--- Log opened Fri Dec 01 00:00:30 2017
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00:25 < heath> .title https://www.youtube.com/watch?v=-h-cz7yY-G8
00:25 < yoleaux> "The Biological Path Towards Strong AI" by Matt Taylor - YouTube
00:25 < heath> was recommended at some dinner tonight
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06:20 < kanzure> oh it's the numenta people? hm.
06:20 < kanzure> i'm not sure i would accept them as biology experts
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06:36 < kanzure> http://rickcarlino.com/2017/11/27/keeping-a-developer-journal-with-jrnl-sh-html.html
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06:39 < kanzure> http://www.cmegroup.com/media-room/press-releases/2017/12/01/cme_group_self-certifiesbitcoinfuturestolaunchdec18.html
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06:42 < JayDugger> Huh. Second time I came across the FarmBot people.
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06:45 < kanzure> https://www.bloomberg.com/news/articles/2017-12-01/bitcoin-futures-to-start-trading-as-regulators-rush-to-catch-up
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06:46 < mindsForge> ha, perfect timing for some BTC derivatives posting
06:46 < mindsForge> just sat down
06:47 < mindsForge> should be 'physicial' delivery imho
06:47 < kanzure> yep...
06:47 < kanzure> i agree.
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06:57 < JayDugger> Bloomberg editor: s/ripe/rife/g
06:57 < JayDugger> You're welcome.
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06:58 < mindsForge> I haven't even really looked at ICOs
07:00 < JayDugger> Don't feel bad. The editor didn't look at the copy.
07:01 < kanzure> news isn't for reading
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07:06 < kanzure> "HVMN, formerly Nootrobox, markets a nootropic supplement called SPRINT, which claims to help boost concentration. A study commissioned by the company indicated its product was less effective than coffee. "
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10:01 < CaptHindsight> http://www.3ders.org/articles/20171127-regenovo-unveils-bio-architect-x-chinas-first-high-throughput-3d-bioprinter-for-mass-producing-human-tissues.html
10:02 < CaptHindsight> while the rest of the world was wasting time printing Yodas with CNC glue guns the Chinese were working away at this
10:02 < CaptHindsight> http://www.3ders.org/images2017/regenovo-unveils-bio-architect-x-chinas-first-high-throughput-3d-bioprinter-for-mass-producing-human-tissues-6.jpg
10:03 < kanzure> are they vascularized?
10:04 < CaptHindsight> do you mean do they have blood vessels?
10:04 < kanzure> ya that's the mjor problem with organoids so far
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10:05 < gradstudentbot> Protip: I wouldn't go to the far end of the lab alone.
10:05 < CaptHindsight> if you've ever seen the movie Sleeper you might get a kick out of that pic
10:06 < CaptHindsight> kanzure: nah, they just aim for the low hanging fruit and then hype it
10:07 < CaptHindsight> nasal cartilage structure but make it sound like you'll be able to order brains sometime next week
10:08 < CaptHindsight> "According to the company, its printed cell survival rate is up to 90% and it has successfully kept cells alive for up to four months."
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10:09 < CaptHindsight> kanzure: do you expect results by just putting more monkeys on the job?
10:14 < kanzure> for organoids?
10:14 < kanzure> actually yes, there's a lot of low-hanging fruit in this area that just needs to be tried
10:15 < kanzure> btw check out https://diyhpl.us/wiki/transcripts/hgp-write/2017-05-09/organoids/
10:15 < CaptHindsight> more hand waving?
10:16 < kanzure> they had some interesting results with vascularization, i dunno if his results have been published yet
10:17 < kanzure> "We took this 2d environment and moved it to a 3d situation where we grew these organoids in something called hanging draw. hiPS/gata6 derived liver organoids, grew for 2.5 months. They are highly deeply vascularized. A lot of nutrients can peentrate this entire organoid, that's on the bottom left there, because of these nutrients we can reach all the cells. The organoids became huge-- we're ...
10:17 < kanzure> ...calling them meganoids. They are large enough to play hacky-sac with or something. They are 100x larger in terms of other organoid"
10:17 < kanzure> "We'd like to move forward on programmable organoids to enhance those organoids and think about the notion of renewable anti-aging tissue and rewritable genomes for organoids.We would like to have new genetic variants, we'd like to be able to create mechanisms to sense everything there genetically, and create different 3d shapes, and being able to dynamically rewrite the genome so do this in ...
10:17 < kanzure> ...an efficient way but also to actual tissues, so that doesn't allow us to use existing technologies for reconfiguring what the human genome is within each of these cells. We want to add/remove functionality as these tissues are operating."
10:30 < nmz787> ALD seller replied to my message about being a hobbyist and my concern about knowing the chemical history, to check for contamination (possibly making it incompatible with other chemistries) "What I can tell you is my boss is motivated to omve this unit, I can't see him refusing a reasonable offer at this point."OC
10:30 < nmz787> move this unit*
10:30 < nmz787> hmm
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10:31 < nmz787> at minimum it's just a tube with a a heater wrapped around it, some injection valves for gasses, and a computer to control the valves
10:32 < CaptHindsight> to them and most buyers it's magic
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10:32 < nmz787> but I guess ensuring you get good  temperature control, that the heat is even in the oven (at a given constant temp/power) could be a lot of debugging
10:33 < CaptHindsight> as always it depends who is working on it
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10:42 < kanzure> drivechain stuff https://lists.linuxfoundation.org/pipermail/bitcoin-dev/2017-December/015339.html
10:46 < kanzure> "Analyzing software requirements errors in safety-critical, embedded systems" https://pdfs.semanticscholar.org/c77e/fb40fa7ad307314e109b7f8fa7429cbacd4b.pdf
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11:34 < nmz787> .tell capthindsight yes but unfortunately I have pulled the wool from my eyes and see there is no magic, just lots of skills/techniques/processes that are complex, and with that info try to determine how to go forward with the best bang-for-my-buck (also considering time is money)
11:34 < yoleaux> nmz787: I'll pass your message to capthindsight.
11:47 < bluebear_> lots of skills/techniques/processes that are complex == magic :-)
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17:30 < kanzure> hmm
17:30 < ebowden> .tell CaptHindSight The US and Australia also do their own bioprinters and work on organoids. The Chinese are by far not the only ones.
17:30 < yoleaux> ebowden: I'll pass your message to CaptHindSight.
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20:14 < kanzure> .tw https://twitter.com/jlee8usa/status/936584773853679616
20:14 < yoleaux> Zador lab: In situ 15-base barcode padlock seq using Illumina SBS w/ increased sensitivity. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkx1206/4668654?searchresult=1 (@jlee8usa)
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20:15 < kanzure> .tw https://twitter.com/gottapatchemall/status/934878232725172224
20:15 < yoleaux> whoa- there are dopaminergic neocortical interneurons in humans but not in closely related non-human primates http://science.sciencemag.org/content/358/6366/1027 (@gottapatchemall)
20:16 < kanzure> "Molecular and cellular reorganization of neural circuits in the human lineage" http://science.sciencemag.org/content/358/6366/1027
20:20 < kanzure> "To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type–specific species expression differences in genes representing distinct ...
20:20 < kanzure> ...functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed ...
20:20 < kanzure> ...diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease."
20:21 < kanzure> "Sousa et al. overlaid transcriptome and histological analyses to see what makes human brains different from those of nonhuman primates. Various differentially expressed genes, such as those encoding transcription factors, could alter transcriptional programs. Others were associated with neuromodulatory systems. Furthermore, the dopaminergic interneurons found in the human neocortex were ...
20:21 < kanzure> ...absent from the neocortex of nonhuman African apes."
20:21 <@fenn> gottapatchemall sounds like someone you would follow
20:25 < kanzure> really crazy that we are still finding basic differences between human and monkey brain
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20:27 <@fenn> apparently we're still making basic human brain anatomy discoveries, like those lymphatic vessels
20:28 < kanzure> hmm i guess i should add "brain depository" to my TODO list
20:28 < gradstudentbot> Yeah, but that was only a sample size of one.
20:28 < kanzure> "and in this room, we have the largetst monkey brain depository in the world"
20:28 < kanzure> "we used to have more, but our electron microscope keeps eating them all"
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21:13 < nmz787> heheh
21:13 < nmz787> does that mean you'll someday fund a weird science museum?
22:04 < maaku> .title https://twitter.com/elonmusk/status/936782477502246912
22:04 < yoleaux> Elon Musk auf Twitter: "Payload will be my midnight cherry Tesla Roadster playing Space Oddity. Destination is Mars orbit. Will be in deep space for a billion years… https://t.co/clunBATxJr"
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22:05 < maaku> Elon, you can do so much better. How about a seed bank? Copy of the internet archive?
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23:16 <@fenn> http://www.maslowcnc.com/ 4x8 wood router based on cable triangulation, like hektor the graffiti bot
23:18 < abetusk> fenn, my friends and I are building a Maslow now
23:19 <@fenn> i don't really see what's new or special about it, like why do they need servos and a custom PCB
23:20 <@fenn> glad someone's making kits though
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23:43 <@fenn> "FreeRTOS was just taken over by Amazon." https://viewer.scuttlebot.io/%25tD5ZsMU5ghpY6xMJSrYhaKvnvqsu5LleZvaaYtZ0iD8%3D.sha256
--- Log closed Sat Dec 02 00:00:31 2017