--- Log opened Mon Mar 12 00:00:16 2018 00:09 -!- juri_ [~juri@205.166.94.162] has quit [Ping timeout: 248 seconds] 00:26 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 264 seconds] 00:31 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 00:34 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 00:36 -!- juri_ [~juri@205.166.94.162] has joined ##hplusroadmap 00:48 -!- juri_ [~juri@205.166.94.162] has quit [Ping timeout: 240 seconds] 00:49 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 248 seconds] 01:16 -!- juri_ [~juri@205.166.94.162] has joined ##hplusroadmap 01:27 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 01:45 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 264 seconds] 02:35 -!- juri_ [~juri@205.166.94.162] has quit [Ping timeout: 264 seconds] 02:50 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 03:15 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 248 seconds] 03:54 -!- juri_ [~juri@205.166.94.162] has joined ##hplusroadmap 04:09 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has joined ##hplusroadmap 04:09 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has quit [Client Quit] 04:12 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-hosktwaqexcdkjjq] has joined ##hplusroadmap 04:25 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 04:26 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Client Quit] 04:28 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 04:41 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Quit: ...and all my responses they stay the same.] 04:51 -!- drewbot_ [~cinch@54.196.106.173] has joined ##hplusroadmap 05:27 -!- bsm117532 [~mcelrath@173-9-124-61-NewEngland.hfc.comcastbusiness.net] has joined ##hplusroadmap 05:40 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has quit [Quit: wrldpc1] 06:08 < kanzure> https://soundcloud.com/heryptohow/snarks-starks-and-bulletproofs-andrew-polestra-pieter-wuille-benedikt-bunz 06:09 < kanzure> .title https://www.darpa.mil/news-events/2018-03-01 06:09 < yoleaux> Slowing Biological Time to Extend the Golden Hour for Lifesaving Treatment 06:10 < kanzure> "DARPA will hold a Proposers Day webinar on March 20, 2018, at 12:30 PM EDT to provide more information about Biostasis and answer questions from potential proposers. For details of the event, including registration requirements, visit: https://go.usa.gov/xnzqE " 06:10 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:10 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 252 seconds] 06:16 < kanzure> .title https://ethresear.ch/t/an-o-log-n-scaling-blockchain-with-validationless-full-nodes-using-data-availability-schemes/1370/1 06:16 < yoleaux> An O(log(n))-scaling blockchain with validationless full nodes using data availability schemes - Sharding - Ethereum Research 06:18 -!- xse_ [~xse@unaffiliated/xse] has joined ##hplusroadmap 06:21 -!- xse [~xse@unaffiliated/xse] has quit [Ping timeout: 264 seconds] 06:26 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:27 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 264 seconds] 06:31 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-hosktwaqexcdkjjq] has quit [Quit: Connection closed for inactivity] 07:02 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 276 seconds] 07:16 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 07:22 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 07:48 < kanzure> someone should consider doing xenotransplantation of animal metabolic circuits. it's probably mostly the same stuff between mammals. 07:52 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 07:57 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has joined ##hplusroadmap 08:03 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 08:40 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 09:08 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 10:42 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 10:43 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 260 seconds] 10:55 < kanzure> cool news tomorrow. 10:57 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 260 seconds] 10:59 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 11:00 < nmz787> tomorrow, tomorrow, only tomorrow, it's only a dayyy awwwayyyyyy 12:42 < kanzure> why not comatose human clones for gene therapy testing (confirm against something biologically nearly identical to you) 12:58 < archels> wouldn't want it to have a cortex, or I'd empathise too much with it 12:58 < kanzure> well a cortex could be removed 12:58 < archels> there might also be a lot of engineering involved to bring into the same epigenetic state 12:59 < kanzure> is same epigenetic state required? 12:59 < archels> I'm not sure how epigenetics is different between embryonic stem cells and IPSCs 12:59 < archels> probably, I'd imagine 12:59 < kanzure> i mean keep in mind that clinical trials right now are testing drugs on people without controlling for epigenetics on large populations 13:00 < archels> ah, there was this evolutionary scientist giving a lecture here last week, and he used the term "junk DNA" in a serious, apparently literal manner 13:00 < archels> should I take him seriously? 13:00 < kanzure> it's not just the junk dna, it's also methylation on top of the dna molecule and other dna modifications 13:01 < kanzure> junk dna can be trivially cloned btw 13:01 < archels> yeah, but I mean, do we still refer to "junk DNA" in 2018? 13:02 < kanzure> i think that's still the name 13:02 < archels> https://en.wikipedia.org/wiki/Noncoding_DNA#Junk_DNA 13:03 < archels> anyway, maybe we can start the gene therapy tests on some cells obtained from a biopsy and go from there 13:05 < kanzure> i think the concern is stuff like, does it get to all the cells in the body? which cells does it fail to efficiently transform? 13:08 < archels> that's true, very basic considerations like tissue geometry, and e.g. the relative position of an injection site, play a big role in outcome 13:13 < archels> our master's internship students tend to complain a lot about how hard it is to hit the right spot in a mouse brain to get the lentiviruses into the right place 13:15 < kanzure> hm interesting. it doesn't diffuse? 13:27 < archels> yeah, locally, with a radius measured in mm 13:28 < archels> for their conditions (injection volume, etc.) 13:32 < kanzure> why tho? are viruses generally not super-diffusible super-motile? 13:34 -!- Guest54521 is now known as abetusk 14:20 < kanzure> .title https://www.tum.de/en/about-tum/news/press-releases/detail/article/33522/ 14:20 < yoleaux> Entering the field of zeptosecond measurement - TUM 14:20 < kanzure> "Attosecond correlation dynamics" https://www.nature.com/articles/nphys3941 14:43 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 264 seconds] 14:50 -!- gnusha [~gnusha@unaffiliated/kanzure/bot/gnusha] has joined ##hplusroadmap 14:50 -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | as investigated by the fbi weapons of mass destruction division | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church 14:50 -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Tue Aug 29 14:28:51 2017] 14:50 [Users ##hplusroadmap] 14:50 [ abetusk ] [ Gurkenglas ] [ pompolic ] 14:50 [ AgenttiX ] [ gwillen ] [ potatope ] 14:50 [ andytoshi ] [ HEx1 ] [ Qfwfq ] 14:50 [ anonnumberanon ] [ Hooloovo0 ] [ rancyd ] 14:50 [ archels ] [ indiebio_ ] [ rancyd_ ] 14:50 [ balrog ] [ Iriez ] [ razzy ] 14:50 [ bbrittain ] [ JayDugger ] [ red-3-2-2019 ] 14:50 [ berndj ] [ Jenda ] [ redlegion ] 14:50 [ bkero- ] [ Joshchamp__ ] [ s0ph1a ] 14:50 [ brujo_biologica] [ jrayhawk ] [ sachy1 ] 14:50 [ bsm117532 ] [ juri_ ] [ sandeepkr ] 14:50 [ Burnin8 ] [ justan0theruser] [ saurik_ ] 14:50 [ catern ] [ kanzure ] [ sivoais ] 14:50 [ cloudcell ] [ kuldeep ] [ solarnetone ] 14:50 [ Cory ] [ maaku ] [ Solgriffin ] 14:50 [ darsie ] [ Madars ] [ soylentb1mb ] 14:50 [ DataPacRat ] [ Malvolio ] [ spurserh ] 14:50 [ dequ ] [ mf1008 ] [ strages ] 14:50 [ Douhet ] [ mgxm ] [ streety ] 14:50 [ drewbot_ ] [ midnightmagic ] [ superkuh ] 14:50 [ dustinm- ] [ mrdata ] [ Taek ] 14:50 [ ebowden ] [ namespace ] [ thundara ] 14:50 [ eleitl ] [ nanotube ] [ TMA ] 14:50 [ EnabrinTain ] [ nickjohnson ] [ traumschule ] 14:50 [ ensign ] [ night ] [ void3301 ] 14:50 [ entity8421[m] ] [ nmz787 ] [ WeirdTolkienishF] 14:50 [ ExeciN ] [ nsh ] [ xse_ ] 14:50 [ fenn ] [ pasky ] [ y0no ] 14:50 [ gnusha ] [ pepesza- ] [ yoleaux ] 14:50 -!- Irssi: ##hplusroadmap: Total of 87 nicks [0 ops, 0 halfops, 0 voices, 87 normal] 14:50 -!- Channel ##hplusroadmap created Thu Feb 25 23:40:30 2010 14:50 -!- Irssi: Join to ##hplusroadmap was synced in 12 secs 14:51 -!- juul [~juul@juul.io] has joined ##hplusroadmap 14:51 -!- caraka [~quassel@102.225.69.111.dynamic.snap.net.nz] has joined ##hplusroadmap 14:56 -!- drewbot_ [~cinch@54.196.106.173] has quit [Remote host closed the connection] 15:36 < kanzure> .tw https://twitter.com/bcbishop/status/973290826796236802 15:36 < yoleaux> This morning I’ve been to another dimension, and hatched a plan to stop a $1.3B tech acquisition. Everything is fine. (@bcbishop) 15:39 < kanzure> "Accurate computational design of multipass transmembrane proteins" http://science.sciencemag.org/content/359/6379/1042 15:40 < kanzure> "The computational design of transmembrane proteins with more than one membrane-spanning region remains a major challenge. We report the design of transmembrane monomers, homodimers, trimers, and tetramers with 76 to 215 residue subunits containing two to four membrane-spanning regions and up to 860 total residues that adopt the target oligomerization state in detergent solution. The designed ... 15:40 < kanzure> ...proteins localize to the plasma membrane in bacteria and in mammalian cells, and magnetic tweezer unfolding experiments in the membrane indicate that they are very stable. Crystal structures of the designed dimer and tetramer—a rocket-shaped structure with a wide cytoplasmic base that funnels into eight transmembrane helices—are very close to the design models. Our results pave the way ... 15:40 < kanzure> ...for the design of multispan membrane proteins with new functions." 15:41 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 15:46 < nmz787> cool! 16:54 -!- ebowden [~ebowden@128.250.0.211] has quit [Remote host closed the connection] 17:00 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 17:05 < kanzure> "A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence" https://www.nature.com/articles/s41380-017-0001-5 17:06 < kanzure> "We found 187 independent loci associated with intelligence, implicating 538 genes, using both SNP-based and gene-based GWAS. We found evidence that neurogenesis and myelination—as well as genes expressed in the synapse, and those involved in the regulation of the nervous system—may explain some of the biological differences in intelligence." 17:08 -!- mrdata- [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 17:10 < kanzure> "An examination of 53 tissue specific gene sets showed that this relationship between transcription changes in the brain and intelligence was evident across cortical tissue types including cerebellar hemisphere, the cerebellum, the frontal cortex, the anterior cingulate cortex, the nucleus accumbens of the basal ganglia, hippocampus, amygdala, hypothalamus, caudate nucleus, putamen, and the ... 17:10 < kanzure> ...substantia nigra." (in descending correlative score spanning a few different orders of magnitude) 17:45 -!- mrdata- [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 17:48 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:09 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:7814:7481:f054:633] has joined ##hplusroadmap 18:09 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 18:32 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 18:34 < kanzure> blort 18:56 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:57 < nmz787> https://www.sciencedirect.com/science/article/pii/S2451929418300421 18:57 < nmz787> .title 18:57 < yoleaux> Redirecting 18:57 < nmz787> pfft 18:57 < nmz787> Massively Multiplexed Tip-Based Photochemical Lithography under Continuous Capillary Flow 18:57 < nmz787> fenn kanzure ^ 19:10 -!- ebowden [~ebowden@128.250.0.211] has quit [Remote host closed the connection] 19:10 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 19:14 -!- ebowden [~ebowden@128.250.0.211] has quit [Ping timeout: 246 seconds] 19:16 < nmz787> traywick+ascendance vs gizmodo+zayner: https://drive.google.com/file/d/1Kht19hynaqK6eK5KcrtXVrFYWwHzSFRM/view 19:17 < yashgaroth> hahahahaha 19:30 -!- ebowden [~ebowden@203-214-67-67.perm.iinet.net.au] has joined ##hplusroadmap 19:52 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 20:04 -!- ebowden [~ebowden@203-214-67-67.perm.iinet.net.au] has quit [Remote host closed the connection] 20:04 -!- ebowden [~ebowden@203-214-67-67.perm.iinet.net.au] has joined ##hplusroadmap 20:08 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:09 -!- ebowden [~ebowden@203-214-67-67.perm.iinet.net.au] has quit [Ping timeout: 264 seconds] 20:10 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 265 seconds] 20:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 20:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:42 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 248 seconds] 20:59 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 21:19 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 260 seconds] 21:59 < maaku> Of the people thinking about nanotechnology things here, I wonder if anyone has compiled a list of near-term business applications / markets if you had access to Drexler-Merkle-Freitas molecular assemblers 21:59 < maaku> We all know the long-term possibilities. Medium-term bulk diamond would revolutionize just about every industry even if that's all you can make. 22:00 < maaku> But what about the very early days where error rates only allow nano-scale or micro-scale simple repetative materials? 22:01 < maaku> What can you do with simple diamondoid rods, gears, buckytubes, etc. at the NEMS scale? 22:05 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 22:17 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: We are all grateful to our wise and fearless OPz for their selfless committment to ensure the safety, openness, and popularity of our beloved channel!!! On behalf of all those who agree with me about this, i would like express our] 23:07 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:7814:7481:f054:633] has quit [Quit: Leaving] 23:08 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:58 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap --- Log closed Tue Mar 13 00:00:17 2018