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host closed the connection] 06:49 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 07:02 < solene> does someone know a place gathering sources for 3D printing prosthesis/enhancement? I can't find anything on thingiverse (maybe the reason is that there is nothing) 07:04 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:05 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Remote host closed the connection] 07:06 < juri_> solene: i know there is a team at novalabs printing prosthetics. 07:07 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:18 -!- ebowden_ [~ebowden@128.250.0.198] has joined ##hplusroadmap 07:22 -!- ebowden [~ebowden@e-nat-mobility-0-114.uniaccess.unimelb.edu.au] has quit [Ping timeout: 256 seconds] 07:24 < kanzure> "Toward machine-guided design of proteins" https://www.biorxiv.org/content/early/2018/06/02/337154 https://twitter.com/SurgeBiswas/status/1002939595233873920 07:28 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:29 -!- l_wl__ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:29 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 07:30 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 07:33 -!- l_wl__ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 07:33 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:35 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 07:35 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 07:51 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 240 seconds] 07:56 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 08:02 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 08:03 -!- jqtrde [~jqtrde@c-76-126-68-88.hsd1.ca.comcast.net] has joined ##hplusroadmap 08:22 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 08:27 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 08:27 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 08:49 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:71bc:8124:51e3:e6ee] has joined ##hplusroadmap 08:57 -!- l_wl_ [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 09:09 -!- t4nk [t4nk@gateway/shell/panicbnc/x-wrsfdvbqeehunuax] has joined ##hplusroadmap 09:47 -!- l_w_ [~Mutter@2600:1:f19d:c9cd:1db7:4b91:4757:67ab] has joined ##hplusroadmap 09:50 -!- l_w_ [~Mutter@2600:1:f19d:c9cd:1db7:4b91:4757:67ab] has quit [Client Quit] 09:55 -!- jqtrde [~jqtrde@c-76-126-68-88.hsd1.ca.comcast.net] has quit [Ping timeout: 265 seconds] 09:57 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 10:09 -!- jqtrde [~jqtrde@c-76-126-68-88.hsd1.ca.comcast.net] has joined ##hplusroadmap 10:25 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 10:32 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 10:37 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 245 seconds] 10:58 -!- jqtrde [~jqtrde@c-76-126-68-88.hsd1.ca.comcast.net] has quit [Ping timeout: 240 seconds] 12:08 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 12:26 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 12:31 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 256 seconds] 13:01 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has quit [Ping timeout: 265 seconds] 13:03 -!- CaptHindsight [~2020@38.84.134.54] has joined ##hplusroadmap 13:03 -!- CaptHindsight [~2020@38.84.134.54] has quit [Changing host] 13:03 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 13:36 -!- Hoolootwo [Hooloovoo@hooloovoo.blue] has quit [Quit: Temporarily refracted into a free-standing prism.] 13:39 -!- Hoolootwo [Hooloovoo@hooloovoo.blue] has joined ##hplusroadmap 14:06 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 276 seconds] 14:23 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 15:01 < adlai> do you people know anything about cholesterol, or just links to peer-reviewed research? 15:01 < adlai> that's a x-or, not ior. 15:26 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Remote host closed the connection] 15:28 -!- sachy [~sachy@78.108.102.220] has quit [Quit: Leaving.] 15:31 < JayDugger> The latter, unless you want second-hand anecdotes about "Why I'll never take statins." 15:37 < adlai> sure, that doesn't sound peer-reviewed :) 15:42 < Douhet> JayDugger, why won't you take statins? 15:47 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 245 seconds] 15:59 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 16:07 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 16:27 < jrayhawk> That's sortof a broad topic. Are you interested in membrane construction (fluidity, permeability, lipid rafts), the pregnenelone pathway (progestogens, androgens, estrogens, glucocorticoids, mineralcorticoids), osysterols (bile acids production, etc), or vitamin D?? 16:36 < streety> jrayhawk: I was aware statins potentially had some serious side effects, rhabdomyolysis, liver damage etc. I have a soft spot for vitamin D though and wasn't aware there was a link there 16:38 < jrayhawk> Yeah, inhibiting the availability of membrane and hormone construction substrates turns out to be a pretty bad idea. 16:45 < jrayhawk> Statins are somewhat effective at reducing heart attacks, mediocre at reducing overall mortality ( https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/416105 ), and disastrous for QALYs. 16:45 < jrayhawk> Unfortunately the Streetlight Effect biases research towards the former and away from the latter. 16:47 < jrayhawk> None of this is surprising when we start to understand that atherosclerosis is caused by interactions between ApoB100 and endothelial cells and that cholesterol was only ever a mediocre proxy measure of ApoB100. 16:54 < jrayhawk> Measuring "LDL cholesterol" makes about as much sense as measuring "LDL palmitate" or "LDL CoQ10"; we don't care about the contents about the lipoprotein, we care about the surface features, under what conditions the liver is predisposed to producing lipoproteins with those features, and under what conditions the endothelium is prone to interacting with them. 16:59 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Ping timeout: 248 seconds] 17:00 < streety> Do you consider an ApoB blood test more useful than an NMR Lipoprofile? 17:00 < jrayhawk> Nah, LDL-P is probably good enough. 17:01 < streety> Fair enough, I recently went for a long overdue physical and found the process underwhelming. Wondering if there are any gaps I should be filling in 17:07 < jrayhawk> What modulates the other side (receptivity of the endothelium) and how to measure that in a healthcare setting is still an open question in the research; the general suspicion is that people with low inflammation and low oxidative stress don't need to care all that much about ApoB100 interactions, but vascular diseases are very hard to do RCTs on because they take decades to get anywhere. 17:10 < jrayhawk> A bunch of the rest of the bloodwork (Trigs, FFAs) winds up acting as a measure of how generally fucked the membranes in your body are. 17:19 < jrayhawk> If you're the sort of contrarian who likes scaring your insurance company, http://cholesterolcode.com/extreme-cholesterol-drop-experiment/ is a fun read. 17:28 < adlai> does just clicking the link scare my insurance company? should i use tor? 17:29 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 17:31 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 276 seconds] 17:31 < adlai> their "food logging protocol" is cute but... practically useless 17:32 < adlai> basically they namedrop one app, forget to mention that you could just write a few words in a notepad that probably weighs less than the smartphone, and then snapchat a bunch of food and trading signals 17:40 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 256 seconds] 17:42 < JayDugger> Douhet, I didn't say I wouldn't take statins, I said "second-hand anecdotes about 'Why I'll never take statins.'" 17:44 < JayDugger> All of which simplify nicely to "I or an immediate family member had an adverse reaction to statins." 18:42 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: Malvolio] 18:56 < jrayhawk> Hmm. There are some observational studies showing various Apolipoprotein measures are better than LDL-P, but I don't have access to them. 19:02 < kanzure> .tw https://twitter.com/cherenkov_d/status/1000983102603264000 19:02 < yoleaux> Bugs in crypto implementatios by Dan Boneh: https://www.youtube.com/watch?v=Y1Tusw2CWKQ (@cherenkov_d) 19:03 < jrayhawk> Which is to say there's a reasonable likelihood I am simply wrong on LDL-P being good enough. 19:07 -!- Cosmophile [~cosmophil@207.189.2.228] has quit [Read error: Connection reset by peer] 19:09 -!- Cosmophile [~cosmophil@207.189.2.228] has joined ##hplusroadmap 19:12 -!- Cosmophile [~cosmophil@207.189.2.228] has quit [Read error: Connection reset by peer] 19:12 -!- Cosmophile [~cosmophil@207.189.2.228] has joined ##hplusroadmap 19:28 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 19:57 < streety> thanks for following up 20:40 -!- lewl [~lewl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 20:45 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 20:47 -!- lewl_ [~lewl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 20:47 -!- lewl [~lewl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 20:47 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 20:47 -!- lewl_ [~lewl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Client Quit] 20:52 -!- Cosmophile [~cosmophil@207.189.2.228] has quit [Read error: Connection reset by peer] 21:39 -!- jtimon [~quassel@226.110.132.37.dynamic.jazztel.es] has quit [Ping timeout: 265 seconds] 21:45 -!- jtimon [~quassel@226.110.132.37.dynamic.jazztel.es] has joined ##hplusroadmap 22:08 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:71bc:8124:51e3:e6ee] has quit [Quit: Leaving] 22:17 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: sleep] 22:58 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 23:01 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 268 seconds] 23:52 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 23:59 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 256 seconds] --- Log closed Mon Jun 04 00:00:36 2018