--- Log opened Thu Feb 01 00:00:40 2018 00:04 -!- sachy [~sachy@78.108.102.220] has quit [Quit: Leaving.] 00:10 -!- bsm117532 [~mcelrath@173-9-124-61-NewEngland.hfc.comcastbusiness.net] has joined ##hplusroadmap 00:14 < maaku> .title https://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates-tumors-in-mice.html 00:14 < yoleaux> Cancer ‘vaccine’ eliminates tumors in mice | News Center | Stanford Medicine 00:16 < maaku> http://stm.sciencemag.org/content/10/426/eaan4488 00:29 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 01:17 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has quit [Ping timeout: 240 seconds] 02:22 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:29 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 03:09 -!- midnightmagic_ [~midnightm@unaffiliated/midnightmagic] has joined ##hplusroadmap 03:10 -!- kuldeep_ [~kuldeep@unaffiliated/kuldeepdhaka] has joined ##hplusroadmap 03:11 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has quit [Ping timeout: 276 seconds] 03:11 -!- kuldeep [~kuldeep@unaffiliated/kuldeepdhaka] has quit [Ping timeout: 276 seconds] 03:11 -!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood] 03:11 -!- traumschule [~traumschu@mehl.schokokeks.org] has quit [Ping timeout: 276 seconds] 03:11 -!- traumschule [~traumschu@mehl.schokokeks.org] has joined ##hplusroadmap 03:12 -!- Joshchamp_ [sid159459@gateway/web/irccloud.com/x-drunjqwzrsxxynts] has quit [Ping timeout: 276 seconds] 03:13 -!- Joshchamp_ [sid159459@gateway/web/irccloud.com/x-adfgppfwmiunkvad] has joined ##hplusroadmap 03:16 -!- nsh- [~lol@wikipedia/nsh] has joined ##hplusroadmap 03:21 -!- midnightmagic_ is now known as midnightmagic 03:49 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 04:13 -!- jtimon [~quassel@41.31.134.37.dynamic.jazztel.es] has quit [Remote host closed the connection] 04:32 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 04:36 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 05:16 -!- fluke` [~user@193.165.236.152] has quit [Read error: Connection reset by peer] 05:26 -!- nsh- is now known as nsh 05:40 -!- fluke` [~user@193.165.236.152] has joined ##hplusroadmap 05:59 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 06:00 < kanzure> maaku: interesting, but i'm wondering why they want that. large tumors that you can directly inject stuff into aren't a problem for a skilled surgeon... are they? 06:00 < kanzure> are large macroscopic tumors sometimes inconveniently grown into the biology and removal would mean removing a vital organ...? 06:12 < fenn> yes 06:12 < fenn> also trying to cut them out can damage the tissue around it 06:13 < fenn> more importantly, you never know if the cancer is actually gone, even if you think you got all of it 06:13 < kanzure> well that's a problem with metastasized cancers anyway... right? 06:14 < kanzure> suddenly your lung cancer cancerous cell is hanging out in your large intestine and you get a new problem 06:15 < fenn> "solid" just means "not liquid" - some tumors are really gloopy and removal is ambiguous 06:15 < kanzure> hm. that sounds like an important detail people should talk about. 06:16 < kanzure> yeah i guess i've paid more attention to visually distinct solid tumors, which are probably a small subclass of the actual cancer problems. 06:16 < kanzure> and solid tumors that play nice are probably relatively benign in comparison... 06:19 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 06:58 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 07:12 < kanzure> http://diyhpl.us/~bryan/papers2/bitcoin/bitcoin-tech-dev-talks-schnorr-signatures.2018-02-01.pdf 07:29 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 268 seconds] 07:36 -!- ebowden [~ebowden@110.141.53.82] has joined ##hplusroadmap 07:40 < kanzure> "certain DNA bases can shape-shift for a thousandth of a second, transiently morphing into alternative states that can allow the replication machinery to incorporate the wrong base pairs." "I had always assumed that it was the shapeshifting of the polymerase that caused replication errors." 07:41 < kanzure> "Dynamic basis of dG-dT misincorporation via tautomerization and ionization" https://www.nature.com/articles/nature25487 07:48 -!- ebowden [~ebowden@110.141.53.82] has quit [Remote host closed the connection] 07:53 -!- ebowden [~ebowden@2001:8003:103f:8600:70f6:c906:7a5:6ea9] has joined ##hplusroadmap 08:04 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 08:11 -!- jaboja [~jaboja@jaboja.pl] has quit [Quit: Leaving] 08:22 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 08:22 -!- jaboja [~jaboja@jaboja.pl] has quit [Client Quit] 08:36 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 08:45 -!- fluke` [~user@193.165.236.152] has quit [Remote host closed the connection] 08:49 -!- augur [~augur@2600:380:475f:603:456b:266d:c3c0:9b56] has joined ##hplusroadmap 08:51 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 08:58 -!- fluke` [~user@193.165.236.152] has joined ##hplusroadmap 08:58 -!- fluke` [~user@193.165.236.152] has quit [Read error: Connection reset by peer] 09:38 < JayDugger> Thank you for "http://diyhpl.us/~bryan/papers2/bitcoin/bitcoin-tech-dev-talks-schnorr-signatures.2018-02-01.pdf". 10:08 -!- drewbot [~cinch@107.21.164.92] has quit [Remote host closed the connection] 10:13 -!- fluke` [~user@193.165.236.152] has joined ##hplusroadmap 10:13 -!- fluke` [~user@193.165.236.152] has quit [Remote host closed the connection] 10:18 -!- ebowden_ [~ebowden@2001:8003:103f:8600:dc4c:bc08:461a:ac9f] has joined ##hplusroadmap 10:21 -!- ebowden [~ebowden@2001:8003:103f:8600:70f6:c906:7a5:6ea9] has quit [Ping timeout: 240 seconds] 10:44 -!- DataPacRat [~dan@vdsl-65.itcanada.com] has joined ##hplusroadmap 10:55 -!- augur [~augur@2600:380:475f:603:456b:266d:c3c0:9b56] has quit [Ping timeout: 252 seconds] 10:57 < MrHindsight> https://www.iarpa.gov/index.php/research-programs/mist pre pre proposal day 10:57 < MrHindsight> anyone going? 11:07 < MrHindsight> Conference attendance is voluntary and is not required to propose to future solicitations (if any) associated with this program. 11:08 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 11:20 < kanzure> MrHindsight: yes. 11:51 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 256 seconds] 11:57 -!- DataPacRat [~dan@vdsl-65.itcanada.com] has quit [Ping timeout: 248 seconds] 12:03 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=45db6504 Bryan Bishop: transcript: hardening lightning (bpase18) >> http://diyhpl.us/diyhpluswiki/transcripts/blockchain-protocol-analysis-security-engineering/2018/hardening-lightning/ 12:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=80508aef Bryan Bishop: add slides link >> http://diyhpl.us/diyhpluswiki/transcripts/blockchain-protocol-analysis-security-engineering/2018/hardening-lightning/ 12:30 < MrHindsight> kanzure: considering it myself 12:43 < nmz787> MrHindsight: I considered and decided not to waste the time and money 12:43 < nmz787> MrHindsight: but if you're there too... maybe it'd be worth meeting 12:46 < MrHindsight> nmz787: I'm in the Chicago area. Where are you near? 12:48 < kanzure> nmz787: tud is going and it's only two per org, so you might have to make up a name or ask them for permission 12:49 < MrHindsight> have to be listed at sam.gov or similar 12:50 < MrHindsight> takes ~2 weeks to get through that process without hangups 12:53 -!- Thaelim [~suhdood@2601:282:903:430b:7053:ab82:f10b:c87b] has joined ##hplusroadmap 12:56 -!- sachy [~sachy@78.108.102.220] has joined ##hplusroadmap 13:03 < MrHindsight> dog and pony show without any commitment to do anything 13:16 < kanzure> nah i got approved to attend today. don't have no listing on sam.gov. 13:18 < MrHindsight> :) 13:29 -!- MrHindsight is now known as CaptHindsight 13:35 < nmz787> CaptHindsight: near Portland OR 13:35 < nmz787> kanzure: I can go as Intel ;) 13:38 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3caa3f15 Bryan Bishop: add link about blind signature powered storage tokens for lightning watchtowers >> http://diyhpl.us/diyhpluswiki/transcripts/blockchain-protocol-analysis-security-engineering/2018/hardening-lightning/ 14:55 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 15:13 -!- MrHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 15:15 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has quit [Ping timeout: 240 seconds] 15:15 -!- MrHindsight is now known as CaptHindsight 15:35 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has quit [Read error: error:1408F10B:SSL routines:SSL3_GET_RECORD:wrong version number] 15:35 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 16:26 -!- mrdata- [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 16:36 -!- winsoff [~foo@unaffiliated/winsoff] has quit [Read error: Connection reset by peer] 16:36 -!- winsoff [~foo@162.217.45.242] has joined ##hplusroadmap 16:36 -!- winsoff [~foo@162.217.45.242] has quit [Changing host] 16:36 -!- winsoff [~foo@unaffiliated/winsoff] has joined ##hplusroadmap 16:46 -!- red-001 is now known as john-titor 17:27 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:31 -!- augur [~augur@192.195.83.130] has quit [Ping timeout: 256 seconds] 17:32 < kanzure> https://www.technologyreview.com/s/610141/the-doctor-responsible-for-gene-therapys-greatest-setback-is-sounding-a-new-alarm/ 17:35 < CaptHindsight> you'll never fly Wibur 17:35 -!- ebowden_ [~ebowden@2001:8003:103f:8600:dc4c:bc08:461a:ac9f] has quit [Remote host closed the connection] 17:36 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:50 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 18:06 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:346f:6e04:e0a:adcd] has joined ##hplusroadmap 18:52 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 18:59 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 252 seconds] 19:01 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 20:07 -!- Thaelim [~suhdood@2601:282:903:430b:7053:ab82:f10b:c87b] has quit [Read error: Connection reset by peer] 20:15 -!- mrdata- [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 20:29 -!- winsoff [~foo@unaffiliated/winsoff] has quit [Quit: Leaving] 20:41 -!- justan0theruser is now known as justanotheruser 20:52 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:346f:6e04:e0a:adcd] has quit [Quit: Leaving] 21:15 < maaku> kanzure: I think the point is that it treats metastasized cancers too -- the T-cells move on to fight other related cancer colonies in the body 21:16 < maaku> that's the 'vaccine' part 21:24 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 21:28 -!- Guest7447 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 260 seconds] 21:50 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:53 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 22:25 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: MAXIMUM SOFTCORE] 23:27 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 23:45 -!- justan0theruser is now known as justanotheruser --- Log closed Fri Feb 02 00:00:17 2018