--- Log opened Wed Dec 13 00:00:42 2017
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05:33 < kanzure> yeah he's a bit snarky i uess
05:33 < kanzure> *guess
05:56 < kanzure> music https://www.youtube.com/watch?v=JABIbHs_bi8
06:02 < kanzure> .tw https://twitter.com/HainseyB/status/940693753341263873
06:02 < yoleaux> Dye-labeled DNA imaging technique provides path to full cell imaging at super resolution levels! http://bit.ly/2Awum8r Impressive work by Ralf Jungmann @LMU_Muenchen & Peng Yin @wyssinstitute Learn more on #imaging and #microscopy in #biophotonics @SPIEevents @PhotonicsWest (@HainseyB)
06:02 < kanzure> "Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT" https://www.nature.com/articles/s41467-017-02028-8
06:02 < kanzure> https://scitechdaily.com/new-technique-visualizes-whole-cells-at-super-resolution/
06:03 < kanzure> "Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components" https://www.nature.com/articles/nature24648?sf175705011=1 https://twitter.com/nature/status/939925213038415873
06:04 < kanzure> cell design labs was acquired the other day..
06:04 < kanzure> .tw https://twitter.com/antonioregalado/status/938894996912201728
06:04 < yoleaux> Here comes the genetic engineering acquisition frenzy.... Gilead just bought cell "design" specialist Cell Design Labs for upto $567 million biobucks.!!! no product....just tech. https://globenewswire.com/news-release/2017/12/07/1247792/0/en/Gilead-Sciences-to-Acquire-Cell-Design-Labs.html (@antonioregalado)
06:05 < kanzure> "Gigadalton-scale shape-programmable DNA assemblies" https://www.nature.com/articles/nature24651
06:05 < kanzure> "Biotechnological mass production of DNA origami" https://www.nature.com/articles/nature24650
06:06 < kanzure> .tw https://twitter.com/bryan_johnson/status/938092867486175233
06:06 < yoleaux> I'm excited @osfund led @ArzedaCo $15.2m Series A, CEO @biopraxis thinks their protein design technology could potentially take the place of the petroleum-based products present in common materials and chemicals from plexiglass to herbicides to sweeteners https://agfundernews.com/arzeda-raises-12m-series-a-for-computational-protein-production-from-plants.html (@bryan_johnson)
06:06 < kanzure> https://agfundernews.com/arzeda-raises-12m-series-a-for-computational-protein-production-from-plants.html
06:08 < gradstudentbot> I think I have ebola.
06:23 < JayDugger> .title https://phys.org/news/2017-12-electromagnetic-cloak.html
06:23 < yoleaux> JayDugger: Sorry, that doesn't appear to be an HTML page.
06:23 < JayDugger> Seriously? Okay...
06:24 < JayDugger> "Electromagnetic water cloak eliminates drag and wake" https://phys.org/news/2017-12-electromagnetic-cloak.html
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07:01  * nmz787 yawn
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08:08 < kanzure> nmz787: what a boring call....
08:08 < nmz787> hehe
08:08 < nmz787> well at least I got good sleep last night and wasn't feeling dead
08:12 < nmz787> http://aip.scitation.org/doi/abs/10.1063/1.4963316?journalCode=apl
08:12 < nmz787> .TITLE
08:12 < nmz787> .title
08:12 < nmz787> yoleaux: get to it
08:12 < nmz787> "Continuous-flow multi-pulse electroporation at low DC voltages by microfluidic flipping of the voltage space topology"
08:13 < nmz787> "The key improvement in our design has been to create a channel topology and a method to fabricate an in situ polymerized binary network of conductive hydrogel, which distributes the voltage along the cell flow path in such a way that the cells move between the voltage polarities at each turn"
08:14 < nmz787> "While the field strength remains the same at every passage of the cell through a constriction, the direction of the field with respect to the cell’s frame of reference reverses at every turn of the serpentine path, if we assume that the cell follows the laminar flow streamlines and does not significantly rotate."
08:14 < nmz787> "In reality though, due to the contraction-expansion, turns, and differential inertial forces, the cell will undergo some rotation when flowing from one constriction to the next"
08:14 < nmz787> "By reversing the hyperpolarized and depolarized halves of the cell at every turn, a larger surface area of the cell is getting electroporated in our device"
08:15 < kanzure> huh.
08:17 < nmz787> basically just a sinusoidal microfluidic channel that snakes between two electrodes
08:18 < nmz787> or zig-zag, more-square sinusoid
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08:50 < kanzure> "nips 2017 notes" https://cs.brown.edu/~dabel/blog/posts/misc/nips_2017.pdf
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09:58 < nmz787> that sounds NSFW
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10:57 < kanzure> is intel a stickler for that?
11:01 < archels_> kanzure: I half-watched the first talk in the background, and it left me kinda wondering what a talk about fusion energy is doing at NIPS
11:02 < archels_> nmz787: NIPS is the machine learning conference to watch
11:04 < kanzure> welp i guess you have to give a talk at some point so why not NIPS *shrug*
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11:29 < kanzure> https://www.reddit.com/r/Bitcoin/comments/7jj0oa/im_donating_5057_btc_to_charitable_causes/dr6r4la/
11:32 < gradstudentbot> Oh man, that's a great scrabble word. I got to write that down.
11:39 < kanzure> the ornithological society only has 3000 members wow
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12:27 < kanzure> https://www.buckinstitute.org/annual-report
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12:56 < nmz787> kanzure: meh, not really, it just a comment on the sound of the name
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15:15 < JayDugger> Does this second coming of Carnegie give any way to verify the donations?
15:16 < JayDugger> Not that I doubt it'll happen, nor wish to invade privacy, just curious about whether this could be checked.
15:16 < JayDugger> Never mind. Held my nose and checked reddit.
15:16 <@fenn> you can follow the bitcoin transactions, presumably the charities donated to have public donation addresses
15:19 < gradstudentbot> I'm making a flamingo cell culture, but first I need to capture a flamingo, are you in?
15:20 < JayDugger> Yeah, found it. More power to them all. Glad to see such charity.
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15:35 < kanzure> the charities probably use bitpay or something- which takes bitcoin on their behalf, so that the charities only receive dollars.
15:35 < kanzure> so if you follow the addresses then you might just be looking at bitpay numbers not charities
15:35 < kanzure> (or some alternative to bitpay of course)
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15:52 < JayDugger> nah, it's fine. I find such examples of charity heartening, just have to invoke the Missouri state motto. It sounded a little too good to be true.
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15:55 <@fenn> yes but the charity address would be listed on the charity's website
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16:08 < kanzure> i wonder what robert mcintyre is up to
16:09 < kanzure> hm his linkedin profile still says nectome (brain vitrification things)
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16:14 < kanzure> ok he is calling me in a minute.
16:14 < kanzure> PROBLEM SOLVED
16:15 < kanzure> https://singularitynet.io/
16:16 < kanzure> maaku: goertzel raised $150M
16:28 < maaku> O_O
16:32 < maaku> wait wat, that's an ICO?
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16:38 < maaku> $36M
16:38 < gradstudentbot> You know, I hear you make more money being a garbage man.
16:50 < rpifan_> gradstudentbot, r u a bot
16:50 < gradstudentbot> Where did all my bands go?
16:51 < kanzure> huh, nectome is... uh. doing okay.
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17:09 < pasky_> wait what, goertzel is in full vanity/scam mode? :(
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17:42 < JayDugger> kanzure, please tell Robert mcintyre to check his org-export settings. They show up at http://aurellem.org/ASC/html/ASC-FAQ.html
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17:51 < kanzure> yashgaroth: hi hello
17:51 < yashgaroth> oh, hi
17:52 < kanzure> see pm
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17:56 < kanzure> yashgaroth: fenn is want enzyme capable of reversing cross-linking
17:57 < yashgaroth> what kind of cross-linking are we talking
17:57 < kanzure> glutaraldahyde
17:58 <@fenn> the cross linking occurs because two functional groups on a molecule covalently bond with something, but it doesn't seem like they have to be close to each other
17:59 <@fenn> the linker could be a specific sequence of sugars in a chain for example
17:59 <@fenn> then your enzyme recognizes only that sequence
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18:00 <@fenn> heh
18:01 < kanzure> kemmishtree: be greeted
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18:01 < kemmishtree> hi, I am greeted, thanks!
18:01 < yashgaroth> yeah if it can be an derivative of glutaraldehyde that's got more structure for specificity by the enzyme, then I don't see why not
18:02 < kanzure> "Aldehyde-stabilized cryopreservation" http://www.sciencedirect.com/science/article/pii/S001122401500245X
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18:09 < yashgaroth> glutaraldehyde fixation seems tough to reverse intracellularly though; you need an enzyme that'll pass the membrane
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18:12 <@fenn> so maybe it's not an enzyme, but some other chemical reaction
18:12 <@fenn> i'm not competent to speculate on hypothetical organic chemistries
18:14 < yashgaroth> much less specificity with a chemical reaction though, don't wanna just tear up every amine; however I am not competent in that either
18:17 <@fenn> i wonder if cross linking, say, only 10% of methionines is enough to prevent degradation
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18:26 < kemmishtree_> hi Malvolio!
18:27 <@fenn> often people will get disconnected and their client automatically reconnects
18:28 <@fenn> i don't think malvolio has ever said anything
18:28 < kanzure> kemmishtree_: yashgaroth is molecular biology person
18:29 < gradstudentbot> When is he back from sabbatical?
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18:29 < kemmishtree_> I'm just wondering who I actually personally know on here besides Nathan and Bryan.  Am I supposed to have a fantasy-inspired handle?
18:30 < kanzure> you can be called whatever you want
18:30 < kanzure> yashgaroth is someone you briefly met
18:30 < kanzure> but it also sort of doesn't matter who they are
18:31 <@fenn> mostly lurkers
18:31 < kemmishtree_> We are Church Borg
18:31 < kanzure> everyone is church borg
18:32 < kemmishtree_> soylent green is church borg
18:32 < kanzure> this is where we plot the new master race
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18:32 < kemmishtree_> anyway... does anyone have any insider info on how DNA synthesis with TdT is going?
18:32 < kanzure> bill efcavitch is on the gp-write work group calls sometimes
18:33 < kanzure> i get the sense that he is looking for more funding
18:33 < kanzure> has some minor preliminary results but he is tightlipped
18:33 < kanzure> dnascript might be doing tdt things.. they just raised a buch of money in france or something.
18:34 < kemmishtree_> I really passionately want to know what theyre ground truth basics are.  Like, has anyone ever simply sequenced a bunch of molecules, preferably really long ones, built up by TdT?  It seems so obvious to do that, but I haven't seen it in the literature (with cursory searches).  Anyone can tell me, gets a nickel.
18:34 < kanzure> tdt falls off
18:35 < kanzure> so fixing that is a first step
18:35 < kemmishtree_> I've read some slightly contradictory things in the literatchoor about that
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18:36 < kemmishtree_> Actually, I probably don't actually believe that.  Someone, anyone show me sequence data of long DNA built up by TdT.
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18:36 < kanzure> we don't have that data :-(
18:36 < kemmishtree_> I
18:36 < kanzure> let's go get some
18:36 < kanzure> do you want to do it?
18:37 < kemmishtree_> I've seen at least one figure in a paper showing that it can actually make at least 50-60 base additions (and possibly much longer), so where the sequence data?
18:38 < kemmishtree_>  yes I do
18:38 < kanzure> seems like a reasonable thing to go do at some point
18:39 < kemmishtree_> but, also, a few phone calls to people who *should* have that data by now, if they'd be open, would go a long way
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18:39 < kanzure> see the problem with that is church has stopped taking my phone calls ever since i started prank calling him
18:40 < kemmishtree_> I think he stopped taking my phone calls when he got rich.
18:40 < kemmishtree_> I'm just kidding.  George is a saint.
18:40 < kanzure> our brain slugs command us to say this
18:40 < kemmishtree_> And we are iconoclasts ;-)
18:40 < yashgaroth> efcavitch and dnascript are using unnatural nucleotides with TdT, I don't think anyone's published much about that aside from patents where they don't need to disclose results
18:40 < kemmishtree_> ah, patents in this field, vomit emoji?
18:41 < kemmishtree_> It's all up for grabs
18:41 < yashgaroth> well I assume dnascript is doing it as well, their presentation was the fluffiest thing outside of a petting zoo
18:41 < kemmishtree_> genuine laughter emoji
18:42 < kanzure> alright so here's what we should do
18:42 < kanzure> we should setup task forces that run into morgues and inject aldehyde into the skulls of the recently deceased
18:42 < kanzure> while hte body goes through funeral services, the brain doesn't decay too much
18:42 < kanzure> and we can pick them up in the graves a few days later
18:43 < kanzure> then we send them to uploader heaven
18:43 < kemmishtree_> As a law-abiding patriotic citizen I must condemn this proposal, and hi NSA!
18:43 < JayDugger> I think you're a little late to the party. The Mormons already have baptism for the dead.
18:44 < kemmishtree_> I do love the idea though, let's get Lincoln Cannon to lead some squads, a la Mormon baptism for the dead!
18:44 < kanzure> there's a serious splitter group in mormonism called transfigurism which is the transhumanist subsect
18:44 < kemmishtree_> wow, JayDugger, great mind!!!
18:44 < JayDugger> This seems a lot like it, but with sufficiently creative theology, and yeah, he might.
18:44 < JayDugger> Really? I thought that was just Lincoln Cannon's own interpretation.
18:45 < kanzure> i get marketing emails from them, they won't stop sending me junk mail
18:45 < kanzure> https://transfigurism.org/
18:45 < kemmishtree_> is Lincoln on here?
18:45 < kanzure> nah
18:45 < kanzure> don't think so
18:46 < JayDugger> Yeah, I thought that was Lincoln Cannon. Did they actually split off from the main LDS church?
18:46 < kanzure> don't know. not interested.
18:46 < kemmishtree_> okay, I just want to see someone make a really pitch-perfect late-night 60-second mini-infomercial version of "let's preserve your brain, only $99", targeted at the same demographics that get life insurance and funeral planning ads
18:47 < JayDugger> At a first glance, they're asking to get excommunicated, but as I said earlier, more power to them.
18:47 < kemmishtree_> You could buy cheap late-night ad time in markets like Austin and wathc hilarity ensure
18:48 < yashgaroth> old people are asleep during late-night ad time
18:48 < kemmishtree_> is efcavitch on here?  I feel like maybe I could just get him to reveal something real, casually.
18:48 < kemmishtree_> that or just do it
18:49 < kanzure> you should just email him and ask
18:50 < kemmishtree_> sure will do and will report back to the roadmap
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18:51 < kemmishtree_> @JayDugger no they didn't split off, but I guess talking about religion is like talking about philosophy, and goes against the rules?  I don't know.  I just got here.
18:51 < kanzure> well it's just boring
18:52 < gradstudentbot> This laproscopic camera is so easy to use.
18:52 < kanzure> we should be talking about quark bombs and synaptic barcoding and super resolution microscopy, not the finer details of lincoln cannon's inevitable trip to hell
18:53 < kemmishtree_> Mormons don't have hell, but... they do have boredom.
18:53 < kanzure> "funding fever" (crispr stuff) https://www.youtube.com/watch?v=f-Y73kscmgc
18:53 < kemmishtree_> we could be talking about gradstudent bot's camera?
18:54 < kanzure> he's a bot, don't mind him
18:54 < kanzure> he's based on the "shit graduate says" youtube video
18:55 < kemmishtree_> I can't wait to develop completely de novo and superior alternatives to CRISPR and totally made the whole patent battle look as ridiculous as it is
18:55 < kanzure> "shit graduate student's say" https://www.youtube.com/watch?v=ovEghdXC4tE
18:55 < kemmishtree_> wait, he's *really* a bot?
18:55 < kanzure> yeah he's a bot
18:55 < kanzure> gradstudentbot: are you going to write that paper?
18:55 < gradstudentbot> You can be fourth author.
18:55 < kemmishtree_> nice
18:56 < kemmishtree_> the creative behind that CRISPR fever video is the head writer at the onion
18:56 < kanzure> oh cool
18:56 < kemmishtree_> I reckoned it was way too well made to just be the work of some grad student making a joke video
18:58 < kemmishtree_> point being that he could be a real force in creative positive singularity technology hype.  or he might be just a deathist who Fucking Loves Science. and has, like kanzure, some comedic styling talent.  You could always email him about gay designer babies?
18:59 < kanzure> there's potential there
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--- Log closed Thu Dec 14 00:00:42 2017