--- Log opened Mon Feb 19 00:00:57 2018
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03:46 < fenn> wow that capsaicin cream had a huge effect on the fat levels
03:50 < fenn> "One capsaicin 8% patch costs approximately $800 (plus clinician fees for application)"
03:50 < fenn> jeebus
04:22 < TMA> what
04:24  * TMA has seen a bottle labeled as capsaicin in a korean food shop. it cost the equivalent of $8 iirc
04:25 < TMA> what is it that costs the other dollars in the patch?
04:28 < fenn> um, read this i guess, or don't: http://slatestarcodex.com/2017/02/09/considerations-on-cost-disease/
04:30 < fenn> also that bottle was almost certainly not pure capsaicin
04:30 < fenn> but it's not the materials that make it expensive, it's the fact that it's somehow related to healthcare
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06:36 < kanzure> "Sixth, might we have changed our level of risk tolerance? That is, might increased caution be due not purely to lawsuitphobia, but to really caring more about whether or not people are protected?"
06:36 < kanzure> wait he doesn't propose an actually realistic answer. what a fucker.
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06:55 < kanzure> .title https://shitpost.plover.com/m/math.jobs-you-dont-want.html
06:55 < yoleaux> Content-Type: text/shitpost : The duties of John von Neumann's assistant
06:55 < kanzure> "To attend von Neumann's lectures on operator theory on Mondays, Tuesdays, and Wednesdays, take copious notes, complete unfinished proofs, see them through the secretarial jungle, and promptly circulate them to all American university libraries. This task alone was consuming the entire energies of a younger person, who had to be very sharp, fast, clever, and tough. These notes ran to over 600 ...
06:55 < kanzure> ...pages."
06:56 < kanzure> "To go once a week to the printers of the Annals of Mathematics in Baltimore in order to instruct them in the art of typesetting mathematical symbols with subscripts, superscripts, subsubscripts, etc. The Annals of Mathematics had been printed in Hamburg, Germany by the firm of Lutke and Wolk. In view of increasing anti-Semitism under Hitler, the German connection was given up in favor of ...
06:56 < kanzure> ...printing in the United States. But no American printer had ever before set up mathematical symbols! They were complete illiterates. Solution: Let von Neumann's assistant teach them!"
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08:20 < kanzure> "Advisory: secret size attack on cross-chain hash lock smart contracts" https://gist.github.com/markblundeberg/7a932c98179de2190049f5823907c016
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09:00 < kanzure> .title https://www.youtube.com/watch?v=c4slzFdykpc
09:00 < yoleaux> Dev++ | Thaddeus Dryja - Lightning Network and Discreet Log Contracts - YouTube
09:16 < kanzure> i guess the thing to do is downregulate lipogenesis, really
09:16 < kanzure> adipocyte-only lipogenesis, of course.
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10:21 < kanzure> rexan: hi.
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10:30 < kanzure> hmph
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10:35 < CaptHindsight> looks like the big bucks are in cancer data mining https://flatiron.com/press/press-release/roche/
10:35 < kanzure> ~data~
10:35 < kanzure> these cowards need to take a laser to tumors
10:37 < CaptHindsight> it really does look like the FDA is really trying hard to keep any cures from hitting the market
10:38 < CaptHindsight> I was trying to see what Flatirons software is really all about
10:39 < CaptHindsight> https://phys.org/news/2018-02-ex-googlers-startup-goldagainwith-billion-sale.html
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10:56 < kanzure> "... aP2-desnutrin mice had significantly higher body temperatures over the course of the day, corresponding to a significantly higher rate of oxygen consumption. Taken together, our findings indicate that increased thermogenesis resulting from oxidation of hydrolyzed FAs within adipose tissue of aP2-desnutrin mice contributed to the leaner phenotype"
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11:08 < kanzure> FTO gene variant stuff https://www.snpedia.com/index.php/Rs17817449
11:08 < kanzure> (was looking up metabolic rate genetics)
11:14 < kanzure> i like the sglt2 idea. and then downregulating lipogenesis somehow.
11:14 < kanzure> but i would first want to check whether triglycerides are stored directly or are they only synthesized from glucose because that would be fatal.
11:21 < kanzure> .wik asprosin
11:21 < yoleaux> "Asprosin is a protein hormone produced by mammals in their fatty (white adipose) tissues that stimulates the liver to release glucose into the blood stream. In these tissues, asprosin is encoded by the gene FBN1, which also encodes the protein fibrillin." — https://en.wikipedia.org/wiki/Asprosin
11:22 < kanzure> .wik lipodystrophy
11:22 < yoleaux> "Lipodystrophy is a disorder in which the body is unable to produce fat." — https://en.wikipedia.org/wiki/Lipodystrophy
11:23 < kanzure> .wik marfanoid–progeroid–lipodystrophy syndrome
11:23 < yoleaux> "Marfanoid–progeroid–lipodystrophy syndrome (MPL), also known as Marfan lipodystrophy syndrome (MFLS) or progeroid fibrillinopathy, is an extremely rare medical condition which manifests as a variety of symptoms including those usually associated with Marfan syndrome, an appearance resembling that seen in neonatal progeroid syndrome (NPS;  …" — https://en.wikipedia.org/wiki/Marfanoid%E2%80%93progeroid%E2%80%
11:23 < yoleaux> 93lipodystrophy_syndrome
11:25 < kanzure> sounds about right ".. Despite consuming between 5,000 and 8,000 calories daily"
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12:16 < kanzure> folding eyelids would be a big one for the kiddos
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12:48 < kanzure> "mutations in the FBN1 gene, which encodes the proprotein of the novel hormone asprosin, and that this mutation results in asprosin deficiency"
12:54 < fenn> "NF-κB activity was blocked in elderly mice by bathing them in bleach solution, the animals' skin began to look younger, going from old and fragile to thicker, with increased cell proliferation. The effect diminished after the baths were stopped"
12:55 < superkuh> Well that's unexpected.
12:55 < fenn> .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859383/
12:55 < yoleaux> Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice
12:56 < fenn> oxidative stress mediates a bunch of hormetic stuff
12:57 < kanzure> don't forget your capsaicin
12:57 < fenn> if it burns it must be good for you
12:58 < kanzure> for that all natural "oh my god i'm going to die" burning feeling
13:00 < fenn> in the same paper, H2O2 didn't work
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13:19 < kanzure> asprosin patent https://patents.google.com/patent/US20160289289A1/en
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13:52 < kanzure> https://news.ycombinator.com/item?id=16415739 "The Broad Institute is sitting on radically superior IP, including the US patent on CRISPR Cas9 and global control of CRISPR Cpf1, which MPEG LA does not have any access to or control over. MPEG LA also doesn't have any rights to Sherlock. Nearly all global rights to all forms of CRISPR are controlled by Berkeley, Vienna and the Broad Institute ...
13:53 < kanzure> ...(with some smaller IP held by a few universities, and some corporations like Editas, Intellia, CRISPR Therapeutics, etc). MPEG LA has essentailly zero power over CRISPR, they own zero patents on CRISPR, they're trying to skim money by being a deal connector of the Berkeley & Vienna patents."
13:53 < kanzure> uhh sure.
14:16 < kanzure> "Advances in the understanding of adipose tissue biology" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465959/
14:19 < kanzure> "Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions" http://www.mgmjournal.com/article/S1096-7192(16)30118-4/abstract
14:19 < kanzure> "Since the C-terminal peptide of fibrillin-1 is a glucogenic hormone, individuals with low fibrillin-1 (for example with FBN1 mutations associated with lipodystrophy) may fail to differentiate adipocytes and/or to accumulate adipocyte lipids, although this still needs to be shown experimentally"
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19:10 < kanzure> aaaaaaaaaaaaaaaaaaaa
19:22 < CaptHindsight> http://twin.sci-hub.tw/172b8451e5dcd9619371968f0dffe9a9/miao2017.pdf
19:22 < CaptHindsight> 4D printing of polymeric materials for tissue and organ regeneration
19:23 < CaptHindsight> or custom ones
19:56 < Douhet> One small step for man, one giant leap for 4D printed reproductive organs
20:35 < nmz787> 4D?
20:35 < nmz787> is the 4th dimension different material?
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21:07 < kanzure> it's a meat dimension
21:12 < nmz787> time/solvent I'd say
21:12 < nmz787> shape memory 3D printing is more understandable though
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22:15 < kanzure> .title https://www.youtube.com/watch?v=oJDlzvqrPLk
22:15 < yoleaux> Panel with Peter Thiel, Aubrey de Grey, Eliezer Yudkowsky - YouTube
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22:59 < kanzure> cryptosoap: hi.
23:02 < cryptosoap> hi there
23:03 < kanzure> what brings you here?
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23:06 < cryptosoap> I saw your tweet quoting roasbeef on the cross chain atomic swaps and then noticed your link to this channel.
23:07 < kanzure> pretty straightforward
23:07 < kanzure> alright
23:07 < kanzure> welcome
23:07 < cryptosoap> ty
23:20 < nmz787> just ordered a hard copy of this https://www.amazon.com/dp/0521860253/
23:20 < nmz787> .title
23:20 < yoleaux> Electrokinetically-Driven Microfluidics and Nanofluidics: Hsueh-Chia Chang, Leslie Y. Yeo: 9780521860253: Amazon.com: Books
23:25 < kanzure> why not you use a libgen?
23:26 < nmz787> couldn't find it
23:27 < nmz787> feel free to check for me... I should be able to cancel it
23:29 < nmz787> https://github.com/RobertBaruch/polychip
23:29 < nmz787> "Python app to extract a netlist of NMOS transistors from an Inkscape diagram.
23:29 < nmz787> "
23:33 < kanzure> ah yes because when i send out my netlists, i use inkscape svg files
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--- Log closed Tue Feb 20 00:00:57 2018