--- Log opened Wed Jan 17 00:00:26 2018 00:19 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: it's time for sleep] 00:47 -!- Mrkva [~mrkva@alpha.mrkva.eu] has quit [Ping timeout: 240 seconds] 00:48 -!- Mrkva [~mrkva@alpha.mrkva.eu] has joined ##hplusroadmap 00:48 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 00:51 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 01:00 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 256 seconds] 01:59 -!- welly [~welly@105.139.36.189] has joined ##hplusroadmap 02:01 -!- welly [~welly@105.139.36.189] has left ##hplusroadmap [] 02:08 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 02:13 < archels> trouble in paradise https://arxiv.org/abs/1711.11561[6~[6~[6~[6~[6~[6~[6~[6~ 02:13 < archels> .title 02:13 < yoleaux> archels: Sorry, that command (.title) crashed. 02:13 < archels> ergh 02:13 < archels> .title https://arxiv.org/abs/1711.11561 02:13 < yoleaux> [1711.11561] Measuring the tendency of CNNs to Learn Surface Statistical Regularities 02:51 -!- pompolic [~A@unaffiliated/pompolic] has quit [Ping timeout: 265 seconds] 02:58 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 04:34 -!- pompolic [~A@unaffiliated/pompolic] has joined ##hplusroadmap 05:20 -!- DataPacRat [~dan@vdsl-22.itcanada.com] has joined ##hplusroadmap 05:29 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has quit [Remote host closed the connection] 05:30 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has joined ##hplusroadmap 05:47 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 05:49 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 05:52 -!- aeiousomething [~aeiousome@27.59.196.41] has joined ##hplusroadmap 05:57 -!- aeiousomething [~aeiousome@27.59.196.41] has quit [Read error: Connection reset by peer] 05:58 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:44 < kanzure> .tw https://twitter.com/DaisyRobinton/status/953312047160274945 06:44 < yoleaux> George Church speaking now at Harvard on “The promise and perils of gene editing” - watch live here! https://hms.harvard.edu/multimedia/hms-live (@DaisyRobinton) 06:44 < kanzure> .title https://www.youtube.com/watch?v=tzyEntE6IHA 06:44 < yoleaux> Talks@12: The Promises and Perils of Gene Editing - YouTube 06:48 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 06:59 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 07:02 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Remote host closed the connection] 07:03 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 07:29 < archels> https://i.imgur.com/JMnqlKF.jpg 07:33 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Ping timeout: 264 seconds] 07:37 < kanzure> .title https://news.ycombinator.com/item?id=16165029 07:37 < yoleaux> Machine Learning-Based End-To-End CRISPR/Cas9 Guide Design | Hacker News 07:41 -!- eudoxia [~eudoxia@190.99.101.24] has joined ##hplusroadmap 08:01 < kanzure> .title http://www.bio-era.net/reports/genome.html 08:01 < yoleaux> Genome Synthesis and Design Futures Report 08:13 -!- dequ [~dequ@natural-flavours.csclub.uwaterloo.ca] has joined ##hplusroadmap 08:14 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 260 seconds] 08:14 -!- dequ [~dequ@natural-flavours.csclub.uwaterloo.ca] has quit [Client Quit] 08:34 -!- bluebear_ [~dluhos@80.95.97.194] has left ##hplusroadmap [] 09:47 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 09:56 -!- DataPacRat 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[~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 13:31 -!- augur [~augur@2600:380:8500:9816:24c9:f126:43ad:a80b] has quit [Remote host closed the connection] 13:33 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 13:36 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 248 seconds] 13:52 -!- ebowden [~ebowden@1.136.108.65] has quit [Read error: Connection reset by peer] 13:53 -!- ebowden [~ebowden@1.136.108.65] has joined ##hplusroadmap 13:54 -!- ebowden_ [~ebowden@2001:8003:10dd:2d00:9cab:625c:8cba:92bb] has joined ##hplusroadmap 13:57 -!- ebowden [~ebowden@1.136.108.65] has quit [Ping timeout: 264 seconds] 14:14 -!- augur [~augur@2600:380:855e:8fbc:ec3c:816:116e:1860] has joined ##hplusroadmap 14:24 -!- Unconnect3d_ [~Unconnect@qubcpq1531w-lp130-01-50-100-143-105.dsl.bell.ca] has left ##hplusroadmap ["Leaving"] 14:27 < kanzure> hmm 14:27 < kanzure> give me aptamers 14:58 -!- DataPacRat [~dan@vdsl-22.itcanada.com] has joined ##hplusroadmap 15:05 -!- augur [~augur@2600:380:855e:8fbc:ec3c:816:116e:1860] has quit [Ping timeout: 276 seconds] 15:21 -!- gwillen [~gwillen@unaffiliated/gwillen] has joined ##hplusroadmap 15:44 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 255 seconds] 15:45 -!- Gurkenglas_ is now known as Gurkenglas 16:22 -!- rpifan [~rpifan@172.56.27.206] has joined ##hplusroadmap 16:22 -!- rpifan [~rpifan@172.56.27.206] has quit [Max SendQ exceeded] 17:08 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has quit [Remote host closed the connection] 17:11 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has joined ##hplusroadmap 17:13 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has quit [Read error: Connection reset by peer] 17:16 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has joined ##hplusroadmap 17:18 -!- ebowden [~ebowden@110.141.26.52] has joined ##hplusroadmap 17:22 -!- ebowden_ [~ebowden@2001:8003:10dd:2d00:9cab:625c:8cba:92bb] has quit [Ping timeout: 276 seconds] 17:40 -!- rpifan [~rpifan@172.56.27.158] has joined ##hplusroadmap 17:41 -!- rpifan [~rpifan@172.56.27.158] has left ##hplusroadmap [] 17:55 -!- Netsplit *.net <-> *.split quits: yorick, jrayhawk, kanzure, heath, kuldeep, Iriez 17:55 -!- Netsplit over, joins: heath, kanzure, Iriez, kuldeep 18:00 -!- jrayhawk [~jrayhawk@unaffiliated/jrayhawk] has joined ##hplusroadmap 18:03 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:17 < kanzure> yashgaroth: hi 18:17 < yashgaroth> yo 18:22 -!- drewbot [~cinch@54.196.210.36] has quit [Remote host closed the connection] 18:34 < kanzure> tell me things 18:39 < yashgaroth> not uh...not much going on. doin' more project research this weekend, I had no idea the cas9 protein was so fucking massive 18:40 < kanzure> how big? 18:40 < yashgaroth> like 1300 amino acids or something, the gene is 4kb 18:41 < yashgaroth> I get that it's got multiple functions but still that's huge 18:42 < kanzure> how big is a recombinase or integrase? 18:43 < yashgaroth> about 400-600 amino acids usually 18:45 < kanzure> how bigs ur butt 18:45 -!- razzy [~user@2001:718:2601:38f::21] has quit [Ping timeout: 255 seconds] 18:45 < yashgaroth> a million amino acids 18:53 -!- razzy [~user@2001:718:2601:38f::21] has joined ##hplusroadmap 19:29 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:30 -!- Netsplit *.net <-> *.split quits: s0ph1a, entity8421[m], nickjohnson, cloudcell, y0no 19:30 -!- Netsplit over, joins: y0no 19:30 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 255 seconds] 19:31 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-nffeizjehhcdxkmj] has joined ##hplusroadmap 19:31 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-ubhdhbbkrbvrlpsg] has joined ##hplusroadmap 19:31 -!- cloudcell [sid266768@gateway/web/irccloud.com/x-owfdyrtknnywoeil] has joined ##hplusroadmap 19:33 -!- entity8421[m] [entity8421@gateway/shell/matrix.org/x-comfbbtxfztptnau] has joined ##hplusroadmap 19:39 < kanzure> https://www.w3.org/TR/webauthn/ https://hacks.mozilla.org/2018/01/using-hardware-token-based-2fa-with-the-webauthn-api/ 19:41 < ebowden> Are there nucleases that do exactly what cas9 does, while being more compact? 19:42 < kanzure> there are many cas9 variants 19:45 < ebowden> I remember there being a bunch of other species of bacteria that had comparatively tiny nucleases that do the same thing. 19:56 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 255 seconds] 20:12 < kanzure> "Second factor authentication from secure hash chains" https://arxiv.org/pdf/1708.08424.pdf 20:16 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 20:19 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: time 4 sleep] 20:39 -!- DataPacRat [~dan@vdsl-22.itcanada.com] has quit [Ping timeout: 240 seconds] 20:46 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:49 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 20:51 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 265 seconds] 20:55 -!- DataPacRat [~dan@vdsl-28.itcanada.com] has joined ##hplusroadmap 21:00 -!- ebowden [~ebowden@110.141.26.52] has quit [Ping timeout: 256 seconds] 21:01 < nmz787> amino asses 21:01 < nmz787> hehe 21:03 -!- ebowden [~ebowden@110.141.111.147] has joined ##hplusroadmap 21:05 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.9.1] 21:05 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:10 < nmz787> fenn: a genetic counselor at a hospital recently told me "the $1000 genome is a misnomer" but I thought kanzure knew of an actual place/service 21:13 < nmz787> .t https://twitter.com/norklemcdorkle/status/953857610540658688 21:13 < yoleaux> nmz787: Sorry, I don't know what timezone that is. If in doubt, see https://en.wikipedia.org/wiki/List_of_tz_database_time_zones for a list of options. 21:13 < nmz787> .tw https://twitter.com/norklemcdorkle/status/953857610540658688 21:13 < yoleaux> @gravislizard multi-pointer X has been around for 10 years... https://en.wikipedia.org/wiki/Multi-Pointer_X (@norklemcdorkle, in reply to tw:953358883073900544) 21:14 < nmz787> juul: and yes it supports multiple keyboard cursors as well as mouse pointers, each pointer get's it's own keyboard attached 21:15 < nmz787> I was actually using this 10 years ago in a college classroom 21:22 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 21:25 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 248 seconds] 21:42 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 260 seconds] 21:45 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 22:31 < nmz787> https://news.nationalgeographic.com/2018/01/largest-underwater-cave-system-in-the-world-discovered-in-mexico-spd/ 22:31 < nmz787> .title 22:31 < yoleaux> World's Largest Underwater Cave Discovered 22:36 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 22:47 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:47 -!- DataPacRat [~dan@vdsl-28.itcanada.com] has quit [Ping timeout: 260 seconds] 23:00 -!- maaku [~maaku@173.234.25.100] has quit [Quit: ZNC - http://znc.in] 23:03 -!- maaku [~maaku@173.234.25.100] has joined ##hplusroadmap --- Log closed Thu Jan 18 00:00:26 2018