--- Log opened Tue Feb 13 00:00:51 2018
00:06 < nmz787> https://www.youtube.com/watch?v=G3_wUxaHBM8
00:06 < nmz787> .title
00:06 < yoleaux> From SolidPython To OpenSCAD to FEM in FreeCAD - YouTube
01:13 < fenn> .title http://youtu.be/fUyU3lKzoio
01:13 < yoleaux> Hey Buddy, Can You Give Me a Hand? - YouTube
01:13 < fenn> boston dynamics yellow dog bot
01:40 < Hooloovo0> that is one of the few youtube channels that I vaguely follow... everything they do is pretty cool
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06:13 < kanzure> .tw https://twitter.com/Miles_Brundage/status/963028788094341120
06:13 < yoleaux> "A [simulated] moth brain learns to read MNIST," Delahunt and Kutz: https://openreview.net/forum?id=HyYuqoCUz (@Miles_Brundage)
06:14 < kanzure> "Mutual inhibition of lateral inhibition: a network motif for an elementary computation in the brain" https://www.sciencedirect.com/science/article/pii/S095943881730291X https://twitter.com/jesseGlab/status/962736267078324224
06:14 < kanzure> "Lentiviral co-packaging mitigates the effects of intermolecular recombination and multiple integrations in pooled genetic screens" https://www.biorxiv.org/content/biorxiv/early/2018/02/08/262121.full.pdf
06:15 < kanzure> "combining a TLR9 ligand with an OX40 antibody" ok
06:17 < kanzure> "Portable, on-demand biomolecular manufacturing" http://www.cell.com/fulltext/S0092-8674(16)31246-6 https://twitter.com/Rohan_Thakur24/status/963125376624021505
06:17 < kanzure> "Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeutic proteins, and other commodities. However, the need for specialized equipment and refrigeration for production and distribution poses a challenge for the delivery of these technologies to the field and to low-resource areas. Here, we present a portable platform that provides the means for ...
06:17 < kanzure> ...on-site, on-demand manufacturing of therapeutics and biomolecules. This flexible system is based on reaction pellets composed of freeze-dried, cell-free transcription and translation machinery, which can be easily hydrated and utilized for biosynthesis through the addition of DNA encoding the desired output. We demonstrate this approach with the manufacture and functional validation of ...
06:17 < kanzure> ...antimicrobial peptides and vaccines and present combinatorial methods for the production of antibody conjugates and small molecules. This synthetic biology platform resolves important practical limitations in the production and distribution of therapeutics and molecular tools, both to the developed and developing world."
06:20 < kanzure> https://www.micropublication.org/ https://twitter.com/ElowitzLab/status/962392252906487808
06:21 < kanzure> cell-free simulation stuff https://github.com/BuildACell/txtlsim-python  https://twitter.com/cellfreetech/status/962370390512222208
06:21 < kanzure> .tw https://twitter.com/curiouswavefn/status/962382215169564672
06:21 < yoleaux> I wonder if I am the only one who thinks it would be fantastic for couples to get married under a canopy (chuppah in case of a Jewish ceremony) shaped like the insulin receptor. https://pbs.twimg.com/media/DVsRfpiU8AARISx.jpg (@curiouswavefn)
06:21 < kanzure> "aww, how sweet"
06:22 < kanzure> someone wants to splice burmese pythons into hulk people https://twitter.com/Pipette_Ninja/status/962402615899426816
06:23 < kanzure> .tw https://twitter.com/VIBTechWatch/status/962341050097467393
06:23 < yoleaux> More than 50 GB output in the first 32 h of #PromethION run with human DNA sample at GSF, amazing result! Final data output for run coming soon! @wouter_decoster @PuniMoj @svenndhert @nanopore @Clive_G_Brown @VIBLifeSciences #InnovationLab https://pbs.twimg.com/media/DVrrFYyXkAEKjqA.jpg (@VIBTechWatch)
06:23 < kanzure> some notes on recent oxford nanopore announcements http://omicsomics.blogspot.com/2018/02/february-2018-clive-brown-webcast-notes.html
06:24 < kanzure> "Programming gene and engineered-cell therapies with synthetic biology" http://science.sciencemag.org/content/359/6376/eaad1067
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07:14 < kanzure> .wik overwinter signature
07:14 < yoleaux> "File:Colin Winter Signature.JPG" — https://en.wikipedia.org/wiki/File:Colin_Winter_Signature.JPG
07:15 < kanzure> uh.
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08:24 < kanzure> .tw https://twitter.com/antonioregalado/status/963175936932892672
08:24 < yoleaux> New DNA emoji is left handed for Pete's sake. https://twitter.com/RodrigoATCG/status/962617995842523136 (@antonioregalado)
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09:47 < nmz787> saw a new Jurassic Park movie trailer last night... made me think that second, inner, eyelids might be a good upgrade
09:48 < nmz787> any resources/links on quitting a job to be stay-at-home dad (for newborn) who also does a startup?
09:50 < kanzure> find remote work before you quit
09:50 < nmz787> well startup would be local
09:50 < nmz787> unpaid, but sweat equity I guess :/
09:51 < kanzure> you want to be unpaid?
09:51 < nmz787> well, no, but I don't have any ideas for getting paid for startup aside from you at this point
09:55 < kanzure> "no pressure tho"
09:57 < nmz787> yeah, I hate selling stuff, especially myself
09:57 < nmz787> ever since elementary school tried making me sell sandwiches door-to-door to fund some school trip... even then I was like, "who the hell wants to buy/pay-for a sandwich that they won't get for a week"
09:59 < kanzure> i don't have an immediate thing to employ you on, but as you know there are multiple things in flight that might (or might not) actualize in you-relevant ways
10:11 < nmz787> yeah
10:12 < nmz787> I was really looking for some historical context, past experiences
10:12 < nmz787> I talked with someone a few weekends ago who was a work-from-home software guy, and he said predictability of kids is the hard/random constraint
10:13 < nmz787> you might be there, on a phone call, and you can't tell the kid "just wait 10 more minutes to start crying like crazy"
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10:13 < nmz787> on the other hand, youtube videos on "stay at home vs daycare" seem to assume you make minimum wage with no benefits
10:13 < andytoshi> doing a startup has way more of this kinda stuff than ordinary remote work .. esp if you are writing software you have a lot of flexibility
10:14 < nmz787> or I guess maybe that's the implicated wage at which it would make sense to quit your job
10:14 < andytoshi> you don't normally have to be on the phone, especially not with important external people
10:14 < nmz787> re: cost of daycare/nannie
10:14 < andytoshi> right it also makes no financial sense to do this, but there is nonfinancial value to being home with your child
10:14 < nmz787> andytoshi: in my case though, it could be like "I need to pipette these fluids before they get warm... wait 5 mins kid"
10:15 < andytoshi> that's ok, the kid can wait, it'll just get louder during the 5 minutes
10:15 < nmz787> hmm, ok, well that is pretty convincing of a statement (makes no financial sense; but nonfinancial value...)
10:15 < andytoshi> (btw i have no children of my own but i am the oldest of five and have spent most of my life around small children)
10:16 < nmz787> worst case would be the kid is strapped to my chest with a carrier/backpack thing.... looking into my SEM or something, and it suddenly vomits into the machine
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10:41 < kanzure> "Just a week ago, Cloudflare has been forced to stop protecting sci-hub. Since then, the other 6 domains this website is hosted on have been going up and down frantically, and the service quality has been severely reduced."
10:44 < kanzure> according to https://www.reddit.com/r/Bitcoin/comments/7x8wr3/calling_rbitcoin_to_help_scihub_survive/
10:45 < andytoshi> :(
10:47 < kanzure> scihub is sort of a dead-end at this point.. she refuses to release the whole library.
10:48 < andytoshi> very frustrating
10:48 < kanzure> it needs to be widely distributed, and it's her responsibility to work towards that since she has the data.
10:48 < andytoshi> i agree, but somewhat surprised to hear you say somebody has a moral responsibility because of resources they possess
10:48 < andytoshi> i'm sure we've disagreed on something like that before
10:49 < kanzure> it's an extremely important resource that nobody else possesses in the world
10:49 < kanzure> "science" is like the 8th wonder of the world
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10:54 < kanzure> all the other wonders are like crumbling stone structures or whatever that just sit there. this is more than 50 million extremely technical work, the most complete record of the technical progress of the human species, and one of the most important tools and results of the enlightenment and keeping us from truly dark ages.
11:07 < andytoshi> 100% with you
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12:16 < JayDugger> Hm.
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13:13 < kanzure> would an optogenetic insulin receptor be useful for anything
13:13 < kanzure> ?
13:14 < kanzure> also, the insulin receptor structure is sort of wild
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15:37 < MrHindsight> how valuable is a DNA service that provides the buyer with a 10mL bottle of any DNA stored on 23andMe or similar?
15:43 < kanzure> like addgene.org ?
15:43 < kanzure> or do you mean the patient's dna?
16:20 < maaku> <nmz787> any resources/links on quitting a job to be stay-at-home dad (for newborn) who also does a startup? <--- I did that, if you have questions
16:20 < maaku> they're now 6 and 4, with my current startup being 4 years old (laid the groundwork while my wife was pregnant)
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19:15 < MrHindsight> kanzure: DNA evidence for crime scenes, paternity tests etc
19:19 < kanzure> dunno
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--- Log closed Wed Feb 14 00:00:24 2018