--- Log opened Mon Nov 13 00:00:14 2017
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00:53 < nmz787> CaptHindsight: they don't sell pico drop generators with a controller for experimentors?
00:54 < heath> who is they? :)
00:54 < nmz787> CaptHindsight: is googling whether a printer is piezo worthwhile? they release that much info?
00:54 < nmz787> heath: manufacturers of pico droplet generators
00:54 < heath> they is the general marketplace?
00:54 < nmz787> yeah
00:54 < heath> got it :)
00:55  * nmz787 sleeps
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06:05 < kanzure> not sure how that is a pun.. if there's a document you are requesting, then please make the request explicit.
06:09 < kanzure> .title https://www.youtube.com/watch?v=mmSuxqaKR2U&t=191s
06:09 < yoleaux> Adam Back, Live from Paralelní Polis - Prague, CZ #HCPP17 - YouTube
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07:26 < Kanzure_> Bryan want to talk to you
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07:35 < kanzure_>  Join
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07:41 < redlegion> That was odd.
07:50 < kanzure> wasn't me.
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07:54 < kanzure> eudoxia: sup
07:54 < eudoxia> hello kanzu
07:54 < eudoxia> how's ledgerx doing in this second bitcoin boom
07:54 < kanzure> heh
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08:22 < archels_> kanzure: I had the feeling that all action points were hard-won
08:24 < archels_> at least one of them came thanks to sheer luck (the "WHO omits aging in their 5 year plan" thing)
08:25 < archels_> some better indexing of mailing lists/other communication channels as well as events will occur via H+pedia
08:26 < archels_> I didn't remember it till on the bus home, but no one brought up H+magazine, maybe it should be slightly less dormant than it is now
08:28 < kanzure> hplusmagazine is a waste of time
08:29 < kanzure> anyway, what else did you think about transvision?
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09:32 < kanzure> "SpringerNature, the publisher of science magazines Nature and Scientific American, is preparing a 2018 stock market listing valuing the company at up to 4 billion euros ($4.7 billion), people close to the matter said."
09:33 < pasky> a weird moment to IPO - maybe the last chance?
09:33 < pasky> (though I think they actually might find something that works - their editing and extra content is top-notch)
09:34 <@fenn> nevermind the lack of retractions
09:34 <@fenn> with the entire world banging down your door you better have something good
09:35 < kanzure> .title https://www.nature.com/articles/nnano.2013.71
09:35 < yoleaux> DNA sequencing using electrical conductance measurements of a DNA polymerase | Nature Nanotechnology
09:35 < kanzure> this one was retracted.
09:35 <@fenn> i mean things that should have been retracted but weren't
09:35 <@fenn> like that CRISPR mis-targeting paper for example
09:35 < kanzure> ah right, "make money from controversy" strategy, what could go wrong
09:35 < ebowden> Was that just detecting background variation?
09:36 <@fenn> yes
09:37 < kanzure> https://pubpeer.com/publications/FC49DC90228D52FCBFBBA68FEA3AB5
09:37 < ebowden> How could they ever retract it, a paper came out criticising it.
09:38 < kanzure> retraction does not mean deleted (well... usually)..
09:38 < ebowden> If they ever dared retract it, it would be akin to not _teaching the controversy_.
09:38 < kanzure> see also:
09:38 < kanzure> http://www.biorxiv.org/content/early/2017/06/21/153338
09:38 < kanzure> http://www.biorxiv.org/content/early/2017/06/30/157925
09:38 < kanzure> http://www.biorxiv.org/content/early/2017/07/05/159707
09:39 < ebowden> Before I click, are these all retracted papers?
09:39 < kanzure> these are about the paper that fenn was complaining about.
09:40 < ebowden> Kanzure, putting a big "retracted" stamp on the paper because it was severely flawed?!
09:41 < ebowden> Let people make up their own mind!
09:41 < kanzure> their whole job is to mediate quality..
09:41 <@fenn> i hope some harvard fat cat decides to short springer stock and announce they will be banning publishing behind paywalls
09:41 < ebowden> Next you'll tell me Wakefield's paper was retracted!
09:42 <@fenn> ebowden: it's their job to put a big "retracted" stamp on flawed papers
09:42 < ebowden> sarcasm
09:42 < ebowden> "Next you'll tell me Wakefield's paper was retracted!"
09:42 <@fenn> i don't know what that is
09:42 < ebowden> Oh, mistake.
09:42 < ebowden> *retracted too!"
09:43 <@fenn> something about MMR and autism
09:43 < kanzure> probably the antivax stuff
09:43 < ebowden> Andrew Wakefield, son of an actual good scientist my father knew, published a fraudulent paper.
09:44 < ebowden> Now that his reputation has been rightfully destroyed, he goes round lying to poor, uneducated communities about vaccines.
09:45 < ebowden> Seems to be the way he makes his money.
09:45 <@fenn> i bet he makes more money now than as a scientist
09:45 < kanzure> scientists generally don't know how to make money
09:46 <@fenn> they're too busy doing science
09:46 <@fenn> wakefield lives in austin
09:47 < ebowden> If I were his father, I would be so ashamed.
09:47 < ebowden> https://www.nature.com/articles/nmeth.4293
09:48 <@fenn> .title
09:48 < yoleaux> Unexpected mutations after CRISPR–Cas9 editing in vivo | Nature Methods
09:48 < ebowden> The controversial article they failed to retract has a nice juicy paywall.
09:49 < ebowden> I cannot possibly guess at what the reason for not retracting might be...
09:49 <@fenn> if they have too many retractions their reputation suffers
09:50 <@fenn> it's like admitting guilt, they're admitting they suck at doing peer review and editing, which is ostensibly their entire reason for existence
09:50 <@fenn> of course we all know it's actually just a dog an pony show for academic career advancement
09:51 < gradstudentbot> Holy crap, I need to add that to my slide collection.
09:51 < ebowden> The delicious dollars from the controversy + paywall can't have helped.
09:54 < ebowden> I heard of some ultra-high fidelity CRISPR variants a while ago.
10:16 < CaptHindsight> nmz787: several vendors require you to spend close to $100K in order to work with them
10:17 < CaptHindsight> nmz787: some will sell you their $20K-30K dev system and two days of training
10:19 < CaptHindsight> nmz787: experimenting hahaha, they just want $$$$ and control over you
10:22 < CaptHindsight> nmz787: I come across lots of inkjet projects that RE Epson printers since they start at <$100
10:40 < heath> "Modeling and Control of Piezo-Actuated Nanopositioning Stages: A Survey" http://ieeexplore.ieee.org/abstract/document/6909086/ "This paper surveys and discusses the progresses of different modeling and control approaches for piezo-actuated nanopositioning stages and highlights new opportunities for the extended studies."
10:41 < heath> 2016
10:54 < CaptHindsight> heath: these often end up for cheap on flebay http://www.pi-usa.us/products/Nanopositioning_Scanning_Stages/index.php  https://www.physikinstrumente.com/en/products/xy-stages/piezo-stages/
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11:10 < heath> http://www.cedrat-technologies.com/fileadmin/user_upload/CTEC/Mechatronic_products/User_s_manual/AN_Position_Control_of_Piezo_Actuators_v1.0.pdf
11:10 < heath> https://www.npoint.com/piezo-stage-sensor-for-closed-loop-control/
11:11 < heath> yeah! they are cheap on ebay
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11:34 < CaptHindsight> heath: I use Linuxcnc for applications like that
11:35 < CaptHindsight> with whatever motor driver/amp is required
11:42 < kanzure> "Powering prolonged hydrothermal activity inside Enceladus" https://www.nature.com/articles/s41550-017-0289-8
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16:26 < kanzure> "Temporally precise single-cell-resolution optogenetics" https://www.nature.com/articles/s41593-017-0018-8
16:26 < kanzure> "Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior" https://www.nature.com/articles/s41598-017-14330-y
16:27 < kanzure> "Understand the cogs to understand cognition" https://www.cambridge.org/core/journals/behavioral-and-brain-sciences/article/understand-the-cogs-to-understand-cognition/389F892F7C6A1F276A9DAFD6DF6DCBC6
16:27 < kanzure> "Building machines that learn and think like people" https://cims.nyu.edu/~brenden/LakeEtAl2017BBS.pdf
16:27 < gradstudentbot> That's definitely a Cell paper.
16:28 < kanzure> .tw https://twitter.com/EricTopol/status/929384973437583360
16:28 < yoleaux> Gene therapy went through a ~20 year "winter" Then this in < 1 month @theLancet @NEJM @Nature https://pbs.twimg.com/media/DOXWeJEU8AANBDf.jpg (@EricTopol)
16:30 < kanzure> .tw https://twitter.com/DWL_Investments/status/929412978553901060
16:30 < yoleaux> @EricTopol @srqstockpicker @TheLancet @NEJM @nature What are the gene editing stocks to buy? What companies will win? Sangamo? Voyager? Crispr? Editdas? (@DWL_Investments, in reply to tw:929384973437583360)
16:30 < kanzure> .tw https://twitter.com/redsonic24/status/929518774553890816
16:30 < yoleaux> @EricTopol @TheLancet @NEJM @nature Question: Is there anything on the horizon via a vis gene therapy to ameliorate some of the complications associated with Downs Syndrome? (@redsonic24, in reply to tw:929384973437583360)
16:32 < kanzure> .tw https://twitter.com/igisci/status/927581633326272513
16:32 < yoleaux> New CRISPR teaching and learning tools! Watch lectures from the 2017 @igisci CRISPR Workshop. https://buff.ly/2zhJvGV https://pbs.twimg.com/media/DN9uk5SXkAAYGZW.jpg (@igisci)
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16:42 < MrHindsight> heh, I'll have to get my stem cell quotes from the 00's
16:42 < MrHindsight> about playing angry invisible man in the sky and similar
16:44 < kanzure> always makes me sad to hear that people think we are merely playing god...
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16:49 < MrHindsight> gene therapy cures vs drug treatments...
16:50 < MrHindsight> will they regulate gene therapies as drugs?
16:50 < kanzure> FDA already does
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16:52 < MrHindsight> are genes still patentable?
16:52 < MrHindsight> how about just a short damaged/mutated section?
16:53 < kanzure> sorta kinda... bill clinton said no, but there was that recent patent trial that went to the supreme court.
16:53 < MrHindsight> synthetic DNA, or cDNA, is patent eligible because it does not occur naturally
16:54 < MrHindsight> heh, blanket patent on all non naturally occurring sequences
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16:56 < MrHindsight> say in a few years you can synthesize a sequence to repair defects in your DNA and edit it for a few $ with not much investment <$10k
16:57 < MrHindsight> who is holding on to the power to keep that from happening?
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17:09 < kanzure> MrHindsight: you can already buy gene therapy (although it has low effectiveness) http://www.the-odin.com/diyhumancrispr
17:09 < kanzure> MrHindsight: http://diyhpl.us/wiki/transcripts/diy-human-gene-therapy-with-crispr/
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17:19 < MrHindsight> Crisper Gene Gum now in Peppermint
17:20 < MrHindsight> delivery is the issue
17:22 < kanzure> fedex
17:22 < MrHindsight> let me get the thesaurus
17:22 < MrHindsight> you can't be clear unless yo say it less than 10 times and 10 different ways  :)
17:25 < kanzure> transformation efficiency
17:25 < kanzure> is the problem still.
17:25 < MrHindsight> delivery
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18:02 < kanzure> "Updates on Confidential Transactions efficiency" https://lists.linuxfoundation.org/pipermail/bitcoin-dev/2017-November/015283.html
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18:51 < Kanzure_> In
18:53 < kanzure> what do you want
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19:31 < redlegion> so that's odd
19:35 < redlegion> [10:26:55] <Kanzure_> Bryan want to talk to you
19:35 < redlegion> noticed he said that earlier
19:36 < kanzure> why do you keep commenting on it
19:37 < redlegion> strikes me as strange, haven't seen that on any of the larger networks
19:38 < redlegion> also sorta rude to impersonate people you're trying to contact
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19:50 < kanzure> andytoshi: http://www.existentialcomics.com/comic/1
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20:01 < jrayhawk_> They're from India and using a web client; I would put way more weight on interface confusion than impersonation.
20:02 < jrayhawk_> Hanlon's razor.
20:02 < kanzure> impressive, but i think that would be a novel confusion of how irc works
20:04 < jrayhawk_> I mean, putting the name of the person you want to talk to in the "name" field does not seem particularly implausible for someone who only understands half of the words on a given webpage.
20:06 < kanzure> an old thing about post-scarcity from the time of satoshi http://p2pfoundation.ning.com/forum/topics/abundance-the-journal-of-post
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