--- Log opened Mon Dec 04 00:00:33 2017
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03:03 < nmz787> https://github.com/nmz787/culture_shock/blob/g30_mcu_code_docs/LAB_MANUAL.md
03:03 < nmz787> .title
03:03 < yoleaux> culture_shock/LAB_MANUAL.md at g30_mcu_code_docs · nmz787/culture_shock · GitHub
03:03 < nmz787> 4 days of lab work protocol -- I need to add more pics
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06:12 < kanzure> nmz787: is that your writeup?
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06:43 < kanzure> "Proof of concept continuous event logging in living cells" https://www.biorxiv.org/content/early/2017/11/25/225151 http://twitter.com/biorxivpreprint/statuses/934603269317505024
06:44 < kanzure> as opposed to dead cells
06:44 < kanzure> important detail
06:45 < kanzure> "RetSynth: Solving all optimal retrosynthesis solutions using dynamically constrained integer linear programming" https://www.biorxiv.org/content/early/2017/11/21/223271
06:45 < kanzure> https://www.github.com/sandialabs/RetSynth/
06:45 < kanzure> "In vivo RNA targeting of point mutations via suppressor tRNAs and adenosine deaminases" https://www.biorxiv.org/content/early/2017/10/28/210278
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08:30 < kanzure> eudoxia: sup
08:30 < kanzure> .title https://news.ycombinator.com/item?id=15843957
08:30 < yoleaux> CBOE Will Start Bitcoin Futures Trading on December 10 | Hacker News
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09:28 < kanzure> "Jim Thomas, a co-director of the ETC group which obtained the emails, said the US military influence they revealed would strengthen the case for a ban.   "
09:29 < kanzure> etc group needs to die in a fire
09:29 < kanzure> .title https://lists.linuxfoundation.org/pipermail/bitcoin-dev/2017-December/015346.html
09:29 < yoleaux> [bitcoin-dev] Updates on Confidential Transactions efficiency
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10:23 < nmz787> kanzure: yep
10:31 < nmz787> man, I'd love to dig into that RetSynth paper now instead of digging into pre-silicon fuse modelling
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11:41  * kanzure mumbles about scheduling the master race
11:44 < nmz787> .wik mumbly peg
11:44 < yoleaux> "Mumblety-peg (also known as mumbley-peg, mumblepeg, mumble-the-peg, mumbledepeg or mumble-de-peg) is an old outdoor game played using pocketknives. The term "Mumblety-peg" came from the practice of putting a peg of about 2 or 3 inches into the ground. The loser of the game had to take it out with his teeth." — https://en.wikipedia.org/wiki/Mumbly-peg
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15:02 < kanzure> we are should do immersive cooling bitcoin mining?
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15:26 < maaku> kanzure: we are should?
15:30 < kanzure> maaku: i'm trying to become the copy editor for "the shadow brokers"
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16:17 < JayDugger> Just the thing for the volcano island secret base. Deep seawater for the cold side of the thermocouple. Lava for the hot side of the thermocouple.
16:17 < JayDugger> Thermocouple design left as an exercise for the reader.
16:23 < nmz787> kanzure: did you hear about GP-Write China?
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16:35 < kanzure> nmz787: no?
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16:42 < kanzure> http://diyhpl.us/~bryan/papers2/financial/Commercializing%20biomedical%20research%20through%20securitization%20techniques.pdf
16:43 < kanzure> "FDA hedges" http://rthakor.mit.edu/sites/default/files/documents/FDAHedge_2017_March_Final.pdf
16:46 < kanzure> "Funding long shots" http://www-2.rotman.utoronto.ca/~hull/downloadablepublications/Long_Shots.pdf
16:47 < kanzure> hm. 'low correlation with other investments'
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16:52 < kanzure> "Buying cures versus renting health: Financing health care with consumer loans" https://pdfs.semanticscholar.org/708b/757b04eb6253819debc0cd6674fd61632aa0.pdf
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17:31 < nmz787> kanzure: let me retween the thing to you..
17:31 < nmz787> retweet*
17:46 < nmz787> ok, I think I did it
17:48 < kanzure> https://en.wikipedia.org/wiki/Eugenics_in_Japan
17:55 < kanzure> nmz787: i've sent a few emails asking around
17:55 < kanzure> in the interest of "release early, release often", here's a draft of our polymerase paper:
17:55 < kanzure> http://diyhpl.us/~bryan/papers2/bio/Electronic%20manipulation%20of%20polymerase%20for%20DNA%20synthesis.2017-12-04.pdf
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18:06 < kanzure> juul: i have uploaded a draft to the public interwebs http://diyhpl.us/~bryan/papers2/bio/Electronic%20manipulation%20of%20polymerase%20for%20DNA%20synthesis.2017-12-04.pdf
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18:17 < juul> cool!
18:17 < juul> btw, the 10k genes project is operational: https://www.reddit.com/r/bionet/
18:19 < kanzure> addgene made a request? hm.
18:19 < kanzure> "Quick first thought. You seemed to not mention the natural method already in place for synthesizing by using an nucleic acid that has a protected end unable to be bound to the next nucleotide until the end is cleaved off. With a magical polymerase or second enzyme that cleaves on queue then the synthesis could be controlled. So - blue (add g) - yellow (deprotect) - red (add c) - yellow ...
18:20 < kanzure> ...(deprotect) - etc thus giving a state machine of sorts."
18:25 < kanzure> .tw https://twitter.com/caiyizhi/status/937227056361955328
18:25 < yoleaux> I am thrilled to launch the GP-Write China centre yesterday, which I will be co-directing with Prof. Junbiao Dai. Writing genomes will become mainstream in China. https://pbs.twimg.com/media/DQGzAmDWkAAOvY4.jpg (@caiyizhi)
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18:31 < kanzure> dear leader http://www-personal.umich.edu/~rorder/brain.gif
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18:46 < kanzure> grown circuits of artificial neurons or something http://www.qstatebio.com/
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20:12 < kanzure> .wik germinal choice technology
20:12 < yoleaux> "Germinal choice technology refers to a set of reprogenetic technologies that, currently or that are expected to in the future, allow parents to influence the genetic constitutions of their children." — https://en.wikipedia.org/wiki/Germinal_choice_technology
20:14 < kanzure> "Graham's original intention was to monitor the outcomes of children produced through the bank's sperm, and he asked families using the bank's sperm to agree to periodic surveys; however, most recipients showed no interest in sharing information on their children once the procedure was over, and when he sent out a survey to recipient families in the early 1990s, few families responded. A ...
20:14 < kanzure> ...later segment of the same Slate article reported on the highlights of the lives of fifteen of the resultant children. Of the fifteen, six reportedly had 4.0 GPAs and two were reported to be "artistically precocious". Still others were reported to be "geniuses" and "whizzes" at various disciplines. All the children contacted by Slate were in good health, except one, who had what his mother ...
20:14 < kanzure> ...described as a "developmental disability".[4]"
20:14 < kanzure> "Geert Hamer at the Academic Medical Center, University of Amsterdam forecast in 2016 that correcting the genetic mutations that cause male infertility could be achieved in five to ten years. This had already been done in mice and, if successful in humans, could be the first case of germline engineering.[7]"
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21:01 <@fenn> "genetic mutations that cause male infertility" would already be strongly selected against, so why do they exist?
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23:32 < mrdata> fenn, just a thought: what's bad for an individual might sometimes be good for a species?
23:35 < mrdata> eg: reduced fertility in response to over crowding, for example
23:35 < mrdata> or pollution, or poor health, or ...
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--- Log closed Tue Dec 05 00:00:34 2017