecutive data elements) are stored as a single data value and count, rather than as the original run. This is most useful on data that contains many such runs." — https://en.wikipedia.org/wiki/Run_length_encoding
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17:34 < kanzure> .title https://www.youtube.com/watch?v=eSIvZp6N-nE
17:34 < yoleaux> "Мы - завтрашние старики. XYZ в старости" - YouTube
17:41 < kanzure> via leonid gavrilov
17:46 < kanzure> .title https://www.reddit.com/r/steroids/comments/6477mr/compound_experience_saturday_gw501516_cardarine/dg0sq37/
17:46 < yoleaux> Too Many Requests
17:47 < kanzure> https://www.reddit.com/r/steroids/comments/6477mr/compound_experience_saturday_gw501516_cardarine/
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17:51 < ebowden> What in the fuck.
17:56 < kanzure> .wik ursolic acid
17:56 < yoleaux> "Ursolic acid (sometimes referred to as urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oic-acid), is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme." — https://en.wikipedia.org/wiki/Ursolic_acid
18:00 < kanzure> .wik clenbuterol
18:00 < yoleaux> "Clenbuterol, marketed as Dilaterol, Spiropent, Ventipulmin, is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier." — https://en.wikipedia.org/wiki/Clenbuterol
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19:04 < kanzure> yashgaroth: thanks for hanging around today
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19:42 < kanzure> .tw https://twitter.com/silcntspring/status/922113314154582017
19:42 < yoleaux> I think there is a world market for maybe five human beings - merge the others (@silcntspring)
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20:00 < nmz787> kanzure: I knew about the microspectrometers, they even have raman versions of that  (microscope with a spectrophotometer in the eye piece, basically)
20:05 < kanzure> tudor sent the link for you
20:09 < nmz787> yeah, that's pretty much what pacbio is doing
20:09 < nmz787> except just having a nice wide-band sensor (black and white camera)
20:09 < nmz787> or maybe it was spectro
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21:06 < yashgaroth> np kanzure, was an informative chat
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--- Log closed Fri Nov 03 00:00:04 2017