--- Log opened Sat Nov 11 00:00:12 2017 00:04 -!- brujo_biologica [~brujo@li1745-37.members.linode.com] has joined ##hplusroadmap 00:09 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 01:35 -!- mabel [~Agatha@unaffiliated/jacco] has joined ##hplusroadmap 02:41 -!- adlai [~adlai@unaffiliated/adlai] has joined ##hplusroadmap 02:49 -!- ebowden [~ebowden@2001:8003:10c9:e00:3dd0:143d:271e:4241] has quit [Remote host closed the connection] 03:12 -!- ebowden [~ebowden@2001:8003:1074:bc00:1de0:766b:5aa3:5da8] has joined ##hplusroadmap 03:29 -!- mabel [~Agatha@unaffiliated/jacco] has quit [Ping timeout: 248 seconds] 03:32 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:32 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 03:33 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:55 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 04:07 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 04:31 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Quit: That's it for today] 04:37 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 04:56 -!- preview [~quassel@2407:7000:842d:4090:22c:efc9:45ae:9445] has quit [Ping timeout: 250 seconds] 05:54 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 05:58 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 06:12 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 07:21 -!- mindsForge [~nak@75-172-162-202.phnx.qwest.net] has joined ##hplusroadmap 07:22 < kanzure> http://blog.addgene.org/enhancing-crispr-targeting-specificity-with-espcas9-and-spcas9-hf1 07:22 < kanzure> .tw https://twitter.com/Addgene/status/929332814780223488 07:22 < yoleaux> Attending #Sfn17? So are we! Learn how and why AAVs are being used for cell & #GeneTherapy at Booth 3317! (@Addgene) 07:25 < kanzure> .tw https://twitter.com/hackaday/status/929124124324007936 07:25 < yoleaux> Jacob Christ came to Hackaday #Superconference prepared. Hacking the official badge into an SLA 3D printer: https://hackaday.io/project/27822 https://pbs.twimg.com/media/DOTpdc1VQAE1JU5.jpg (@hackaday) 07:25 < kanzure> oh is the igem jamboree today? 07:26 < kanzure> .tw https://twitter.com/biobricks/status/928979893769007106 07:26 < yoleaux> Look for golden 10k Gene Tickets at #iGEM2017 #GiantJamboree to make your DNA wishes come true! https://pbs.twimg.com/media/DORmJ_jVoAAySc5.jpg (@biobricks) 07:27 < kanzure> .tw https://twitter.com/GWAS_lit/status/929103733182664704 07:27 < yoleaux> GWAS finds novel genetic associations w broadly-defined headache in UK Biobank (N = 223,773) https://www.biorxiv.org/content/early/2017/11/10/217786 https://pbs.twimg.com/media/DOTW6oCXUAEpslF.jpg (@GWAS_lit) 07:27 < kanzure> "A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)" https://www.biorxiv.org/content/early/2017/11/10/217786 07:29 < kanzure> "We performed a genome-wide association study of headache as a single entity, using 74,461 cases and 149,312 controls. We identified 3,343 SNPs which reached the genome-wide significance level of P < 5 x 10^-8. The SNPs were located in 28 loci, with the top SNP of rs11172113 in the LRP1 gene having a P value of 4.92 x 10^-47. Of the 28 loci, 14 have previously been associated with migraine. ... 07:29 < kanzure> ...Among 14 new loci, rs77804065 with a P value of 5.87 x 10^-15 in the LINC02210-CRHR1 gene was the top SNP." 07:31 < kanzure> anti-migraine is gonna be a popular one 07:36 <@fenn> what if it turns out that migraines are necessary for genius level intelligence 07:45 < kanzure> you would have to first kill all the geniuses that don't have migraines 07:47 < kanzure> hard work, but someone has to do it. 07:48 < kanzure> http://channels.readthedocs.io/en/stable/faqs.html 07:49 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 08:07 <@fenn> .title http://youtube.com/watch?v=D52hg9ogvWc 08:07 < yoleaux> Wrong Heads Disney Wrong Ears Wrong Legs Kids Learn Colors Finger Family 2017 Nursery Rhymes - YouTube 08:12 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 08:12 <@fenn> "content warning: this video is not inappropriate in any way" opinions? thoughts? 08:14 < pompolic> i hope it outcompetes school 08:18 < kanzure> is this the stuff from https://medium.com/@jamesbridle/something-is-wrong-on-the-internet-c39c471271d2 08:20 < kanzure> the comments are a bit weird on that video. 08:20 < kanzure> "this is lovecraftian in scope" 08:21 <@fenn> apparently bots speak russian as their native language 08:22 < kanzure> because of all that soviet research into.. uh.. troll farms. 08:25 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:cc7e:9886:1e5b:b2b0] has joined ##hplusroadmap 09:09 -!- NikopolSohru [~NSohru@notice.dldbr.com] has joined ##hplusroadmap 09:15 < kanzure> https://blog.addgene.org/adeno-associated-virus-aav-for-cell-and-gene-therapy 09:18 < kanzure> "you must be doing something right if everyone is complaining" for gene therapy https://news.ycombinator.com/item?id=15672414 09:20 < kanzure> "Aum Shinrikyo actually had a bio-weapons program that failed, seemingly due to a lack of technical expertise" http://www.nti.org/analysis/articles/revisiting-aum-shinrikyo-new-insights-most-extensive-non-state-biological-weapons-program-date-1/ 09:20 < kanzure> .title https://www.youtube.com/watch?v=HKQDSgBHPfY 09:20 < yoleaux> DEF CON 25 - John Sotos - Genetic Diseases to Guide Digital Hacks of the Human Genome - YouTube 09:24 -!- ebowden [~ebowden@2001:8003:1074:bc00:1de0:766b:5aa3:5da8] has quit [Read error: Connection reset by peer] 09:26 -!- ebowden [~ebowden@2001:8003:1074:bc00:1de0:766b:5aa3:5da8] has joined ##hplusroadmap 10:02 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 10:06 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 10:09 < kanzure> .title https://www.youtube.com/watch?v=kYmnXxs9kUM 10:09 < yoleaux> Towards Transparent and Scalable Computational Integrity and Privacy - YouTube 10:09 < kanzure> .title https://www.youtube.com/watch?v=HJ9K_o-RRSY 10:09 < yoleaux> Transparent scalable computational integrity - Eli Ben Sasson, Silicon Valley ethereum meetup - YouTube 10:09 < kanzure> .title https://news.ycombinator.com/item?id=15675898 10:09 < yoleaux> STARKs, Part I: Proofs with Polynomials | Hacker News 10:09 < kanzure> http://vitalik.ca/general/2017/11/09/starks_part_1.html 10:10 < kanzure> https://blog.appsecco.com/a-penetration-testers-guide-to-sub-domain-enumeration-7d842d5570f6 10:12 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:7cf5:7436:560d:1dab] has joined ##hplusroadmap 10:37 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 10:39 < kanzure> bulletproofs https://eprint.iacr.org/2017/1066 10:44 < kanzure> "Sharding PoW-based Blockchains via Proofs of Knowledge" https://eprint.iacr.org/2017/1067 10:44 < kanzure> https://torrentfreak.com/sci-hub-wont-be-blocked-by-us-isps-anytime-soon-171111/ 10:46 < kanzure> "News of the Sci-Hub injunction has sparked controversy and confusion in recent days, not least because Sci-hub.cc became unavailable soon after. Instead of showing the usual search box, visitors now see a “403 Forbidden” error message. On top of that, the bulletproof Tor version of the site also went offline." 10:46 < kanzure> "bulletproof" ? 10:47 < kanzure> seychelles no longer good place to host it? works for bitmex... scihub isn't likely to leave. 10:56 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 11:03 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 11:06 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:cc7e:9886:1e5b:b2b0] has quit [Ping timeout: 258 seconds] 11:40 < superkuh> It's available now... (sci-hub.cc) 11:43 < kanzure> Works For Me 12:05 < kanzure> https://groups.google.com/d/msg/diybio/i8zmpw24VCg/0ztb5d62AAAJ 12:06 < kanzure> (gene therapy things) 12:58 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 13:27 -!- mindsForge [~nak@75-172-162-202.phnx.qwest.net] has quit [Quit: Leaving.] 13:43 -!- NikopolSohru [~NSohru@notice.dldbr.com] has quit [Ping timeout: 260 seconds] 14:03 < yashgaroth> annoyed me enough that I posted a reply 14:06 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 14:08 < kanzure> hehe 14:08 < kanzure> that's the spirit 14:08 < kanzure> ALSO: if we are going to be encouraging reckless behavior, then let's at least encourage them to do useful reckless behavior (e.g. useful plasmids) 14:10 < yashgaroth> gonna need you to jam this needle electrode into yourself 500 times and record how much it hurts. hack the planet!!!1 14:13 < kanzure> i think that's a fine strategy as long as they get the details right... and as long as the chance of actual transformation is above like 0.1% 14:14 < kanzure> meanwhile we have a large contingent of morons that have been hoping to grow wings and fly off into the stratosphere for the last two decades 14:15 < yashgaroth> I mean it'd be real useful to get human data on pain for electroporation, there's a fine line between effective pore formation and necrosis, depending on voltage, duration, duty cycle, all that stuff;there's not much published data for humans and our muscle fibers respond much differently than mice 14:16 < kanzure> so, on a related note, aren't cells still alive after heart death for a little while? 14:16 < yashgaroth> they can put a plasmid in too if they want, but >0.1% is optimistic 14:16 < kanzure> i think we should be able to do transformation of chunks of meat from the butcher shop, right? 14:16 < kanzure> doesn't help with your pain problem but at least you can visibly measure how much you've cooked it 14:17 < yashgaroth> yeah they'll live for a few hours, that's why tourniquets are so effective 14:17 < kanzure> plus you can eat the fuker hen you're done 14:17 < kanzure> *eat the fucker when you're done 14:18 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 248 seconds] 14:18 < yashgaroth> certainly worth a try, but then I am hungry 14:18 < gradstudentbot> I think I just cured cancer. Wow. 14:19 < kanzure> <3 i missed you 14:19 < kanzure> .botsnack 14:19 < yoleaux> :D 14:32 -!- mindsForge [~nak@75-172-162-202.phnx.qwest.net] has joined ##hplusroadmap 14:32 < nmz787> fenn: well I like that as they heads are matched, they're removed from the pool of options to match on 14:35 < nmz787> hooked up an 0.96" OLED screen to my culture_shock last night and got it to display text and a bar graph of the ADC waveform reading the high-voltage 14:47 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 14:49 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 14:50 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 15:01 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 248 seconds] 15:32 < nmz787> .title https://imgur.com/a/LBorg 15:32 < yoleaux> culture_shock OLED 0.96" screen tests - Album on Imgur 16:02 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 16:05 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 16:12 -!- andytoshi [~apoelstra@wpsoftware.net] has quit [Changing host] 16:12 -!- andytoshi [~apoelstra@unaffiliated/andytoshi] has joined ##hplusroadmap 16:17 -!- jaboja [~jaboja@jaboja.pl] has quit [Quit: Leaving] 16:20 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 16:28 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 16:47 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:01 < kanzure> https://hvmn.com/ketone 17:09 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 17:09 -!- mindsForge [~nak@75-172-162-202.phnx.qwest.net] has quit [Remote host closed the connection] 17:11 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:24 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 17:29 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:36 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:cdaf:2a1c:cc4a:5e68] has joined ##hplusroadmap 17:45 < kanzure> yerp... 17:48 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:cdaf:2a1c:cc4a:5e68] has quit [Remote host closed the connection] 17:55 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 17:57 < kanzure> http://slatestarcodex.com/2017/11/09/ars-longa-vita-brevis/ 17:58 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 18:02 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 18:03 < kanzure> not really sure what his point is. 18:03 < kanzure> programming, etc., in very general terms offers a general advantage over almost all domains simultaneously, so you do get interesting speedups for many types of problems and projects 18:03 < kanzure> there are different regions of tamed wildness that we have mastered, and by combining them in new ways, we can conquer new territories, but general conquering of literally everything is probably not in reasonable scope yet 18:16 < JayDugger> Neither Borges nor Lem, as suggested by https://twitter.com/anderssandberg/status/929481803051819009 18:19 < JayDugger> Borges would have recursion and Lem would have humor. 18:22 < kanzure> borges labryinths https://wizchan.org/hob/src/1449201237263-0.pdf 18:24 < JayDugger> Yup. Haven't read as much of Borges as I might or should, but I think I'm right. 18:24 < kanzure> without a doubt that is the most should sentence you can't but it really ought to like it do 18:28 < JayDugger> Point taken. "but I think I'm right about recursion appearing as frequently in Borges as humor does in Lem. I think my objection is reasonable." 18:55 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 19:00 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 19:04 -!- ebowden [~ebowden@2001:8003:1074:bc00:1de0:766b:5aa3:5da8] has quit [Ping timeout: 246 seconds] 19:04 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has joined ##hplusroadmap 19:05 -!- ebowden [~ebowden@110.141.11.39] has joined ##hplusroadmap 19:09 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has quit [Remote host closed the connection] 19:10 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has joined ##hplusroadmap 19:20 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has quit [Quit: Leaving.] 19:21 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has joined ##hplusroadmap 19:22 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has quit [Client Quit] 19:22 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has joined ##hplusroadmap 19:23 -!- fltrz [4d6d6154@gateway/web/freenode/ip.77.109.97.84] has quit [Ping timeout: 260 seconds] 19:34 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 19:36 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 19:37 -!- dequ [christy@taurine.csclub.uwaterloo.ca] has joined ##hplusroadmap 19:37 -!- dequ [christy@taurine.csclub.uwaterloo.ca] has quit [Client Quit] 19:39 -!- mindsForge [~nak@75-172-162-202.phnx.qwest.net] has joined ##hplusroadmap 19:41 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 19:44 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 19:51 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 20:55 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Remote host closed the connection] 21:07 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 21:18 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 21:59 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:7cf5:7436:560d:1dab] has quit [Quit: Leaving] 22:01 -!- bsm117532 [~mcelrath@2601:182:cd00:2dd1:83:aa9:b3ea:fa55] has quit [Ping timeout: 240 seconds] 22:12 < kanzure> yep... 22:18 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 240 seconds] 22:52 < adlai> kanzure: that math question's gonna take a while but my first thoughts are that any sane solution has to stem from considerations of transport, steerage, tonnage, ... is a human allowed to drive as fast as he likes on the autobahn? cycle as slow as he likes down the beach? so many questions, so far to reach. humans need mobility. 22:52 < adlai> at the very least, figure out how many self-piloting planes can orbit in the kuiper belt without crashing into the sun. 22:55 < adlai> .tw https://twitter.com/anderssandberg/status/929481803051819009 22:55 < yoleaux> This story feels like it is channelling Stanisław Lem and Jorge Borges simultaneously: http://slatestarcodex.com/2017/11/09/ars-longa-vita-brevis/ (@anderssandberg) 22:56 * adlai reads partway into 2nd paragraph, dies of danglingpointeroverloaitis 23:52 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] --- Log closed Sun Nov 12 00:00:13 2017