--- Log opened Tue Apr 03 00:00:37 2018
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02:50 < fltrz> which polymer bond is stronger, between nucleotides in DNA or the peptide bond in protein?
02:52 < fltrz> I read the half life of peptide bond is hundreds of years, do they mean for a single bond it would take hundreds of years to break spontaneously, or do they mean for a typical protein length the protein would break up in roughly hundred years?
02:53 < fltrz> if the halflife refers to a single bond, it would imply that a protein of length ~hundred would take a single year before one of them breaks, for ~1000 about a month etc
02:56 < fltrz> how do living organisms deal with protein breakdown (spontaneous or catabolic) in order to have predictable remainder products? or does it place weak bonds so that the number of different kinds of protein fragments is much smaller and hence easier to recycle (i.e. detect, further anabolize etc)
02:59 < fltrz> i.e. consider a single species of protein of length 100, theres about 100*100/2=50 000 possible subsequences, so if we allow proteins to degrade at random, our recycling machinery must be able to detect and cope with 50 000 species
03:02 < fltrz> now I can imagine for the shorter sequences say up to length 5 or so for there to be a direct solution (common to all protein), but above that I would expect 'intended' weak points
03:08 < TMA> fltrz: I gather that the recycling is triggered by some 'recycle if known bad' mechanism. most broken proteins are probably harmless, just sitting there occupying space
03:09 < TMA> fltrz: therefore there is probably no selection pressure to clean them up
03:10 < TMA> however, for sufficiently "bad" debris, there might be enough of a selection pressure for cleaning mechanism
03:11 < fltrz> TMA, but wouldnt that pollute the cell with valuable protein? if it is thrown away, what about the human body? we don't piss it away, perhaps feces? its the 'lets send all trash away' solution... some organism in the biosphere is recycling it, and I suspect roughly every cell is doing it
03:12 < fenn> A-T and G-C is mediated by hydrogen bonding, which is orders of magnitude weaker than covalent bonds along the dna backbone or along the protein backbone
03:13 < fltrz> fenn, ok, I misphrased my question, I was then intending to ask which backbone is stronger, the DNA one or the protein one?
03:13 < TMA> fltrz: well, there is the mechanism to decompose just about any protein (digestion). if it is given the broken one it will happily digest it as it will the whole one
03:14 < fltrz> TMA, at the rate we consume protein, it cant just be left in the cells (divide your weight by the protein intake, then compare this with a human lifetime)
03:15 < TMA> fltrz: the wholes are synthetized, while all are broken up again. even assuming infinite time, there exists an equilibrium, where the broken ones do not constitute 100%
03:15 < fltrz> TMA, so broken protein go back to the digestive system, and the gut fauna and flora do it for us, and then we get them back (minus expenses for the gut fauna and flora to thrive)
03:15 < fenn> hmm i'd have to look at bond dissociation energies in a chemistry reference which is not handy.. i'd imagine a P-O bond is weaker than a C-N bond
03:16 < fltrz> this broken protein is carried by blood? lymph?
03:16 < fenn> at least a C-O bond is weaker than a C-N bond
03:17 < fenn> we all know that bonds are lies we tell children, right?
03:18 < fltrz> TMA, and even if it works like this, you still need a detection mechanism to carry out the trash to be recycled, so if you as a cell have a detection mechanism you could as well encapsulate them in a vacuole, and expose them to aggressive polymerases right?
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03:19 < fenn> proteins are broken down by intracellular proteases, and in large globs they get destroyed in lysozomes during autophagy
03:20 < TMA> fenn: we all know that atoms are lies. (there is some probability concentration in the wave function, but that's it)
03:21 < fenn> "Within the lysosome, the contents of the autophagosome are degraded via acidic lysosomal hydrolases."
03:22 < fenn> "Acid hydrolases may be nucleases, proteases, glycosidases, lipases, phosphatases, sulfatases and phospholipases and make up the approximately 50 degradative enzymes"
03:25 < fltrz> fenn, I understand proteins can be broken down, but how does the cell know which amino acid polymer constitutes a good protein, and which constitute broken protein fragments?
03:26 < TMA> fenn: thank you for confirming my guess based on probability theory and statistics ; I know next to nothing about detailed biochemistry, beyond the basic biology lessons twenty years ago
03:26 < fltrz> if we randomly break down and replace with known good, the cell would be full of broken protein fragments, and it would seem like an enormous energy waste
03:26 < TMA> fltrz: it need not to know
03:27 < fltrz> so its the randomly break down, and constantly produce known good model?
03:27 < TMA> fltrz: if there is 'break everything while synthetizing new stuff' the result can be 'insignificant amount of debris'
03:28 < fenn> fltrz: it breaks down good and bad
03:28 < fenn> the pieces then get recycled into new proteins
03:28 < fenn> unless they don't, and then you get old, or something
03:28 < TMA> say that you throw out your furniture and buy a new one. if you do that faster than you break the furniture the chances are pretty high, there will be no broken furniture in your house
03:28 < fltrz> what are typically largest protein sequences?
03:29 < fenn> muscle fibers
03:29 < TMA> or silk strand
03:29 < fltrz> I meant for a majority of cells, how long are its longest proteins?
03:30 < fenn> hmm i guess tubulin in that case?
03:30 < fltrz> how many amino acids in that protein?
03:30 < fenn> the tubulin dimer is 100kDa
03:30 < fenn> .wa 100kDa in number amino acids
03:30 < yoleaux> fenn: Sorry, no result!
03:31 < fenn> "The average molecular weight of an amino acid is 110Da"
03:31 < TMA> Average MW of an amino acid = 110 DaltonsAverage MW of a protein = (# of amino acids) x 110.
03:31 < fltrz> so about a 1000
03:32 < fltrz> so half would degrade in about a month?
03:32 < fltrz> (spontaneously not by catabolism)
03:32 < fenn> i don't really know what this "half life" stuff is about. degradation depends strongly on local environment
03:34 < fltrz> so the explanations is something like, cell has a recycling vacuole, all protein are sent in there within about a week (before spontaneous breakdown) indiscriminately, in there we have indiscriminate aggressive recycling, out come fresh amino acids... that could work
03:36 < fltrz> not only could it work, the cell could probably regulate catabolism & anabolism
03:36 < fltrz> I meant regulate their rate
03:36 < fenn> yes autophagy only happens when you're hungry (fasting)
03:36 < fltrz> thanks for explaining this to me
03:37 < fenn> moral of the story: to live longer and accumulate less garbage, do intermittent fasting
03:38 < fltrz> once a week should be good? :)
03:38 < fenn> ya
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03:47 < fltrz> it would seem the cell could relatively easy detect if reactions slow down because the concentration of useful protein decreases, and fasting or not increase the metabolism? also a person who does not fast at all, lives longer than weeks... but that does not take away we can induce autophagy with fasting like you say
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04:48 < fenn> autophagy still happens a little bit even without fasting
04:48 < fenn> we can tolerate a lot of garbage
04:48 < kanzure> "More than just IQ: School achievement is predicted by self-perceived abilities: But for genetic rather than environmental reasons" http://journals.sagepub.com/doi/abs/10.1111/j.1467-9280.2009.02366.x
04:59 < kanzure> .title https://www.media.mit.edu/posts/the-media-lab-and-nectome/
04:59 < yoleaux> Statement regarding the relationship between the MIT Media Lab and Nectome — MIT Media Lab
04:59 < kanzure> " In response to questions being raised about the relationships of Professor Ed Boyden and MIT with the company Nectome, the MIT Media Lab is releasing the following statement. MIT is party to a subcontract under an NIMH small business grant awarded to Nectome, with the Boyden group working on an academic research project to combine aspects of Nectome's chemistry with the Boyden group's ...
04:59 < kanzure> ...invention, expansion microscopy, to better visualize mouse brain circuits for basic science and research purposes."
04:59 < kanzure> "Upon consideration of the scientific premises underlying the company’s commercial plans, as well as certain public statements that the company has made, MIT has informed Nectome of its intent to terminate the subcontract between MIT and Nectome in accordance with the terms of their agreement."
05:04 < kanzure> .tw https://twitter.com/eboyden3/status/979782035211505664
05:04 < yoleaux> A bowtie featuring an expansion microscopy-processed brain circuit. #expansionmicroscopy #SciArt https://pbs.twimg.com/media/DZjicMNVoAEbJdr.jpg (@eboyden3)
05:05 < kanzure> .tw https://twitter.com/kanzure/status/981140142386753536
05:05 < yoleaux> @eboyden3 Hmm but meanwhile MIT is endorsing consciousness (the existence of which has not been empirically validated, not really). What did Nectome say, or just cold feet because of journalists misinterpreting brain vitrification? (@kanzure, in reply to tw:980853841234186240)
05:07 < kanzure> .title https://www.youtube.com/watch?v=Y524FbBaVHM
05:07 < yoleaux> This Brain Freeze Will Kill You: Robert McIntyre on Cryopreservation at the 1517 Social - YouTube
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05:14 < fenn> .wik growth mindset
05:14 < yoleaux> "In decision theory and general systems theory, a mindset is a set of assumptions, methods, or notations held by one or more people or groups of people." — https://en.wikipedia.org/wiki/Growth_mindset
05:14 < fenn> hmm
05:15 < fenn> anyway the Rationalists have this kooky idea that people who think they are better at things are lacking in "growth mindset" or something
05:15 < fenn> i'm not sure how strongly anyone believes it
05:16 < fenn> this is the general idea https://www.mindsetworks.com/Assets/images/science/the-science/the-growth-mindset-i-can-get-smarter.png
05:16 < kanzure> so if you believe you have an ability somewhere beyond the point of non-ability, then the rationlists believe you're somehow low value..?
05:16 < fenn> the whole thing seems like a crock of shit to me personally
05:17 < kanzure> 'scuse me, i meant Rationalists not rationalists of course
05:17 < fenn> they gave kids impossible questions and then measured how long they took to give up
05:17 < kanzure> you know, we should really self-appropriate a general word for ourselves too, like "thinkers" we should be the Thinkers
05:18 < fenn> those with "growth mindset" persevered in trying to solve the problem, and meanwhile the terrible evil self-believers were staring out the window bored
05:18 < fenn> dweck decided this meant that growth mindset leads to higher achievement
05:18 < fenn> oh, also they were told that the impossible problems were solvable
05:18 < kanzure> this seems to only measure someone's propensity to reject the social reality presented to them ("answer this question please") ("correct! the true test was telling us that we're full of shit!")
05:20 < fenn> i'm sure Thinkers is taken already
05:20 < fenn> maybe a more obscure one like Squidfuckers
05:20 < pompolic> graduating with honors in Following Orders
05:20 < kanzure> .botsnack
05:20 < yoleaux> :D
05:22 < pompolic> i like Squidfuckers
05:22 < fenn> yeah it's a good general term that describes my outlook on life
05:23 < kanzure> y'all got issues
05:23 < fenn> i was subjected to child abuse of years of people telling me to show my work on math problems
05:24 < fenn> 0 points for getting the right answer
05:31 < kanzure> .tw https://twitter.com/AysuOkbay/status/975040488632930305
05:31 < yoleaux> Data from "Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment", i.e. EA3, are online! https://www.thessgac.org/data (@AysuOkbay)
05:36 < kanzure> "In vivo tissue regeneration with robotic implants" http://robotics.sciencemag.org/content/3/14/eaaq0018
05:36 < kanzure> "The robot is designed to induce lengthening of tubular organs, such as the esophagus and intestines, by computer-controlled application of traction forces. Esophageal testing in swine demonstrates that the applied forces can induce cell proliferation and lengthening of the organ without a reduction in diameter, while the animal is awake, mobile, and able to eat normally."
05:36 < kanzure> looooool
05:37 < kanzure> now i'm not saying you should put a robot in your throat to lengthen your esophagus, i'm just saying i *could* do such a thing
05:39 < fenn> let's not turn this into a length contest
05:39 < kanzure> https://www.wired.com/story/a-robot-that-tugs-on-pig-organs-could-save-human-babies/
05:40 < kanzure> of course there's a wired article. i mean why not.
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06:22 < fenn> time to clone some russian mutant supersoldiers
06:23 < fenn> .title https://www.rand.org/pubs/issue_papers/IP162/index2.html
06:23 < yoleaux> Russia's Demographic "Crisis": How Real Is It? | RAND
06:26 < fenn> "mutations in alcohol dehydrogenase may have been naturally selected because they protect against alcoholism. It could be that they speed up the conversion of alcohol into acetaldehyde causing drinkers to feel unwell."
06:26 < fenn> it's not genetic engineering if it could have been naturally selected for, right?
06:27 < fenn> holy cow "In 1992, there were 225 abortions per 100 births" in russia
06:29 < fenn> no access to contraceptives
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06:51 < kanzure> i wonder if there is market interest in better alcohol dehydrogenases. or worse? i'm not really sure.
07:06 < kanzure> hmm
07:19 < kanzure> pasky: any of y'all brmlab people in kyiv by any chance?
07:22 < fenn> geography fail
07:23 < kanzure> it's like 14 hours
07:23 < kanzure> i checked
07:23 < kanzure> that's less than the time to cross the state of texas
07:24 < TMA> kanzure: we do not track our members that close. there might be a member travelling there at the moment
07:25 < kanzure> TMA: i am doing a thing in ukraine soon, sending someone over to oversee some operations
07:25 < TMA> kanzure: we do not even have comon borders with ukraine
07:25 < TMA> *common
07:25 < kanzure> it's only a 14 hour drive
07:26 < TMA> plus 14 days wait for visas, presumably
07:26 < kanzure> ah
07:26 < kanzure> yeah that would hinder cross-pollination. fine.
07:31 < TMA> ah, we can go there visa free; since 11th June 2017 they can go here too as well
07:31  * TMA was not up to date
07:35 < TMA> kanzure: sorry about that
07:35 < kanzure> whatevs; the point you made is that, no, not much particular overlap.
07:36 < TMA> it is too far by european standards
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07:39 < TMA> europe is much, much smaller. for most of the history the people were rarely travelling more than 100 miles from the place they were born
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09:49 < archels> "Real-Time Semantic Depth Layer Decomposition for Augmented Reality (in collaboration with SnapChat)"
09:49 < archels> heh
09:49 < archels> fully-funded PhD
09:53 < kanzure> i'd rather mount a DLP/DMD projector array to my head
09:55 < kanzure> (pointing to the walls)
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11:28 < kanzure> yashgaroth: have people mixed ssDNA and dsDNA in the same molecule?
11:28 < kanzure> like multiple repeating stretches of both types
11:29 < yashgaroth> I suppose you could generate it, not sure if people have tried outside of DNA origami
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11:43 < kanzure> https://www.technologyreview.com/s/610743/mit-severs-ties-to-company-promoting-fatal-brain-uploading/
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12:09 < kanzure> .tw https://twitter.com/antonioregalado/status/981218601519722496
12:09 < yoleaux> @kanzure @eboyden3 in what way are we misinterpreting brain vitrification? (@antonioregalado, in reply to tw:981140142386753536)
12:09 < kanzure> .tw https://twitter.com/kanzure/status/981242410129817605
12:09 < yoleaux> @antonioregalado @eboyden3 Brain vitrification is not uploading. "Scientific premise" of vitrification has been demonstrated & known. "Certain public statements the company has made"... sounds like misinterpretation of vitrification, brain uploading doesn't exist yet- AFAIK, Nectome agrees. (@kanzure, in reply to tw:981218601519722496)
12:09 < kanzure> .tw https://twitter.com/kanzure/status/981247148460306433
12:10 < yoleaux> @antonioregalado @eboyden3 My concern is that some journalists published "brain uploading" instead of "vitrification" -- e.g. "mind-uploading service", which is not Nectome's offering. Can't see good reason for MIT to distance from work on brain vitrification specifically. (@kanzure, in reply to tw:981242410129817605)
12:24 < fenn> people really jumped on that whole "100% fatal" thing
12:24 < fenn> well duh
12:25 < fenn> average joe doesn't know what "vitrification" is
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12:52 < kanzure> so, nectome isn't offering mind-uploading
12:52 < kanzure> does this mean that MIT is disputing "scientific premises".... of vitrification?
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12:56 < kanzure> .title https://news.ycombinator.com/item?id=16746948
12:56 < yoleaux> MIT severs ties to company promoting fatal brain uploading | Hacker News
13:02 < fenn> “Fundamentally, the company is based on a proposition that is just false. It is something that just can’t happen,”
13:02 < kanzure> .tw https://twitter.com/kanzure/status/981250126445449216
13:02 < yoleaux> @antonioregalado @eboyden3 It may sound morbid but I doubt "it's better to vitrify a recently-alive brain than a decayed dead brain" is a dispute of "scientific premise" as mentioned in the letter. More data would be good, sure. (@kanzure, in reply to tw:981247533753171969)
13:02 < fenn> “That is just not something we do in medical research.”
13:03 < kanzure> i was trying to estimate how many human cadavers that medical science has actually looked at in full detail throughout history
13:03 < kanzure> i think it's probably been less than 1 million. there's no way it can be a high number.
13:03 < fenn> these people sound less like scientists and more like befuddled old people
13:04 < kanzure> and out of the full autopsies that have been performed, how many of them were stopped as soon as cause of death was found?
13:04 < kanzure> (and also where does the definition of "full autopsy" come from?)
13:04 < kanzure> nectome should call it an extremely rigorous autopsy :-) if they were actually selling a brain uploading product. which they aren't.
13:05 < fenn> how the hell do they think impossible things become possible?
13:05 < fenn> somebody has to do the research to figure out how to make it possible.. duh!
13:09 < kanzure> this is an interesting case study of academic backlash against our ideas
13:09 < fenn> nah they just got wind of "cryonics" and released the hounds
13:10 < fenn> utterly predictable
13:10 < kanzure> ed boyden is highly supportive of these concepts in general, and often teams with george church who similarly pra--- oh maybe ed is less protected than george.
13:10 < kanzure> ed probably got pressured
13:10 < fenn> this is exactly in line with ed's research, there's no way he didn't get pressured
13:11 < fenn> probably some self-appointed bureaucrat bioethicist
13:11 < fenn> fiend, show yourself!
13:12 < kanzure> hmmmm i wonder if some sort of private-endorsement of crazy science platform/method would be helpful here... specifically, an org that verifies endorsements but anonymizes them or something, or tells an investor who the endorsement is coming from under the requirement of a non-disclosure agreement.
13:12 < kanzure> the endorser would have to pledge to provide rebuttals to outside due diligence as long as the anonymity is preserved
13:12 < fenn> that does sound useful
13:13 < fenn> it would need actually functioning opsec
13:13 < kanzure> the endorsement is only valuable if you can tell the investor who the person is... and the investor wont know that "ed boyden" is a good name... so they usually have to ask around anyway.. hrm.
13:14 < fenn> you ought to be able to write a coherent argument why you are endorsing something
13:14 < kanzure> sure, i think ed would be able to do that
13:14 < kanzure> for nectome
13:14 < fenn> name-dropping is a bad practice
13:14 < fenn> "considered harmful"
13:14 < kanzure> name-dropping is how endorsement works though
13:15 < kanzure> that's the only reason why george church is "advising" 2,000 startups
13:15 < fenn> ok so part of it is because they suffer backlash when they endorse something that doesn't pan out
13:15 < fenn> losing reputation and credibility
13:15 < kanzure> it's also about the extreme conservativism in academia.... you can't propose wacky ideas because your colleagues will look at you like you're fucking insane.
13:16 < fenn> but many things that should be endorsed will directly cost you in credibility and political capital
13:16 < kanzure> you are socially prohibited from exercising imagination and producing feats of imagination
13:16 < fenn> nah it's not wacky ideas, just ones with political opposition
13:17 < kanzure> even in gp-write some of the ideas i've proposed make conservative academic types kind of uncomfortable, not for political reasons but because all of their training has taught them to stray away from "well why don't you just..." ideas.
13:17 < fenn> if you propose the female birth orgasm theory, they'll look at you funny but won't call for your resignation
13:17 < kanzure> i don't know if resignation would be sufficient to force boyden to issue a retraction of endorsement
13:17 < fenn> yeah calling people out on their stupidity produces cognitive dissonance
13:18 < kanzure> or i mean, if resignation is the requirement-- i bet even lesser harms would make boyden issue a retraction
13:18 < kanzure> right, so, they need a private venue to be able to endorse these things
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13:18 < fenn> that's what TED and the like are for, i guess
13:18 < kanzure> no that's public
13:19 < fenn> i meant the schmoozing
13:22 < kanzure> i guess private endorsements already exist. this wasn't even a public endorsement really, this was a subcontracting relationship that a MIT lab had with a startup. geeze.
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13:27 < kanzure> "The current state of the pursuit of biological immortality" http://diyhpl.us/~bryan/papers2/longevity/The%20current%20state%20of%20the%20pursuit%20of%20biological%20immortality%20-%202018.pdf
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13:50 < fenn> this review paper looks familiar, who wrote this?
13:50 < fenn> also i disagree that heterochronic parabiosis is evil
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13:51 < fenn> forcing people to do things is evil
13:51 < fenn> such sloppy thinking
13:55 < kanzure> author might want to be anonymous and also i don't know if i should keep the file there because he might want it to be non-public
13:56 < kanzure> there's a lot of weird gaps in this report
13:56 < kanzure> like clear lack of knowledge about recent developments
13:57 < fenn> it looks very polished to be intended for non-public use
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14:50 < kanzure> artificial kidney thing https://pharm.ucsf.edu/kidney
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14:58 < fenn> http://www.ultimax.com/whitepapers/2001_3e.html giant sunshade for geoengineering
14:59 < kanzure> "dymaxion circumpolar grid"
14:59 < fenn> it makes sense if you see it on a dymaxion map
15:00 < fenn> the majority of land mass is in the northern hemisphere
15:02 < kanzure> what is their actual proposal for constructing these things
15:06 < fenn> presumably along the same lines as the space solar power stuff from the 1970s, but with robotic assembly
15:06 < fenn> it's not a detailed design study, just the general concept
15:06 < fenn> something i stumbled across while evaluating a similar proposal
15:07 < fenn> .title https://www.sciencedirect.com/science/article/pii/S1364032112005059
15:07 < yoleaux> Mirrors in the sky: Status, sustainability, and some supporting materials experiments - ScienceDirect
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17:17 < kanzure> "Venus' spectral signatures and the potential for life in the clouds" https://www.liebertpub.com/doi/full/10.1089/ast.2017.1783
17:22 < kanzure> .tw https://twitter.com/antonioregalado/status/981192486793220096
17:22 < yoleaux> Here is the grant in question. "WHOLE BRAIN NANOSCALE PRESERVATION/IMAGING" MIT/Boyden lab was a subcontractor. https://projectreporter.nih.gov/project_info_description.cfm?aid=9355699&icde=38841583 https://pbs.twimg.com/media/DZ3hgw_WsAEU-jQ.jpg (@antonioregalado, in reply to tw:981186486522478592)
17:23 < kanzure> .tw https://twitter.com/antonioregalado/status/981192492900024321
17:23 < yoleaux> The research involved how to reconstruct "dense neural morphology" from imaging preserved brains. Along the lines of this paper. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660712/ https://pbs.twimg.com/media/DZ3h3THXkAAuVBJ.jpg (@antonioregalado, in reply to tw:981192486793220096)
17:24 < kanzure> .tw https://twitter.com/kristinclift/status/980853055078969345
17:24 < yoleaux> Prenatal Exomes Give Diagnosis For Skeletal Abnormalities Seen in Ultrasound https://www.nature.com/articles/gim201830 (@kristinclift)
17:24 < kanzure> .tw https://twitter.com/antonioregalado/status/980880845362880512
17:24 < yoleaux> 40/ Last November, we wrote about a company Genomic Prediction, that is trying to implement polygenic scoring systems in IVF (not easy). One of the founders, Steve Hsu, is on the record wanting to select smarter people. https://www.technologyreview.com/s/609204/eugenics-20-were-at-the-dawn-of-choosing-embryos-by-health-height-and-more/ (@antonioregalado, in reply to tw:980880842896691201)
17:25 < kanzure> .tw https://twitter.com/antonioregalado/status/980842867425009671
17:25 < yoleaux> Can we predict intelligence from DNA? Not very well. Here's the take of @erlichya from last summer. https://medium.com/@dl1dl1/can-we-predict-intelligence-from-genetic-data-9ab5e5b57d41 (@antonioregalado)
17:26 < kanzure> https://www.technologyreview.com/s/610339/dna-tests-for-iq-are-coming-but-it-might-not-be-smart-to-take-one/
17:26 < kanzure> oh brother "Dalton Conley, a sociologist at Princeton University, says as soon as the IQ predictions reach the double digits—something that could occur very soon—we will need to have a “serious policy debate” about such “personal eugenics.”"
17:30 < kanzure> "But which specific genes are responsible? The search did not go well at first. Plomin failed to discover any links when he looked at the genomes of 7,900 children in 2010. He later became involved in a misadventure involving a Chinese sequencing company, BGI, to which he supplied the DNA of more than a thousand American geniuses. The project got derailed after news reports accused the ...
17:30 < kanzure> ...Chinese of hatching a plot to breed “genius babies.”"
17:30 < kanzure> bgi stopped because of it appearing in the news..?
17:35 < kanzure> ( https://www.nature.com/news/chinese-project-probes-the-genetics-of-genius-1.12985 )
17:36 < kanzure> ( https://www.vice.com/en_us/article/5gw8vn/chinas-taking-over-the-world-with-a-massive-genetic-engineering-program )
17:41 < nmz787> wait so chinese superbabies are on hold or not?
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18:05 < nmz787> https://www.sciencedaily.com/releases/2018/04/180403111056.htm
18:05 < nmz787> .title
18:05 < yoleaux> Scientists create 'Swiss army knife' for electron beams: Pocket accelerator combines four functions in one device -- ScienceDaily
18:06 < nmz787> "With this single device, powered by few-microjoule, single-cycle, 0.3 THz pulses, we demonstrate record terahertz acceleration of >30 keV, streaking with <10 fs resolution, focusing with >2 kT m–1 strength, compression to ~100 fs as well as real-time switching between these modes of operation."
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18:12 < kanzure> "wait so chinese superbabies are on hold or not?" yes.
18:15 < nmz787> hrmm, I am still unclear
18:15 < nmz787> yes they are on hold, or yes they are not?
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19:49 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d6d409e6 Bryan Bishop: transcript: nectome (january 2018) >> http://diyhpl.us/diyhpluswiki/transcripts/nectome-1517-2018/
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19:52 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=9bce14b6 Bryan Bishop: add tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/nectome-1517-2018/
19:52 < kanzure> .tw https://twitter.com/kanzure/status/981363642598920192
19:52 < yoleaux> Transcript: Nectome and aldehyde-stabilized cryopreservation http://diyhpl.us/wiki/transcripts/nectome-1517-2018/ https://www.youtube.com/watch?v=Y524FbBaVHM cc @Lets_Upgrade @antonioregalado (@kanzure)
19:55 < kanzure> cc andytoshi
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20:14 < nmz787> I am taking off of work tomorrow, whee! Time to catch up on some stuff.
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22:21 < juul> does anyone know of a list of genetic components that have been cleared of third party rights? (patents)
22:21 < juul> especially in E. coli and P. pastoris
22:23 < nmz787> https://www.youtube.com/watch?v=-wUPb1BDSOs
22:23 < nmz787> .title
22:23 < yoleaux> How can quantum computers change chemistry? — Speaking of Chemistry - YouTube
22:26 < nmz787> juul: closest I know of https://www.atum.bio/products/protein-paintbox
22:27 < nmz787> "DNA2.0’s Protein Paintbox™ is available without intellectual property restrictions, for the Synthetic Biology research community to improve upon and to incorporate into innovative products. A subset of the Paintbox proteins reported here have been contributed to the public domain via the BioBrick Public Agreement."
22:29 < nmz787> juul: I believe there's been good commentary on the diybio list
22:29 < nmz787> at least in regards to that protein paintbox
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22:52 < nmz787> http://ibm.biz/qx-introduction
22:52 < nmz787> .title
22:52 < yoleaux> IBM Q Experience
22:53 < nmz787> "Explore the world of quantum computing! Check out our User Guides and interactive Demos to learn more about quantum principles. Or, dive right in to create and run algorithms on real quantum computing hardware, using the Quantum Composer and QISKit software developer kit."
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23:12 < juul> nmz787: cool thanks
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23:14 < juul> oh that's DNA 2.0
23:14 < juul> don't trust those fuckers. they've repeatedly claimed that their stuff is IP-Free when it actually isn't
23:19 < juul> if you actually read the terms and conditions:
23:19 < juul> "Customer may not (1) modify the ProteinPaintbox product or (2) use the ProteinPaintbox product for commercial purposes without the prior written consent of ATUM."
23:19 < juul> from https://www.atum.bio/company/terms-and-conditions
23:19 < juul> fucking fuckers
23:20 < juul> the Open Plant project and things out of BIOFAB / EndyLab are the only things I know of
23:20 < juul> but not of that is for yeast
23:21 < juul> oh btw the patent on GFP expired so I guess that part is open as long as you don't get it from DNA 2.0
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